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    GENETIC MARKER OF RESPONSE TO ATYPICAL ANTIPSYCHOTICS AND ANTIDEPRESSANTS AND METHODS FOR USE THEREOF
    23.
    发明申请
    GENETIC MARKER OF RESPONSE TO ATYPICAL ANTIPSYCHOTICS AND ANTIDEPRESSANTS AND METHODS FOR USE THEREOF 审中-公开
    抗生素和抗病毒药物的遗传标记及其使用方法

    公开(公告)号：WO2005007871A3

    公开(公告)日：2005-09-15

    申请号：PCT/US2004022064

    申请日：2004-07-08

    Applicant: UNIV CALIFORNIA ,  NOBLE ERNEST P ,  YOUNG ROSS M ,  LAWFORD BRUCE R ,  STATE OF QUEENSLAND ACTING THR ,  UNIV QUEENSLAND

    Inventor： NOBLE ERNEST P ,  YOUNG ROSS M ,  LAWFORD BRUCE R

    IPC: C07H21/04 ,  C12N15/00 ,  C12P19/34 ,  C12Q20060101 ,  C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

    Abstract: The invention provides methods of identifying candidate psychiatric patients, or patients with movement disorder, for treatment with medication that acts at a D2 dopan-line receptor site or increases density of D2 dopamine receptors. The method comprises determining a patient's DRD2 genotype. Patients having the Taq1A (A1) allele (A1 + allelic status) are candidates for treatment with high dose, high binding antipsychotics and/or SSRIs that influence D2 receptor density. Patients lacking the Taq1A allele (A1- allelic status) are candidates for treatment with low dose, low binding atypical antipsychotics, and are not likely to respond well to these SSRIs.

    Abstract translation: 本发明提供了鉴定候选精神病患者或运动障碍患者用于用D2多巴线受体位点作用的药物治疗或增加D2多巴胺受体密度的方法。 该方法包括确定患者的DRD2基因型。 具有Taq1A（A1）等位基因（A1 +等位基因状态）的患者是影响D2受体密度的高剂量，高结合抗精神病药和/或SSRI的治疗的候选者。 缺乏Taq1A等位基因的患者（A1-等位基因状态）是用低剂量，低结合非典型抗精神病药物治疗的候选者，并且不太可能对这些SSRIs做出良好反应。

    SYSTEMS AND METHODS FOR DETECTING BIOLOGICAL FEATURES
    24.
    发明申请
    SYSTEMS AND METHODS FOR DETECTING BIOLOGICAL FEATURES 审中-公开
    用于检测生物特征的系统和方法

    公开(公告)号：WO2005042760A3

    公开(公告)日：2005-09-09

    申请号：PCT/US2004032006

    申请日：2004-09-29

    Applicant: PATHWORK INFORMATICS INC ,  ANDERSON GLENDA G

    Inventor： ANDERSON GLENDA G

    IPC: C12Q20060101 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

    CPC classification number: G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G06N7/005

    Abstract: A computer having a memory stores instructions for receiving data. The data comprises one or more characteristics for each cellular constituent in a plurality of cellular constituents that have been measured in a test organism of a species or a test biological specimen from an organism of the species. The memory further stores instructions for computing a model in a plurality of models, wherein the model is characterized by a model score that represents the likelihood of a biological feature in the test organism or the test biological specimen. Computation of the model comprises determining the model score using one or more characteristics for one or more cellular constituents in the plurality of cellular constituents. The memory also stores instructions for repeating the instructions for computing one or more times, thereby computing the plurality of models. The memory also stores instructions for communicating computed model scores.

    Abstract translation: 具有存储器的计算机存储用于接收数据的指令。 数据包括已经在物种的测试生物体中测量的多种细胞组分中的每种细胞成分的一个或多个特征或来自该物种的生物体的测试生物标本。 存储器还存储用于计算多个模型中的模型的指令，其中模型的特征在于模型评分，其表示测试生物体或测试生物样本中生物特征的可能性。 模型的计算包括使用针对多个细胞组分中的一个或多个细胞组分的一个或多个特征来确定模型得分。 存储器还存储用于重复计算一次或多次的指令的指令，从而计算多个模型。 存储器还存储用于传达计算的模型分数的指令。

    CONTROLLED PLATELET ACTIVATION TO MONITOR THERAPY OF ADP ANTAGONISTS
    25.
    发明申请
    CONTROLLED PLATELET ACTIVATION TO MONITOR THERAPY OF ADP ANTAGONISTS 审中-公开
    控制血小板活化监测ADP拮抗剂治疗

    公开(公告)号：WO2005007868A3

    公开(公告)日：2005-08-18

    申请号：PCT/US2004021785

    申请日：2004-07-06

    Applicant: ACCUMETRICS INC ,  COLLER BARRY S ,  DURBIN DENNIS

    Inventor： COLLER BARRY S ,  DURBIN DENNIS

    IPC: A61K31/557 ,  A61K39/395 ,  A61K49/00 ,  C12Q20060101 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/567 ,  G01N33/86

    CPC classification number: G01N33/86

    Abstract: A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIlb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within a range suitable for platelet aggregation; 3) a platelet GPIIb/IIIa receptor ligand immobilized on a solid surface; 4) one or more agents to enhance a signal transduction pathway and 5) a receptor activator. The combination is incubated under conditions for agglutinating particles. Platelet-mediated agglutination is assessed in the agitated mixture. The absence of agglutination indicates that the individual has a reduced ability to form platelet thrombi.

    Abstract translation: 提供了确定个体是否由于抑制血小板活化启动，信号转导和/或GPI1b / IIIa阻断而降低形成血小板血栓的能力的方法。 血液样本从被评估的个体获得。 将血样与1）抗凝血剂混合; 2）足够的缓冲液，以将抗凝血的pH和盐浓度保持在适合于血小板聚集的范围内; 3）固定在固体表面上的血小板GPIIb / IIIa受体配体; 4）一种或多种增强信号转导途径的试剂和5）受体激活剂。 在凝集粒子的条件下温育组合物。 在搅拌的混合物中评估血小板介导的凝集。 没有凝集表明个体具有降低的形成血小板血栓的能力。

    DARK QUENCHERS FOR FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) IN BIOASSAYS
    26.
    发明申请
    DARK QUENCHERS FOR FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) IN BIOASSAYS 审中-公开
    生物多样性的荧光共振能量转移（FRET）的暗号

    公开(公告)号：WO2005030979A3

    公开(公告)日：2005-07-21

    申请号：PCT/US2004030980

    申请日：2004-09-22

    Applicant: QTL BIOSYSTEMS LLC

    Inventor： XIA WENSHENG ,  WHITTEN DAVID ,  MCBRANCH DUNCAN

    IPC: C07D213/76 ,  C07D401/12 ,  C07K17/00 ,  C07K17/02 ,  C12Q20060101 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/533

    CPC classification number: G01N33/533

    Abstract: Non-fluorescent dyes (i.e., dark quenchers) which can be used to quench the fluorescence of energy donors in bioassays through fluorescence resonance energy transfer (FRET) are described. The dark quenchers can be associated with (e.g., conjugated to) peptides, proteins, antibodies, DNA/RNA, or other biological molecules or receptors or complexed to metal containing compounds to develop bioassays based on donor-acceptor energy transfer. Bioassays are also described wherein an increase or a decrease in separation distance between a fluorescent donor compound and a dark quencher or dark quencher conjugate is detected. Kits including the dark quenchers or dark quencher conjugates are also described.

    Abstract translation: 描述了可用于通过荧光共振能量转移（FRET）在生物测定中淬灭能量供体的荧光的非荧光染料（即暗猝灭剂）。 暗猝灭剂可以与（例如缀合的）肽，蛋白质，抗体，DNA / RNA或其它生物分子或受体或与含金属的化合物络合以发展基于供体 - 受体能量转移的生物测定。 还描述了其中检测到荧光供体化合物和暗猝灭剂或暗猝灭剂缀合物之间的间隔距离的增加或减少的生物测定。 还描述了包括暗猝灭剂或暗猝灭剂缀合物的试剂盒。

    METHOD FOR DETERMINING FUNCTIONAL SITES IN A PROTEIN
    28.
    发明申请
    METHOD FOR DETERMINING FUNCTIONAL SITES IN A PROTEIN 审中-公开
    确定蛋白质功能位点的方法

    公开(公告)号：WO2004074505A3

    公开(公告)日：2005-06-16

    申请号：PCT/US2004001970

    申请日：2004-01-22

    Applicant: EIDOGEN INC ,  DEBE DEREK A ,  DANZER JOSEPH F ,  XIE LEI

    Inventor： DEBE DEREK A ,  DANZER JOSEPH F ,  XIE LEI

    IPC: C12Q20060101 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F17/00 ,  G06F17/10 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

    CPC classification number: G06F19/18 ,  G06F19/22 ,  G06F19/24

    Abstract: The present invention relates to improved methods for determining functional residues on the surface of a query protein. The claimed methods rely on determining a plurality of functional annotation scores for a query protein and comparing these functional annotation scores to distributions of similar functional annotation scores derived from a plurality of reference proteins. Based upon these comparisons, a putative functional cluster may be annotated as a functional cluster or a non-functional cluster.

    Abstract translation: 本发明涉及用于测定查询蛋白表面功能性残基的改进方法。 要求保护的方法依赖于确定查询蛋白质的多个功能注释分数，并将这些功能注释分数与从多个参考蛋白质衍生的相似功能注释分数的分布进行比较。 基于这些比较，推定的功能集群可以注释为功能集群或非功能集群。

    COMPOSITIONS AND METHODS FOR DETECTING A SEQUENCE MUTATION IN THE CINNAMYL ALCOHOL DEHYDROGENASE GENE ASSOCIATED WITH ALTERED LIGNIFICATION IN LOBLOLLY PINE
    29.
    发明申请
    COMPOSITIONS AND METHODS FOR DETECTING A SEQUENCE MUTATION IN THE CINNAMYL ALCOHOL DEHYDROGENASE GENE ASSOCIATED WITH ALTERED LIGNIFICATION IN LOBLOLLY PINE 审中-公开
    用于检测在LOLLOLLY PINE中与改变的配体相关的CINNAMYL酒精脱氢酶基因中的序列突变的组合物和方法

    公开(公告)号：WO2004072237A3

    公开(公告)日：2005-06-09

    申请号：PCT/US2004003112

    申请日：2004-02-04

    Applicant: UNIV CALIFORNIA ,  US AGRICULTURE ,  GILL GEOFFREY P ,  BROWN GARTH R ,  NEALE DAVID B

    Inventor： GILL GEOFFREY P ,  BROWN GARTH R ,  NEALE DAVID B

    IPC: A01H7/00 ,  C07H21/04 ,  C12N20060101 ,  C12Q20060101 ,  C12Q1/68 ,  C12Q

    CPC classification number: C12Q1/6895 ,  C12Q2600/156

    Abstract: Loblolly pine (Pinus taeda L.) is the most important commercial tree species in the USA harvested for pulp and solid wood products. Increasing the efficiency of chemical pulping may be achieved through the manipulation of genes involved in the lignin biosynthetic pathway. A null allele of cinnamyl alcohol dehydrogenase (CAD) has been discovered in the loblolly pine clone 7-56 which displays altered lignin composition. During identification of single nucleotide polymorphisms (SNPs) in the cad gene, a two-base pair adenosine insertion located in exon five and unique to clone 7-56 was discovered. The sequence mutation causes a frame-shift predicted to result in premature termination of the protein. For routine detection of the mutation, a diagnostic assay was developed utilizing Template-directed Dye-terminator Incorporation and Fluorescence Polarization detection (FT-TDI).

    Abstract translation: 檀香松（Pinus taeda L.）是美国最重要的商业树种，用于纸浆和实木制品。 通过操作涉及木质素生物合成途径的基因可以提高化学制浆的效率。 在具有改变的木质素组成的火炬松克隆7-56中已经发现了肉桂醇脱氢酶（CAD）的无效等位基因。 发现在cad基因中单核苷酸多态性（SNPs）的鉴定中，发现位于5号外显子中的2-碱基对腺苷插入物，克隆7-56独特。 序列突变导致预测的帧移位导致蛋白质的过早终止。 对于常规检测突变，使用模板定向染色终止子结合和荧光偏振检测（FT-TDI）开发了诊断测定。

    NUCLEIC ACID AMPLIFICATION
    30.
    发明申请
    NUCLEIC ACID AMPLIFICATION 审中-公开
    核酸放大

    公开(公告)号：WO2004058987A3

    公开(公告)日：2005-05-19

    申请号：PCT/US0340364

    申请日：2003-12-19

    Applicant: QIAGEN GMBH

    Inventor： LASKEN ROGER S ,  EGHOLM MICHAEL ,  ALSMADI OSAMA A ,  BORNARTH CAROLE ,  WISNIEWSKI MICHELE ,  HOSONO SEIYU ,  RAGHUNATHAN ARUMUGHAM

    IPC: C07H21/04 ,  C12P19/34 ,  C12Q20060101 ,  C12Q1/68

    CPC classification number: C12Q1/6844 ,  C12Q2531/119

    Abstract: Disclosed are compositions and a method for amplification of nucleic acid sequences of interest. The method is based on strand displacement replication of the nucleic acid sequences by primers. The disclosed method is a form of multiple displacement amplification (MDA) useful for amplifying genomic nucleic acid samples and other nucleic acid samples of high complexity. The disclosed method can be used to amplify such highly complex nucleic acid samples using only one or a limited number of primers. It has been discovered that one or a small number of primers can effectively amplify whole genomes an other nucleic acid samples of high sequence complexity. The primers are specially selected or designed to be able to prime and efficiently amplify the broad range of sequences present in highly complex nucleic acid samples despite the limited amount of primer sequence represented in the primers. It has been discovered that generation of high molecular weight artifacts, in an isothermal amplification procedure, is substantially reduced or eliminated while still allowing the desired amplification of input DNA by carrying out the reaction at a higher temperature and, optionally, in the presence of one or more additives. It has also bee discovered that amplification reactions can produce amplification products of high quality, such as low amplification bias, if performed on an amount of nucleic acid at or over a threshold amount and/or on nucleic acids at or below a threshold concentration.

    Abstract translation: 公开了用于扩增感兴趣的核酸序列的组合物和方法。 该方法基于通过引物对核酸序列的链置换复制。 所公开的方法是用于扩增高度复杂的基因组核酸样品和其他核酸样品的多位置扩增（MDA）的形式。 所公开的方法可用于仅使用一个或有限数量的引物扩增这种高度复杂的核酸样品。 已经发现，一个或少数引物可以有效地扩增整个基因组具有高序列复杂性的其他核酸样品。 引物被特别选择或设计成能够引发并有效地扩增存在于高度复杂的核酸样品中的广泛范围的序列，尽管引物中表示的引物序列有限。 已经发现，在等温扩增过程中产生高分子量伪像被显着减少或消除，同时仍然通过在较高温度下进行反应并且任选地在一种 或更多的添加剂。 还发现扩增反应可以产生高质量的扩增产物，例如对于阈值量以上或超过阈值量的核酸量和/或在阈值浓度或低于阈值浓度的核酸上进行的低扩增偏差。

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