公开(公告)号：WO2022182260A1

公开(公告)日：2022-09-01

申请号：PCT/PL2022/050009

申请日：2022-02-24

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： HEDDLE, Jonathan ,  AZUMA, Yusuke ,  NASKALSKA, Antonina ,  BORZĘCKA-SOLARZ, Kinga ,  RÓŻYCKI, Jan ,  GAWEŁ, Szymon

IPC: C07K14/195 ,  C07K1/13

Abstract: The present invention provides an artificial TRAP-cage decorated with particular molecules (proteins, peptides, small molecules, nucleic acids) on the exterior.

公开(公告)号：WO2021210997A1

公开(公告)日：2021-10-21

申请号：PCT/PL2021/050026

申请日：2021-04-16

Applicant: UNIWERSYTET JAGIELLOŃSKI ,  WARSZAWSKI UNIWERSYTET MEDYCZNY

Inventor： KAMIŃSKI, Krzysztof ,  ABRAM, Michał ,  JAKUBIEC, Marcin ,  RAPACZ, Anna ,  MOGILSKI, Szczepan ,  LATACZ, Gniewomir ,  STRUGA, Marta

IPC: A61P25/08 ,  A61P25/22 ,  A61P25/24 ,  C07D207/263 ,  C07D207/416 ,  A61K31/4015

Abstract: Water-soluble analogs of compounds intended for the treatment of neurological diseases, epilepsy, neuropathic pain and migraine, and psychiatric disorders, including anxiety and depression, especially suitable for the preparation of oral or parenteral drug forms, are disclosed.

公开(公告)号：WO2020013719A1

公开(公告)日：2020-01-16

申请号：PCT/PL2019/050040

申请日：2019-07-10

Applicant: UNIWERSYTET JAGIELLOŃSKI ,  UNIWERSYTET MEDYCZNY W LUBLINIE

Inventor： PŁACHNO, Bartosz Jan ,  BOGUCKA-KOCKA, Anna ,  KOCKI, Janusz

IPC: C12N5/02 ,  C12N5/077

Abstract: Disclosed is a surface for stem cell culture containing plant secretion obtained from carnivore plants, its use and a method for stem cell culture.

公开(公告)号：WO2019059792A1

公开(公告)日：2019-03-28

申请号：PCT/PL2018/050049

申请日：2018-09-21

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： MAJKA, Marcin ,  SUŁKOWSKI, Maciej

IPC: C12N5/071 ,  A61K35/12 ,  A61K35/545

Abstract: The invention discloses the method of differentiating human induced Pluripotent Stem cells (iPS cells) to obtain pigmented cells which produce melanin. The protocol described is much more efficient than any other method used to obtain melanin in vitro .

公开(公告)号：WO2018143832A1

公开(公告)日：2018-08-09

申请号：PCT/PL2018/050003

申请日：2018-02-04

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： TARACH, Karolina ,  GÓRA-MAREK, Kinga ,  BUDZIOCH, Janusz

IPC: G01N21/03

Abstract: The invention relates to a reactor for spectroscopic studies, operating in transmission mode, comprising a reaction chamber (1 ), which includes a cylindrical tube, from which at least two connectors (21, 22, 23) extend perpendicularly, delivering a gaseous working medium to a reaction zone in the reaction chamber (1), where the tested sample (6) is placed, at least two optical windows (17), located at the ends of the reaction chamber's (1 ) cylindrical tube, pressed to the reaction chamber (1) and sealed with it by a window seal (16), heating and cooling system supported directly by the reaction chamber (1) and placed basically around the reaction zone, at least two reactor fastenings (14) fixing the opposite ends of the reaction chamber (1), with the reactor fastening (14) including a cooling agent duct (20), having an internal surface constituting the external surface of the reaction chamber (1), the cooling agent duct (20) being sealed from the side of the heating and cooling system and from the vacuum side by a hydraulic seal (19), being in direct contact with the reaction chamber (1).

公开(公告)号：WO2018063017A1

公开(公告)日：2018-04-05

申请号：PCT/PL2017/050048

申请日：2017-09-25

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： AWSIUK, Kamil ,  RYSZ, Jakub ,  MARZEC, Mateusz ,  BUDKOWSKI, Andrzej

IPC: B29C41/12 ,  B05C11/02 ,  B29C41/50 ,  H01L51/00 ,  B29D7/01 ,  C08J5/18

Abstract: The invention relates to device for production of polymer films having a predefined spatial structure, comprising a linear stage (1), a cylinder (3) spreading a polymer solution, a platform (8) for a substrate, a cylinder height adjustment system (9), a control system for the cylinder height and tilt in relation to the substrate, and a controllable voltage source, wherein at least one metallic electrode is fixed onto the cylinder (3), the substrate onto which the polymer film is deposited is conductive for electric current; and the electric voltage from the controllable voltage source is applied between the at least one metallic electrode and the substrate during deposition of the polymer films onto the substrate. The invention relates also to a method for preparation of polymer films having a predefined predetermined spatial structure, using electrical field applied during the formation of the polymer films.

Abstract translation: 本发明涉及用于制造具有预定空间结构的聚合物膜的装置，包括线性台（1），展开聚合物溶液的圆柱体（3），用于基底的平台（8） ，气缸高度调节系统（9），用于气缸高度和相对于基板倾斜的控制系统，以及可控电压源，其中至少一个金属电极固定在气缸（3）上，基板上 沉积聚合物膜对电流是导电的; 并且在将聚合物膜沉积到基底上期间，将来自可控电压源的电压施加在至少一个金属电极和基底之间。 本发明还涉及使用在形成聚合物膜期间施加的电场来制备具有预定的预定空间结构的聚合物膜的方法。

公开(公告)号：WO2017213529A1

公开(公告)日：2017-12-14

申请号：PCT/PL2017/000063

申请日：2017-06-09

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： MIELECZAREK, Jakub ,  GAZDOWICZ, Grzegorz

IPC: C12M1/12 ,  C12M1/00

CPC classification number: C12M25/14 ,  C12M29/10

Abstract: A method for manufacturing the cell-culture substrate (5) from a biocompatible material, for perfusive cell cultures with three-dimensional geometry, in which the material of the substrate solidifies around the matrix (13), which is subsequently removed to obtain a passable culture-medium-supplying channel (6), or set of channels (6), with the previously designed three-dimensional structure. A device for perfusion cell cultures with three-dimensional geometry, containing a mainframe, a system of the cell-culture medium supply and a cell- culture substrate, in which the substrate is manufactured using the method according to the invention. A method for maintaining cell cultures with the use of the device according to the invention, and the set containing the elements of the device and the ingredients necessary to manufacture the cell-culture substrate (5).

Abstract translation: 由生物相容性材料制造细胞培养基材（5）的方法，用于具有三维几何形状的灌注细胞培养物，其中基材的材料在基体（13）周围凝固， 随后用先前设计的三维结构除去培养基供应通道（6）或一组通道（6）。 一种用于具有三维几何形状的灌注细胞培养物的装置，其包含主框架，细胞培养基供应系统和细胞培养基底，其中使用根据本发明的方法来制造基底。 使用根据本发明的装置维持细胞培养物的方法以及包含装置的元件和制造细胞培养基材所需的成分的组（5）。

公开(公告)号：WO2016135540A1

公开(公告)日：2016-09-01

申请号：PCT/IB2015/056711

申请日：2015-09-03

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： MAK, Paweł ,  WŁADYKA, Benedykt ,  PIEJKO, Marcin ,  DUBIN, Adam ,  BUKOWSKI, Michał ,  BONAR, Emilia ,  MIĘDZOBRODZKI, Jacek ,  BEREŹNICKA, Anna ,  KRZYSIK, Monika

IPC: A23L3/3463 ,  A61K38/16 ,  C07K14/31

CPC classification number: C07K14/31 ,  A23L33/17 ,  A61K38/00 ,  C12R1/44

Abstract: Polypeptide of antibacterial or lytic effect to bacterial cells or lytic or cytotoxic effect to eukaryotic cells, its encoding polynucleotide or expression vector, the new Staphylococcus pseudintermedius strain and their applications and production method of the said polypeptides were revealed.

Abstract translation: 揭示了对细菌细胞的抗细菌或溶解作用的多肽或对真核细胞的裂解或细胞毒性作用，其编码多核苷酸或表达载体，新的葡萄球菌假间断菌株及其应用和所述多肽的制备方法。

公开(公告)号：WO2016036264A1

公开(公告)日：2016-03-10

申请号：PCT/PL2015/050021

申请日：2015-06-08

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： SILARSKI, Michał ,  MOSKAL, Paweł

IPC: G01V5/00 ,  G01N23/222

CPC classification number: G01N23/222 ,  G01N33/18 ,  G01N2223/637 ,  G01N2223/652 ,  G01V5/0016

Abstract: The present invention is a device and method for the non-invasive detection of hazardous materials in an aquatic environment, wherein the device comprises a sealed housing, in which there is a fast neutron generator (101) surrounded by α particle detectors (106), and gamma quantum detector (111), wherein the fast neutron generator (101) emits neutrons in the direction of the tested object (107) through the neutron and/or gamma quanta guide (108), and the gamma quanta detector records gamma quanta emitted by the nuclei of the tested object (107) transmitted through neutron and/or gamma quanta guide (110).

Abstract translation: 本发明是一种在水生环境中非侵入式检测有害物质的装置和方法，其中该装置包括密封的壳体，其中存在由α粒子检测器（106）包围的快中子发生器（101） 和伽马量子检测器（111），其中快中子发生器（101）通过中子和/或伽马量子引导件（108）在被测物体（107）的方向上发射中子，伽马量子检测器记录发射的伽马量子 通过通过中子和/或伽马量子引导件（110）传输的被测物体（107）的核。

公开(公告)号：WO2016016820A2

公开(公告)日：2016-02-04

申请号：PCT/IB2015/055727

申请日：2015-07-29

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： NOWAKOWSKA, Maria ,  SZCZUBIAŁKA, Krzysztof ,  PYRĆ, Krzysztof ,  CIEJKA, Justyna ,  WYTRWAŁ, Magdalena ,  MILEWSKA, Aleksandra

IPC: C08F8/36

CPC classification number: A61K31/795 ,  A61K9/0073 ,  C08F8/36 ,  C08F8/44 ,  C08F126/02 ,  C08F8/00

Abstract: The subject of the invention is an N-sulfonic polyallylamine derivative (NSPAH) with Formula 1, wherein R is -SO 3 - or -H, and n is an integer from 150 to 15000; an application of the N-sulfonic polyallylamine derivative as a medicine, particularly for prevention and treatment of respiratory tract infections caused by the human metapneumovirus (hMPV), respiratory tract infections caused by the human rhinoviruses (HRV), and infections caused by the influenza A virus; as well as a pharmaceutical composition comprising the N-sulfonic polyallylamine derivative and the application thereof.

Abstract translation: 本发明的主题是式1的N-磺酸聚烯丙基胺衍生物（NSPAH），其中R为-SO 3 - 或-H，n为150至15000的整数; N-磺酸多烯丙胺衍生物作为药物的应用，特别是用于预防和治疗由人类重型肺炎病毒（hMPV）引起的呼吸道感染，由人类鼻病毒引起的呼吸道感染（HRV）以及由甲型流感引起的感染 病毒; 以及包含N-磺基聚烯丙胺衍生物的药物组合物及其应用。