公开(公告)号：WO2019224702A2

公开(公告)日：2019-11-28

申请号：PCT/IB2019/054162

申请日：2019-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： GILAR, Martin ,  MCDONALD, Thomas S. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  MUMMA, Rachel ,  FADGEN, Keith ,  GERHARDT, Geoff C.

IPC: G01N30/06 ,  B01D15/38 ,  B01J20/00 ,  G01N30/54 ,  G01N1/40

Abstract: Sample preparation and separation can be performed using a sample cartridge. The cartridge incudes a barrel with a first and second end, a column segment connected to the second end of the barrel, and a column containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：WO2019224702A3

公开(公告)日：2019-11-28

申请号：PCT/IB2019/054162

申请日：2019-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： GILAR, Martin ,  MCDONALD, Thomas S. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  MUMMA, Rachel ,  FADGEN, Keith ,  GERHARDT, Geoff C.

IPC: G01N30/06 ,  B01D15/38 ,  B01J20/00 ,  G01N30/54 ,  G01N1/40 ,  G01N30/60 ,  G01N30/00 ,  G01N30/88

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：WO2019224701A1

公开(公告)日：2019-11-28

申请号：PCT/IB2019/054161

申请日：2019-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： GILAR, Martin ,  MCDONALD, Thomas S. ,  MICHIENZI, Joseph D. ,  MUSACCHIO, Jeffrey ,  MUMMA, Rachel ,  FADGEN, Keith ,  GERHARDT, Geoff C.

IPC: G01N1/40 ,  G01N30/06 ,  G01N30/60 ,  G01N30/00

Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.