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    PESTICIDAL AND PARASITICIDAL VINYL ISOXAZOLINE COMPOUNDS
    42.
    发明申请
    PESTICIDAL AND PARASITICIDAL VINYL ISOXAZOLINE COMPOUNDS 审中-公开
    杀虫剂和杀虫剂乙烯基异恶唑啉化合物

    公开(公告)号：WO2018071535A1

    公开(公告)日：2018-04-19

    申请号：PCT/US2017/056130

    申请日：2017-10-11

    Applicant: MERIAL, INC.

    Inventor： LONG, Alan ,  LE HIR DE FALLOIS, Loic Patrick

    IPC: A01N43/80 ,  C07D413/12 ,  C07D263/16 ,  A01P7/04

    Abstract: The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: Formula (I) wherein variables B 1 , B 2 , B 3 , R 1 , P 1 , P 2 , Y and Q are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

    Abstract translation: 本发明涉及式（I）的杀虫和杀寄生虫异恶唑啉及其盐：式（I）其中变量B 1，B 2， B 3，R 1，P 1，P 2，Y和Q在本文中被描述为 在说明中定义。 本发明还涉及包含式（I）的异恶唑啉化合物的杀寄生物和杀虫组合物，它们的制备方法以及它们用于预防或治疗动物中的寄生虫感染或侵染和作为杀虫剂的用途。

    METHOD FOR REDUCING UNWANTED EFFECTS IN PARASITICIDAL TREATMENTS
    43.
    发明申请
    METHOD FOR REDUCING UNWANTED EFFECTS IN PARASITICIDAL TREATMENTS 审中-公开
    减少寄生虫治疗中的不利影响的方法

    公开(公告)号：WO2018039508A1

    公开(公告)日：2018-03-01

    申请号：PCT/US2017/048527

    申请日：2017-08-25

    Applicant: MERIAL, INC.

    Inventor： LE HIR DE FALLOIS, Lois, Patrick

    IPC: A01N43/80 ,  A01P7/00

    CPC classification number: A01N25/32 ,  A61K9/0019 ,  A61K31/42 ,  A61K47/10 ,  A61P33/14 ,  A01N43/80

    Abstract: The present intention provides for, inter alia, a method for reducing a withdrawal period when treating livestock for parasitic infestations, which comprises administering an effective amount of a parasiticidal composition comprising an (S) enantiomer of an isoxazoline compound of the formula (S)-1 or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein, and an inert carrier or formulation adjuvant; wherein the composition contains less than 10% by weight of an (R) enantiomer of an isoxazoline compound or a pharmaceutically acceptable salt thereof. Moreover, the present invention further provides for method for reducing at least one unwanted effect while treating a non-human animal for a parasitic infestation by administering an effective amount of a parasiticidal composition comprising an (S) enantiomer of an isoxazoline compound of the formula (S)-l or a pharmaceutically acceptable salt thereof and an inert carrier or formulation adjuvant, wherein the composition contains less than 10% by weight of an (R) enantiomer of an isoxazoline compound or a pharmaceutically acceptable salt thereof.

    Abstract translation: 本发明特别提供了一种用于减少处理家畜寄生虫害时的停药期的方法，该方法包括给予有效量的包含异恶唑啉（S）对映异构体的杀寄生虫组合物 式（S）-1化合物或其药学上可接受的盐，其中变量如本文所定义，以及惰性载体或制剂助剂; 其中所述组合物包含小于10重量％的异恶唑啉化合物或其药学上可接受的盐的（R）对映异构体。 此外，本发明进一步提供了通过给药有效量的杀虫组合物来减少至少一种不希望的效果，同时治疗非人动物寄生虫侵染的方法，所述组合物包含式（I）的异恶唑啉化合物的（S）对映体 S）-1或其药学上可接受的盐和惰性载体或配制助剂，其中所述组合物包含小于10重量％的异恶唑啉化合物或其药学上可接受的盐的（R）对映体。

    ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS
    46.
    发明申请
    ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS 审中-公开
    安全性杀虫剂化合物

    公开(公告)号：WO2016187534A1

    公开(公告)日：2016-11-24

    申请号：PCT/US2016/033522

    申请日：2016-05-20

    Applicant: MERIAL, INC.

    Inventor： DE FALLOIS, Loic, Le Hir ,  PACOFSKY, Gregory ,  LONG, Alan ,  MENG, Charles ,  LEE, Hyoung, Ik ,  OGBU, Cyprian, O.

    IPC: C07K11/02 ,  A01N43/72 ,  C07D273/00

    CPC classification number: C07K11/02 ,  A01N43/72 ,  A61K38/00 ,  C07D273/00 ,  A01N37/46 ,  A01N43/90

    Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

    Abstract translation: 本发明提供式（I）的环状缩肽化合物和包含有效对抗伤害动物的寄生虫的化合物的组合物。 化合物和组合物可用于对抗哺乳动物和鸟类中或哺乳动物上的寄生虫。 本发明还提供了用于消除，控制和预防鸟类和哺乳动物中的寄生虫感染的改进方法。

    ANTHELMINTIC COMBINATIONS AND METHODS OF USE THEREOF
    47.
    发明申请
    ANTHELMINTIC COMBINATIONS AND METHODS OF USE THEREOF 审中-公开
    ANTHELMINTIC组合及其使用方法

    公开(公告)号：WO2016161369A1

    公开(公告)日：2016-10-06

    申请号：PCT/US2016/025714

    申请日：2016-04-01

    Applicant: MERIAL, INC.

    Inventor： BONDESEN, Brenda

    IPC: A61K38/15 ,  A61K31/7048 ,  A61P33/00 ,  A61P33/14

    CPC classification number: A61K38/15 ,  A61K9/0056 ,  A61K31/365 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/7048 ,  A61K2300/00

    Abstract: The present invention relates to a veterinary composition comprising an effective amount of at least one cyclic depsipeptide and at least one macrocyclic lactone; and a pharmaceutically acceptable carrier, for the treatment or prophylaxis of parasitic infection in a mammal wherein the parasite shows resistance to treatment or prophylaxis with the macrocyclic lactone alone.

    Abstract translation: 本发明涉及一种兽用组合物，其包含有效量的至少一种环状缩肽和至少一种大环内酯; 和药学上可接受的载体，用于治疗或预防哺乳动物的寄生虫感染，其中寄生虫对单独的大环内酯显示出对治疗或预防的抵抗力。

    METHOD AND DEVICE FOR CONDITIONAL IN OVO INJECTION
    49.
    发明申请
    METHOD AND DEVICE FOR CONDITIONAL IN OVO INJECTION 审中-公开
    在OVO注射条件下的方法和装置

    公开(公告)号：WO2015179417A1

    公开(公告)日：2015-11-26

    申请号：PCT/US2015/031605

    申请日：2015-05-19

    Applicant: MERIAL, INC.

    Inventor： LESLIE, Christopher, Davis ,  NGUYEN, Chien, Dinh ,  BEVENSEE, Erich

    IPC: A01K45/00

    CPC classification number: A01K45/007 ,  A01K43/00 ,  A61D1/02 ,  A61D7/00 ,  A61M5/46

    Abstract: The present invention provides in ovo injection devices, including a novel vaccine/substance conservation valve (VCV), a needle depth adjuster (NDA), and methods for selectively delivering vaccines and other substances to eggs in the context of poultry hatcheries. The valve of the present invention allows for the conditional dispensing of vaccines and other substances dependent upon the presence or absence of an egg. When an egg is present, the valve becomes activated, allowing vaccines or other substances to be injected. When an egg is absent, the valve is not activated, thus vaccines and other valuable substances are conserved. The NDA allows embryonated eggs to be more safely injected by reducing the depth of needle penetration, particularly in smaller eggs.

    Abstract translation: 本发明提供了包括新型疫苗/物质保存阀（VCV），针深度调节器（NDA）在内的ovo注射装置，以及在家禽孵化场的情况下选择性地将疫苗和其它物质输送到鸡蛋的方法。 本发明的阀允许根据蛋的存在或不存在来有条件地分配疫苗和其它物质。 当蛋存在时，阀被激活，允许注射疫苗或其他物质。 当鸡蛋不存在时，阀门不被激活，因此疫苗和其他有价值的物质是保守的。 NDA通过减少穿刺深度，特别是在较小的鸡蛋中，可以更加安全地注射胚胎蛋。

    TOPICAL DELIVERY FORMULATION
    50.
    发明申请
    TOPICAL DELIVERY FORMULATION 审中-公开
    主题交付配方

    公开(公告)号：WO2015109312A1

    公开(公告)日：2015-07-23

    申请号：PCT/US2015/012031

    申请日：2015-01-20

    Applicant: MERIAL INC.

    Inventor： PATE, James ,  SHUB, Natalya

    IPC: A61K9/00

    CPC classification number: A01N25/10 ,  A01N43/56 ,  A01N53/00 ,  A61K9/0014

    Abstract: The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94%> w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.

    Abstract translation: 本发明是具有优异防水性能的浇注抗寄生虫制剂。 倾注配方使用一种或多种聚合物（水溶性或不含水溶性）在约5至约40％w / w的范围内，一种或多种溶剂在约50至约94％> w / w，有或没有添加剂（例如异丙醇或乙醇）在约5至约30％w / w的范围内，和任选的增塑剂在约0.5至约25％w / w的范围内。 灌注抗寄生虫制剂在施用于动物（牛，绵羊，狗等）时具有有限的扩散。 浇注抗寄生虫制剂进一步部分蒸发，留下将至少一种活性成分扩散至动物皮肤的防水聚合物基质。

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