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公开(公告)号：WO2018057467A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/052084
申请日：2017-09-18
申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
IPC分类号： C12N15/866 , C07K14/14 , A61K39/12 , A61K39/15
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55566 , C07K14/14 , C12N15/866 , C12N2710/14043 , C12N2720/12134
摘要： The present disclosure provides for an immunogenic composition against epizootic hemorrhagic disease virus (EHDV). The immunogenic composition has been shown to be efficacious in inducing serum neutralizing antibodies against EHDV and intended to be used to prevent or reduce clinical symptoms associated with EHDV infection in susceptible animals. The disclosure provides for composition and methods that represent an improvement over previous strategies for treating and preventing EHDV.
摘要翻译： 本公开提供了针对流行性出血症病毒（EHDV）的免疫原性组合物。 已显示该免疫原性组合物在诱导针对EHDV的血清中和抗体方面是有效的并且旨在用于预防或减轻易感动物中与EHDV感染相关的临床症状。 本公开提供了代表相对于先前用于治疗和预防EHDV的策略的改进的组合物和方法。
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公开(公告)号：WO2018029301A1
公开(公告)日：2018-02-15
申请号：PCT/EP2017/070336
申请日：2017-08-10
发明人： CHANG, Siow, Foong , NG, Kah, Sing , GRISEZ, Luc , DE GROOF, Ad , VOGELS, Wannes , VAN DER HOEK, Lia , DEIJS, Martin
IPC分类号： A61K39/00 , A61K39/245 , C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C07K14/005 , C12N2710/16021 , C12N2710/16022 , C12N2710/16034
摘要： The present invention pertains to a novel fish pathogenic virus causing disease in fish, tentatively called Lates Calcarifer Herpes Virus (LCHV), to cell cultures comprising said virus, DNA fragments and corresponding proteins of the said virus, to vaccines on the basis of said virus, DNA and/or protein and to antibodies reactive with said virus and diagnostic test kits for the detection of said virus.
摘要翻译： 本发明涉及一种在鱼中引起疾病的新型鱼病原病毒，暂时称为Lates Calcarifer Herpes Virus（LCHV），包含所述病毒的细胞培养物，所述病毒的DNA片段和相应的蛋白质， 基于所述病毒，DNA和/或蛋白质的疫苗以及与所述病毒反应的抗体和用于检测所述病毒的诊断测试试剂盒。
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公开(公告)号：WO2017109228A1
公开(公告)日：2017-06-29
申请号：PCT/EP2016/082667
申请日：2016-12-23
申请人： VALNEVA AUSTRIA GMBH
IPC分类号： A61K39/12 , C07K14/005
CPC分类号： A61K39/12 , A61K2039/5252 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , Y02A50/383 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392
摘要： Described herein are processes for purifying infectious Zika virus particles and uses of protamine in such processes.
摘要翻译： 本文描述了用于纯化感染性寨卡病毒颗粒的方法和在这些方法中使用鱼精蛋白。
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公开(公告)号：WO2017109223A1
公开(公告)日：2017-06-29
申请号：PCT/EP2016/082662
申请日：2016-12-23
申请人： VALNEVA SE
IPC分类号： A61K39/12 , C07K14/005
CPC分类号： A61K39/12 , A61K2039/5252 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , Y02A50/383 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392
摘要： Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.
摘要翻译： 本文描述了用于病毒疫苗和组合物的改进的纯化方法。 还描述了Zika，基孔肯雅热，登革热和黄热病疫苗以及生产所述疫苗并将其施用给有需要的受试者的方法。
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公开(公告)号：WO2017015463A2
公开(公告)日：2017-01-26
申请号：PCT/US2016/043348
申请日：2016-07-21
申请人： MODERNATX, INC.
CPC分类号： A61K9/0019 , A61K9/5123 , A61K39/12 , A61K2039/505 , A61K2039/5252 , A61K2039/53 , A61K2039/543 , A61K2039/6056 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
摘要翻译： 本公开的方面涉及核酸疫苗。 疫苗包括一种或多种具有编码一种或多种基孔肯雅抗原，一种或多种Zika病毒抗原和一种或多种登革热抗原的开放阅读框的RNA多核苷酸。 还描述了制备和使用这种疫苗的方法。
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公开(公告)号：WO2017009873A1
公开(公告)日：2017-01-19
申请号：PCT/IN2016/050241
申请日：2016-07-15
CPC分类号： A61K39/12 , A61K9/0019 , A61K47/02 , A61K47/183 , A61K47/26 , A61K47/42 , A61K2039/5252 , A61K2039/55505 , A61K2039/55511 , A61K2039/5555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55583 , A61K2039/58 , A61K2039/70 , C07K16/1081 , C12N2710/14143 , C12N2770/24134 , C12N2770/24151 , C12N2770/36134 , Y02A50/383 , Y02A50/39 , Y02A50/392
摘要： The present disclosure provides vaccine compositions for prophylaxis and treatment of Zika virus infections comprising Zika virus antigens in immunogenic compositions, and in combination of Zika antigens with one or more arbovirus antigens such as Chikungunya virus and Japanese encephalitis virus antigens, methods of preparation and production of such compositions for use as vaccines for eliciting immune response in mammals against the above mentioned pathogens.
摘要翻译： 本公开提供用于预防和治疗Zika病毒感染的疫苗组合物，其包含免疫原性组合物中的Zika病毒抗原，以及Zika抗原与一种或多种伞状病毒抗原如基孔肯雅病毒和日本脑炎病毒抗原的组合，制备和生产方法 这种用于疫苗的组合物用于在哺乳动物中引发针对上述病原体的免疫应答。
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7.发明申请NOVEL VACCINE COMPOSITIONS FOR PORCINE EPIDEMIC DIARRHEA VIRUS AND PORCINE DELTACORONAVIRUS 审中-公开用于猪流行性腹泻病毒和猪冠状病毒的新型疫苗组合物
公开(公告)号：WO2016007576A8
公开(公告)日：2016-12-22
申请号：PCT/US2015039475
申请日：2015-07-08
申请人： ZOETIS SERVICES LLC
发明人： MARX JACQUELINE GAYLE , HARDHAM JOHN MORGAN , DOMINOWSKI PAUL J , RAPP GABRIELSON VICKI JON , BALASCH SANUY MONICA , CABANA SUMSI MARTA , PLAJA DILME LAIA , URNIZA HOSTENCH ALICIA , ROMERO GALINDO OSCAR
IPC分类号： A61K39/215 , A61K39/00 , C07K14/165 , C12N7/00
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/20022 , C12N2770/20034 , C12N2770/20063 , C12N2770/20071
摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.
摘要翻译： 本发明涉及保护猪免受由猪流行性腹泻病毒（PEDV）引起的疾病的新的免疫原性组合物。 本发明还涉及新的免疫原性组合物，其保护猪免于由单独的猪或猪冠状病毒（PDCoV）引起的疾病或作为保护免受PEDV的组合疫苗。 本发明的组合物提供杀死的病毒，其效力通过选择优选的佐剂而增强。 新的培养方法也被用来提高培养病毒的可重复产量。 活疫苗也由Calaf14 PEDV分离株提供。
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8.发明申请A COMPOSITION COMPRISING PEDV ANTIGENS AND METHODS FOR MAKING AND USING THE COMPOSITION 审中-公开包含PEDV抗原的组合物和用于制备和使用组合物的方法
公开(公告)号：WO2016130569A4
公开(公告)日：2016-11-10
申请号：PCT/US2016017183
申请日：2016-02-09
发明人： KIM BYOUNG KWAN , BROWN KAREN , MILLER LARRY
IPC分类号： A61K39/12
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/5252 , A61K2039/54 , A61K2039/541 , A61K2039/543 , A61K2039/55 , A61K2039/552 , A61K2039/55511 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2770/20034 , C12N2770/20051 , C12N2770/20063
摘要： Disclosed herein are embodiments of an immunogenic composition for porcine epidemic diarrhea virus, and a method for making the immunogenic composition. Also disclosed is a method for administrating the immunogenic composition to a subject in need thereof. The immunogenic composition comprises PEDV proteins and/or antigens from one or more strains of PEDV, and may additionally comprise proteins and/or antigens from one or more additional porcine pathogens, such as PRRSV. Additionally disclosed in a combination comprising a PEDV immunogenic composition as disclosed herein, and an immunogenic composition or other therapeutic composition directed toward an additional porcine pathogen.
摘要翻译： 本文公开了猪流行性腹泻病毒的免疫原性组合物的实施方案，以及制备免疫原性组合物的方法。 还公开了将有针对性的受试者给予免疫原性组合物的方法。 免疫原性组合物包含来自一种或多种PEDV菌株的PEDV蛋白和/或抗原，并且还可以包含来自一种或多种另外的猪病原体如PRRSV的蛋白质和/或抗原。 另外公开在包含本文公开的PEDV免疫原性组合物和免疫原性组合物或针对另外的猪病原体的其它治疗组合物的组合中。
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公开(公告)号：WO2016145149A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/021696
申请日：2016-03-10
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, ON BEHALF OF THE WALTER REED ARMY INSTITUTE OF RESEARCH , THOMAS, Stephen J. , ECKELS, Kenneth H. , PUTNAK, Joseph R.
IPC分类号： A61K39/12 , A61K39/395
CPC分类号： A61K39/12 , A61K39/395 , A61K2039/5252 , A61K2039/545 , A61K2039/70 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392 , Y02A50/394
摘要： Disclosed herein are immunogenic compositions comprising one or more inactivated dengue viruses and one or more inactivated non-dengue flaviviruses and methods of making and using thereof.
摘要翻译： 本文公开了包含一种或多种灭活的登革热病毒和一种或多种灭活的非登革热黄病毒的免疫原性组合物及其制备和使用方法。
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10.发明申请METHODS AND COMPOSITIONS USEFUL IN GENERATING NON CANONICAL CD8+ T CELL RESPONSES 审中-公开用于产生非典型CD8 + T细胞应答的方法和组合物
公开(公告)号：WO2016130693A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017373
申请日：2016-02-10
申请人： OREGON HEALTH & SCIENCE UNIVERSITY , FRUEH, Klaus , PICKER, Louis , HANSEN, Scott , SACHA, Jonah
发明人： FRUEH, Klaus , PICKER, Louis , HANSEN, Scott , SACHA, Jonah , MALOULI, Daniel
IPC分类号： C12N15/86 , C12N15/12 , C12N15/33 , C07K14/705 , C07K14/725 , C12N5/0783 , C12Q1/68 , A61K48/00 , A61P35/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C12N9/0093 , C12N15/00 , C12N2710/16143 , C12N2740/15034 , C12Q1/68 , Y02A50/412
摘要： Methods of inducing a CD8+ T cell response to a heterologous antigen in which at least 10% of the CD8+ T cells are MHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 proteins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 protein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein.
摘要翻译： 公开了诱导针对其中至少10％的CD8 + T细胞是MHC-E限制性的异源抗原的CD8 + T细胞应答的方法。 该方法涉及用不表达UL128和UL130蛋白质的CMV载体免疫。 还公开了包含编码异源蛋白质抗原，UL40蛋白质和US28蛋白质但不表达活性UL128和UL130蛋白质的核酸的重组CMV载体。 还公开了包含编码异源蛋白质抗原但不表达活性UL40蛋白质，UL128蛋白质，UL130蛋白质和任选的US28蛋白质的核酸的重组CMV载体。 还公开了包含编码异源蛋白质抗原但不表达活性US28蛋白质，UL128蛋白质，UL130蛋白质和任选的UL40蛋白质的核酸的重组CMV载体。
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