CORE-EXTENDED PERYLENE BISIMIDES
    42.
    发明申请
    CORE-EXTENDED PERYLENE BISIMIDES 审中-公开
    CORE高级perylenebisimides及其使用荧光染料

    公开(公告)号:WO00023446A1

    公开(公告)日:2000-04-27

    申请号:PCT/EP1999/007614

    申请日:1999-10-11

    Abstract: The invention relates to core-extended perylene bisimides of formula (I) and (II), wherein R and R independently represent unsubstituted or substituted C1-C24alkyl, C1-C24cycloalkyl or C6-C10aryl and A and A independently represent -S-, -S-S-, -CH=CH-, R OOC-C(-)=C(-)-COOR , -N=N- or -N(R )- or a compound selected from the group consisting of organic radicals of formulae (III), (IV), (V), (VI) and (VII), wherein R represents hydrogen, C1-C24alkyl or C1-C24cycloalkyl, and R represents unsubstituted or substituted C1-C24alkyl, C1-C24cycloalkyl, phenyl, benzyl, -CO-C1-C4alkyl, -CO-C6H5 or C1-C4alkyl carboxylic acid-(C1-C4alkyl)-ester and A represents a compound having formulae (III), (IV) or (V), in addition to intermediate products for the production of the compounds. The invention also relates to a method for producing said intermediate products and to a method for the production of compounds (I) and (II) as well as to their uses as colorants.

    Abstract translation: 芯高级perylenebisimides通式(I)和(II)其中,R <1>和R <2>表示未取代的或取代的C1-C24烷基,C1-24环烷基,或C6-C独立为<10>的芳基,和A < 1>和A <3>独立地为-S - , - S-S-,-CH = CH-,R <3> OOC-C( - )= C( - ) - COOR <3>,-N = N- 或-N(R <4>) - ,或表示选自下式(III),(IV),(V),(VI)和有机基团(VII),其中,所述组中选择的化合物 [R <3>代表氢,C1-C24烷基或C1-24环烷基,且R <4>是未取代的或取代的C1-C24烷基,C1-24环烷基,苯基,苄基,-CO-C1-C4烷基,-CO-C 6 H 5,或C 1 -C C4Alkylcarbonsäure-(C1-C4烷基)是酯,和<2>是式(III),(IV)或(V),进一步的中间体用于制备化合物(I)和(II)和方法的化合物 这些中间体的制备,以及用于制备所述化合物(I)和(II)的方法,以及它们的VERWEIJ 发明作为Fluoreszenzfarmittel。

    CYTOTOXIC ALKALOID DERIVATIVES INCLUDING ASMARINE A AND B ISOLATED FROM A SPONGE
    43.
    发明申请
    CYTOTOXIC ALKALOID DERIVATIVES INCLUDING ASMARINE A AND B ISOLATED FROM A SPONGE 审中-公开
    细胞毒素碱性衍生物,包括从海绵中分离的阿斯马林A和B

    公开(公告)号:WO99033832A1

    公开(公告)日:1999-07-08

    申请号:PCT/GB1998/003884

    申请日:1998-12-23

    CPC classification number: C07D487/16

    Abstract: Asmarine A and B, novel cytotoxic diterpene-alkaloids, have been isolated from the sponge Raspailia sp. The structure of these compounds have been established on the basis of NMR data and confirmed by X-ray analysis. Also claimed are compounds (I) or (II), wherein R represents hydrogen or lower alkyl or lower alkanoyl; R represents hydrogen or lower alkyl; R is either an alkyl or a cycloalkyl group containing one or more isopreneunits, or a monoterpene or a sesquiterpene or a sesquiterpene or a diterpene group; R or R represent hydrogen or lower alkyl; R represents lower alkyl; X represents F or Cl or Br or (I).

    Abstract translation: Asmarine A和B,新型细胞毒二萜生物碱已从海绵Raspailia sp。 这些化合物的结构已经建立在NMR数据的基础上,并通过X射线分析证实。 还要求的是化合物(I)或(II),其中R 1表示氢或低级烷基或低级烷酰基; R 2表示氢或低级烷基; R 3是含有一个或多个异戊二烯单元或单萜或倍半萜烯或倍半萜烯或二萜烯基团的烷基或环烷基; R 4或R 5表示氢或低级烷基; R 6表示低级烷基; X表示F或Cl或Br或(I)。

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