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    MULTIPLE DRUG DELIVERY FROM A BALLOON AND A PROSTHESIS
    2.
    发明申请
    MULTIPLE DRUG DELIVERY FROM A BALLOON AND A PROSTHESIS 审中-公开
    从气球和PROSTHESIS提供的多种药物

    公开(公告)号：WO2010093800A2

    公开(公告)日：2010-08-19

    申请号：PCT/US2010/023910

    申请日：2010-02-11

    Applicant: ABBOTT LABORATORIES ,  TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  OEPEN, Randolf, Von

    Inventor： TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  OEPEN, Randolf, Von

    IPC: A61L29/16

    CPC classification number: A61L31/16 ,  A61F2/91 ,  A61F2/958 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606 ,  A61M25/10 ,  A61M2025/105

    Abstract: Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

    Abstract translation: 公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

    COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES
    4.
    发明申请
    COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
    使用医疗设备管理吡虫啉类似物的组合物和方法

    公开(公告)号：WO2008045961A3

    公开(公告)日：2008-08-28

    申请号：PCT/US2007080987

    申请日：2007-10-10

    Applicant: ABBOTT LAB ,  TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW

    Inventor： TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R ,  MACK MATTHEW

    IPC: A61K31/37 ,  A61K31/436 ,  A61P9/00

    CPC classification number: A61K31/337 ,  A61K9/0024 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  C07D498/18

    Abstract: Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    Abstract translation: 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

    COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES
    5.
    发明申请
    COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
    使用医疗设备用紫杉醇施用雷帕霉素类似物的组合物和方法

    公开(公告)号：WO2008045961A2

    公开(公告)日：2008-04-17

    申请号：PCT/US2007/080987

    申请日：2007-10-10

    Applicant: ABBOTT LABORATORIES ,  TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  MACK, Matthew

    Inventor： TONER, John, L. ,  BURKE, Sandra, E. ,  CROMACK, Keith, R. ,  MACK, Matthew

    CPC classification number: A61K31/337 ,  A61K9/0024 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  C07D498/18

    Abstract: Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    Abstract translation: 包括紫杉醇和第二药物如雷帕霉素，其类似物，衍生物，盐和酯的系统和组合物以及递送方法，其中药物具有彼此互补的作用。 包含能够包含或承载药学上可接受的载体或赋形剂的载体结构的医疗器械，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层，并且包含治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。 这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂 ，抗血液流变剂，基质金属蛋白酶抑制剂，细胞抑制药物或这些与其他药物的组合。

    SURFACE INTERACTIONS TO IMPROVE RETENTION OF MEDICAL DEVICES
    6.
    发明申请
    SURFACE INTERACTIONS TO IMPROVE RETENTION OF MEDICAL DEVICES 审中-公开
    表面相互作用改善医疗器械的保留

    公开(公告)号：WO2007130366A2

    公开(公告)日：2007-11-15

    申请号：PCT/US2007010481

    申请日：2007-04-30

    Applicant: ABBOTT LAB ,  TONER JOHN L ,  VON OEPEN RANDOLF

    Inventor： TONER JOHN L ,  VON OEPEN RANDOLF

    IPC: A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14

    CPC classification number: A61F2/958 ,  A61F2002/9583 ,  A61L29/085 ,  A61L29/14 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14

    Abstract: A method for improving the retention between the surfaces of medical devices. The method includes coating a surface of one medical device such as a stent with a coating that includes a functional group and coating a surface of another medical device such as a balloon with a coating that includes an identical or different functional group. The method further includes interacting the coated surfaces to produce a plurality of bonds between the surfaces, thereby improving retention.

    Abstract translation: 一种用于改善医疗装置表面之间的保持性的方法。 该方法包括用包括官能团的涂层涂覆诸如支架的一个医疗装置的表面，并用包括相同或不同官能团的涂层涂覆其它医疗装置例如气囊的表面。 该方法还包括使涂覆的表面相互作用以在表面之间产生多个键，从而改善保留。

    ZOTAROLIMUS-CONTAINING DRUG DELIVERY SYSTEMS FOR IMPLANTATION INTO A BODY LUMEN OF A SUBJECT
    7.
    发明申请
    ZOTAROLIMUS-CONTAINING DRUG DELIVERY SYSTEMS FOR IMPLANTATION INTO A BODY LUMEN OF A SUBJECT 审中-公开
    含ZOTAROLIMUS的药物输送系统，用于植入身体的身体

    公开(公告)号：WO2007111925A3

    公开(公告)日：2007-11-15

    申请号：PCT/US2007007090

    申请日：2007-03-21

    Applicant: ABBOTT LAB ,  TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R

    Inventor： TONER JOHN L ,  BURKE SANDRA E ,  CROMACK KEITH R

    IPC: A61K9/00 ,  A61F2/06 ,  A61K31/00 ,  A61L27/00 ,  A61L29/00 ,  A61L31/16

    CPC classification number: A61K9/0019 ,  A61F2/91 ,  A61K31/192 ,  A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/602

    Abstract: Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    Abstract translation: 公开了包含佐他莫司的系统和组合物，其比雷帕霉素和紫杉醇系统更安全，更有效并且产生较少的炎症。 医疗装置包括能够包含或支持药学上可接受的载体或赋形剂的载体结构的载体或赋形剂，所述载体或赋形剂可以包含一种或多种治疗剂或物质，载体包括其表面上的涂层，以及具有治疗化合物的涂层， 包括例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

    DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES
    8.
    发明申请
    DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES 审中-公开
    通过医疗器械交付高效液相代谢物

    公开(公告)号：WO2007112006A2

    公开(公告)日：2007-10-04

    申请号：PCT/US2007007255

    申请日：2007-03-22

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

    Inventor： CROMACK KEITH R ,  TONER JOHN L ,  BURKE SANDRA E ,  KRASULA RICHARD W ,  SCHWARTZ LEWIS B

    IPC: A61F2/24 ,  A61L29/16 ,  A61L31/14

    CPC classification number: A61L31/16 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/22 ,  A61L2300/416 ,  A61L2300/45

    Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

    Abstract translation: 一种用于递送与医疗装置相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数为统计学上显着的 至少约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至 课程。 此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

    ALPHA-(CYCLOALKYL, ARYL AND ARALKYL)SUBSTITUTED POLYIODINATED AROYLOXY COMPOUNDS
    9.
    发明申请
    ALPHA-(CYCLOALKYL, ARYL AND ARALKYL)SUBSTITUTED POLYIODINATED AROYLOXY COMPOUNDS 审中-公开
    ALPHA-（CYCLOALKYL，ARYL和ARALKYL）取代的聚氧乙烯醚化合物

    公开(公告)号：WO1996000211A1

    公开(公告)日：1996-01-04

    申请号：PCT/US1995007421

    申请日：1995-06-09

    Applicant: EASTMAN KODAK COMPANY ,  BACON, Edward, R. ,  ILLIG, Carl, R. ,  OSIFO, Irennegbe, K. ,  PENG, Xin ,  TONER, John, L.

    Inventor： EASTMAN KODAK COMPANY

    IPC: C07C233/81

    CPC classification number: C07C237/46 ,  A61K49/0433 ,  C07C233/54 ,  C07C233/88 ,  C07C2601/08 ,  C07C2601/12

    Abstract: Compounds having structure (I) wherein m is 1, 2, 3 or 4; Z-(-COO-)-m is the residue of a polyiodinated aromatic mono- or polyacid; R is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; n is an integer from 0 to 20; R is cycloalkyl or aryl; and R , R and R are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido are useful as x-ray contrast agents in medical diagnostic x-ray imaging compositions and methods.

    Abstract translation: 具有结构（I）的化合物，其中m为1,2,3或4; Z - （ - COO - ） - m是多元芳族单或多酸的残基; R 1是H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基烷基或乙酰氨基烷基; n为0〜20的整数， R 2是环烷基或芳基; R 3和R 5独立地为H，烷基，氟烷基，环烷基，芳基，芳烷基，卤素，羟基，酰氨基，乙酰氨基烷基，氰基，磺酰基，甲酰氨基或亚磺酰氨基，可用作x-射线 医疗诊断x射线成像组合物和方法中的造影剂。

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