公开(公告)号：WO2011048007A9

公开(公告)日：2011-07-07

申请号：PCT/EP2010065450

申请日：2010-10-14

Applicant: BASF PLANT SCIENCE CO GMBH ,  PROKOUDINE ALEXANDRE ,  WALK TILMANN B ,  WIEMER JAN C ,  LOOSER RALF ,  HEROLD MICHAEL MANFRED ,  VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  FABIAN ERIC ,  STRAUSS VOLKER ,  KAMP HENNICKE

Inventor： PROKOUDINE ALEXANDRE ,  WALK TILMANN B ,  WIEMER JAN C ,  LOOSER RALF ,  HEROLD MICHAEL MANFRED ,  VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  FABIAN ERIC ,  STRAUSS VOLKER ,  KAMP HENNICKE

IPC: G06F19/18

CPC classification number: G06F19/18

公开(公告)号：WO2011018288A1

公开(公告)日：2011-02-17

申请号：PCT/EP2010/060086

申请日：2010-07-13

Applicant: BASF SE ,  STRAUSS, Volker ,  KAMP, Hennicke ,  FABIAN, Eric ,  COELHO PALERMO CUNHA, Georgia ,  MELLERT, Werner ,  VAN RAVENZWAAY, Bennard ,  WALK, Tilmann ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar

Inventor： STRAUSS, Volker ,  KAMP, Hennicke ,  FABIAN, Eric ,  COELHO PALERMO CUNHA, Georgia ,  MELLERT, Werner ,  VAN RAVENZWAAY, Bennard ,  WALK, Tilmann ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar

IPC: G01N33/50

CPC classification number: G01N33/6893 ,  G01N2800/046

Abstract: The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses.

Abstract translation: 本发明涉及一种诊断甲状腺疾病的方法。 它还涉及确定化合物是否能够诱导受试者中的甲状腺疾病的方法以及鉴定用于治疗甲状腺疾病的药物的方法。 此外，本发明涉及用于诊断甲状腺疾病和诊断用途的装置。

公开(公告)号：WO2009153136A3

公开(公告)日：2010-03-18

申请号：PCT/EP2009056367

申请日：2009-05-26

Applicant: BASF SE ,  VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  COELHO PALERMO CUNHA GEORGIA ,  FABIAN ERIC ,  STRAUSS VOLKER ,  KAMP HENNICKE ,  WALK TILMANN B ,  LOOSER RALF ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE ,  LEIBOLD EDGAR

Inventor： VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  COELHO PALERMO CUNHA GEORGIA ,  FABIAN ERIC ,  STRAUSS VOLKER ,  KAMP HENNICKE ,  WALK TILMANN B ,  LOOSER RALF ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE ,  LEIBOLD EDGAR

IPC: G01N33/66 ,  G01N33/82 ,  G01N33/84 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N2500/00 ,  G01N2560/00 ,  G01N2800/085 ,  G01N2800/60 ,  Y02A90/26

Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention- pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol,myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (dl8:1, C24:1), Ceramide (dl8:2, C24:0), Sphingomyelin (dl8:1, C16:0), 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, CoenzymeQ9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.

Abstract translation: 本发明涉及化学化合物危险分层的毒理学评估领域。 具体地说，涉及一种诊断肝毒性的方法。 它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏毒性的系统和装置。 最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。 对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。 肝毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯基丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（dl8：1，C24：1） 神经酰胺（dl8：2，C24：0），鞘磷脂（dl8：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖， 甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌氨酸，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

公开(公告)号：WO2013038341A1

公开(公告)日：2013-03-21

申请号：PCT/IB2012/054731

申请日：2012-09-12

Applicant: BASF SE ,  BASF (CHINA) COMPANY LIMITED ,  WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WIEMER, Jan C ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  PROKOUDINE, Alexandre

Inventor： WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WIEMER, Jan C ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  PROKOUDINE, Alexandre

IPC: G01N33/50

CPC classification number: G01N33/53 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/22 ,  G01N2800/60 ,  G01N2800/709

Abstract: A method for diagnosing hematopoietic toxicity comprises: a) determining the amount of at least one biomarker in a test sample of a subject suspected to suffer from hematopoietic toxicity, and b) comparing the amounts determined in step a) to a reference, whereby hematopoietic toxicity is to be diagnosed. A method for determining whether a compound is capable of inducing such hematopoietic toxicity in a subject, a method of identifying a drug for treating hematopoietic toxicity, a device and a kit for diagnosing hematopoietic toxicity are also disclosed.

Abstract translation: 用于诊断造血毒性的方法包括：a）确定疑似患有造血毒性的受试者的测试样品中至少一种生物标志物的量，以及b）将步骤a）中测定的量与参考文献比较，由此造血毒性 被诊断。 还公开了一种用于确定化合物是否能够在受试者中诱导造血毒性的方法，鉴定用于治疗造血毒性的药物的方法，用于诊断造血毒性的装置和试剂盒。

公开(公告)号：WO2013038369A1

公开(公告)日：2013-03-21

申请号：PCT/IB2012/054790

申请日：2012-09-14

Applicant: BASF SE ,  BASF (China) Company Limited ,  KAMP, Hennicke ,  WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WIEMER, Jan C. ,  LOOSER, Ralf ,  HEROLD, Michael, Manfred ,  PROKOUDINE, Alexandre

Inventor： KAMP, Hennicke ,  WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WIEMER, Jan C. ,  LOOSER, Ralf ,  HEROLD, Michael, Manfred ,  PROKOUDINE, Alexandre

IPC: G01N33/53

CPC classification number: G01N33/5014 ,  G01N33/62 ,  G01N33/6893 ,  G01N33/70 ,  G01N33/92 ,  G01N2500/04 ,  G01N2800/347 ,  Y10T436/171538 ,  Y10T436/173845 ,  Y10T436/24

Abstract: The present invention pertains to the field of diagnostics for kidney toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it discloses a method for diagnosing kidney toxicity. It also discloses a method for determining whether a compound is capable of inducing such kidney toxicity in a subject and a method of identifying a drug for treating kidney toxicity. Furthermore, the present invention discloses a device and a kit for diagnosing kidney toxicity.

Abstract translation: 本发明涉及用于化学化合物的危险分层的肾毒性和毒理学评估的诊断领域。 具体地说，它公开了一种诊断肾毒性的方法。 它还公开了一种用于确定化合物是否能够在受试者中诱导这种肾毒性的方法以及鉴定用于治疗肾毒性的药物的方法。 此外，本发明公开了一种用于诊断肾毒性的装置和试剂盒。

公开(公告)号：WO2009153139A3

公开(公告)日：2010-02-18

申请号：PCT/EP2009056386

申请日：2009-05-26

Applicant: BASF SE ,  VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  FABIAN ERIC ,  STRAUSS VOLKER ,  WALK TILMANN B ,  LOOSER RALF ,  LEIBOLD EDGAR ,  KAMP HENNICKE ,  COELHO PALERMO CUNHA GEORGIA ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE

Inventor： VAN RAVENZWAAY BENNARD ,  MELLERT WERNER ,  FABIAN ERIC ,  STRAUSS VOLKER ,  WALK TILMANN B ,  LOOSER RALF ,  LEIBOLD EDGAR ,  KAMP HENNICKE ,  COELHO PALERMO CUNHA GEORGIA ,  HEROLD MICHAEL MANFRED ,  WIEMER JAN C ,  PROKOUDINE ALEXANDRE

IPC: G01N33/92 ,  G01N33/68 ,  G01N33/82 ,  G01N33/84

CPC classification number: G01N33/487 ,  G01N33/50 ,  G01N33/68 ,  G01N33/6812 ,  G01N33/82 ,  G01N33/92 ,  G01N2405/00 ,  G01N2500/00 ,  G01N2800/046 ,  G01N2800/10 ,  G01N2800/24 ,  G01N2800/60 ,  H01J49/0036 ,  Y10T436/200833 ,  Y10T436/24

Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects.

Abstract translation: 本发明涉及化学化合物危险分层的毒理学评估领域。 具体而言，涉及用于（i）诊断，（ii）确定化合物是否能够诱导，（iii）鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断的系统和装置。 最后，本发明涉及一组代谢物或装置用于制造诊断装置或组合物的用途。 代谢组胺的代谢物标记选自：辅酶Q10,16-甲基十七烷酸，17-甲基十八烷酸，二十碳三烯酸（C20：3），苏氨酸，脯氨酸，酪氨酸，反式-4-羟基丙酸，泛酸，辅酶Q9，甘油 ，棕榈酸（C16：0），Lmoleic acid（C18：顺式（9,12）2），14-甲基十六烷酸，γ-亚油酸（C18：顺式（6,9,12）3），苏氨酸， ，磷脂酰胆碱（C18：0 / C22：6）。 男性和女性受试者提出了不同的多标记组合。

公开(公告)号：WO2009153139A2

公开(公告)日：2009-12-23

申请号：PCT/EP2009/056386

申请日：2009-05-26

Applicant: BASF SE ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WALK, Tilmann, B. ,  LOOSER, Ralf ,  LEIBOLD, Edgar ,  KAMP, Hennicke ,  COELHO PALERMO CUNHA, Georgia ,  HEROLD, Michael, Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre

Inventor： VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WALK, Tilmann, B. ,  LOOSER, Ralf ,  LEIBOLD, Edgar ,  KAMP, Hennicke ,  COELHO PALERMO CUNHA, Georgia ,  HEROLD, Michael, Manfred ,  WIEMER, Jan, C. ,  PROKOUDINE, Alexandre

IPC: G01N33/68 ,  G01N33/82 ,  G01N33/92 ,  G01N33/84

CPC classification number: G01N33/487 ,  G01N33/50 ,  G01N33/68 ,  G01N33/6812 ,  G01N33/82 ,  G01N33/92 ,  G01N2405/00 ,  G01N2500/00 ,  G01N2800/046 ,  G01N2800/10 ,  G01N2800/24 ,  G01N2800/60 ,  H01J49/0036 ,  Y10T436/200833 ,  Y10T436/24

Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.

Abstract translation: 本发明涉及化学化合物危险分层的毒理学评估领域。 具体而言，涉及诊断增加的过氧化物酶体增殖的方法。 它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。 最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

公开(公告)号：WO2013038371A1

公开(公告)日：2013-03-21

申请号：PCT/IB2012/054799

申请日：2012-09-14

Applicant: BASF SE ,  BASF (China) Company Limited ,  WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WIEMER, Jan C ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  PROKOUDINE, Alexandre

Inventor： WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WIEMER, Jan C ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  PROKOUDINE, Alexandre

IPC: G01N33/49 ,  G01N33/68 ,  G01N33/70 ,  G01N33/92 ,  G01N33/74 ,  G01N33/64

CPC classification number: G01N33/52 ,  G01N33/574 ,  G01N33/689 ,  G01N2500/04 ,  G01N2800/36 ,  H01J49/26

Abstract: The present invention pertains to the field of diagnostics for gonadal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing gonadal toxicity. It also relates to a method for determining whether a compound is capable of inducing such gonadal toxicity in a subject and to a method of identifying a drug for treating gonadal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing gonadal toxicity.

Abstract translation: 本发明涉及化学化合物危险分层的性腺毒性和毒理学评估的诊断领域。 具体地说，它涉及一种用于诊断性腺毒性的方法。 它还涉及一种用于确定化合物是否能够在受试者中诱导这种性腺毒性的方法以及鉴定用于治疗性腺毒性的药物的方法。 此外，本发明涉及用于诊断性腺毒性的装置和试剂盒。

公开(公告)号：WO2011048007A2

公开(公告)日：2011-04-28

申请号：PCT/EP2010/065450

申请日：2010-10-14

Applicant: BASF PLANT SCIENCE COMPANY GMBH ,  PROKOUDINE, Alexandre ,  WALK, Tilmann, B. ,  WIEMER, Jan, C. ,  LOOSER, Ralf ,  HEROLD, Michael, Manfred ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke

Inventor： PROKOUDINE, Alexandre ,  WALK, Tilmann, B. ,  WIEMER, Jan, C. ,  LOOSER, Ralf ,  HEROLD, Michael, Manfred ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke

IPC: G06F19/18

CPC classification number: G06F19/18

Abstract: Die vorliegende Erfindung betrifft Verfahren zur Auswertung von Biomarkern. Insbesondere betrifft die Erfindung ein Verfahren zur Erstellung mindestens eines Patterns für mindestens einen vorgegebenen Effektor mit mindestens einer bestimmbaren Wirkung auf ein biologisches System, ein Verfahren zur Erstellung einer Effektorenklasse zu einer vorgegebenen Wirkung oder Gruppe von Wirkungen, ein Verfahren zur Erstellung einer Effektorenklasse zu einer vorgegebenen Wirkung oder Gruppe von Wirkungen und ein Verfahren zur Identifikation mindestens einer Wirkung eines vorgegebenen Effektors sowie ein Computerprogramm und einen Computer, die zur Durchführung dieser Verfahren eingerichtet sind.

Abstract translation: 本发明涉及一种用于生物标志物的分析方法。 特别地，本发明涉及一种用于至少与生物系统，用于创建Effektorenklasse到预定动作的方法在至少一个可确定的效果的预定执行创建至少一个图案或一组操作，用于创建Effektorenklasse到预定的方法 效果或效果集和用于识别一个给定执行器的至少一个效果和一种计算机程序和其适合用于执行这些方法的计算机的方法。

公开(公告)号：WO2009153136A2

公开(公告)日：2009-12-23

申请号：PCT/EP2009/056367

申请日：2009-05-26

Applicant: BASF SE ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  COELHO PALERMO CUNHA, Georgia ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WALK, Tilmann B. ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar

Inventor： VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  COELHO PALERMO CUNHA, Georgia ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WALK, Tilmann B. ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar

IPC: G01N33/66 ,  G01N33/68 ,  G01N33/82 ,  G01N33/84 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N2500/00 ,  G01N2560/00 ,  G01N2800/085 ,  G01N2800/60 ,  Y02A90/26

Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject.

Abstract translation: 本发明涉及化学化合物危险分层的毒理学评估领域。 具体地说，涉及一种诊断肝毒性的方法。 它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝毒性的系统和装置。 最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。