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    METHOD AND APPARATUS FOR DELIVERING OXYGEN INTO BLOOD
    32.
    发明申请
    METHOD AND APPARATUS FOR DELIVERING OXYGEN INTO BLOOD 审中-公开
    将氧气输送到血液中的方法和装置

    公开(公告)号：WO1995013843A1

    公开(公告)日：1995-05-26

    申请号：PCT/US1994012815

    申请日：1994-11-07

    Applicant: WAYNE STATE UNIVERSITY

    Inventor： WAYNE STATE UNIVERSITY ,  SPEARS, James, Richard

    IPC: A61M37/00

    CPC classification number: D21C9/147 ,  A23L2/54 ,  A61K9/5089 ,  A61M1/1678 ,  A61M1/32 ,  A61M1/322 ,  A61M25/0029 ,  A61M25/09 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/0039 ,  A61M2025/004 ,  A61M2025/0057 ,  A61M2202/0476 ,  B01F3/04439 ,  B01J13/04 ,  C01B5/00 ,  C01B13/00 ,  C01B13/02 ,  A61M2202/0007

    Abstract: A method and apparatus for delivering oxygen into an environment of interest, such as blood plasma (22), having the characteristic of a low concentration of oxygen before delivery. The method includes the steps of preparing a mixture of oxygen and liquid, compressing the mixture so that the oxygen dissolves in the liquid to form an oxygen-enriched liquid, delivering the oxygen-enriched liquid to a catheter having an internal diameter and length which retains the oxygen in solution and prevents the formation of bubbles, positioning the catheter in the environment of interest, and injecting the oxygen-enriched liquid into the environment through the catheter, such that the environment rapidly becomes enriched in oxygen. The apparatus includes a catheter with drawn silica tubing (20) having narrowly defined passages through which oxygen-enriched liquid passes to oxygenate blood plasma (22).

    Abstract translation: 一种用于将氧输送到感兴趣的环境中的方法和装置，例如血浆（22），其具有在输送之前氧浓度低的特征。 该方法包括制备氧气和液体的混合物的步骤，压缩混合物，使得氧气溶解在液体中以形成富氧液体，将富氧液体输送到具有保持的内径和长度的导管 溶液中的氧气并防止气泡的形成，将导管定位在感兴趣的环境中，并且通过导管将富氧液体注入环境中，使得环境迅速富集氧气。 该装置包括具有拉伸二氧化硅管（20）的导管，其具有窄定义的通道，富氧液体通过该通道通过氧合血浆（22）。

    TETRAPHENYLPORPHYRIN COMPOUNDS AND METHOD
    33.
    发明申请
    TETRAPHENYLPORPHYRIN COMPOUNDS AND METHOD 审中-公开
    四苯并噻吩化合物和方法

    公开(公告)号：WO1994011371A1

    公开(公告)日：1994-05-26

    申请号：PCT/US1993010790

    申请日：1993-11-08

    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD ...

    Inventor： THE BOARD OF TRUSTEES OF THE LELAND STANFORD ... ,  ZHANG, Xumu ,  UFFELMAN, Erich, S. ,  COLLMAN, James, P.

    IPC: C07D481/29

    CPC classification number: C07D487/22 ,  C01B13/00 ,  C07D498/22 ,  C07F15/025

    Abstract: Disclosed is a metalloporphyrin-ligand complex which includes (a) a meso-tetraphenylporphyrin, (b) a crown ether rigidly attached to the meso-tetraphenylporphyrin by covalent attachment on one side of the porphyrin to two diagonally opposing phenyl groups, (c) a metal bound to the pyrrole nitrogens of the portphyrin, (d) a bridge covalently linking two diagonally opposing phenyl groups on the other side of the porphyrin, effective to hinder mu -oxo dimer formation, and (e) a ligand having (i) a primary amine which is held noncovalently by the crown ether and (ii) a metal-coordinating atom which is coordinately bound to the metal. In another aspect, the invention includes a water-soluble oxygen carrier. The oxygen carrier includes a meso- alpha , alpha , alpha , alpha -tetrakis(o-propanoyl-amino)phenylporphyrin, in which the 3-carbons of the propanoyl groups are each covalently bound to an amine nitrogen, and iron or cobalt is bound to the pyrrole nitrogens of the porphyrin. The oxygen carrier also includes a ligand L for protecting the open face of the porphyrin form mu -oxo dimer formation.

    Abstract translation: 公开了一种金属卟啉 - 配体络合物，其包括（a）内消旋 - 四苯基卟啉，（b）通过在卟啉的一面上共价连接到两个对角线相对的苯基上而刚性连接到内消旋 - 四苯基卟啉上的冠醚，（c） 金属与卟啉的吡咯氮结合，（d）共价连接卟啉另一侧的两个对角相对的苯基的桥，有效阻碍多氧二聚体形成，和（e）具有（i） 由伯醚非共价保持的伯胺和（ii）与金属配位结合的金属配位原子。 另一方面，本发明包括水溶性氧载体。 氧载体包括中和α，α，α，α-四（邻 - 丙酰基 - 氨基）苯基卟啉，其中丙酰基的3-碳各自共价结合到胺氮上，并且铁或钴被结合 到卟啉的吡咯氮。 氧载体还包括用于保护卟啉形式的mu-氧化二聚体形成的开放面的配体L.

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