公开(公告)号：WO2013012724A1

公开(公告)日：2013-01-24

申请号：PCT/US2012/046674

申请日：2012-07-13

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CAPELLI, Christopher C.

Inventor： CAPELLI, Christopher C.

IPC: A61H1/00

CPC classification number: A61N7/00 ,  A61B2017/00769 ,  A61N2007/0034 ,  A61N2007/0056

Abstract: Apparatuses and methods to generate high frequency shock waves in a controlled manner. The generated shock waves can be delivered to certain cellular structures of a patient for use in medical and/or aesthetic therapeutic applications. The shock waves can be configured to impose sufficient mechanical stress to the targeted cells of the tissue to rupture the targeted cells. Embodiments of the apparatuses and methods of the present invention provide targeted rupturing of specific cells without damaging side effects such as cavitation or thermal degradation of surrounding non-targeted cells.

Abstract translation: 以受控的方式产生高频冲击波的装置和方法。 所产生的冲击波可被传送到患者的某些细胞结构，以用于医学和/或美学治疗应用。 冲击波可以被配置为对组织的靶细胞施加足够的机械应力以破坏靶细胞。 本发明的装置和方法的实施例提供特定细胞的靶向破裂，而不损害诸如周围非靶细胞的空化或热降解的副作用。

公开(公告)号：WO2009042889A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/077902

申请日：2008-09-26

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  SHVETS, Gennady

Inventor： SHVETS, Gennady

IPC: G02B6/10

CPC classification number: G02B6/107 ,  B82Y20/00

Abstract: Embodiments herein provide an optical apparatus (100) for focusing and guiding optical energy. An optical apparatus includes a dielectric fiber(104), a group of metallic wires (102) embedded within the dielectric fiber, and a layer of metal (106) covering an outer surface of the dielectric fiber. The metallic wires may be organized in a converging/diverging manner to guide optical waves. Other embodiments may be disclosed and claimed.

Abstract translation: 本文的实施例提供了用于聚焦和引导光能的光学设备（100）。 一种光学设备包括介电纤维（104），嵌入介质纤维内的一组金属线（102）和覆盖介质纤维的外表面的一层金属（106）。 金属线可以以会聚/发散方式组织以引导光波。 可以公开和要求保护其他实施例。

公开(公告)号：WO2008067504A2

公开(公告)日：2008-06-05

申请号：PCT/US2007/086000

申请日：2007-11-30

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  RANGAN, Giri, N., K. ,  SWARTZLANDER, Earl, E., Jr.

Inventor： RANGAN, Giri, N., K. ,  SWARTZLANDER, Earl, E., Jr.

IPC: H03B5/24 ,  H03K3/03

CPC classification number: H03K3/0322 ,  H03K2005/00026 ,  H03K2005/00208 ,  H03K2005/00234

Abstract: A ring oscillator based voltage controlled oscillator (VCO) is disclosed. The VCO includes a set of delay cells connected to each other in a ring configuration. Each of the delay cells includes a source-coupled input transistor pair, a current- steering transistor pair and a pair of load resistors. The source-coupled input transistor pair receives a pair of differential voltage inputs. The load resistors, which are connected to the source-coupled input transistor pair, provide a pair of differential voltage outputs. The current-steering transistor pair, which is connected to the source-coupled input transistor pair, receives a pair of differential bias voltage inputs. The output frequency of the VCO is directly proportional to the differential bias voltages at the pair of differential bias voltage inputs.

Abstract translation: 公开了一种基于环形振荡器的压控振荡器（VCO）。 VCO包括一组延迟单元以环形配置相互连接。 每个延迟单元包括源极耦合输入晶体管对，电流导引晶体管对和一对负载电阻。 源极耦合输入晶体管对接收一对差分电压输入。 连接到源极耦合输入晶体管对的负载电阻提供一对差分电压输出。 连接到源极耦合输入晶体管对的电流导引晶体管对接收一对差分偏置电压输入。 VCO的输出频率与一对差分偏置电压输入端的差分偏置电压成正比。

公开(公告)号：WO2008045871A2

公开(公告)日：2008-04-17

申请号：PCT/US2007/080807

申请日：2007-10-09

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  KUMAR, Karthik ,  ZHANG, Xiaojing

Inventor： KUMAR, Karthik ,  ZHANG, Xiaojing

IPC: G01L1/24

CPC classification number: G01L1/24 ,  G01L1/04

Abstract: An optical-encoded force sensor is disclosed. The optical-encoded force sensor includes a cantilever probe having a probe tip, a set of reflective phase gratings and multiple nano-photonic displacement sensors. The reflective phase gratings are mechanically coupled to the cantilever probe, and the nano-photonic displacement sensors are mechanically coupled to the reflective phase gratings. In response to a load being applied to the probe tip, the reflective phase gratings can be compressed such that a diffraction order of the reflective phase gratings changes according to the force of the applied load.

Abstract translation: 公开了一种光学编码的力传感器。 光编码力传感器包括具有探针尖端的悬臂探针，一组反射相位光栅和多个纳米光子位移传感器。 反射相位光栅机械耦合到悬臂探针，并且纳米光子位移传感器机械耦合到反射相位光栅。 响应于施加到探针尖端的负载，可以压缩反射相位光栅，使得反射相位光栅的衍射级根据施加的负载的力而改变。

公开(公告)号：WO2007021863A1

公开(公告)日：2007-02-22

申请号：PCT/US2006/031248

申请日：2006-08-10

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  TSANG, Robin, M.

Inventor： TSANG, Robin, M.

IPC: H03M1/66

CPC classification number: H03M1/0678 ,  H03M1/0697 ,  H03M1/74

Abstract: A current-steering type digital-to-analog converter (DAC) is disclosed. The DAC includes a first sub-DAC, a second sub-DAC and a controlling device. Both the first sub-DAC and the second sub-DAC are configured to receive input signals. The controlling device selectively and periodically sends output signals of either the first sub-DAC or the second sub-DAC to a resistive load while sending output signals of the remaining one of the two sub-DACs to a dummy resistive load. An output of the DAC is provided at the resistive load.

Abstract translation: 公开了一种电流导向型数模转换器（DAC）。 DAC包括第一子DAC，第二子DAC和控制装置。 第一子DAC和第二子DAC都被配置为接收输入信号。 控制装置选择性地并且周期地将第一子DAC或第二子DAC的输出信号发送到电阻性负载，同时将两个子DAC中的剩余的一个的输出信号发送到虚拟电阻负载。 在电阻负载下提供DAC的输出。

公开(公告)号：WO2007008755A2

公开(公告)日：2007-01-18

申请号：PCT/US2006/026669

申请日：2006-07-07

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ROY, Krishnendu ,  RAJA, Lazminariyan, L.

Inventor： ROY, Krishnendu ,  RAJA, Lazminariyan, L.

CPC classification number: C08J7/123 ,  A61K47/6927 ,  C08J3/128 ,  C08J2367/04

Abstract: The present invention relates to methods for functionalizing a surface, comprising exposing a surface of a polymeric material to an atmospheric pressure glow plasma discharge, wherein exposure to the plasma discharge functionalizes the surface of the polymeric material. The present invention further provides for methods for functionalizing a polymeric material, wherein the functionalized surface has conjugated thereto bioactive agents. The present invention is also directed to compositions comprising a functionalized surface with attached bioactive agents.

Abstract translation: 本发明涉及官能化表面的方法，包括将聚合物材料的表面暴露于大气压辉光等离子体放电，其中暴露于等离子体放电使聚合物材料的表面功能化。 本发明进一步提供官能化聚合物材料的方法，其中官能化表面与生物活性剂偶联。 本发明还涉及包含具有连接的生物活性剂的官能化表面的组合物。

公开(公告)号：WO2006124266A2

公开(公告)日：2006-11-23

申请号：PCT/US2006/016771

申请日：2006-05-03

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CIULIK, James, R. ,  TALEFF, Eric, M.

Inventor： CIULIK, James, R. ,  TALEFF, Eric, M.

IPC: C30B15/00

CPC classification number: C30B1/04 ,  C30B1/02 ,  C30B29/02 ,  Y10T117/10

Abstract: A method for growing large single crystals of metals is disclosed. A polycrystalline form of a metal specimen is initially heated in a non-oxidizing environment. A minimum plastic strain is then applied to the heated metal specimen to initiate the growth of a selected grain within the heated metal specimen. Additional plastic strain is subsequently applied to the heated metal specimen to propagate the growth of the selected grain to become a large single crystal.

Abstract translation: 公开了一种生长大单晶金属的方法。 金属样品的多晶形式最初在非氧化环境中加热。 然后将最小的塑性应变施加到加热的金属样品上以引起加热的金属样品内选定的晶粒的生长。 随后将附加的塑性应变施加到加热的金属试样上，以使所选择的晶粒的生长传播成为大的单晶。

公开(公告)号：WO2004014937A2

公开(公告)日：2004-02-19

申请号：PCT/US2003/020635

申请日：2003-07-01

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CARNEY, Darrell, H.

Inventor： CARNEY, Darrell, H.

IPC: C07K

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

Abstract: Disclosed are thrombin peptide derivatives comprising a polypeptide having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

Abstract translation: 公开了包含具有氨基酸序列SEQ ID NO.1的多肽的凝血酶肽衍生物。 2：Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val或具有至少6个氨基酸的多肽的C末端截短的片段。 Xaa是丙氨酸，甘氨酸，丝氨酸或S-保护的半胱氨酸。 多肽或多肽片段中的一个，一个，两个或三个氨基酸不同于SEQ ID NO。 还公开了用凝血酶受体激动剂治疗需要治疗的受试者的方法。 所述方法包括施用有效量的上述凝血酶肽衍生物的步骤。

公开(公告)号：WO1997016547A1

公开(公告)日：1997-05-09

申请号：PCT/US1996017979

申请日：1996-10-31

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ROTH, Jack, A. ,  ALEMANY, Ramon ,  ZHANG, Wei-Wei ,  MUKHOPADHYAY, Tapas

IPC: C12N15/11

CPC classification number: C12N15/1135 ,  A61K38/00 ,  C12N2799/022

Abstract: A variety of genetic constructs are disclosed that will find both in vitro and in vivo use in the area of tumor biology and cancer therapy. In particular, adenoviral expression vectors are provided that contain a K-ras nucleic acid positioned antisense to regulatory control regions. In one embodiment, the adenoviral expression vector is a replication-deficient adenoviral vector lacking the E1 region and containing a K-ras nucleic acid. Also provided are methods for the inhibition of cancer cell proliferation.

Abstract translation: 公开了在肿瘤生物学和癌症治疗领域中体外和体内使用的多种遗传构建体。 特别地，提供了含有与调控区域反义的K-ras核酸的腺病毒表达载体。 在一个实施方案中，腺病毒表达载体是缺少E1区并且含有K-ras核酸的复制缺陷型腺病毒载体。 还提供了抑制癌细胞增殖的方法。

公开(公告)号：WO1996029926A1

公开(公告)日：1996-10-03

申请号：PCT/US1996004307

申请日：1996-03-29

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  RICHARDS-KORTUM, Rebecca ,  PITRIS, Costas ,  MITCHELL, Michele, Follen

IPC: A61B05/00

CPC classification number: A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/4331

Abstract: A probe, and an apparatus incorporating the probe, for detecting tissue abnormality, particularly precancerous cervical tissue, through fluorescence spectroscopy are disclosed. In vivo fluorescence excitation and detection can be accomplished easily and accurately using a probe whose tip conforms to the surface of the cervix. In addition, a higher number of fiber pairs provides more information and, therefore, more accurate diagnosis.

Abstract translation: 公开了一种用于通过荧光光谱法检测组织异常，特别是癌前期宫颈组织的探针和结合有探针的装置。 可以使用尖端符合子宫颈表面的探针，容易且精确地实现体内荧光激发和检测。 此外，更多数量的光纤对提供更多信息，因此提供更准确的诊断。