公开(公告)号：WO2021222055A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/029055

申请日：2021-04-26

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LEVEILLE, Wade P. ,  MICHIENZI, Joseph D. ,  ANTOCCI, Joseph D. ,  MUSACCHIO, Jeffrey

IPC: G01N30/60

Abstract: A clamp assembly includes a rail 62 extending along a length and configured to receive a first fluidic assembly, and a carriage 64 movably attachable to the rail 62 such that the carriage moves along the rail, the carriage 64 configured to receive a second fluidic assembly, the carriage including an actuator 65 and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage 64 relative to the rail 62. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：WO2022094031A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056981

申请日：2021-10-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LEVEILLE, Wade P. ,  CORMIER, Sylvain G. ,  FOGWILL, Michael O. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  ANTOCCI, Joseph D.

IPC: G01N30/60 ,  G01N30/46

Abstract: Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.

公开(公告)号：WO2019200388A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/027499

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： FOGWILL, Michael, O. ,  DEVLIN, Curt ,  DOURDEVILLE, Theodore, A. ,  FAIRCHILD, Jacob, N. ,  GERHARDT, Geoff, C. ,  LEVEILLE, Wade, P. ,  MICHIENZI, Joseph, D. ,  MUSACCHIO, Jeffrey

IPC: G01N30/72 ,  H01J49/16

Abstract: Techniques and apparatus for ion source devices with minimized post- column volumes are described. In one embodiment, for example, an ion source assembly (330) may include a chromatography column (334) in fluid communication with an ion source device (336), the chromatography column (334) arranged within a minimum distance of the ion source (336), the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：WO2019224702A3

公开(公告)日：2019-11-28

申请号：PCT/IB2019/054162

申请日：2019-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： GILAR, Martin ,  MCDONALD, Thomas S. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  MUMMA, Rachel ,  FADGEN, Keith ,  GERHARDT, Geoff C.

IPC: G01N30/06 ,  B01D15/38 ,  B01J20/00 ,  G01N30/54 ,  G01N1/40 ,  G01N30/60 ,  G01N30/00 ,  G01N30/88

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：WO2019224701A1

公开(公告)日：2019-11-28

申请号：PCT/IB2019/054161

申请日：2019-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： GILAR, Martin ,  MCDONALD, Thomas S. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  MUMMA, Rachel ,  FADGEN, Keith ,  GERHARDT, Geoff C.

IPC: G01N1/40 ,  G01N30/06 ,  G01N30/60 ,  G01N30/00

Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.

公开(公告)号：WO2021149003A1

公开(公告)日：2021-07-29

申请号：PCT/IB2021/050501

申请日：2021-01-22

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LEVEILLE, Wade P. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  JONES, Emrys ,  PRINGLE, Steven Derek ,  HATTAN, Stephen Joseph ,  ROMAN, Gregory T.

IPC: H01J49/14 ,  H01J49/16 ,  B05B12/32 ,  B05B5/03 ,  H01J49/142 ,  H01J49/167

Abstract: A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.

公开(公告)号：WO2021087212A1

公开(公告)日：2021-05-06

申请号：PCT/US2020/058129

申请日：2020-10-30

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： BASILE, Mark J. ,  MUSACCHIO, Jeffrey ,  FOGWILL, Michael O. ,  BESNER, Sebastien ,  MICHIENZI, Joseph D. ,  LEVEILLE, Wade P.

IPC: G01N30/30 ,  G01N30/74 ,  G01N30/62 ,  G01N21/03 ,  G01N21/05

Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.

公开(公告)号：WO2021021780A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/043826

申请日：2020-07-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MUSACCHIO, Jeffrey

IPC: F16G13/20

Abstract: Described is a chain including a plurality of links pivotally connected to each other such that the chain is configured to bend in one direction without back-bending. Each of the plurality of links including a link body include: an inner side facing a bending direction of the chain; an outer side facing opposite the bending direction of the chain; a back-bending prevention portion; a post feature extending laterally across the link body, and a connection feature configured to engage with the post feature of the first other of the pivotally connected plurality of links to create one direction pivotal attachment without back-bending between the links. Further disclosed is a chain system and methods of moving devices with a chain or chain system.

公开(公告)号：WO2021021702A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/043685

申请日：2020-07-27

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MUSACCHIO, Jeffrey

IPC: G01N35/04 ,  G01N35/02 ,  G01N30/24 ,  G01N35/00

Abstract: Described is a method for loading a sample-vial carrier into a sample manager of a liquid chromatography system. The method includes placing a sample-vial carrier onto a transfer drawer having first and second drawer magnets. The transfer drawer is transported into a sample tray of a sample manager using a drawer drive system of a transfer drawer receiving apparatus. The drawer drive system has a drive magnet that is engaged with the first drawer magnet during transport. The transport of the transfer drawer is terminated when the second drawer magnet is engaged with a sample tray magnet on the sample tray. The sample tray is rotated about an axis substantially perpendicular to a direction of transport of the transfer drawer to provide a shear force to disengage the first drawer magnet from the drive magnet.

公开(公告)号：WO2018031443A1

公开(公告)日：2018-02-15

申请号：PCT/US2017/045687

申请日：2017-08-07

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MUSACCHIO, Jeffrey ,  MICHIENZI, Joseph D. ,  FADGEN, Keith

IPC: F16K15/12 ,  F16K1/12 ,  F16K1/46 ,  F16K15/00 ,  F16K15/02 ,  F16K15/10 ,  F16K15/08

Abstract: A check valve includes a first valve body having a chamber in which second and third valve bodies are located. The check valve also includes a spring-energized seal disposed in the chamber. The spring-energized seal includes a compliant seal body having an annular shape and a resilient member, such as a cantered spring or O-ring, disposed in a pocket of the seal body. The resilient member applies a force to portions of the seal body to prevent the passage of fluid from a valve inlet port to a valve outlet port unless the differential fluid exceeds the cracking pressure of the check valve.

Abstract translation: 止回阀包括具有腔室的第一阀体，第二阀体和第三阀体位于该腔室中。 止回阀还包括设置在腔室中的弹簧加压密封件。 弹簧加压密封件包括具有环形形状的柔性密封体和设置在密封体的口袋中的弹性构件，诸如带刻度的弹簧或O形环。 弹性构件对密封体的部分施加力，以防止流体从阀入口端口流向阀出口端口，除非差动流体超过止回阀的开启压力。