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    APPARATUS, METHODS AND COMPUTER-ACCESSIBLE MEDIA FOR IN SITU THREE-DIMENSIONAL RECONSTRUCTION OF LUMINAL STRUCTURES
    2.
    发明申请
    APPARATUS, METHODS AND COMPUTER-ACCESSIBLE MEDIA FOR IN SITU THREE-DIMENSIONAL RECONSTRUCTION OF LUMINAL STRUCTURES 审中-公开

    公开(公告)号：WO2018175878A1

    公开(公告)日：2018-09-27

    申请号：PCT/US2018/024014

    申请日：2018-03-23

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： TEARNEY, Guillermo, J. ,  GERDECKI, Joseph, A. ,  SINGH, Kanwarpal

    IPC分类号： A61B5/00 ,  A61B8/12

    摘要： An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.

    IMAGING APPARATUS AND METHOD WHICH UTILIZES MULTIDIRECTIONAL FIELD OF VIEW ENDOSCOPY
    3.
    发明申请
    IMAGING APPARATUS AND METHOD WHICH UTILIZES MULTIDIRECTIONAL FIELD OF VIEW ENDOSCOPY 审中-公开
    使用多视野内窥镜的成像装置和方法

    公开(公告)号：WO2015009932A1

    公开(公告)日：2015-01-22

    申请号：PCT/US2014/047034

    申请日：2014-07-17

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： TEARNEY, Guillermo, J. ,  WU, Tao ,  WOODS, Kevin, E. ,  FORD, Timothy, Nehiley

    IPC分类号： A61B1/00

    CPC分类号： A61B1/0014 ,  A61B1/00016 ,  A61B1/00029 ,  A61B1/00177 ,  A61B1/00179 ,  A61B1/00181 ,  A61B1/05 ,  A61B1/053 ,  A61B1/0607 ,  A61B1/0615 ,  A61B1/0623 ,  A61B1/0638 ,  A61B1/0676 ,  G02B23/2484

    摘要： Exemplary apparatus for coupling to a probe and providing information regarding at least one structure can be provided. For example, the apparatus can include an electronics arrangement which is configured to obtain the information and transmit the information wirelessly, and a structural connection configuration which is structured and configured to be attached to the probe. The electronics arrangement can include a detector arrangement which is configured to detect at least one return radiation from at least one portion of at least one sample based on the predetermined patterns, and provide the data for the portion(s) based on the return radiation(s). In addition, a computer arrangement can be provided which is configured to generate the information with includes image data for the portion(s) as a function of the data and prior knowledge of the predetermined patterns.

    摘要翻译： 可以提供用于耦合到探针并提供关于至少一个结构的信息的示例性装置。 例如，该装置可以包括被配置为获得信息并且无线地发送信息的电子装置，以及被构造和配置为附接到探针的结构连接配置。 电子装置可以包括检测器装置，其被配置为基于预定模式来检测来自至少一个样本的至少一部分的至少一个返回辐射，并且基于返回辐射提供该部分的数据（ S）。 此外，可以提供一种计算机装置，其被配置为生成信息，其中包括作为数据的函数的部分的图像数据和预定模式的先验知识。

    APPARATUS, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR SPECTRAL ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY IMAGES
    4.
    发明申请
    APPARATUS, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR SPECTRAL ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY IMAGES 审中-公开
    用于光学相干图像图像的光谱分析的装置，系统，方法和计算机可访问介质

    公开(公告)号：WO2011150069A2

    公开(公告)日：2011-12-01

    申请号：PCT/US2011/037916

    申请日：2011-05-25

    申请人： THE GENERAL HOSPITAL CORPORATION ,  FLEMING, Christine ,  BOUMA, Brett, E. ,  GARDECKI, Joseph ,  TEARNEY, Guillermo, J.

    发明人： FLEMING, Christine ,  BOUMA, Brett, E. ,  GARDECKI, Joseph ,  TEARNEY, Guillermo, J.

    IPC分类号： A61B5/00 ,  G01N21/17 ,  G01B9/02

    CPC分类号： A61B5/0066 ,  A61B5/02007 ,  A61B5/7264 ,  G01B9/02091 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2201/129 ,  G01N2201/1293

    摘要： According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation. Further, with at least one second arrangement, it is possible to generate spectroscopic data as a function of the at least one third radiation, and reduce at least one scattering effect in the spectroscopic data to generate the information. In addition or as an alternative, according to a further exemplary embodiment of the present disclosure, it is possible to classify a type of the structure based on the spectroscopic data to generate the information.

    摘要翻译： 根据本公开的示例性实施例，可以提供装置和方法来生成用于至少一个结构的信息。 例如，使用至少一个第一布置，可以接收来自至少一个结构的至少一个第一辐射和来自参考的至少一个第二辐射，并且干扰第一和第二辐射以产生至少一个第三辐射 。 此外，利用至少一个第二布置，可以产生作为至少一个第三辐射的函数的光谱数据，并且减少光谱数据中的至少一个散射效应以产生信息。 另外或作为替代，根据本公开的另一示例性实施例，可以基于光谱数据对结构的类型进行分类以生成信息。

    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION
    5.
    发明申请
    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 审中-公开
    在特定分辨率下提供至少一个解剖结构的显微图像的系统，方法和计算机可访问介质

    公开(公告)号：WO2011109835A2

    公开(公告)日：2011-09-09

    申请号：PCT/US2011/027450

    申请日：2011-03-07

    申请人： THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GARDECKI, Joseph, A. ,  LIU, Linbo

    发明人： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GARDECKI, Joseph, A. ,  LIU, Linbo

    CPC分类号： A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

    摘要： Exemplary embodiments of probes, apparatus, systems and methods can be provided which provide at least one electro-magnetic radiation to at least one sample. For example, a plurality of axicon lenses can be provided which are configured to provide the electro-magnetic radiation(s) having at least partially annulus shape. In addition or alternatively, at least one optical arrangement can be provided which is configured to forward at least one radiation to the sample therethrough having at least partially circularly-symmetric pattern. For example, at least one first portion of the radiation transmitted through a circular section of the pattern can have an optical path-length that is different from an optical path- length of at least one second portion of the radiation transmitted through at least one other section of the pattern.

    摘要翻译： 可以提供探针，装置，系统和方法的示例性实施例，其向至少一个样本提供至少一个电磁辐射。 例如，可以提供多个轴锥透镜，其被配置为提供具有至少部分环形形状的电磁辐射。 附加地或替代地，可以提供至少一个光学装置，其被配置为将至少一个辐射传送到通过其中的具有至少部分圆形对称图案的样本。 例如，通过图案的圆形部分透射的辐射的至少一个第一部分可以具有与通过至少一个其它透射部分透射的辐射的至少一个第二部分的光学路径长度不同的光学路径长度 部分模式。

    SYSTEM AND METHOD FOR PROVIDING NONINVASIVE DIAGNOSIS OF COMPARTMENT SYNDROME EXEMPLARY LASER SPECKLE IMAGING PROCEDURE
    7.
    发明申请
    SYSTEM AND METHOD FOR PROVIDING NONINVASIVE DIAGNOSIS OF COMPARTMENT SYNDROME EXEMPLARY LASER SPECKLE IMAGING PROCEDURE 审中-公开
    系统和方法提供无组织诊断的房间综合征激光照相成像程序

    公开(公告)号：WO2008116010A1

    公开(公告)日：2008-09-25

    申请号：PCT/US2008/057533

    申请日：2008-03-19

    申请人： THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  VELMAHOS, George ,  BOUMA, Brett, E.

    发明人： TEARNEY, Guillermo, J. ,  VELMAHOS, George ,  BOUMA, Brett, E.

    IPC分类号： A61B5/026 ,  A61B5/00 ,  A61B5/103 ,  G01N21/47 ,  G01P5/00

    CPC分类号： A61B5/0261 ,  A61B5/0059 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/103 ,  A61B5/4878 ,  A61B2562/0242 ,  G01N2021/479

    摘要： Exemplary systems and methods can be provided for providing information associated with tissue. For example, it is possible to illuminate the tissue with at least one electro-magnetic radiation which is a coherent light and/or a partially coherent light. The electro-magnetic radiation reflected from the tissue can be received and speckle patterns may be formed associated with the electro-magnetic radiation. In addition, changes can be analyzed in the speckle patterns at time intervals sufficient to measure motion of or within a fascial compartment of the tissue. For example, it is also possible that the electro-magnetic radiation is an interfered radiation from a sample and a reference. Further, the speckle patterns can be measured at different depths within the sample by moving the reference.

    摘要翻译： 可以提供示例性系统和方法来提供与组织相关联的信息。 例如，可以用至少一个作为相干光和/或部分相干光的电磁辐射照射组织。 可以接收从组织反射的电磁辐射，并且可以形成与电磁辐射相关联的斑点图案。 此外，可以以足以测量组织的筋膜室内或内部的时间间隔的斑点图案来分析变化。 例如，电磁辐射也可能是来自样品和参考物的干扰辐射。 此外，可以通过移动参考来在样本内的不同深度处测量斑点图案。

    APPARATUS FOR APPLYING A PLURALITY OF ELECTRO-MAGNETIC RADIATIONS TO A SAMPLE
    8.
    发明申请
    APPARATUS FOR APPLYING A PLURALITY OF ELECTRO-MAGNETIC RADIATIONS TO A SAMPLE 审中-公开

    公开(公告)号：WO2007149603A3

    公开(公告)日：2007-12-27

    申请号：PCT/US2007/061481

    申请日：2007-02-01

    申请人： THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

    发明人： TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

    IPC分类号： A61B5/00 ,  A61B18/24

    摘要： An apparatus for applying a plurality of electro-magnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.

    SYSTEMS AND PROCESSES FOR PROVIDING ENDOGENOUS MOLECULAR IMAGING WITH MID-INFARED LIGHT
    9.
    发明申请
    SYSTEMS AND PROCESSES FOR PROVIDING ENDOGENOUS MOLECULAR IMAGING WITH MID-INFARED LIGHT 审中-公开
    提供具有中间入射光的内源分子成像的系统和过程

    公开(公告)号：WO2007084933A2

    公开(公告)日：2007-07-26

    申请号：PCT/US2007/060657

    申请日：2007-01-18

    申请人： THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

    发明人： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

    CPC分类号： G01N21/3563 ,  G01J3/02 ,  G01J3/021 ,  G01J3/42 ,  G01N21/031 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787

    摘要： Exemplary systems and processes for generating information associated with at least one portion of a sample are provided. In one exemplary embodiment, at least one electro-magnetic radiation can be received from the at least one portion, whereas the electro-magnetic radiation has a wavenumber that is between approximately 5,000 cm -1 and 600 cm -1 . The information can be generated which includes structural data, molecular data and/or chemical data of the portion. The information can be generated based on (a) at least one phase of the at least one electro-magnetic radiation, and/or (b) at least one refractive index of the at least one portion. According to another exemplary embodiment, the electro-magnetic radiation having a first wavenumber can be transmitted to the portion which has at least two substances, whereas a refractive index of one of the substances at a second wavenumber is approximately the same as a refractive index of another one of the substances at the second wavenumber. The electro-magnetic radiation can be controlled such that the first wavenumber substantially matches the first wavenumber to reduce scattering within the portion.

    摘要翻译： 提供了用于生成与样本的至少一部分相关联的信息的示例性系统和过程。 在一个示例性实施例中，可以从至少一个部分接收至少一个电磁辐射，而电磁辐射具有介于约5000cm -1与600cm -1之间的波数， SUP> -1 。 可以生成包括该部分的结构数据，分子数据和/或化学数据的信息。 可以基于（a）至少一个电磁辐射的至少一个相位，和/或（b）至少一个部分的至少一个折射率来生成信息。 根据另一个示例性实施方式，具有第一波数的电磁辐射可以被传送到具有至少两种物质的部分，而第二波数处的物质之一的折射率近似等于 另一种是第二种波数的物质。 可以控制电磁辐射，使得第一波数基本上匹配第一波数以减少该部分内的散射。