公开(公告)号：WO2022094016A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056956

申请日：2021-10-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LEVEILLE, Wade P. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  FOGWILL, Michael O.

IPC: G01N30/60 ,  G01N30/46

Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.

公开(公告)号：WO2021021700A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/043683

申请日：2020-07-27

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MUSACCHIO, Jeffrey ,  KELLEY, Scott

IPC: G01N35/04 ,  G01N35/02 ,  G01N30/24

Abstract: Described is an interface module for robotic loading and unloading of a liquid chromatography sample manager. The module includes a transfer drawer receiving apparatus having a device track and a drawer drive system configured to transport a transfer drawer along the device track into and out from a sample tray of a sample manager. The transfer drawer receives a sample-vial carrier that holds samples to be analyzed. The module further includes a window apparatus that has a window controllable to be in an open state or a closed state. When in the open state, transport of the transfer drawer through the window into or out from the sample manager permits loading of the sample-vial carrier into the sample tray and unloading of the sample-vial carrier from the sample tray. In the closed state, the window apparatus substantially seals the internal environment of the sample manager from the ambient environment.

公开(公告)号：WO2020061041A1

公开(公告)日：2020-03-26

申请号：PCT/US2019/051507

申请日：2019-09-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MUSACCHIO, Jeffrey ,  EGGERTSON, Michael ,  MICHIENZI, Joseph

IPC: G01N30/32 ,  F16H57/04 ,  F16K31/53

Abstract: A liquid chromatography solvent pump includes at least one motor, a first piston, a second piston, and a continuously variable output drive system coupling the at least one motor to at least one of the first and second pistons. The first piston and the second piston are configured to deliver a flow of solvent in a liquid chromatography system.

公开(公告)号：WO2020061025A1

公开(公告)日：2020-03-26

申请号：PCT/US2019/051483

申请日：2019-09-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MUSACCHIO, Jeffrey ,  MICHIENZI, Joseph

IPC: G01N30/32 ,  F16H57/04 ,  F16K31/53

Abstract: Disclosed is a liquid chromatography solvent pump including a motor, a first piston, a second piston, and a variable output drive system coupling the motor to at least one of the first piston and the second piston. The variable output drive system includes a gearbox configured to provide a non-equal ratio between an input from the motor and an output delivered to at least one of the first piston and the second piston. The first piston and the second piston are configured to deliver a flow of solvent in a liquid chromatography system.

公开(公告)号：WO2019224702A2

公开(公告)日：2019-11-28

申请号：PCT/IB2019/054162

申请日：2019-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： GILAR, Martin ,  MCDONALD, Thomas S. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  MUMMA, Rachel ,  FADGEN, Keith ,  GERHARDT, Geoff C.

IPC: G01N30/06 ,  B01D15/38 ,  B01J20/00 ,  G01N30/54 ,  G01N1/40

Abstract: Sample preparation and separation can be performed using a sample cartridge. The cartridge incudes a barrel with a first and second end, a column segment connected to the second end of the barrel, and a column containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.