SURGICAL MICROSCOPE SYSTEM
    1.
    发明申请

    公开(公告)号:WO2023086565A1

    公开(公告)日:2023-05-19

    申请号:PCT/US2022/049696

    申请日:2022-11-11

    摘要: A surgical microscope system having a head unit microscope assembly and a foot control assembly in operative communication with the head unit microscope assembly. The head unit microscope assembly being configured to selectively couple to a floor stand assembly such that the head unit microscope assembly can be positioned in a desired operative location by the user. The head unit microscope assembly including one or more of: a mounting adaptor, an XY directional stage, a tilt drive, a focus drive; a microscope subassembly, and/or an illumination system.

    手術顕微鏡用光学素子およびその製造方法、医療用光学機器

    公开(公告)号:WO2023062932A1

    公开(公告)日:2023-04-20

    申请号:PCT/JP2022/030836

    申请日:2022-08-12

    摘要: 【課題】防曇性、抗菌性、オートクレーブ処理に対する耐久性を併せ持つ手術顕微鏡用光学素子を提供する。 【解決手段】基板と、前記基板上に設けられた反射防止膜と、前記反射防止膜上に設けられたアクリルポリマーを含有する防汚コート層からなる手術顕微鏡用光学素子であって、前記防汚コート層表面の末端炭素のC-H結合が、燃焼化学気相蒸着法によりC-OSi(OH)3に置換されている手術顕微鏡用光学素子。反射防止膜上にアクリル基を有するアルコキシシランを含む溶液を塗布して防汚コート層を形成し、シラン系ガスを用いた燃焼化学気相蒸着法により前記防汚コート層表面の末端炭素のC-H結合をC-OSi(OH)3に置換する手術顕微鏡用光学素子の製造方法。

    総合倍率を利用した制御が可能な顕微鏡補助装置、顕微鏡補助装置の制御方法およびプログラム

    公开(公告)号:WO2023047927A1

    公开(公告)日:2023-03-30

    申请号:PCT/JP2022/033237

    申请日:2022-09-05

    IPC分类号: G02B21/00 G02B21/26

    摘要: 【課題】顕微鏡を用いて観察される対象物をカメラで撮像する際に、対象物に対する総合倍率を迅速に取得可能にし、総合倍率を利用した制御が可能な顕微鏡補助装置、顕微鏡補助装置の制御方法およびプログラムを提供する。 【解決手段】顕微鏡補助装置110は、顕微鏡100の視野内で対象物103を操作する操作手段10を移動させる操作手段稼動部1と、視野内の画像を取得する画像処理回路2dと、操作手段稼動部1を制御する制御部2とを備える。画像処理回路2dは、操作手段稼動部1で操作手段10を対物レンズ201の光軸方向以外の方向に移動させた際、その移動前の第1画像と移動後の第2画像とを取得する。制御部2は、第1画像での操作手段10の位置と、第2画像での操作手段10の位置と、移動時の操作手段10の移動量とに基づいて、対象物103をカメラ106で撮像する際の倍率としての総合倍率Mを取得する。

    METHOD AND SYSTEM FOR MEASURING POLARIZATION AND ANISOTROPY OF FLUOROPHORES

    公开(公告)号:WO2023022647A1

    公开(公告)日:2023-02-23

    申请号:PCT/SE2022/050757

    申请日:2022-08-18

    IPC分类号: G01N21/64 G02B21/00 G02B21/16

    摘要: A method for measuring polarization and anisotropy of fluorophores comprises activating (S2) reversibly switchable fluorophores in a sample. The activating comprises applying (S20) of a first activation light pulse of a wavelength suitable for switching the reversibly switchable fluorophores into a long-lived photo-selected state. Polarization and anisotropy of the reversibly switchable fluorophores in the long-lived photo-selected state are read out (S4). The reading out in turn comprises applying (S40) of a read-out light pulse and detecting (S45) emission from the reversibly switchable fluorescent proteins. The first activation light pulse or the read-out light pulse comprises non- polarized light or circularly polarized light. The other one of the first activation light pulse and the read-out light pulse comprises linearly polarized light. A system for measuring polarization and anisotropy of fluorophores is also disclosed.

    显微成像装置及其光照芯片、成像方法、电子设备和介质

    公开(公告)号:WO2023019400A1

    公开(公告)日:2023-02-23

    申请号:PCT/CN2021/112816

    申请日:2021-08-16

    IPC分类号: G02B21/06 G02B21/00 G01N21/64

    摘要: 一种显微成像装置及其光照芯片(8)、成像方法、电子设备(30)和介质。光照芯片(8)包括:光照阵列结构,包括衬底(81)及周期性分布于衬底(81)的若干光照单元(83);光照井(84),设置于光照阵列结构上光照单元(83)延伸的一表面,光照井(84)上划分有用于放置样品(9)的若干放置单元(841),每个放置单元(841)分别分布于对应的光照单元(83)上,其中,光照单元(83)用于被光源(1)照射时,产生表面等离子体结构光以激发对应的放置单元(841)上的样品(9)中的荧光染料并产生荧光信号。这种显微成像装置及其光照芯片(8)、成像方法针对阵列排列生物样品(9),通过改变入射光照明角度,有效地实现样品(9)选择性被激发,可有效地实现分辨率的提升,从而有效地降低了原始图像数量。

    OPTICAL ELEMENT FOR USE IN METROLOGY SYSTEMS

    公开(公告)号:WO2023011905A1

    公开(公告)日:2023-02-09

    申请号:PCT/EP2022/070108

    申请日:2022-07-18

    IPC分类号: G02B21/00 G03F7/20

    摘要: Described herein is an optical element, and a metrology tool or system employing the optical element for measurements of structures on a substrate. The optical element includes an optical element includes a first portion configured to reflect the light received from the illumination source towards the substrate, and a second portion configured to transmit the light reflected from the substrate or the desired location in the optical tool, the first portion having higher coefficient of reflectivity than the second portion, and the second portion having higher coefficient of transmissivity than the first portion. The metrology tool may further include a sensor configured to receive diffraction pattern caused by the patterned substrate, and a processor configured to receive signal comprising the diffraction pattern from the sensor, and determine overlay associated with the patterned substrate by analyzing the signal comprising the diffraction pattern.

    KONTAKTLOSES VISUALISIERUNGSSYSTEM FÜR EIN OPERATIONSMIKROSKOP FÜR DIE AUGENCHIRURGIE

    公开(公告)号:WO2023006366A1

    公开(公告)日:2023-02-02

    申请号:PCT/EP2022/068719

    申请日:2022-07-06

    摘要: Es wird ein kontaktloses Visualisierungssystem (1) für ein Operationsmikroskop (2) für die Augenchirurgie bereitgestellt, wobei das kontaktlose Visualisierungssystem (1) eine Ophthalmoskopierlupe (3) aufweist, die vor einem Patientenauge (6) positionierbar ist und ein reelles sowie höhen- und seitenverkehrtes Bild des Augenhintergrunds (7) des Patientenauges (6) in eine Zwischenbildebene (8) liefert, die mit dem Operationsmikroskop (2) betrachtbar ist, und wobei die Ophthalmoskopierlupe (3) eine erste und eine zweite Linse (271, 272) aufweist, wobei die erste Linse (271) im vor dem Patientenauge (6) positionierten Zustand näher am Patientenauge (6) ist als die zweite Linse (272), wobei sich von der ersten Linse (271) zur zweiten Linse (272) eine Wandung (30) erstreckt, deren freies Ende (31) als Fassung (32) ausgebildet ist, in der die zweite Linse (272) gefasst ist, und wobei die Fassung (32) mindestens eine Aussparung (50, 51) aufweist, in der der Rand der zweiten Linse (272) freiliegt, um einem Chirurgen Arbeitsraum bereitzustellen.

    LOCALIZING A SINGULARIZED FLUOROPHORE MOLECULE BY CONTINUOUSLY MOVING A FOCUSED LIGHT BEAM AROUND THE MOLECULE

    公开(公告)号:WO2023006176A1

    公开(公告)日:2023-02-02

    申请号:PCT/EP2021/070852

    申请日:2021-07-26

    IPC分类号: G01N21/64 G02B21/16 G02B21/00

    摘要: For determining a molecule position of a singularized fluorophore molecule, a light beam including fluorescence excitation light and fluorescence influencing light is shaped and focused such as to form a light intensity distribution having a central intensity minimum of the fluorescence influencing light. The central intensity minimum is continuously moved along a track (31) repeatedly extending around an estimated position (34). Individual photons of fluorescence light emitted by the fluorophore molecule due to excitation by the fluorescence excitation light are registered; and an intensity minimum position of the intensity minimum is recorded for the excitation of each individual photon registered. In response, the estimated position (34) around which the track extends is updated on basis of the recorded intensity minimum position, and extensions of the track (31) around the estimated position (34) are reduced and an effectiveness of the fluorescence influencing light is increased.

    SYSTEMS AND METHODS FOR COVERSLIPPING
    10.
    发明申请

    公开(公告)号:WO2022249191A1

    公开(公告)日:2022-12-01

    申请号:PCT/IL2022/050565

    申请日:2022-05-26

    申请人: SCOPIO LABS LTD.

    摘要: A microscope system may be integrated with a coverslipping device. A method of preparing a microscope slide for imaging a sample on the microscope slide may include placing a transparent flowable material on the sample while the slide is supported with one or more linkages coupled to a processor, covering the sample with a coverslip, and placing the microscope slide on a microscope stage with the one or more linkages coupled to the slide and the processor. Various other systems and methods are provided.