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    PREPARATIONS OF NON-STEROIDAL ANALGESICS
    34.
    发明申请
    PREPARATIONS OF NON-STEROIDAL ANALGESICS 审中-公开
    非类固醇的筹备镇痛

    公开(公告)号：WO1997026866A2

    公开(公告)日：1997-07-31

    申请号：PCT/EP1997000185

    申请日：1997-01-17

    Applicant: BASF AKTIENGESELLSCHAFT ,  BREITENBACH, Jörg ,  ROSENBERG, Joerg

    Inventor： BASF AKTIENGESELLSCHAFT

    IPC: A61K09/20

    CPC classification number: A61K31/192 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2095

    Abstract: The invention concerns preparation of non-steroidal analgesics with antipyretic and antiphlogistic effect, obtained through extrusion and moulding of a melt containing in addition one or more substances in a mixture of: a) 40 to 99.5 wt% of a homopolymer of N -vinylpyrrolidone with a K value according to Fikentscher of 30; b) 0.25 to 59.75 wt% of a water-soluble copolymer of N-vinylpyrr olidone; and c) 0.25 to 10 wt% of one or more physiologically ac ceptable sodium or potassium salts, where the quantities refer to the total of the components a), b) and c).

    Abstract translation: 本发明涉及一种具有解热和抗炎作用的非甾体止痛剂，通过挤出获得的，熔体的成形的制品，其特征在于，除了一种或多种活性成分的混合物：a）40至99.5重量具有K A N-乙烯基吡咯烷酮的均聚物的％ 根据30 Fikentscher，值b）0.25至59.75重量的N-乙烯基吡咯烷酮的水溶性共聚物的％和钠或钾的一种或多种生理上可接受的盐C）0.25至10重量％ 其中给出的量是指组分的总和），b）和c）。

    METHOD OF PRODUCING MEDICAMENTS IN SOLID FORM
    35.
    发明申请
    METHOD OF PRODUCING MEDICAMENTS IN SOLID FORM 审中-公开
    用于固体药物剂型的研制

    公开(公告)号：WO1997015291A1

    公开(公告)日：1997-05-01

    申请号：PCT/EP1996004585

    申请日：1996-10-22

    Applicant: BASF AKTIENGESELLSCHAFT ,  BREITENBACH, Jörg ,  HÄRTL, Axel, Paul ,  ROSENBERG, Joerg ,  SCHIESSL, Michael ,  ZETTLER, Hans, Dieter

    Inventor： BASF AKTIENGESELLSCHAFT

    IPC: A61K09/20

    CPC classification number: A61K9/2095

    Abstract: The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping the mixture to form the desired medicament, mixing and melting being carried out in separate stages. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.

    Abstract translation: 本发明涉及一种用于通过至少一种药理学上可接受的聚合物粘合剂，至少一种药物活性成分和任选的常规的药物添加剂的混合和熔化，在不存在溶剂的，在塑料混合物制备固体剂型，塑造成所需的剂型，其中所述混合物 进行在分开的阶段的混合和熔融。 本发明的方法允许简单和温和的生产具有高产品质量的剂型。

    SOLID ACTIVE AGENT PREPARATIONS
    37.
    发明申请
    SOLID ACTIVE AGENT PREPARATIONS 审中-公开
    积极准备节日

    公开(公告)号：WO1996025151A1

    公开(公告)日：1996-08-22

    申请号：PCT/EP1996000417

    申请日：1996-02-01

    Applicant: BASF AKTIENGESELLSCHAFT ,  GRABOWSKI, Sven ,  BREITENBACH, Jörg ,  ROSENBERG, Joerg ,  SANNER, Axel

    Inventor： BASF AKTIENGESELLSCHAFT

    IPC: A61K09/22

    CPC classification number: A61K9/2054 ,  A61K9/2095

    Abstract: Solid preparations obtainable by the melt extrusion of A) at least one active agent, B) a mixture of B1) 10 to 90 wt.% of a water-soluble, thermoplastic polymer and B2) 10 to 90 wt.% of a low-substituted hydroxypropyl cellulose and C) 0 to 50 wt.% in relation to the total quantity of the preparation of common pharmaceutical auxiliaries.

    Abstract translation: 由A的熔融挤出）至少一种活性化合物，B）B1的混合物）10至90重量的水溶性，热塑性聚合物和B2）10〜90重量的低取代羟丙基纤维素的％％，和C获得的固体制剂 ）0至50重量％，基于制剂常规的药物赋形剂，总量。

    SOLID ACTIVE AGENT PREPARATIONS CONTAINING HYDROXYPROPYL CELLULOSE
    38.
    发明申请
    SOLID ACTIVE AGENT PREPARATIONS CONTAINING HYDROXYPROPYL CELLULOSE 审中-公开
    积极准备包含羟丙基节日

    公开(公告)号：WO1996025149A1

    公开(公告)日：1996-08-22

    申请号：PCT/EP1996000418

    申请日：1996-02-01

    Applicant: KNOLL AKTIENGESELLSCHAFT ,  ROSENBERG, Joerg ,  GRABOWSKI, Sven

    Inventor： KNOLL AKTIENGESELLSCHAFT

    IPC: A61K09/16

    CPC classification number: A61K9/2054 ,  A61K9/2095

    Abstract: Preparations containing active agents obtainable by the melt extrusion of A) a water-soluble thermoplastic hydroxypropyl cellulose, B) one or more active agents, C) if desired, pharmaceutical auxiliaries, in which the proportion of A) is 10 to 30 % wt. in relation to the entire preparation.

    Abstract translation: 含活性成分的制剂，由A）一种水溶性热塑性羟丙基纤维素，B）一种或多种活性物质，C）的混合物的熔融挤出获得的任选的药用赋形剂，其中A为10〜30重量％的）的比例，基于总制剂的重量， ，

    METHOD OF PRODUCING LENTICULAR TABLETS BY MELT CALENDERING
    39.
    发明申请
    METHOD OF PRODUCING LENTICULAR TABLETS BY MELT CALENDERING 审中-公开
    受理并熔体中制造LENS粒形

    公开(公告)号：WO1996019964A1

    公开(公告)日：1996-07-04

    申请号：PCT/EP1995005119

    申请日：1995-12-22

    Applicant: BASF AKTIENGESELLSCHAFT ,  ROSENBERG, Joerg ,  MAIER, Werner ,  BREITENBACH, Jörg

    Inventor： BASF AKTIENGESELLSCHAFT

    IPC: A61J03/10

    CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/2072 ,  B30B11/165

    Abstract: The invention concerns a method of producing lenticular tablets by melt calendering, using form cylinders provided with ellipsoid-segment recesses. The proposed method produces tablets which are easy to trim and in which any misalignement between the top and bottom halves of the tablet is such that only a small residue needs to be ground off.

    Abstract translation: 本发明涉及一种用于通过熔融压延生产双凸透镜片，其特征在于，一个使用具有凹陷ellipsoidsegmentartigen成型辊。 片剂本发明的方法的结果，其是容易被去除毛刺，并且其中在上和下半片之间的偏移量的片剂残余低的磨损。

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