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    SYSTEMS AND METHODS FOR A CONFORMABLE MODULAR ELECTRODE FOR APPLICATION OF AN ALTERNATING ELECTRIC FIELD TO TISSUE
    41.
    发明申请
    SYSTEMS AND METHODS FOR A CONFORMABLE MODULAR ELECTRODE FOR APPLICATION OF AN ALTERNATING ELECTRIC FIELD TO TISSUE 审中-公开

    公开(公告)号：WO2022216614A1

    公开(公告)日：2022-10-13

    申请号：PCT/US2022/023321

    申请日：2022-04-04

    Applicant: DIGNITY HEALTH

    Inventor： HENDRICKS, Benjamin

    IPC: A61B5/256

    Abstract: A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.

    SYSTEMS AND METHODS FOR OPERATIVE MICROSCOPE TRACKING FOR TECHNICAL GUIDANCE
    42.
    发明申请
    SYSTEMS AND METHODS FOR OPERATIVE MICROSCOPE TRACKING FOR TECHNICAL GUIDANCE 审中-公开

    公开(公告)号：WO2022067241A1

    公开(公告)日：2022-03-31

    申请号：PCT/US2021/052371

    申请日：2021-09-28

    Applicant: DIGNITY HEALTH

    Inventor： HENDRICKS, Benjamin ,  LAWTON, Michael

    IPC: G06F3/00

    Abstract: A system provides a computer-implemented rendered visualization of a surgeon's path or "roadmap" to a particular target region during a surgical case are disclosed herein. The system includes an approach library in communication with an operating microscope that includes data related to various surgical approach sequences, or "roadmaps" to various target regions. The approach library can be populated by the system and analyzed for variance and trends, as well as provide direct or indirect instruction and guidance through a display member during a surgical case.

    SYSTEMS AND METHODS FOR AN EXPANDABLE INTERBODY DEVICE
    43.
    发明申请
    SYSTEMS AND METHODS FOR AN EXPANDABLE INTERBODY DEVICE 审中-公开

    公开(公告)号：WO2022051380A1

    公开(公告)日：2022-03-10

    申请号：PCT/US2021/048689

    申请日：2021-09-01

    Applicant: DIGNITY HEALTH

    Inventor： WHITE, Michael D. ,  GRAHAM, Dakota

    IPC: A61F2/44

    Abstract: Various embodiments of an expandable interbody cage device configured to reduce subsidence into an endplate of a vertebral body by including a plurality of arms that engage the cortical tissue of the vertebral body. The plurality of arms increase the surface area and improve distribution of force, especially around stronger parts of the endplate such as the cortical bone at the rim of the endplate. The expandable interbody cage device maintains a low or slim profile while in a "closed" configuration during insertion between vertebrae and is further operable to laterally expand into an "open" configuration that increases the surface area of the expandable interbody cage device after insertion to securely engage the expandable interbody cage device between the vertebra. The expandable interbody cage device further includes one or more ports and/or cavities in which bone graft material can be disposed within.

    SYSTEMS AND METHODS FOR A HYDROPHILIC CATHETER INTRODUCTION SYSTEM
    44.
    发明申请
    SYSTEMS AND METHODS FOR A HYDROPHILIC CATHETER INTRODUCTION SYSTEM 审中-公开

    公开(公告)号：WO2022011230A1

    公开(公告)日：2022-01-13

    申请号：PCT/US2021/041043

    申请日：2021-07-09

    Applicant: DIGNITY HEALTH

    Inventor： FARBER, S. Harrison ,  DUCRUET, Andrew

    IPC: A61M25/02

    Abstract: Various embodiments of a hydrophilic catheter introduction system for improved insertion of a shunt catheter are disclosed herein. The catheter introduction system includes an introducer sheath defining an inner surface that includes a hydrophilic coating to aid in passage of a catheter through the introducer sheath. Evaluation of the catheter introduction system with respect to other catheter introduction systems resulted in a significant decrease in average catheter threading time.

    INHIBITORY INTERNEURON TREATMENT METHODS, USES AND COMPOSITIONS FOR DIABETES
    48.
    发明申请
    INHIBITORY INTERNEURON TREATMENT METHODS, USES AND COMPOSITIONS FOR DIABETES 审中-公开

    公开(公告)号：WO2020236696A1

    公开(公告)日：2020-11-26

    申请号：PCT/US2020/033368

    申请日：2020-05-18

    Applicant: DIGNITY HEALTH

    Inventor： MIRZADEH, Zaman

    IPC: A61K35/30 ,  A61P3/08 ,  A61P3/10 ,  C12N5/0793 ,  C12N5/0797

    Abstract: Disclosed herein are compositions, methods of treatment, and uses of inhibitory interneuron precursors, derived from the brain's medial ganglionic eminence, or differentiated from iPSC or ESCs, for the treatment of pre-diabetes or diabetes. In some embodiments, compositions including inhibitory interneuron precursors are transplanted into the arcuate nucleus of the hypothalamus region of the brain, to treat, for example, diabetes, such as, type-2 diabetes, In further embodiments, inhibitory interneuron precursors are used in the manufacture of a medicament for the treatment of diabetes, for example, type-2 diabetes.

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