公开(公告)号：WO2017079061A3

公开(公告)日：2017-06-29

申请号：PCT/US2016059439

申请日：2016-10-28

Applicant: UNIV DUKE

Inventor： LEVERING VRAD W ,  CAO CHANGYONG ,  LOPEZ GABRIEL P ,  ZHAO XUANHE ,  LEVINSON HOWARD

IPC: B08B7/02

CPC classification number: A61M25/0026 ,  A61M25/0017 ,  A61M2025/0019 ,  A61M2025/0035 ,  A61M2025/0036 ,  A61M2025/004

Abstract: Catheters for debonding fouling agents from an interior surface thereof and related methods are disclosed. According to an aspect, a catheter includes a lumen defining a flexible, interior surface that extends substantially along a length of the lumen for contacting a biological material. The catheter also includes cavities extending along the length and positioned within the lumen adjacent to the surface. The cavities each define a cavity opening. The catheter also includes an inflation hub defining hub openings connected to respective cavity openings. The inflation hub defines a pump port configured to interface with a pump. The inflation hub defines one or more fluid pathways that extend between the hub openings and the pump port for permitting flow of gas between the pump and the cavities.

Abstract translation: 公开了用于从其内表面剥离污垢剂的导管和相关方法。 根据一个方面，一种导管包括内腔，所述内腔限定基本沿着所述内腔的长度延伸的用于接触生物材料的柔性内表面。 导管还包括沿着长度延伸并定位在邻近表面的管腔内的空腔。 每个空腔限定一个空腔开口。 该导管还包括膨胀轮毂，该膨胀轮毂限定连接到相应空腔开口的毂开口。 充气中心定义了一个配置为与泵连接的泵端口。 膨胀轮毂限定了一个或多个在轮毂开口和泵端口之间延伸的流体路径，以允许气体在泵和空腔之间流动。

公开(公告)号：WO2017079061A2

公开(公告)日：2017-05-11

申请号：PCT/US2016/059439

申请日：2016-10-28

Applicant: DUKE UNIVERSITY

Inventor： LEVERING, Vrad, W. ,  CAO, Changyong ,  LOPEZ, Gabriel, P. ,  ZHAO, Xuanhe ,  LEVINSON, Howard

IPC: A61M25/10

CPC classification number: A61M25/0026 ,  A61M25/0017 ,  A61M2025/0019 ,  A61M2025/0035 ,  A61M2025/0036 ,  A61M2025/004

Abstract: Catheters for debonding fouling agents from an interior surface thereof and related methods are disclosed. According to an aspect, a catheter includes a lumen defining a flexible, interior surface that extends substantially along a length of the lumen for contacting a biological material. The catheter also includes cavities extending along the length and positioned within the lumen adjacent to the surface. The cavities each define a cavity opening. The catheter also includes an inflation hub defining hub openings connected to respective cavity openings. The inflation hub defines a pump port configured to interface with a pump. The inflation hub defines one or more fluid pathways that extend between the hub openings and the pump port for permitting flow of gas between the pump and the cavities.

Abstract translation: 公开了用于从其内表面剥离污垢的导管和相关方法。 根据一个方面，一种导管包括内腔，所述内腔限定基本沿着所述内腔的长度延伸的用于接触生物材料的柔性内表面。 导管还包括沿着长度延伸并定位在邻近表面的管腔内的空腔。 每个空腔限定一个空腔开口。 该导管还包括膨胀轮毂，该膨胀轮毂限定连接到相应空腔开口的毂开口。 充气中心定义了一个配置为与泵连接的泵端口。 膨胀轮毂限定一个或多个流体通道，其在轮毂开口和泵端口之间延伸，以允许气体在泵和腔体之间流动。

公开(公告)号：WO2012088346A2

公开(公告)日：2012-06-28

申请号：PCT/US2011066637

申请日：2011-12-21

Applicant: BIO2 MEDICAL INC ,  ANGEL LUIS F ,  STEINMETZ JEFFREY N

Inventor： ANGEL LUIS F ,  STEINMETZ JEFFREY N

IPC: A61M25/01 ,  A61M29/02

CPC classification number: A61F2/01 ,  A61B2017/2212 ,  A61F2/013 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2230/0006 ,  A61F2230/008 ,  A61F2230/0093 ,  A61F2240/001 ,  A61M25/0009 ,  A61M2025/0036 ,  A61M2025/0681 ,  B29C65/02 ,  B29C65/10 ,  B29C65/68 ,  B29C66/304 ,  B29C66/348 ,  B29C66/52272 ,  B29C66/532 ,  B29L2031/14 ,  B29L2031/7542 ,  Y10T29/49817 ,  Y10T29/49865

Abstract: An attachment configuration for a vascular filter assembly including a self-expanding filter member attached to a catheter body and constrained from expansion in a first configuration by a constraining sheath is presented. The attachment configuration includes an outer tube of material that is overlaid over an end of the filter member and bonded to the catheter body through cutouts disposed through the end of the filter member.

Abstract translation: 提供了一种用于血管过滤器组件的附接构造，其包括附接到导管主体并受约束护套以第一构造的膨胀约束的自膨胀过滤构件。 附接构造包括材料的外管，其覆盖在过滤构件的端部上并通过穿过过滤构件的端部设置的切口而结合到导管主体。

公开(公告)号：WO2011085266A2

公开(公告)日：2011-07-14

申请号：PCT/US2011/020599

申请日：2011-01-07

Applicant: BIO2 MEDICAL, INC. ,  ANGEL, Luis, F. ,  STEINMETZ, Jeffrey, N.

Inventor： ANGEL, Luis, F. ,  STEINMETZ, Jeffrey, N.

IPC: A61M5/00 ,  A61B17/22 ,  A61M5/165

CPC classification number: A61F2/01 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0093 ,  A61M25/0029 ,  A61M2025/0002 ,  A61M2025/0003 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2205/3523

Abstract: A combined multi-lumen central access catheter and an embolic filter including ports proximal and distal the filter for fluid infusion and/or pressure sensing and infusion ports in the catheter to permit infusion of bioactive agents, flushing agents and/or contrast agents. The embolic filter may be removably coupled to the multi-lumen catheter for temporary placement and retrieval under recommended indications.

Abstract translation: 组合的多内腔中央通路导管和栓塞过滤器包括用于流体输注和/或压力感测的过滤器的近端和远端的端口以及导管中的输注端口以允许输注生物活性剂，冲洗剂 和/或造影剂。 根据推荐的适应症，栓塞过滤器可以可拆卸地连接到多腔导管，用于临时放置和取出。

公开(公告)号：WO2011056181A1

公开(公告)日：2011-05-12

申请号：PCT/US2009/063744

申请日：2009-11-09

Applicant: DELCATH SYSTEMS, INC. ,  KANDARPA, Krishna

Inventor： KANDARPA, Krishna

IPC: A61M25/00

CPC classification number: A61M25/1011 ,  A61M1/3653 ,  A61M1/3659 ,  A61M1/3679 ,  A61M25/0023 ,  A61M25/0029 ,  A61M25/0032 ,  A61M25/007 ,  A61M2025/0031 ,  A61M2025/0036 ,  A61M2025/1052 ,  A61M2205/7563

Abstract: The instant invention encompasses a catheter, comprising: a first expandable occlusion device and a second expandable occlusion device, expandable beyond a wall of the catheter, the first occlusion device and the second occlusion device spaced along the catheter for generating an occluded segment of the blood vessel between the first occlusion device and the second occlusion device when the first occlusion device and the second occlusion device are expanded, a lumen or catheter for removing uncontaminated blood from a location upstream of a first expandable occlusion device; a lumen or catheter for reintroducing the uncontaminated blood into a subject downstream from the second expandable occlusion device; apparati encompassing the above technology; and methods of use incorporating same.

Abstract translation: 本发明包括一种导管，包括：第一可扩张闭塞装置和第二可扩张闭塞装置，其可扩张超过导管壁，第一闭塞装置和第二闭塞装置沿着导管间隔开以产生血液的封闭部分 当所述第一闭塞装置和所述第二闭塞装置膨胀时，所述第一闭塞装置和所述第二闭塞装置之间的容器，用于从第一可膨胀闭塞装置的上游位置除去未受污染的血液的管腔或导管; 用于将未受污染的血液重新引入到第二可膨胀闭塞装置下游的受试者的管腔或导管; 包含上述技术; 和使用方法。

公开(公告)号：WO2009099464A1

公开(公告)日：2009-08-13

申请号：PCT/US2008/073004

申请日：2008-08-13

Applicant: CVDEVICES, LLC ,  KASSAB, Ghassan, S. ,  NAVIA, Jose, A.

Inventor： KASSAB, Ghassan, S. ,  NAVIA, Jose, A.

IPC: A61M25/01

CPC classification number: A61M25/0147 ,  A61B17/122 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2018/00392 ,  A61M25/003 ,  A61M25/007 ,  A61M25/0071 ,  A61M25/0074 ,  A61M25/0084 ,  A61M25/0105 ,  A61M25/0133 ,  A61M29/02 ,  A61M2025/0004 ,  A61M2025/0006 ,  A61M2025/0024 ,  A61M2025/0036 ,  A61M2025/0039 ,  A61M2025/004 ,  A61M2025/015 ,  A61M2025/0161 ,  A61N1/0587 ,  C12Q1/6888

Abstract: Steering engagement catheter devices, systems, and methods of using the same for accessing tissue, including the internal and external tissues of the heart, are disclosed. In at least one embodiment, a steering engagement catheter is provided, comprising an elongated tube having a proximal end, a distal end, and a first wall positioned circumferentially along a length of the elongated tube, the elongated tube configured such that a delivery catheter is capable of at least partial insertion into the elongated tube, at least one steering wire having a proximal end and a distal end, the distal end of the steering wire coupled to the first wall of the elongated tube at or near the distal end of the elongated tube, and a controller operably coupled to the at least one steering wire at or near the proximal end of the at least one steering wire.

Abstract translation: 公开了转向接合导管装置，系统及其使用方法来访问组织，包括心脏的内部和外部组织。 在至少一个实施例中，提供了一种转向接合导管，其包括具有近端，远端和沿着细长管的长度周向定位的第一壁的细长管，细长管构造成使得输送导管 能够至少部分地插入细长管中，至少一个操纵线具有近端和远端，所述操纵线的远端在细长管的远端处或远端附近连接到细长管的第一壁 管和控制器，所述控制器在所述至少一个操纵线的近端处或附近可操作地联接到所述至少一个操纵线。

公开(公告)号：WO2008020967A3

公开(公告)日：2008-11-20

申请号：PCT/US2007016701

申请日：2007-07-25

Applicant: PEAK BIOSCIENCES INC ,  MATSUURA JAMES E ,  WARREN STEPHEN L

Inventor： MATSUURA JAMES E ,  WARREN STEPHEN L

IPC: A61M5/00

CPC classification number: A61M25/0662 ,  A61M25/0021 ,  A61M25/0032 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0074 ,  A61M25/008 ,  A61M25/0084 ,  A61M2025/0036 ,  A61M2025/0081 ,  A61M2025/0175

Abstract: A catheter array system adapted for implanting a plurality of catheters within the tissue of a patient in a spatially defined array, comprising a plurality of catheters, a catheter guide template adapted to guide the implantation of catheters, and a liquid supply system including a pressurizer and a manifold, is provided. A method of treatment of a malcondition in a patient comprises implantation of a spatially definted array of catheters using the system is also provided. The bioactive agent can be a radiotherapeutic agent, a chemotherapeutic agent, a protein, an antibody, an oligonucleotide-based therapeutic agent such as siRNA, or a combination of agents. A preferred radiotherapeutic agent is 123 I- or 125 I-IUDR, for example in the treatment of locally advanced tumors, such as glioblastoma multiforme.

Abstract translation: 适于以空间限定阵列将多个导管植入患者组织内的导管阵列系统包括多个导管，适于引导导管植入的导管引导模板以及包括加压器的液体供应系统和 提供歧管。 还提供了一种治疗患者恶化的方法，该方法包括使用该系统植入空间限定的导管阵列。 生物活性剂可以是放射治疗剂，化学治疗剂，蛋白质，抗体，基于寡核苷酸的治疗剂例如siRNA，或者药剂的组合。 优选的放射治疗剂是例如用于局部晚期肿瘤如多形性成胶质细胞瘤的治疗中的I-123或I-IUDR。

公开(公告)号：WO2008100446A2

公开(公告)日：2008-08-21

申请号：PCT/US2008/001741

申请日：2008-02-08

Applicant: KCI LICENSING INC. ,  SANDERS, Blane ,  HEATON, Keith, Patrick ,  HARDMAN, Ian, James ,  LOCKE, Christopher, Brian ,  ROBINSON, Timothy, Mark ,  BEARD, Mark Stephan, James ,  JAEB, Jonathan, Paul ,  KIESWETTER, Kristine ,  JOHNSON, Royce, W. ,  INGRAM, Shannon, C.

Inventor： SANDERS, Blane ,  HEATON, Keith, Patrick ,  HARDMAN, Ian, James ,  LOCKE, Christopher, Brian ,  ROBINSON, Timothy, Mark ,  BEARD, Mark Stephan, James ,  JAEB, Jonathan, Paul ,  KIESWETTER, Kristine ,  JOHNSON, Royce, W. ,  INGRAM, Shannon, C.

IPC: A61M27/00

CPC classification number: A61M1/0088 ,  A61M1/0001 ,  A61M1/0025 ,  A61M1/0027 ,  A61M1/0049 ,  A61M25/0029 ,  A61M27/00 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2205/15 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3379 ,  A61M2205/583 ,  A61M2205/7527 ,  A61M2205/7536

Abstract: The illustrative embodiments described herein are directed to a system and method for administering reduced pressure at a tissue site. The apparatus includes a reduced pressure source. The reduced pressure source generates a reduced pressure. The apparatus includes a tube having a plurality of lumens. The plurality of lumens includes at least one collection lumen. The reduced pressure source applies the reduced pressure to the tissue site through the plurality of lumens such that the at least one collection lumen receives fluid from the tissue site. The at least one collection lumen stores the fluid received from the tissue site.

Abstract translation: 本文描述的说明性实施例涉及用于在组织部位施用减压的系统和方法。 该装置包括减压源。 减压源产生减压。 该装置包括具有多个管腔的管。 多个管腔包括至少一个收集腔。 减压源通过多个管腔将减压力施加到组织部位，使得至少一个收集腔从组织部位接收流体。 至少一个收集腔存储从组织部位接收的流体。

公开(公告)号：WO2007136829A1

公开(公告)日：2007-11-29

申请号：PCT/US2007/012067

申请日：2007-05-21

Applicant: CONMED ENDOSCOPIC TECHNOLOGIES, INC. ,  REMISZEWSKI, Stan ,  MASTRI, Dominick, L. ,  ABRAMS, Michael, E. ,  GAMBALE, Rich ,  RADZIUNAS, Jeffrey ,  GREEN, Ronald, L. ,  FERREIRA, Danial

Inventor： REMISZEWSKI, Stan ,  MASTRI, Dominick, L. ,  ABRAMS, Michael, E. ,  GAMBALE, Rich ,  RADZIUNAS, Jeffrey ,  GREEN, Ronald, L. ,  FERREIRA, Danial

IPC: A61M25/01 ,  A61B17/00 ,  A61B10/00 ,  A61B18/14 ,  A61M25/00

CPC classification number: A61B17/32056 ,  A61B1/0052 ,  A61B1/0055 ,  A61B1/0057 ,  A61B17/00 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/00323 ,  A61B2017/00867 ,  A61B2018/00482 ,  A61B2018/00494 ,  A61B2018/00595 ,  A61B2018/1407 ,  A61B2018/144 ,  A61M25/0029 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0147 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2025/0163

Abstract: A steerable medical instrument (136) includes a control handle (144), a shaft (140), steering control wires, and an end effector (100) at the distal end of the shaft. The end effector is a separate component engineered to distribute the stress and strain of bending moments along the length of the end effector to achieve predicable, repeatable, fine motion control over the distal end of the instrument. The end effector may be customized for any medical application. For example, the end effector may comprise a grasping device, a cutting devise, a snare, a specimen retrieval device, or a wound closure device (such as a stapler).

Abstract translation: 可操纵的医疗器械（136）包括控制手柄（144），轴（140），转向控制线和位于轴远端的端部执行器（100）。 末端执行器是一个单独的部件，设计用于沿着末端执行器的长度分布弯矩的应力和应变，以在仪器的远端实现可预测的，可重复的精细运动控制。 末端执行器可以针对任何医疗应用而定制。 例如，末端执行器可以包括抓握装置，切割装置，圈套，样本取出装置或伤口闭合装置（诸如吻合器）。

公开(公告)号：WO2006122061A1

公开(公告)日：2006-11-16

申请号：PCT/US2006/017785

申请日：2006-05-06

Applicant: ACUMEN MEDICAL, INC. ,  LEEFLANG, Stephen, A. ,  MORRISON, George, A. ,  MOURLAS, Nicholas, J. ,  EVERSULL, Christian, S.

Inventor： LEEFLANG, Stephen, A. ,  MORRISON, George, A. ,  MOURLAS, Nicholas, J. ,  EVERSULL, Christian, S.

IPC: A61M25/01

CPC classification number: A61M25/0105 ,  A61B1/00165 ,  A61M25/0023 ,  A61M25/0032 ,  A61M25/005 ,  A61M25/0147 ,  A61M25/10 ,  A61M2025/0036 ,  A61M2025/0161

Abstract: Apparatus is provided for accessing a body lumen within a patient's body. Generally, the apparatus (40) includes a tubular member (42) including proximal and distal ends (16) , a steering element extending between the proximal and distal ends, and an actuator (32) for directing the distal end between a relaxed configuration and a complex curved configuration. In the relaxed configuration, the distal end may assume a straight or curved shape. In the complex curved configuration, the distal end may assume a curvilinear shape. In one embodiment, the complex curved configuration may include a first curved portion defining an arc within a plane, and a second portion that extends out of the plane. An embodiment with a left hand rule configuration may be introduced into the right atrium of a heart from a superior approach, and the complex curved configuration may facilitate accessing the coronary sinus.

Abstract translation: 提供了用于访问患者身体内的体腔的装置。 通常，装置（40）包括管状构件（42），其包括近端和远端（16），在近端和远端之间延伸的操纵元件和致动器（32），用于将远端引导在松弛构型和 复杂的弯曲配置。 在松弛构造中，远端可呈直线或弯曲形状。 在复杂的弯曲构型中，远端可呈现曲线形状。 在一个实施例中，复合弯曲构造可以包括在平面内限定弧的第一弯曲部分和延伸出平面的第二部分。 具有左手规则配置的实施例可以从优越的方法引入心脏的右心房，并且复曲线配置可以有助于进入冠状窦。