公开(公告)号：WO2019149673A1

公开(公告)日：2019-08-08

申请号：PCT/EP2019/052054

申请日：2019-01-29

申请人： MYWAY GENETICS S.R.L.

发明人： FAVALLI, Valentina

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention provides methods relating to detecting donor cell-free DNA in the circulation of an organ transplant recipient for the early identification of transplant rejection.

公开(公告)号：WO2019147779A1

公开(公告)日：2019-08-01

申请号：PCT/US2019/014914

申请日：2019-01-24

申请人： GENENTECH, INC. ,  QUEEN MARY UNIVERSITY OF LONDON

发明人： LEWIS, Myles ,  PITZALIS, Costantino ,  RAMAMOORTHI, Nandhini ,  TOWNSEND, Michael, John ,  HACKNEY, Jason

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides prognostic, predictive, and therapeutic methods for the treatment of rheumatoid arthritis (RA). The invention is based, at least in part, on the discovery that the expression level of one or more biomarkers described herein in a sample (e.g., a synovial tissue sample, a synovial fluid sample, or a combination thereof) from an individual having RA can be used in methods of determining whether an individual having RA is likely to exhibit disease progression, identifying an individual having RA who is likely to respond to a treatment including a disease modifying anti-rheumatic drug (DMARD), predicting responsiveness of an individual having RA to a treatment including a DMARD, selecting a therapy for an individual having RA, and treating an individual having RA, as well as related kits.

公开(公告)号：WO2019113277A1

公开(公告)日：2019-06-13

申请号：PCT/US2018/064180

申请日：2018-12-06

申请人： NEURODIAGNOSTICS LLC

发明人： CHIRILA, Florin Valentin ,  ALKON, Daniel L.

IPC分类号： G01N33/50 ,  G01N33/68 ,  C12Q1/6883

CPC分类号： G01N33/5091 ,  C12Q1/6883 ,  G01N33/5023

摘要： This invention provides a method for determining whether a human subject is afflicted with a predetermined disorder comprising the steps of (a) synchronizing a population of suitable cells derived from the subject; and (b) in the resulting synchronized cell population, measuring the expression level of a gene known to be differentially expressed between corresponding synchronized cells derived from patients afflicted with the disorder and those derived from non-afflicted patients, whereby the subject is afflicted with the disorder if the expression level measured in step (b) is consistent with that gene's expression level in corresponding synchronized cells derived from patients afflicted with the disorder, and the subject is not afflicted with the disorder if the expression level measured in step (b) is consistent with that gene's expression level in corresponding synchronized cells derived from non-afflicted patients.

公开(公告)号：WO2019094578A1

公开(公告)日：2019-05-16

申请号：PCT/US2018/059805

申请日：2018-11-08

申请人： ALNYLAM PHARMACEUTICALS INC.

发明人： HINKLE, Gregory ,  TU, Ho-Chou ,  SEHGAL, Alfica

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The invention relates to methods and assays for determining the activity or expression of LECT2 gene in a subject.

公开(公告)号：WO2019092438A1

公开(公告)日：2019-05-16

申请号：PCT/GB2018/053255

申请日：2018-11-12

申请人： PREMAITHA LIMITED

发明人： FORMAN, Matthew

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2535/122 ,  C12Q2537/16 ,  C12Q2537/165

摘要： The invention relates to a novel method of detecting a fetal chromosomal abnormality, in particular, the invention relates to the detection of trisomy 21 (Down's syndrome) which comprises the step of calculating the probability (w) of each fragment size (s) being fetal in origin. The invention also relates to kits for performing said method. The invention also relates to a method of predicting the gender of a fetus within a pregnant female subject.

公开(公告)号：WO2019066621A1

公开(公告)日：2019-04-04

申请号：PCT/KR2018/011645

申请日：2018-10-01

申请人： 주식회사 젠큐릭스 ,  재단법인 록원바이오융합연구재단

发明人： 신영기 ,  김성수 ,  조상래 ,  문영호 ,  김지은 ,  강병일 ,  류다연

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883

摘要： 본 발명은 RAS/BRAF 돌연변이 검출용 조성물 및 이를 포함하는 키트에 관한 것으로, 보다 상세하게는 RAS/BRAF 돌연변이 검출용 프라이머 및 프로브 세트 조성 물과 상기 조성물을 포함하는 RAS/BRAF돌연변이 검출용 키트에 관한 것이다. 본 발명의 방법은 암 환자 예후의 치료제에 대한 반응성 예측, 진단뿐만 아 니라 암의 전이 또는 재발에 대한 예측이 가능하므로 항암치료제의 투여 필요성 판 단을 비롯하여 향후 치료의 방향에 대한 단서를 제시하는 목적 및 암의 전이 또는 재발에 대한모니터링 하는 데에 유용하게 이용될 수 있다.

公开(公告)号：WO2019051103A1

公开(公告)日：2019-03-14

申请号：PCT/US2018/049775

申请日：2018-09-06

申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

发明人： HART, Bradley Ryan ,  ANEX, Deon Stafford ,  MASON, Katelyn Elizabeth ,  PAUL, Phillip Harris

IPC分类号： G01N33/68 ,  G01N30/72 ,  C12Q1/68 ,  G01N30/88

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  G01N30/72 ,  G01N30/88 ,  G01N33/6848 ,  G01N2030/8827 ,  G01N2030/8831

摘要： Methods and systems to perform genetically variant protein analysis and related marker genetic protein variations and databases, which in several embodiments allow performing a reliable genetic variation protein analysis in biological samples of different types and conditions taking into account the features of the biological sample where the analysis is performed.

公开(公告)号：WO2018228875A1

公开(公告)日：2018-12-20

申请号：PCT/EP2018/064813

申请日：2018-06-06

申请人： NESTEC S.A.

发明人： BOWMAN, Gene ,  DAYON, Loïc ,  RAYMOND, Frederic

IPC分类号： C12Q1/6883 ,  G01N33/50

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

摘要： A method for determining whether a subject has an impaired blood-brain barrier (BBB) or is at risk of developing an impaired blood-brain barrier (BBB) comprising determining the level of one or more biomarkers in one or more samples obtained from the subject, wherein the one or more biomarkers comprise a micro-RNA.

公开(公告)号：WO2018222022A2

公开(公告)日：2018-12-06

申请号：PCT/KR2018/006367

申请日：2018-06-04

申请人： 울산대학교 산학협력단 ,  재단법인 아산사회복지재단

发明人： 송규영 ,  양석균 ,  박상형 ,  예병덕 ,  홍명희 ,  백지원

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883

摘要： 본 발명은 항-TNF 제제에 대한 반응성 예측용 단일염기다형성 마커 조성물 및 이를 이용한 항-TNF 제제에 대한 반응성 예측 방법에 관한 것이다. 본 발명자들은 총 349명의 CD 등록 환자 중, IFX에 대해 42명의 환자가 좋은 반응군, 70명의 환자가 비-반응군 및 237명의 환자가 중간 반응군으로 분류되었고, 연관 분석을 통해 총 112명의 환자를 분석하였는데, 발굴 분석에서 58명 환자(15명 좋은 반응군 및 43명 비-반응군) 및 재현 분석에서 54명의 환자(27명 좋은 반응군 및 27명 비-반응군)를 분석하였다. 분석 결과, IFX 치료에 대한 좋은 반응과 관련되어 있는 rs2158962 SNP의 변이를 확인하였으며, "A" allele가 좋은 반응군에서 높게 나타났다. 이에, 본 발명은 CD 환자의 IFX 치료에 있어, 치료 전략을 수립하고 환자 맞춤 치료를 진행하는데 유용하게 활용될 수 있다.

公开(公告)号：WO2018209223A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/032304

申请日：2018-05-11

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： OSTMEYER, Jared ,  COWELL, Lindsay ,  CHRISTLEY, Scott ,  ROUNDS, William ,  TOBY, Inmary ,  MONSON, Nancy ,  GREENBERG, Benjamin

IPC分类号： C07K9/00 ,  C07K16/00 ,  C12Q1/68 ,  C12Q1/06 ,  G01N33/68

CPC分类号： C07K14/70503 ,  C07K16/2803 ,  C07K2317/565 ,  C12Q1/06 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N33/563 ,  G01N33/574 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/68 ,  G01N33/6896 ,  G01N2800/285 ,  G01N2800/50

摘要： The present disclosure relates to the identification and application of adaptive immune receptor sequences that indicate an elevated risk of developing an adaptive immune receptor-related disease, such as an autoimmune disease ( e.g ., multiple sclerosis). The biomarkers and methods can further aid in the prophylaxis and treatment of such diseases.