公开(公告)号：WO1997032846A1

公开(公告)日：1997-09-12

申请号：PCT/US1997002568

申请日：1997-03-03

Applicant: PHARMACIA & UPJOHN COMPANY ,  JACOBSEN, E., Jon

Inventor： PHARMACIA & UPJOHN COMPANY

IPC: C07D207/26

CPC classification number: C07D207/26 ,  C07D231/08 ,  C07D233/76 ,  C07D401/12 ,  C07D403/06 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention provides novel hydroxamic acid derivatives represented by the compound of formula (I), or pharmaceutical acceptable salts thereof, wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, including collagenase, stromelysin, and gelatinase, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthrits, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.

Abstract translation: 本发明提供由式（I）化合物或其药学上可接受的盐代表的新型异羟肟酸衍生物，其中本发明的化合物抑制基质金属蛋白酶家族中的各种酶，包括胶原酶，溶基质蛋白酶和明胶酶，因此 可用于治疗骨关节炎，类风湿关节炎，脓毒性关节炎，骨质疏松症，骨质疏松症，肿瘤转移（侵袭和生长），牙周炎，牙龈炎，角膜溃疡，皮肤溃疡，胃溃疡等疾病相关基质金属内蛋白酶疾病 结缔组织退化。

公开(公告)号：WO1994025440A1

公开(公告)日：1994-11-10

申请号：PCT/AU1994000180

申请日：1994-04-14

Applicant: DUNLENA PTY. LIMITED ,  WATSON, Keith, Geoffrey ,  LIEPA, Andris, Juris ,  NEARN, Roland, Henry

Inventor： DUNLENA PTY. LIMITED

IPC: C07D231/08

CPC classification number: C07D231/08 ,  A01N43/56 ,  A01N43/58 ,  A01N47/38 ,  C07D237/04

Abstract: Compounds of the formula (I): R -SO2-O-Q, their isomeric forms and salts thereof, wherein Q is the group (a), G is selected from the group S, S(=O), S(=O)2, C=S and C=O; R is selected from the group C1-C3 alkyl and C1-C3 haloalkyl; R , R , R , R , R , R and R are various substituents. Arthropodicidal and nematocidal compositions comprising the compounds of formula (I).

Abstract translation: 式（I）的化合物：R 1 -SO 2 -OQ，其异构形式及其盐，其中Q是基团（a），G选自S，S（= O），S（= O）2，C = S和C = O; R 1选自C 1 -C 3烷基和C 1 -C 3卤代烷基; R 2，R 3，R 4，R 5，R 6，R 7和R 8是各种取代基。 包含式（I）化合物的节肢动物杀线虫和杀线虫组合物。

公开(公告)号：WO1993012791A1

公开(公告)日：1993-07-08

申请号：PCT/US1991009555

申请日：1991-12-20

Applicant: WARNER-LAMBERT COMPANY ,  HORWELL, David, Christopher ,  HUGHES, John ,  WOODRUFF, Geoff, Neil

Inventor： WARNER-LAMBERT COMPANY

IPC: A61K31/445

CPC classification number: C07D231/08 ,  A61K31/195 ,  A61K31/40 ,  A61K31/415 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/55

Abstract: Pharmaceutical compositions and methods of using CCK-ligands as antipsychotic, antianxiety, and agents useful in treatment or prevention of withdrawal symptoms caused by withdrawal of chronic or long-term use of diazepam, alcohol, cocaine, or nicotine, and antianxiety agents are described.

Abstract translation: 描述了使用CCK-配体作为抗精神病药，抗焦虑剂和用于治疗或预防由于戒断慢性或长期使用地西泮，可卡因或尼古丁引起的戒断症状的药物组合物和方法以及抗焦虑剂。