公开(公告)号：WO2004045527A3

公开(公告)日：2005-02-03

申请号：PCT/US0336587

申请日：2003-11-14

Applicant: ISIS PHARMACEUTICALS INC ,  DOBIE KENNETH W

Inventor： DOBIE KENNETH W

IPC: A61K38/00 ,  A61K48/00 ,  C12N5/02 ,  C12N15/113 ,  C07H21/02 ,  C07H21/04 ,  C12N15/00

CPC classification number: C12N15/1137 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of NIMA-related kinase 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding NIMA-related kinase 6. Methods of using these compounds for modulation of NIMA-related kinase 6 expression and for diagnosis and treatment of disease associated with expression of NIMA-related kinase 6 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节NIMA相关激酶6的表达。该组合物包含针对编码NIMA相关激酶6的核酸的寡核苷酸。使用这些化合物调节NIMA相关激酶6表达和 提供了与NIMA相关激酶6表达相关的疾病的诊断和治疗。

公开(公告)号：WO2004044181A3

公开(公告)日：2004-10-14

申请号：PCT/US0336411

申请日：2003-11-13

Applicant: ISIS PHARMACEUTICALS INC ,  CROOKE ROSANNE ,  GRAHAM MARK ,  LEMONIDIS-TARBET KRISTINA ,  DOBIE KENNETH W

Inventor： CROOKE ROSANNE ,  GRAHAM MARK ,  LEMONIDIS-TARBET KRISTINA ,  DOBIE KENNETH W

IPC: A61K38/00 ,  C12N15/113 ,  A61K48/00 ,  C07H21/00 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节载脂蛋白B的表达。组合物包含靶向编码载脂蛋白B的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节载脂蛋白B表达和治疗疾病的方法 与载脂蛋白B的表达相关。

公开(公告)号：WO2004052306A3

公开(公告)日：2004-09-30

申请号：PCT/US0339429

申请日：2003-12-11

Applicant: ISIS PHARMACEUTICALS INC ,  MCKAY ROBERT ,  DOBIE KENNETH W

Inventor： MCKAY ROBERT ,  DOBIE KENNETH W

IPC: C07H21/04 ,  C12N15/113 ,  A61K48/00 ,  C12N15/00

CPC classification number: C12N15/1138 ,  C07H21/04 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of PPAR-alpha. The compositions comprise oligonucleotides, targeted to nucleic acid encoding PPAR-alpha. Methods of using these compounds for modulation of PPAR-alpha expression and for diagnosis and treatment of disease associated with expression of PPAR-alpha are provided.

Abstract translation: 提供化合物，组合物和方法用于调节PPAR-α的表达。 组合物包含靶向编码PPAR-α的核酸的寡核苷酸。 提供了使用这些化合物调节PPAR-α表达和用于诊断和治疗与PPAR-α表达相关的疾病的方法。

公开(公告)号：WO2004048526A2

公开(公告)日：2004-06-10

申请号：PCT/US0337383

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS INC ,  WARD DONNA T ,  DOBIE KENNETH W ,  FREIER SUSAN M ,  MARCUSSON ERIC G

Inventor： WARD DONNA T ,  DOBIE KENNETH W ,  FREIER SUSAN M ,  MARCUSSON ERIC G

IPC: A61K38/00 ,  C07F9/6558 ,  C07F9/6561 ,  C12N15/113 ,  C12N

CPC classification number: C07F9/65586 ,  A61K38/00 ,  C07F9/65616 ,  C12N15/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of HIF1a and/or HIF2a. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIFlalpha and HIF2alpha. Methods of using these compounds for modulation of HIFlalpha and/or HIF2alpha expression and for diagnosis and treatment of disease associated with expression of HIFlalpha and/or HIF2alpha are provided.

Abstract translation: 提供化合物，组合物和方法用于调节HIF1a和/或HIF2a的表达。 组合物包含靶向编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。

公开(公告)号：WO2004043391A2

公开(公告)日：2004-05-27

申请号：PCT/US0335845

申请日：2003-11-12

Applicant: ISIS PHARMACEUTICALS INC ,  BENNETT C FRANK ,  DEAN NICHOLAS M ,  DOBIE KENNETH W

Inventor： BENNETT C FRANK ,  DEAN NICHOLAS M ,  DOBIE KENNETH W

IPC: A61K38/00 ,  C12N15/113 ,  A61K

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y207/11025 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of mitogen-activated protein kinase kinase kinase 11. The compositions comprise oligonucleotides, targeted to nucleic acid encoding mitogen-activated protein kinase kinase kinase 11. Methods of using these compounds for modulation of mitogen-activated protein kinase kinase kinase 11 expression and for diagnosis and treatment of disease associated with expression of mitogen­activated protein kinase kinase kinase 11 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节丝裂原活化蛋白激酶激酶激酶11的表达。组合物包含针对编码丝裂原活化蛋白激酶激酶激酶11的核酸的寡核苷酸。使用这些化合物调节丝裂原活化蛋白激酶激酶激酶 提供活化的蛋白激酶激酶激酶11表达和用于诊断和治疗与丝裂原活化蛋白激酶激酶激酶11的表达相关的疾病。

公开(公告)号：WO2004005460A3

公开(公告)日：2004-04-01

申请号：PCT/US0316249

申请日：2003-07-02

Applicant: ISIS PHARMACEUTICALS INC ,  DEAN NICHOLAS M ,  FREIER SUSAN M ,  DOBIE KENNETH W

Inventor： DEAN NICHOLAS M ,  FREIER SUSAN M ,  DOBIE KENNETH W

IPC: A61K38/00 ,  C07H21/04 ,  C12N5/02 ,  C12N15/113 ,  C12Q1/68 ,  A01N43/04 ,  C07H21/02 ,  C12N15/63 ,  C12P19/34

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C07H21/04 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y101/01034 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of HMG-CoA reductase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding HMG-CoA reductase. Methods of using these compounds for modulation of HMG-CoA reductase expression and for treatment of diseases associated with expression of HMG-CoA reductase are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节HMG-CoA还原酶的表达。 组合物包含靶向编码HMG-CoA还原酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节HMG-CoA还原酶表达和治疗与HMG-CoA还原酶的表达有关的疾病的方法。

公开(公告)号：WO2004010956A2

公开(公告)日：2004-02-05

申请号：PCT/US0323994

申请日：2003-07-31

Applicant: ISIS PHARMACEUTICALS INC ,  MONIA BRETT P ,  BHANOT SANJAY ,  DOBIE KENNETH W ,  FREIER SUSAN M

Inventor： MONIA BRETT P ,  BHANOT SANJAY ,  DOBIE KENNETH W ,  FREIER SUSAN M

IPC: A61K38/00 ,  C12N15/113 ,  A61K

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/03048 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of LAR. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids LAR. Methods of using these compounds for modulation of LAR expression and for treatment of diseases associated with expression of LAR are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节LAR的表达。 该组合物包含靶向核酸LAR的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节LAR表达和治疗与LAR表达相关的疾病的方法。

公开(公告)号：WO2005019418A8

公开(公告)日：2008-01-17

申请号：PCT/US2004024384

申请日：2004-08-18

Applicant: ISIS PHARMACEUTICALS INC ,  BHANOT SANJAY ,  DOBIE KENNETH W ,  YU XING-XIAN

Inventor： BHANOT SANJAY ,  DOBIE KENNETH W ,  YU XING-XIAN

IPC: C07H21/02 ,  C12N15/113

CPC classification number: C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14

Abstract: Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。

公开(公告)号：WO2006026485A3

公开(公告)日：2006-06-08

申请号：PCT/US2005030513

申请日：2005-08-25

Applicant: ISIS PHARMACEUTICALS INC ,  MARCUSSON ERIC G ,  HENRY SCOTT ,  KIM YOUNGSOO ,  DOBIE KENNETH W

Inventor： MARCUSSON ERIC G ,  HENRY SCOTT ,  KIM YOUNGSOO ,  DOBIE KENNETH W

IPC: C07H21/04 ,  A61K48/00 ,  C12N15/00

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of HIF 1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIFI-beta are provided.

Abstract translation: 提供了用于调节HIF1-β表达的化合物，组合物和方法。 该组合物包含靶向编码HIF1-β的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1-β表达以及诊断和治疗与HIFI-β表达相关的疾病和病症的方法。

公开(公告)号：WO2004001061A3

公开(公告)日：2006-02-23

申请号：PCT/US0319433

申请日：2003-06-18

Applicant: ISIS PHARMACEUTICALS INC ,  DOBIE KENNETH W

Inventor： DOBIE KENNETH W

IPC: A61K38/00 ,  C12N5/02 ,  C12N15/113 ,  C07H21/04

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y114/99003 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of heme oxygenase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding heme oxygenase 1. Methods of using these compounds for modulation of heme oxygenase 1 expression and for treatment of diseases associated with expression of heme oxygenase 1 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节血红素加氧酶1的表达。该组合物包含靶向编码血红素加氧酶的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节血红素加氧酶1表达和 提供了与血红素加氧酶1表达相关的疾病的治疗。