公开(公告)号：WO2006130797A3

公开(公告)日：2006-12-07

申请号：PCT/US2006/021343

申请日：2006-05-31

申请人： THE GENERAL HOSPITAL CORPORATION ,  BOUMA, Brett, Eugene ,  TEARNEY, Guillermo, J. ,  YELIN, Dvir ,  YUN, Seok-hyun

发明人： BOUMA, Brett, Eugene ,  TEARNEY, Guillermo, J. ,  YELIN, Dvir ,  YUN, Seok-hyun

IPC分类号： A61B5/00 ,  G01N21/47 ,  G01B9/02

摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source (100) can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample (140) to generate a spectrally encoded line. A second Electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay (160), where the first and second Electro-- magnetic radiation’s can be based on the particular radiation. An interference between a third Electro-magnetic radiation (associated with the first Electro-magnetic radiation) and a fourth Electro-magnetic radiation (associated with the second Electro-magnetic radiation) can be detected. The spectrally encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.

公开(公告)号：WO2004066824A2

公开(公告)日：2004-08-12

申请号：PCT/US2004/002563

申请日：2004-01-26

申请人： THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SHISHKOV, Milen, Stefanov ,  IFTIMIA, Nicursor ,  BOUMA, Brett, E. ,  PITMAN, Martha

发明人： TEARNEY, Guillermo, J. ,  SHISHKOV, Milen, Stefanov ,  IFTIMIA, Nicursor ,  BOUMA, Brett, E. ,  PITMAN, Martha

IPC分类号： A61B

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/6848

摘要： An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.

摘要翻译： 一种用于使用一维干涉测量成像进行实时组织分化的针活检装置，包括具有镜筒和针的活检装置，插入针中的光纤以及连接到光纤的光纤成像系统。 成像系统获得图像，并将光学性质和图案与标准化组织样本图像的数据库进行比较，以确定不同的组织类型。 执行活组织检查的医师通过与活检装置相关联的反馈单元获得反馈，并且连接到成像系统。 反馈单元可以提供当针朝向目标组织插入时遇到的组织类型的视觉，听觉或振动反馈。 反馈单元可以被编程用于不同的活检程序，使得用户可以致动按钮以选择用于期望的程序和要预期的组织的显示器或其他反馈机构。

公开(公告)号：WO2003062802A3

公开(公告)日：2003-07-31

申请号：PCT/US2003/002349

申请日：2003-01-24

申请人： THE GENERAL HOSPITAL CORPORATION ,  DE BOER, Johannes, Fitzgerald ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, Eugene

发明人： DE BOER, Johannes, Fitzgerald ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, Eugene

IPC分类号： G01N21/47

摘要： Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry ("LCI") signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source can be split into N spectral bands. The N spectral bands can be individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band may be detected by a separate photo detector and amplified. For each spectral band, the signal can be band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is likely reduced by a factor equal to the number of spectral bands, while the signal amplitude can remain the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

公开(公告)号：WO2023028032A1

公开(公告)日：2023-03-02

申请号：PCT/US2022/041171

申请日：2022-08-23

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： THRAPP, Andrew, D. ,  AHSEN, Osman, O. ,  TEARNEY, Guillermo, J. ,  JAFFER, Farouc, A. ,  GARDECKI, Joseph, A. ,  KASSAB, Mohamad, B. ,  MAUSKAPF, Adam

IPC分类号： A61B5/00 ,  A61B6/00 ,  G01N21/64

摘要： A method for detecting inflammatory activity, including: providing a catheter including a near-infrared fluorescence (NIRF) imaging system configured to perform NIRF imaging and an optical coherence tomography (OCT) imaging system configured to perform structural imaging; introducing a near-infrared fluorescent cathepsin-activatable imaging agent into a blood vessel; placing a distal end of the catheter within the blood vessel; obtaining, using the OCT imaging system, structural images of an atherosclerotic plaque within the blood vessel; obtaining, using the NIRF imaging system, NIRF images of the atherosclerotic plaque within the blood vessel; detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images; and identifying inflammation within the atherosclerotic plaque based on detecting the near- infrared fluorescent cathepsin-activatable imaging agent in the NIRF images.

公开(公告)号：WO2018045284A1

公开(公告)日：2018-03-08

申请号：PCT/US2017/049850

申请日：2017-09-01

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： LI, Li ,  TEARNEY, Guillermo, J.

IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K41/00 ,  A61K49/00 ,  A61M37/00

CPC分类号： A61M37/0092 ,  A61B5/055 ,  A61B8/0833 ,  A61K38/00 ,  A61K41/0028 ,  A61K49/223 ,  A61N2/004

摘要： The present disclosure includes system, methods, and kits relating to creating a second structure with a plurality of first structures at a target site inside or adjacent to a host object. The methods include the step of generating a field that non-invasively penetrates into the host object. The methods further include the step of positioning a first portion of the plurality of first structures at the target site using a force corresponding to the field. Additionally, the methods include the step of linking the first portion of the plurality of first structures with one another and/or the host object at the target site to form the second structure.

摘要翻译： 本公开包括涉及在宿主对象内部或邻近的目标站点创建具有多个第一结构的第二结构的系统，方法和套件。 这些方法包括产生非侵入性地渗入宿主物体的场的步骤。 该方法还包括使用对应于该场的力将多个第一结构的第一部分定位在目标部位的步骤。 此外，该方法包括将多个第一结构的第一部分彼此连接和/或将宿主对象连接在目标部位以形成第二结构的步骤。

公开(公告)号：WO2014121193A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014432

申请日：2014-02-03

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： TEARNEY, Guillermo, J. ,  WARGER, II, William, C. ,  CARRUTH, Robert ,  WURSTER, Lara ,  GORA, Michalina

IPC分类号： F16C41/00 ,  G01D5/34

CPC分类号： A61B1/00172 ,  A61B1/04 ,  A61B1/07

摘要： These and other objects of the present disclosure can be achieved by provision of an apparatus for illuminating a structure(s), which can include a first arrangement and a second arrangement which can each be configured to rotate and deflect a radiation(s) transmitted therethrough at an angle with respect to an axis of rotation thereof. There can be a plurality of rotating third arrangements, where at least one can be connected to the first arrangement, and at least another one can be connected to the second arrangement. A fourth arrangement can be connected to the third arrangements, and can be configured to rotate the third arrangements. One of the rotating third arrangements can be flexible, can have a length that is greater than ten times a diameter of the first arrangement or the second arrangement, can be surrounded by a housing, and/or can contain an optical waveguide arrangement extending therethrough.

摘要翻译： 本公开的这些和其它目的可以通过提供用于照亮结构的装置来实现，该结构可以包括第一布置和第二布置，其可以被配置成旋转和偏转穿过其中的辐射 相对于其旋转轴线成一定角度。 可以有多个旋转的第三布置，其中至少一个可以连接到第一布置，并且至少另一个可以连接到第二布置。 第四布置可以连接到第三布置，并且可以被配置为旋转第三布置。 旋转的第三布置中的一个可以是柔性的，可以具有大于第一布置或第二布置的直径的十倍的长度，可以被壳体包围，和/或可以包含延伸穿过其中的光波导装置。

公开(公告)号：WO2014121186A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014413

申请日：2014-02-03

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： TEARNEY, Guillermo, J. ,  GARDECKI, Joseph, A. ,  JACQUES, Paulino, Vacas

IPC分类号： H01S3/10

CPC分类号： H01S3/105 ,  H01S3/083 ,  H01S3/1003 ,  H01S3/10053 ,  H01S5/06213 ,  H01S5/146

摘要： Systems, methods and computer-accessible mediums for providing a radiation(s) can be provided. For example, a hardware arrangement can be configured to provide the radiation(s) that can have a wavelength(s) that continuously changes over time and over a predetermined bandwidth with a predetermined envelope in a single sweep. The hardware arrangement can include a gain arrangement and a controller arrangement, and the controller arrangement can be configured to electronically control the gain arrangement such that the wavelength(s) provided by the hardware arrangement (i) spans a subset of the predetermined bandwidth, or (ii) changes a wavelength dependent distribution in the single sweep.

摘要翻译： 可以提供用于提供辐射的系统，方法和计算机可访问介质。 例如，硬件布置可以被配置为提供可以具有在一次扫描中具有预定包络的时间上和超过预定带宽连续变化的波长的辐射。 硬件布置可以包括增益布置和控制器布置，并且控制器布置可以被配置为电子控制增益布置，使得由硬件布置（i）提供的波长跨越预定带宽的子集，或 （ii）在单次扫描中改变波长相关分布。

公开(公告)号：WO2013109883A1

公开(公告)日：2013-07-25

申请号：PCT/US2013/022136

申请日：2013-01-18

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： GORA, Michalina, Jozefina ,  DIERKSEN, Gregory ,  BOUMA, Brett, Eugene ,  TEARNEY, Guillermo, J.

IPC分类号： A61B5/00 ,  A61B1/32 ,  A61M29/00

CPC分类号： A61B1/00082 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6858 ,  A61B18/18

摘要： Exemplary apparatus and method can be provided for obtaining data for at least one portion within at least one luminal or hollow sample. It is possible, e.g., using a first optical arrangement, to transceive at least one electromagnetic radiation to and from the portion(s). Further, it is possible, e.g., to actuate an expandable second basket arrangement so as to position the first arrangement at a predetermined location within the luminal or hollow sample(s). The second arrangement can have at least one prong or strip that has a flat shape on at least one side thereof.

摘要翻译： 可以提供示例性的装置和方法来获得至少一个管腔或中空样品中的至少一个部分的数据。 例如，使用第一光学装置可以将至少一个电磁辐射收发到所述部分或从所述部分收发。 此外，例如，可以致动可膨胀的第二筐布置，以将第一布置定位在管腔或空心样品内的预定位置。 第二布置可以具有在其至少一侧上具有平坦形状的至少一个插脚或条带。

公开(公告)号：WO2013059673A1

公开(公告)日：2013-04-25

申请号：PCT/US2012/061135

申请日：2012-10-19

申请人： THE GENERAL HOSPITAL CORPORATION ,  AIR LIQUIDE

发明人： WARGER, William, C. ,  NAMATI, Eman ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, Eugene ,  UNGLERT, Carolin

IPC分类号： G01N21/01 ,  G01N21/45 ,  A61M37/00 ,  G02B6/10 ,  A61N5/06

CPC分类号： A61B5/0077 ,  A61B1/00147 ,  A61B1/00172 ,  A61B5/0031 ,  A61B5/0066 ,  A61B5/0084 ,  A61B2503/40 ,  A61M37/00 ,  A61N5/062 ,  G01N21/01 ,  G02B6/262

摘要： According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for obtaining information associated with at least one anatomical structure. The exemplary apparatus can include at least one first arrangement which can be configured to provide at least one electro-magnetic radiation to at least one portion of the at least one anatomical structure. The first arrangement(s) can include a configuration which is configured to relatively permanently attach the apparatus to or in the at least one anatomical structure. The exemplary apparatus can further include at least one interferometric arrangement configured to receive a further radiation from the portion(s) which can be associated with the electro-magnetic radiation(s).

摘要翻译： 根据本公开的示例性实施例，可以提供装置和方法来获得与至少一个解剖结构相关联的信息。 示例性设备可以包括至少一个第一布置，其可以被配置为向至少一个解剖结构的至少一个部分提供至少一个电磁辐射。 第一布置可以包括被配置为将设备相对永久地附接到或在至少一个解剖结构中的构造。 示例性装置还可以包括至少一个干涉装置，其配置成从可与电磁辐射相关联的部分接收另外的辐射。

公开(公告)号：WO2011153434A2

公开(公告)日：2011-12-08

申请号：PCT/US2011/039066

申请日：2011-06-03

申请人： THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GORA, Michalina ,  SUTER, Melissa ,  YOO, Hongki ,  SHISHKOV, Milen

发明人： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GORA, Michalina ,  SUTER, Melissa ,  YOO, Hongki ,  SHISHKOV, Milen

IPC分类号： A61B1/227 ,  A61B1/24 ,  G01B9/02

CPC分类号： A61B1/00082 ,  A61B1/00165 ,  A61B1/00179

摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

摘要翻译： 根据本公开的示例性实施例，可以提供可以使用光学技术来促进生物组织例如体内器官的成像的装置和方法。 示例性装置可以包括不同的设计，一个或多个导管的特征可以照亮组织，并从内腔收集信号。 在根据本公开的另一示例性实施例中，球囊导管可以设置有柔性颈部，其可以吸收大部分的弯曲。 根据本公开的另一示例性实施例，可以提供球囊 - 导管系留胶囊，并且根据另外的示例性实施例，结构化球囊设计可以设置有一个或多个突起，从而能够使结构在近距离成像 接触，例如，不压缩组织。