公开(公告)号：WO2014143342A9

公开(公告)日：2017-05-18

申请号：PCT/US2013077487

申请日：2013-12-23

Applicant: ABBOTT LAB

Inventor： MUERHOFF SCOTT A ,  MAROHNIC CHRISTOPHER ,  BIRKENMEYER LARRY ,  PROSTKO JOHN ,  BOGDAN FELISHA ,  GUTIERREZ ROBIN

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/12 ,  A61K39/38

CPC classification number: C12N9/14 ,  C07K14/005 ,  C07K2319/20 ,  C07K2319/21 ,  C12N2770/24222 ,  C12N2800/22 ,  G01N33/5767 ,  G01N2469/20

Abstract: The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of HCV antibodies. More specifically, the present invention describes specific NS3 antigens that can be used for the detection of anti-HCV antibodies.

Abstract translation: 本公开涉及用于检测HCV抗体存在的多肽，包括其融合物，核酸，载体，宿主细胞，免疫诊断试剂，试剂盒和免疫测定。 更具体地说，本发明描述了可用于检测抗-HCV抗体的特定NS3抗原。

公开(公告)号：WO2015105981A3

公开(公告)日：2015-10-22

申请号：PCT/US2015010631

申请日：2015-01-08

Applicant: ABBOTT LAB

Inventor： EDENS NEILE ,  GELLING RICHARD ,  SATHYAVAGEESWARAN SHREERAM

IPC: A23L1/29 ,  A23L1/305 ,  A61K31/19

CPC classification number: A61K45/06 ,  A23L33/10 ,  A23L33/17 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/155 ,  A61K31/19 ,  A61K31/573 ,  A61K2300/00 ,  A23V2200/316

Abstract: A method of increasing or maintaining lean body mass in leucine conversion-compromised subjects and subjects undergoing treatment for diabetes is provided. The method includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to a subject with compromised leucine conversion efficiency or a subject undergoing treatment for insulin resistance associated with diabetes. Administration of HMB to a leucine conversion-compromised subject or a subject undergoing treatment for diabetes is effective to increase or maintain the human's lean body mass.

Abstract translation: 提供了在亮氨酸转化受损的受试者和经历糖尿病治疗的受试者中增加或维持瘦体重的方法。 所述方法包括向受试者施用有效量的β-羟基-β-甲基丁酸酯（HMB），所述对象具有降低的亮氨酸转化效率或经历与糖尿病相关的胰岛素抵抗治疗的受试者。 将HMB给予亮氨酸转化受损对象或正在接受糖尿病治疗的受试者有效地增加或维持人的瘦体重。

公开(公告)号：WO2014143343A8

公开(公告)日：2015-03-19

申请号：PCT/US2013077499

申请日：2013-12-23

Applicant: ABBOTT LAB

Inventor： ZIEMANN ROBERT ,  AHLBERG APRIL ,  HAWKSWORTH DAVID ,  TIEMAN BRYAN ,  MUERHOFF A SCOTT ,  MAROHNIC CHRISTOPHER ,  OTIS KATHY

IPC: C12P21/08 ,  A61K39/29 ,  C07K16/00 ,  C12Q1/70

CPC classification number: G01N33/5767 ,  C07K16/109 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2800/52

Abstract: Monoclonal antibodies for the detection of Hepatitis C Virus (HCV) antigen are provided. The antibodies specifically immunoreactive with at least one epitope of the lipid binding domain of amino acid residues 134-171 of HCV core antigen. Immunoassay methods of using antibodies, kits and compositions comprising the antibodies for detecting HCV infection are further provided.

Abstract translation: 提供用于检测丙型肝炎病毒（HCV）抗原的单克隆抗体。 与HCV核心抗原的氨基酸残基134-171的脂质结合结构域的至少一个表位特异性免疫反应的抗体。 进一步提供了使用抗体，试剂盒和包含用于检测HCV感染的抗体的组合物的免疫测定方法。

公开(公告)号：WO2014144355A2

公开(公告)日：2014-09-18

申请号：PCT/US2014028725

申请日：2014-03-14

Applicant: ABBOTT LAB

Inventor： TU BAILIN ,  ZIEMANN ROBERT N ,  TIEMAN BRYAN C ,  HEMKEN PHILIP M ,  RAMSAY CAROL S ,  STROBEL CAROLYN J ,  HAWKSWORTH DAVID J ,  BIRKENMEYER LARRY G ,  ZHAO CHENG ,  BROPHY SUSAN E ,  DOWELL BARRY L ,  MUERHOFF ANTHONY S

IPC: C07K16/18

CPC classification number: C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2800/085 ,  G01N2800/50

Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.

Abstract translation: 本文公开了使用所述抗体检测样品中的高尔基体蛋白73（GP73）和岩藻糖基化GP73的抗体和方法。

公开(公告)号：WO2014099351A2

公开(公告)日：2014-06-26

申请号：PCT/US2013072810

申请日：2013-12-03

Applicant: ABBOTT LAB

Inventor： GUSTAFSON STEPHANIE ,  LOUGHRIN THOMAS ,  COX CHRISTOPHER

IPC: B65D55/08

CPC classification number: B65D23/0878 ,  B65D55/0854

Abstract: A product package for storing nutritional or pharmaceutical products includes a container having a body and an opening, a closure removably engaged with the container to selectively close the opening of the container, and a sleeve that surrounds at least a portion of one or both of the container and the closure. The sleeve comprises one or more gripping features to facilitate removing the sleeve and/or the closure from the container.

Abstract translation: 用于储存营养或药物产品的产品包装包括具有主体和开口的容器，可拆卸地与容器接合以便选择性地关闭容器的开口的封闭件，以及围绕至少一个或多个 集装箱和关闭。 套筒包括一个或多个抓握特征，以便于从容器移除套筒和/或封闭件。

公开(公告)号：WO2012112419A8

公开(公告)日：2014-03-06

申请号：PCT/US2012024817

申请日：2012-02-13

Applicant: ABBOTT LAB ,  PEDROSA JOSE MARIA LOPEZ ,  MARTIN MANUEL MANZANO ,  PEREZ ALEJANDRO BARRANCO ,  GONZALEZ MARIA RAMIREZ ,  CABRERA RICARDO RUEDA

Inventor： PEDROSA JOSE MARIA LOPEZ ,  MARTIN MANUEL MANZANO ,  PEREZ ALEJANDRO BARRANCO ,  GONZALEZ MARIA RAMIREZ ,  CABRERA RICARDO RUEDA

IPC: A23L1/305

CPC classification number: A61K31/19 ,  A23L33/10 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/06

Abstract: Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases.

Abstract translation: 公开了用于增强个体如老年人中的神经功能的方法。 所述方法包括向个体施用包含HMB的营养组合物。 营养组合物对于具有或可能具有认知衰退，认知障碍和神经功能障碍（通常由与神经变性疾病相关的认知疾病引起）的风险的个体提供益处。

公开(公告)号：WO2013163583A3

公开(公告)日：2014-01-16

申请号：PCT/US2013038468

申请日：2013-04-26

Applicant: ABBOTT LAB

Inventor： MCBROOM JEREMY ,  PERRY JAMES

IPC: B65D51/24 ,  B65D43/16

CPC classification number: B65D45/18 ,  B65D43/163 ,  B65D43/169 ,  B65D43/22 ,  B65D45/22 ,  B65D51/247 ,  B65D53/02 ,  B65D2543/00101 ,  B65D2543/00296 ,  B65D2543/00351 ,  B65D2543/00435 ,  B65D2543/00564 ,  B65D2543/00842 ,  B65D2543/00888 ,  B65D2543/0099

Abstract: A container (10) for holding granular or powdered material. The container (10) includes walls, a collar (14), a lid (16) and a latch (200). The walls define an interior space (26) and an upper portion, the upper portion defining a sealing flange (30) and an opening to the interior space. The collar (14) is attached to the upper portion. The lid 816) is attached to the collar (14) for positioning between an open position and a closed position, and adapted to cover the opening while in the closed position. The latch (200) is attached to an outer surface of the lid (16). The latch may have an actuator (202) rotatable in two directions relative to the lid and detachably engaged to a catch (220) which protrudes from an outside surface of the collar (14).

Abstract translation: 用于容纳颗粒或粉末材料的容器（10）。 容器（10）包括壁，轴环（14），盖（16）和闩锁（200）。 壁限定内部空间（26）和上部，上部限定密封凸缘（30）和到内部空间的开口。 轴环（14）附接到上部。 盖816）连接到套环（14）上，用于在打开位置和关闭位置之间定位，并且适于在处于关闭位置时覆盖开口。 闩锁（200）附接到盖（16）的外表面。 闩锁可以具有可相对于盖子在两个方向上旋转的致动器（202），并且可拆卸地接合到从套环（14）的外表面突出的卡扣（220）。

公开(公告)号：WO2013181125A2

公开(公告)日：2013-12-05

申请号：PCT/US2013042817

申请日：2013-05-28

Applicant: ABBOTT LAB

Inventor： HUANG SHIHAI X ,  SU HONG ,  ERICKSON BRIAN J

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6858 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2525/185 ,  C12Q2535/125

Abstract: A method of designing a primer for detecting a single nucleotide polymorphism (SNP), a method of detecting an SNP, a method of distinguishing SNPs, primers, detectable oligonucleotides, and kits.

Abstract translation: 设计用于检测单核苷酸多态性（SNP）的引物的方法，检测SNP的方法，区分SNP的方法，引物，可检测的寡核苷酸和试剂盒。

公开(公告)号：WO2013026541A2

公开(公告)日：2013-02-28

申请号：PCT/EP2012003464

申请日：2012-08-14

Applicant: ABBOTT LAB VASCULAR ENTPR LTD ,  BREGULLA RAINER

Inventor： BREGULLA RAINER

IPC: A61F2/06 ,  A61F2/00 ,  A61F2/90

CPC classification number: A61F2/07 ,  A61F2/852 ,  A61F2/89 ,  A61F2/915 ,  A61F2002/9155 ,  A61F2250/0063

Abstract: The invention relates to a stent graft, adapted for being inserted into a blood vessel, and to a method for forming a stent graft. The stent graft (1) comprises a first stent (2) comprising a plurality of first rings (4) being connected by at least one first connector, wherein the first stent (2) is arranged at least partly in an inner part of the stent graft (1), a second stent (3) comprising a plurality of second rings (5) being connected by at least one second connector, wherein the second stent (3) is arranged at least partly in an outer part of the stent graft (1), and a graft layer is arranged at least partly between the first stent (2) and the second stent (3), wherein the first stent (2) and the second stent (3) having each a predetermined length and the plurality of first rings (4) and the plurality of second rings (5) are axially arranged along the length such that the plurality of second rings (5) fit into the plurality of first rings (4). In this way, a possibility is provided to avoid the problem of integrity in connection with having as less as possible interaction between the first stent and the second stent and thus to minimize the risks of shear effects.

Abstract translation: 本发明涉及一种适于插入血管的支架移植物，以及用于形成支架移植物的方法。 支架移植物（1）包括第一支架（2），其包括通过至少一个第一连接器连接的多个第一环（4），其中第一支架（2）至少部分地布置在支架的内部 移植物（1），包括通过至少一个第二连接器连接的多个第二环（5）的第二支架（3），其中所述第二支架（3）至少部分地布置在所述支架移植物的外部部分 1），并且接枝层至少部分地布置在第一支架（2）和第二支架（3）之间，其中第一支架（2）和第二支架（3）具有预定长度，并且多个 第一环（4）和多个第二环（5）沿着长度轴向布置，使得多个第二环（5）装配到多个第一环（4）中。 以这种方式，提供了一种可能性，以避免在第一支架和第二支架之间具有尽可能少的相互作用并因此使剪切效应的风险最小化的完整性的问题。

公开(公告)号：WO2013025594A2

公开(公告)日：2013-02-21

申请号：PCT/US2012050549

申请日：2012-08-13

Applicant: ABBOTT LAB ,  GORDON GARY M ,  MILLIKEN ADAM S

Inventor： GORDON GARY M ,  MILLIKEN ADAM S

IPC: A23L3/54 ,  A23L5/30 ,  A23L33/00

CPC classification number: A23L1/0252 ,  A23L3/54 ,  A23L5/32 ,  A23L33/40

Abstract: Disclosed are ultrasonically-produced nutritional powders and methods of manufacturing the nutritional powders, including ultrasonically-produced infant nutritional powders and ultrasonically-produced adult nutritional powders.

Abstract translation: 公开了超声波生产的营养粉末和制造营养粉末的方法，包括超声波产生的婴儿营养粉末和超声产生的成人营养粉末。