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公开(公告)号：WO2007137301A2
公开(公告)日：2007-11-29
申请号：PCT/US2007069587
申请日：2007-05-23
Applicant: ISIS PHARMACEUTICALS INC , BHANOT SANJAY , DOBIE KENNETH W , MURRAY SUSAN F
Inventor： BHANOT SANJAY , DOBIE KENNETH W , MURRAY SUSAN F
IPC: A61K48/00
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/322 , C12N2310/341 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions, and methods for modulating the expression of ChREBP in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and conditions.
Abstract translation: 本文公开了用于调节细胞，组织或动物中ChREBP表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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2.发明申请COMPOSITIONS AND THEIR USES DIRECTED TO THYMUS AND ACTIVATION-REGULATED CHEMOKINE (TARC) 审中-公开组合物及其与三氯乙烯和激活性调节化学药物（TARC）的用途及其用途
公开(公告)号：WO2006105204A3
公开(公告)日：2007-01-04
申请号：PCT/US2006011478
申请日：2006-03-28
Applicant: ISIS PHARMACEUTICALS INC , KARRAS JAMES G , DOBIE KENNETH W
Inventor： KARRAS JAMES G , DOBIE KENNETH W
CPC classification number: C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of TARC, airway hyperresponsiveness, and/or pulmonary inflammation.
Abstract translation: 本文公开了用于调节细胞，组织或动物中TARC表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与TARC表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：WO2006086821A1
公开(公告)日：2006-08-24
申请号：PCT/AU2005/001634
申请日：2005-10-20
Applicant: ANTISENSE THERAPEUTICS LTD , TACHAS, George , KARRAS, James, G. , GREGORY, Susan , CROSBY, Jeffrey, R. , DOBIE, Kenneth, W. , BENNETT, C., Frank
Inventor： TACHAS, George , KARRAS, James, G. , GREGORY, Susan , CROSBY, Jeffrey, R. , DOBIE, Kenneth, W. , BENNETT, C., Frank
IPC: A61K31/711 , A61P11/00
CPC classification number: A61K31/711 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
Abstract: A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 µg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.
Abstract translation: 用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞增多症，白细胞或过度产生粘液和/或与整联蛋白a4表达有关的呼吸系统疾病或病症的动物的方法，包括向动物施用包含 。 0.001至1000μg/ kg体重的靶向编码整联蛋白a4的核酸分子的反义化合物的动物。
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公开(公告)号：WO2004093783A3
公开(公告)日：2006-05-04
申请号：PCT/US2004010946
申请日：2004-04-15
Applicant: ISIS PHARMACEUTICALS INC , CROOKE ROSANNE M , GRAHAM MARK J , LEMONIDIS TARBET KRISTINA M , DOBIE KENNETH W
Inventor： CROOKE ROSANNE M , GRAHAM MARK J , LEMONIDIS TARBET KRISTINA M , DOBIE KENNETH W
IPC: C07H21/04 , A61K38/00 , C12N15/113
CPC classification number: C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
Abstract translation: 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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公开(公告)号：WO2005054518A3
公开(公告)日：2005-07-07
申请号：PCT/US2004041019
申请日：2004-12-06
Applicant: ISIS PHARMACEUTICALS INC , BENNETT FRANK C , BUTLER MADELINE M , DEAN NICHOLAS M , DOBIE KENNETH W , FINGER JOSHUA , JAIN RAVI , MCKAY ROBERT , MONIA BRETT P , MYERS KATHLEEN
Inventor： BENNETT FRANK C , BUTLER MADELINE M , DEAN NICHOLAS M , DOBIE KENNETH W , FINGER JOSHUA , JAIN RAVI , MCKAY ROBERT , MONIA BRETT P , MYERS KATHLEEN
CPC classification number: C07H21/04
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
Abstract translation: 本文公开了用于调节细胞，组织或动物中骨生长调节剂表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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Patent Agency Ranking
公开(公告)号：WO2005006958A2
公开(公告)日：2005-01-27
申请号：PCT/US2004022384
申请日：2004-07-12
Applicant: ISIS PARMACEUTICALS INC , BENNETT C FRANK , DOBIE KENNETH W , JAIN RAVI
Inventor： BENNETT C FRANK , DOBIE KENNETH W , JAIN RAVI
IPC: A61B20060101 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , A61B
CPC classification number: C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of CEACAM1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding CEACAM1 Methods of using these compounds for modulation of CEACAM1 expression and for diagnosis and treatment of disease associated with expression of CEACAM1 are provided. I
Abstract translation: 提供化合物，组合物和方法用于调节CEACAM1的表达。 组合物包含靶向编码CEACAM1的核酸的寡核苷酸。提供了使用这些化合物调节CEACAM1表达的方法和用于诊断和治疗与CEACAM1表达相关的疾病的方法。 一世
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公开(公告)号：WO2004071407A3
公开(公告)日：2004-08-26
申请号：PCT/US2004/002003
申请日：2004-02-06
Applicant: ISIS PHARMACEUTICALS, INC. , BHANOT, Sanjay , COWSERT, Lex, M. , WYATT, Jacqueline, R. , FREIER, Susan, M. , MONIA, Brett, P. , BUTLER, Madeline, M. , MCKAY, Robert , DOBIE, Kenneth, W.
Inventor： BHANOT, Sanjay , COWSERT, Lex, M. , WYATT, Jacqueline, R. , FREIER, Susan, M. , MONIA, Brett, P. , BUTLER, Madeline, M. , MCKAY, Robert , DOBIE, Kenneth, W.
IPC: C12Q1/68
Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：WO2004052309A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039492
申请日：2003-12-11
Applicant: ISIS PHARMACEUTICALS, INC. , SHANAHAN, William, R. , FREIER, Susan, M. , DOBIE, Kenneth, W.
Inventor： SHANAHAN, William, R. , FREIER, Susan, M. , DOBIE, Kenneth, W.
IPC: A61K
CPC classification number: C12N15/113 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT 6. Methods of using these compounds for modulation of STAT 6 expression and for diagnosis and treatment of disease associated with expression of STAT 6 are provided.
Abstract translation: 提供化合物，组合物和方法用于调节STAT6的表达。组合物包含靶向编码STAT6的核酸的寡核苷酸。使用这些化合物调节STAT6表达并用于诊断和治疗与表达相关的疾病 提供STAT 6。
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9.发明申请
公开(公告)号：WO2004052300A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039230
申请日：2003-12-10
Applicant: ISIS PHARMACEUTICALS INC. , DOBIE, Kenneth, W. , JAIN, Ravi
Inventor： DOBIE, Kenneth, W. , JAIN, Ravi
IPC: A61K
CPC classification number: C12N15/1137 , C07H21/02 , C07H21/04 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12Y501/99004 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of alpha-methylacyl-CoA racemase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding alpha-methylacyl-CoA racemase. Methods of using these compounds for modulation of alpha-methylacyl-CoA racemase expression and for diagnosis and treatment of disease associated with expression of alpha-mathylacyl-CoA racemase are provided.
Abstract translation: 提供化合物，组合物和方法用于调节α-甲基酰基-CoA消旋酶的表达。 组合物包含靶向编码α-甲酰基-CoA消旋酶的核酸的寡核苷酸。 提供了使用这些化合物调节α-甲酰基-CoA消旋酶表达以及用于诊断和治疗与α-叶酸酰辅酶A消旋酶的表达相关的疾病的方法。
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公开(公告)号：WO2004048534A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/037493
申请日：2003-11-21
Applicant: ISIS PARMACEUTICALS, INC. , DOBIE, Kenneth, W. , WARD, Donna, T.
Inventor： DOBIE, Kenneth, W. , WARD, Donna, T.
IPC: C12N
CPC classification number: C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/01037 , C12N2310/3525
Abstract: Compounds, compositions and methods are provided for modulating the expression of cytokine-inducible kinase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding cytokine-inducible kinase. Methods of using these compounds for modulation of cytokine-inducible kinase expression and for diagnosis and treatment of disease associated with expression of cytokine-inducible kinase are provided.
Abstract translation: 提供化合物，组合物和方法用于调节细胞因子诱导型激酶的表达。 组合物包含靶向编码细胞因子诱导型激酶的核酸的寡核苷酸。 提供了使用这些化合物调节细胞因子诱导型激酶表达和用于诊断和治疗与细胞因子诱导型激酶表达相关的疾病的方法。
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