公开(公告)号：WO2017013411A1

公开(公告)日：2017-01-26

申请号：PCT/GB2016/052157

申请日：2016-07-15

Applicant: MEDESCIA LIMITED

Inventor： AHMADI, Farhana Hassan Mohammad Kazem ,  WAGSTAFF, Steve ,  WHITE, Neil, Stephen ,  SMITH, Stephen, Robin ,  MASON, Jonathan, Edward ,  WOZNIAK, Maximiliam, Vincent ,  STROHMEIER, Martin, Georg

IPC: A61M5/32 ,  B09B3/00

CPC classification number: A61M5/3278 ,  A61M2005/328 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/8206 ,  B09B3/005 ,  B09B3/0075

Abstract: The present invention relates to an improvement to the treatment of needles for safe disposal. The device (300) comprises a support member (303) having at least one recess (304). Each said at least one recess is configured to receive a needle contained in a corresponding plastic needle cap. The device further comprises a heating element configured to heat the support member, such that the plastic material of the needle cap softens and flows to encapsulate the corresponding needle. Each said at least one recess has dimensions such that, after heating, the needle is fully encapsulated by the plastic material of the corresponding needle cap. A corresponding method is disclosed.

Abstract translation: 本发明涉及对针头进行安全处置的改进。 装置（300）包括具有至少一个凹部（304）的支撑构件（303）。 每个所述至少一个凹部被配置为接收容纳在相应的塑料针帽中的针。 该装置还包括被配置为加热支撑构件的加热元件，使得针帽的塑料材料软化并流动以封装相应的针。 每个所述至少一个凹部具有这样的尺寸，使得在加热之后，针被相应针帽的塑料材料完全包封。 公开了相应的方法。

公开(公告)号：WO2014100526A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/076773

申请日：2013-12-20

Applicant: ARCHER DANIELS MIDLAND COMPANY ,  INSTITUTE OF CELL BIOLOGY

Inventor： SEMKIV, Marta ,  DMYTRUK, Kostyantyn ,  SIBIRNY, Andriy, A. ,  ABBAS, Charles

IPC: C12N15/00 ,  C12P7/10 ,  C12P7/06 ,  C12P19/34

CPC classification number: C12P7/06 ,  C12N9/16 ,  C12Y301/03001 ,  Y02E50/16 ,  Y02E50/17

Abstract: Described herein is a method to increase ethanol yield during alcoholic fermentation by expression a truncated versions of the Saccharomyces cerevisiae PHO8 gene coding for vacuolar or cytosolic form of alkaline phosphatase, which expression lowers biomass accumulation while diverting greater carbon to ethanol production. Also described are as nucleic acid sequences and vectors for expression of the PHO8 gene and strains carrying the same. Strains containing intact PHO8 gene encoding vacuolar form of alkaline phosphatase, had slightly lower intracellular ATP levels with insignificant changes in biomass accumulation and up to 13% increase in ethanol production.

Abstract translation: 本文描述了通过表达编码嗜碱性磷酸酶的液泡或胞质形式的酿酒酵母PHO8基因的截短形式来提高酒精发酵期间乙醇产量的方法，其表达降低了生物质积累，同时将更大的碳转移到乙醇生产中。 还描述了用于表达PHO8基因的核酸序列和载体以及携带相同载体的载体。 含有编码液泡形式碱性磷酸酶的完整PHO8基因的菌株细胞内ATP含量稍低，生物量积累变化不大，乙醇产量增加高达13％。

公开(公告)号：WO2013012589A1

公开(公告)日：2013-01-24

申请号：PCT/US2012/045933

申请日：2012-07-09

Applicant: ARCHER DANIELS MIDLAND COMPANY ,  MA, Chi-cheng ,  WERPY, Todd

Inventor： MA, Chi-cheng ,  WERPY, Todd

IPC: C12P7/64

CPC classification number: C07C51/493 ,  C07C29/149 ,  C07C51/412 ,  C07C51/42 ,  C07D207/267 ,  C07D307/33 ,  C12P7/46 ,  C07C55/02 ,  C07C57/15 ,  C07C59/245 ,  C07C55/10

Abstract: Methods for forming ammonium salts of C4 diacids in a fermentation process with removal of divalent metal carbonate salts are disclosed. The pH of fermentation broths for production of C4 diacids is controlled by adding alkaline oxygen containing calcium or magnesium compounds, which forms divalent metal salts of the diacids. The divalent metal salts of the diacids are substituted with ammonium by introduction of ammonium salts at elevated temperature and pressure forming soluble ammonium salts thereof. C02 or bicarbonate is simultaneously added to the fermentation media at the elevated temperature and pressure. Reducing the temperature and pressure forms insoluble divalent metal carbonate salts that are separated from the solubilized ammonium diacid salts. The recovered carbonate salts can be recycled as pH control matelials in subsequent fermentations. The solubilized ammonium diacid salts may form the derivatives N-methyl-2-pyrrolidone (NMP) gamma-butyrolactone (GBL) and 1,4-butane-diol (BDO) in single pot reactions.

Abstract translation: 公开了在除去二价金属碳酸盐的发酵过程中形成C4二酸铵盐的方法。 用于生产C4二酸的发酵液的pH值通过加入形成二酸的二价金属盐的含钙或镁化合物的碱性氧来控制。 二元酸的二价金属盐通过在升高的温度下引入铵盐和压力形成其可溶性铵盐而被铵取代。 在升高的温度和压力下，将CO 2或碳酸氢盐同时加入到发酵培养基中。 降低温度和压力形成不溶性二价金属碳酸盐，其与可溶性二铵酸盐分离。 回收的碳酸盐可以在随后的发酵中作为pH控制物质再循环。 可溶性二铵酸盐可在单锅反应中形成N-甲基-2-吡咯烷酮（NMP）γ-丁内酯（GBL）和1,4-丁烷二醇（BDO）的衍生物。

公开(公告)号：WO2012143702A1

公开(公告)日：2012-10-26

申请号：PCT/GB2012/050824

申请日：2012-04-13

Applicant: UCL BUSINESS PLC ,  KIRKBY, Paul, A ,  NADELLA, K. M. Naga Srinivas ,  SILVER, R. Angus

Inventor： KIRKBY, Paul, A ,  NADELLA, K. M. Naga Srinivas ,  SILVER, R. Angus

IPC: G02F1/33 ,  G02B21/00

CPC classification number: G02F1/33 ,  G02B21/0024 ,  G02F1/11 ,  G02F1/113 ,  G02F1/332 ,  G02F2201/16 ,  G02F2203/28

Abstract: The invention is directed to an acousto-optic lens (AOL) and corresponding method. The AOL of the invention comprises a first and second acousto-optic deflector, each being arranged to support a respective acoustic wave. The AOL includes a driver for synthesizing first and second drive signals for the respective first and second acousto-optic deflectors. The driver is arranged to synthesize the drive signals so as to be phase-modulated by functions that can be expressed as a Taylor series having one or more coefficients greater than second order. The functions are preferably non-sinusoidal and have sufficient magnitude at the higher orders to effect one or more of fixed aberration correction, dynamic aberration correction and Z-scanning.

Abstract translation: 本发明涉及一种声光透镜（AOL）和相应的方法。 本发明的AOL包括第一和第二声光偏转器，每个声光偏转器被布置成支撑相应的声波。 AOL包括用于合成用于相应的第一和第二声光偏转器的第一和第二驱动信号的驱动器。 驱动器被布置为合成驱动信号，以便通过可以表示为具有大于二阶的一个或多个系数的泰勒级数的函数进行相位调制。 这些功能优选地是非正弦的，并且在较高阶上具有足够的量值以实现固定像差校正，动态像差校正和Z扫描中的一个或多个。

公开(公告)号：WO2012082665A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/064513

申请日：2011-12-13

Applicant: ARCHER DANIELS MIDLAND COMPANY ,  HOWARD, Stephen J. ,  SANBORN, Alexandra J.

Inventor： HOWARD, Stephen J. ,  SANBORN, Alexandra J.

IPC: C07D307/02

CPC classification number: C07D307/12 ,  C07D307/14 ,  C07D307/42 ,  C07D307/44 ,  C07D307/52

Abstract: Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H 2 , an acid catalyst and hydrogenation catalyst in the presence of an alkylamide solvent. The hydrogenation catalyst is a heterogeneous catalyst comprising a metal selected from the group consisting of Pt, Pd, and nickel. The acid catalysts may be homogeneous mineral acid or a heterogeneous acid catalyst on substrate. In a preferred practice the two catalysts are provided on a common heterogeneous bifunctional support. Using similar combinations of acid and hydrogenation catalysts, there is also described single step methods for making furandimethanol by simultaneously contacting a hexose with the two separate catalysts in the presence of H 2 in an aprotic solvent, such as dimethylformamide. With the same catalyst system and similar reaction conditions, 2, 5 furan dialkylethers can also be made in a single step when the solvent includes an ROH alcohol.

Abstract translation: 本文描述了通过在烷基酰胺溶剂存在下，通过糖与H 2，酸催化剂和氢化催化剂的同时接触来制备呋喃和四氢呋喃的各种类型的烷基胺衍生物的单步方法。 氢化催化剂是包含选自Pt，Pd和镍的金属的多相催化剂。 酸催化剂可以是均匀的无机酸或基质上的多相酸催化剂。 在优选的实践中，两种催化剂提供在共同的异质双功能载体上。 使用酸和氢化催化剂的类似组合，还描述了通过在非质子溶剂如二甲基甲酰胺中在H 2存在下同时使己糖与两种分离的催化剂接触来制备呋喃二甲醇的单步方法。 在相同的催化剂体系和类似的反应条件下，当溶剂包括ROH醇时，也可以在一个步骤中制备2,5-呋喃二烷基醚。

公开(公告)号：WO2012031320A1

公开(公告)日：2012-03-15

申请号：PCT/AU2011/001148

申请日：2011-09-06

Applicant: PETER MACCALLUM CANCER INSTITUTE ,  STAGG, John ,  SMYTH, Mark, John ,  LOI, Sherene

Inventor： STAGG, John ,  SMYTH, Mark, John ,  LOI, Sherene

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N33/57484 ,  G01N2333/70596 ,  G01N2800/52 ,  G01N2800/54

Abstract: CD73 may be used as a prognostic marker to detect the recurrence of triple negative breast cancer in patients who have undergone a cancer therapy, in particular a chemotherapy based treatment. There is provided a method for diagnosing or predicting the recurrence of triple negative breast cancer in a subject who has undergone a cancer therapy, the method the comprising (i) obtaining a triple negative breast cancer cell sample from the subject; and (ii) detecting CD73 activity or expression in a cell of the sample, wherein increased activity or expression of CD73 in the cell, when compared to a normal breast tissue cell, indicates that the subject has or is at risk of developing recurrent triple negative breast cancer. There is also provided a method for predicting the efficacy of a triple negative breast cancer therapy in a subject comprising: (i) administering a cancer therapy to the subject; (ii) obtaining a triple negative breast cancer cell sample from the subject; and (iii) detecting CD73 activity or expression in a cell of the sample, wherein decreased activity or expression of CD73 in the triple negative breast cancer cell, when compared to a triple negative breast cancer cell of the same type prior to therapy, indicates that the therapy is efficacious.

Abstract translation: 可以将CD73用作预后标记物，以检测经历了癌症治疗的患者中三重阴性乳腺癌的复发，特别是基于化学疗法的治疗。 提供了一种用于诊断或预测经历了癌症治疗的受试者中三重阴性乳腺癌复发的方法，所述方法包括（i）从受试者获得三阴性乳腺癌细胞样品; 和（ii）检测样品细胞中的CD73活性或表达，其中当与正常乳腺组织细胞相比时细胞中CD73的活性或表达增加表明该受试者具有或具有发展复发性三重阴性的风险 乳腺癌。 还提供了一种用于预测受试者中三重阴性乳腺癌治疗的功效的方法，包括：（i）向受试者施用癌症治疗; （ii）从受试者获得三阴性乳腺癌细胞样品; 和（iii）当与治疗前相同类型的三阴性乳腺癌细胞相比时，检测样品细胞中的CD73活性或表达，其中三阴性乳腺癌细胞中CD73的活性或表达降低表明， 治疗有效。

公开(公告)号：WO2012003550A1

公开(公告)日：2012-01-12

申请号：PCT/AU2011/000868

申请日：2011-07-08

Applicant: ST. VINCENT'S HOSPITAL (MELBOURNE) LIMITED ,  DIXON, Barry ,  STODDART, Paul, Randall

Inventor： DIXON, Barry ,  STODDART, Paul, Randall

IPC: A61B5/145

CPC classification number: A61B5/14551 ,  A61B5/0261 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6817 ,  A61B5/7246

Abstract: A method for non-invasive determination of oxygen saturation of blood within a deep vascular structure of a human or animal patient comprising locating on skin of the patient in a vicinity of the deep vascular structure of interest emitter and receiver elements of a light oximeter device, wherein optimal location of said elements is achieved through matching of a plethysmography trace obtained from the oximeter device to known plethysmography characteristics of the deep vascular structure of interest, wherein the emitter element emits light at wavelengths of from about 1045nm to about 1055nm and from about 1085nm to about 1095nm, and wherein oxygen saturation is determined from a ratio of light absorbed at these two wavelengths by haemoglobin in blood within the vascular structure of interest.

Abstract translation: 一种用于非侵入性地确定人或动物患者深部血管结构内的血液氧饱和度的方法，包括在所述感兴趣的深血管结构发射器和轻度血液计装置的受体元件附近位于患者的皮肤上， 其中所述元件的最佳位置通过将从所述血氧计装置获得的体积描记图与匹配感兴趣的深血管结构的已知体积描记图特征的匹配来实现，其中所述发射体元件发射波长约1045nm至约1055nm和约1085nm的光 至约1095nm，并且其中氧饱和度由在感兴趣的血管结构内的血液中的血红蛋白在这两个波长处吸收的光的比率确定。

公开(公告)号：WO2011017768A1

公开(公告)日：2011-02-17

申请号：PCT/AU2010/001036

申请日：2010-08-13

Applicant: WATER HARVESTING TECHNOLOGIES PTY LTD AUSTRALIA ,  MCCARTHY, David, Thomas ,  DELETIC, Ana ,  FLETCHER, Timothy, David

Inventor： MCCARTHY, David, Thomas ,  DELETIC, Ana ,  FLETCHER, Timothy, David

IPC: C02F9/00 ,  B01D39/00 ,  C02F1/28 ,  B01D15/00 ,  B01J20/00 ,  C02F1/42 ,  B01D24/02 ,  C01B31/08

CPC classification number: C02F1/288 ,  B01D39/06 ,  B01D39/2058 ,  B01D2239/0485 ,  B01J20/18 ,  B01J20/20 ,  B01J20/3204 ,  B01J20/3236 ,  B01J2220/42 ,  C02F1/281 ,  C02F1/283 ,  C02F1/66 ,  C02F1/688 ,  C02F1/76 ,  C02F2101/105 ,  C02F2101/16 ,  C02F2101/20 ,  C02F2101/32 ,  C02F2103/001 ,  C02F2303/04 ,  C02F2303/24

Abstract: In one embodiment the invention relates to a filter media for removal of contaminants from water comprising aluminium coated granular activated carbon and granular zeolite. Another embodiment relates to a method of producing aluminium coated granular activated carbon comprising exposing granular activated carbon to an aqueous solution comprising one or more aluminium salts which is acidified to a pH of between about 5 and about 6.8, removing the aqueous solution and washing and drying the aluminium coated granular activated carbon that is produced. Further embodiments relate to: a filter system for removal of contaminants from water comprising (i) a middle zone comprising granular activated carbon and granular zeolite and (ii) a lower barrier zone comprising screening material, wherein the system allows a flow rate of water there through of from about 0.5Lsec-1m -2 to about 10Lsec -1 m -2 ; a cartridge containing the filter system and related methods of removing contaminants from water.

Abstract translation: 在一个实施方案中，本发明涉及一种用于从水中除去污染物的过滤介质，包括涂覆铝的颗粒活性炭和颗粒沸石。 另一个实施方案涉及一种生产铝包覆的粒状活性炭的方法，其包括将颗粒状活性炭暴露于含有一种或多种酸化至约5至约6.8的pH的铝盐的水溶液中，除去水溶液并洗涤和干燥 生产的铝涂层颗粒状活性炭。 另外的实施方案涉及：用于从水中除去污染物的过滤系统，其包括（i）包含颗粒活性炭和颗粒沸石的中间区域和（ii）包含筛选材料的下部阻挡区域，其中该系统允许水的流速在那里 通过约0.5Lsec-1m-2至约10Lsec-1m-2; 含有过滤系统的墨盒和从水中去除污染物的相关方法。

公开(公告)号：WO2010060151A1

公开(公告)日：2010-06-03

申请号：PCT/AU2009/001552

申请日：2009-11-27

Applicant: HOWARD FLOREY INSTITUTE ,  PETROU, Steven ,  THOMAS, Evan, Alexander

Inventor： PETROU, Steven ,  THOMAS, Evan, Alexander

IPC: G01N33/483 ,  C12M1/34 ,  G01N27/00

CPC classification number: G01N33/48728

Abstract: This invention relates to a method of assaying a compound for its ability to modulate an ion channel or receptor type, the method comprising: a) providing a dynamic clamp in electrical contact with a biological cell (or part thereof) in which one or more ion channel or receptor types for providing a waveform are functional and in which one or more ion channel or receptor types for providing a waveform are either not present or not functional; b) causing the dynamic clamp to apply a signal simulating the function of at least one of the one or more ion channel or receptor types that are either not present or not functional in the biological cell (or part thereof) based on modulation of the ion channel or receptor types that are functional in the biological cell (or part thereof) to thereby provide the waveform at the biological cell (or part thereof); c) exposing at least one of the one or more functional ion channel or receptor types to a compound; and d) detecting modulation of the waveform at the biological cell (or part thereof), wherein modulation of the waveform is indicative of a compound that modulates the at least one functional ion channel or receptor types.

Abstract translation: 本发明涉及测定化合物调节离子通道或受体类型的能力的方法，所述方法包括：a）提供与生物细胞（或其部分）电接触的动态夹具，其中一个或多个离子 用于提供波形的通道或受体类型是功能性的，其中用于提供波形的一种或多种离子通道或受体类型不存在或不起作用; b）使得动态钳位器基于离子的调制施加模拟在生物细胞（或其部分）中不存在或不起作用的一种或多种离子通道或受体类型中的至少一种的功能的信号 通道或受体类型，其在生物细胞（或其部分）中起作用，从而在生物细胞（或其部分）处提供波形; c）将一种或多种功能性离子通道或受体类型中的至少一种暴露于化合物; 以及d）检测所述生物细胞（或其部分）处的波形的调制，其中所述波形的调制指示调节所述至少一种功能性离子通道或受体类型的化合物。

公开(公告)号：WO2009143571A1

公开(公告)日：2009-12-03

申请号：PCT/AU2009/000663

申请日：2009-05-27

Applicant: BIOTA SCIENTIFIC MANAGEMENT PTY LTD ,  RYAN, Jane ,  BUTT, Margaret Anne

Inventor： RYAN, Jane ,  BUTT, Margaret Anne

IPC: C07D413/14 ,  A61K31/423 ,  A61K31/50 ,  A61K31/444 ,  A61P31/16

CPC classification number: C07D413/14 ,  A61K31/501 ,  A61K45/06 ,  Y02A50/463 ,  Y02A50/465

Abstract: This invention relates to antiviral agents, in particular to salts useful in the treatment of infections caused by Picornaviridae, such as human rhinovirus (HRV) and methods for their preparation. The invention also relates to the use of these salts in the treatment of picornavirus infections. The salts of this invention are especially suitable for use in the treatment of HRV, however it is to be understood that the invention is also applicable to other viruses of the picornavirus family.

Abstract translation: 本发明涉及抗病毒剂，特别涉及可用于治疗由微小核糖核酸病毒（例如人鼻病毒（HRV））引起的感染的盐及其制备方法。 本发明还涉及这些盐在治疗小RNA病毒感染中的用途。 本发明的盐特别适用于治疗HRV，但是应当理解本发明也适用于小RNA病毒家族的其他病毒。