公开(公告)号：WO2007111885A2

公开(公告)日：2007-10-04

申请号：PCT/US2007/006916

申请日：2007-03-19

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  CROMACK, Keith R. ,  TONER, John L. ,  BURKE, Sandra E. ,  KRASULA, Richard W. ,  SCHWARTZ, Lewis B.

Inventor： CROMACK, Keith R. ,  TONER, John L. ,  BURKE, Sandra E. ,  KRASULA, Richard W. ,  SCHWARTZ, Lewis B.

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/604

Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical including : a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

Abstract translation: 用于递送与医学相关的亲脂性试剂的装置和系统包括：医疗装置，能够穿透体腔的第一亲脂试剂，其中第一亲脂试剂的转移系数是通过 在统计学上有意义的量为至少约5,000，其中第一种亲脂性试剂与医疗器械结合，其中第一种亲脂性试剂/医疗器械放置在所述体腔附近，并且其中治疗有效量的第一种亲脂性试剂 被递送到对象内的期望区域。 此外，本发明涉及用于改善对象中的开放的方法，其涉及将医疗装置放置在体腔中以用于治疗和/或预防邻近疾病或维持体腔的开放。

公开(公告)号：WO2007047473A3

公开(公告)日：2007-08-09

申请号：PCT/US2006040155

申请日：2006-10-12

Applicant: ABBOTT LAB ,  TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW

Inventor： TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW

IPC: A61F2/00 ,  A61K31/44

CPC classification number: A61L31/16 ,  A61K31/192 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/256 ,  A61L2300/416

Abstract: A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coating on its surface, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures suitable for use include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative, anti-platelet, anti-inflammatory and anti-thrombotic agents; cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

Abstract translation: 一种医疗装置，包括能够包含或支持药学上可接受的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以包括一种或多种治疗剂或物质，所述载体包括其表面上的涂层，所述涂层包括治疗物质 ，例如药物。 适合使用的支撑结构包括但不限于冠状动脉支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统的药物递送球囊。 适用于本发明的药物包括但不限于：该药物可与包括选自抗增殖，抗血小板，抗炎和抗血栓形成剂的那些药物组合使用。 细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

公开(公告)号：WO2007046935A3

公开(公告)日：2007-07-05

申请号：PCT/US2006031879

申请日：2006-08-15

Applicant: ABBOTT LAB ,  BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW ,  TONER JOHN L

Inventor： BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW ,  TONER JOHN L

IPC: A61F6/06

CPC classification number: A61L31/16 ,  A61K31/192 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/256 ,  A61L2300/416

Abstract: A system and compositions including zotarolimus and paditaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including antiproliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de- differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

Abstract translation: 公开了一种包含佐他莫司和紫杉醇的系统和组合物，以及递送方法，其中所述药物具有彼此互补的作用。 公开了包括支撑结构的医疗装置，所述支撑结构包括至少一种药学上可接受的载体或赋形剂，所述载体或赋形剂可以包括一种或多种治疗剂或物质，其中所述载体在其表面上包含至少一个涂层， 与治疗物质，例如药物一起使用。 适用于本发明的医疗装置的支撑结构包括但不限于冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。 这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂，抗 血压药，基质金属蛋白酶抑制剂，细胞生长抑制药或这些与其他药物的组合。