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公开(公告)号：WO2016036966A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/048381
申请日：2015-09-03
Applicant: PRECERES INC.
Inventor： HEIDEBRECHT, Richard, W. , ZHONG, Cheng
IPC: C07C243/14
CPC classification number: C07C243/14 , A01N25/00 , A01N25/08 , A01N25/12 , A01N33/26 , A01N37/44 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N57/16 , A61K9/1617 , A61K9/5015 , A61K9/51 , A61K9/5123 , A61K31/7105 , A61K31/713 , A61K47/16 , A61K47/22 , C07C229/26 , C07C243/16 , C07C243/22 , C07D213/77 , C07D231/08 , C07D233/52 , C07D295/30 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/351 , C12N2320/30 , C12N2320/32 , C12N2320/50
Abstract: The present disclosure is directed to hydrazinyl lipidoids, formulations thereof further comprising at least one active agent, as well as methods of delivering the at least one active agent to a target organism. The present disclosure also relates generally to methods of preparing such hydrazinyl lipidoids, their formulation with one or more active agents, and the delivery of such formulations to target organisms.
Abstract translation: 本公开涉及肼基类脂质，其制剂还包含至少一种活性剂，以及将所述至少一种活性剂递送至靶生物体的方法。 本公开还一般涉及制备这种肼基类脂质的方法，它们与一种或多种活性剂的制剂以及将这些制剂递送至靶标生物体。
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2.发明申请
公开(公告)号：WO2011009551A1
公开(公告)日：2011-01-27
申请号：PCT/EP2010/004285
申请日：2010-07-14
Applicant: BAYER CROPSCIENCE AG , PAZENOK, Sergii , LUI, Norbert
Inventor： PAZENOK, Sergii , LUI, Norbert
IPC: C07D231/08 , C07D231/12
CPC classification number: C07D231/08 , C07D231/12
Abstract: Die vorliegende Erfindung betrifft ein Verfahren zum Herstellen von 1-Aryl-substituierten Pyrazolen umfassend die Umsetzung von Alkoxyenonen und Enaminoketonen mit Hydrazin-Derivaten zu 1- Aryl-substituierten dihydro-1H Pyrazolen, deren Weiterreaktion unter Wasserabspaltung zu 1-Aryl substituierten -Trihalogenmethylpyrazolen und deren Weiterverarbeitung.
Abstract translation: 本发明涉及一种用于制造1-芳基取代的吡唑，其包括反应Alkoxyenonen并用肼衍生物烯酮，得到1-芳基取代的二氢-1H-吡唑，其同时消除水进一步反应，得到1-芳基取代的-Trihalogenmethylpyrazolen及其 进一步的处理。
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公开(公告)号：WO2009092276A1
公开(公告)日：2009-07-30
申请号：PCT/CN2009/000001
申请日：2009-01-04
IPC: C07D231/20 , C07D307/79 , C07D311/04 , A61K31/4152 , A61K31/343 , A61K31/352 , A61K31/655 , A61P7/00
CPC classification number: C07D417/12 , C07D231/08 , C07D231/22 , C07D231/38 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/12
Abstract: The bicycle-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents of formula (I) are the same as the description.
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4.发明申请CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES 审中-公开用于治疗代谢障碍的CANNABINOID受体拮抗剂/反转激素有助于包括糖尿病和糖尿病
公开(公告)号：WO2007131219A2
公开(公告)日：2007-11-15
申请号：PCT/US2007068342
申请日：2007-05-07
Applicant: JENRIN DISCOVERY , MCELROY JOHN F , CHORVAT ROBERT J
Inventor： MCELROY JOHN F , CHORVAT ROBERT J
IPC: A61K31/415 , C07D231/06
CPC classification number: C07D231/06 , C07D231/08 , C07D403/12
Abstract: The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders.
Abstract translation: 本发明提供了可用作大麻素受体拮抗剂及其药物组合物的新型吡唑，以及用于治疗肥胖症，糖尿病和/或心脏代谢障碍的方法。
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5.发明申请
公开(公告)号：WO99006373A1
公开(公告)日：1999-02-11
申请号：PCT/EP1998/004490
申请日：1998-07-20
IPC: C07D231/20 , C07B39/00 , C07C205/11 , C07D231/08 , C07D231/22
CPC classification number: C07D231/08 , C07C201/12 , C07C205/11
Abstract: The invention relates to a method for producing 2-(3-pyrazolyl-oxymethylene) nitrobenzene derivatives of formula (I), wherein the substituents and indices have the meaning given in the Description, by bromination of an o-nitrotoluene of formula (II) and subsequent reaction with a 3-hydroxypyrazol of formula (IV).
Abstract translation: 一种用于式（I），其中取代基和指数具有说明书中给出的含义的2-（3-吡唑基 - 氧亚甲基）硝基苯衍生物的制备过程中，由式（II）的邻硝基甲苯的溴化，并用随后的反应 下式的3-羟基吡（IV）。
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Patent Agency Ranking6.发明申请DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS 审中-公开具有杂环体的DI-TERT-BUTYLPHENOL化合物可用作抗炎剂
公开(公告)号：WO1996012710A1
公开(公告)日：1996-05-02
申请号：PCT/US1995012878
申请日：1995-10-18
Applicant: THE PROCTER & GAMBLE COMPANY
IPC: C07D261/04
CPC classification number: C07D231/06 , C07D231/08 , C07D261/04
Abstract: The subject of the invention relates to compounds having structure (I), wherein: a) each R is independently alkyl having from 1 to about 7 carbon atoms; b) Z is O or N-X; c) X is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, C(O)Y, C(S)Y, and SO2Y; d) Y is selected from R', OR' and NR'2; and e) R' is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, and phenyl. The subject invention also relates to pharmaceutical compositions comprising the above compounds, and methods of treating inflammation or pain using the compounds.
Abstract translation: 本发明的主题涉及具有结构（I）的化合物，其中：a）每个R独立地为具有1至约7个碳原子的烷基; b）Z是O或N-X; c）X选自氢，具有1至约7个碳原子的烷基，C（O）Y，C（S）Y和SO 2 Y; d）Y选自R'，OR'和NR'2; 和e）R'选自氢，具有1至约7个碳原子的烷基和苯基。 本发明还涉及包含上述化合物的药物组合物，以及使用该化合物治疗炎症或疼痛的方法。
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7.发明申请USE OF 2-[(DIHYDRO)PYRAZOLYL-3'-OXYMETHYLENE]-ANILIDES AS PEST-CONTROL AGENTS AND FUNGICIDES 审中-公开2 - [（二氢）吡唑基-3'-氧甲基]苯胺AS杀虫剂和杀菌剂
公开(公告)号：WO1996001256A1
公开(公告)日：1996-01-18
申请号：PCT/EP1995002396
申请日：1995-06-21
Applicant: BASF AKTIENGESELLSCHAFT , MÜLLER, Bernd , KÖNIG, Hartmann , KIRSTGEN, Reinhard , OBERDORF, Klaus , RÖHL, Franz , GÖTZ, Norbert , SAUTER, Hubert , LORENZ, Gisela , AMMERMANN, Eberhard
Inventor： BASF AKTIENGESELLSCHAFT
IPC: C07D231/22
CPC classification number: C07D401/04 , A01N47/24 , A01N47/30 , C07D231/08 , C07D231/20 , C07D231/22 , C07D403/04
Abstract: The invention concerns 2-[(dihydro)pyrazolyl-3'-oxymethylene]-anilides of formula (I) in which -- is a single or double bond and the subscripts and substituents are as follows: n 0, 1, 2, 3 or 4; m 0, 1 or 2; X a direct bond or CH2, oxygen or NR , R being hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl; R nitro, cyano, halogen or optionally substituted alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy or alkinyloxy; R nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, alkylthio or alkoxycarbonyl; R optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R hydrogen or optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkylcarbonyl or alkoxycarbonyl; R hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl. The invention also concerns methods of preparing such compounds, intermediates used in their preparation and their use.
Abstract translation: 2 - [（二氢）吡唑基-3'-氧亚甲基的式（I），其中的酰苯胺 - 代表单键或双键，该指数和取代基具有以下含义： n为0，1，2，3或4; m是0，1或2; X是直接键或CH 2，O或NR ; ř氢，烷基，烯基，炔基，环烷基或环烯基; [R <1>硝基，氰基，卤素，未取代或取代的。 烷基，烯基，炔基，烷氧基，烯氧基或炔氧基; [R <2>硝基，氰基，卤素，烷基，卤代烷基，烷氧基，烷硫基或烷氧基羰; [R <3>是未取代的或取代的。 烷基，烯基，炔基，环烷基，杂环基，芳基或杂芳基; [R <4>氢，未取代或取代的。 烷基，烯基，炔基，环烷基，环烯基，烷基羰基或烷氧羰; [R <5>是氢，烷基，烯基，炔基，环烷基或环烯基，它们的制备和它们的用途的方法和中间体。
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8.发明申请ALPHA-(PYRAZOL-3-YL)-OXYMETHYLENE-PHENYLBUTENIC ACID METHYL ESTERS AND THE USE THEREOF AGAINST HARMFUL FUNGI OR ANIMAL PESTS 审中-公开ALPHA（吡唑-3-基）-OXYMETHYLEN-PHENYLBUTENSÄUREMETHYLESTER及其用途防治有害真菌和动物害虫
公开(公告)号：WO1995029896A1
公开(公告)日：1995-11-09
申请号：PCT/EP1995001554
申请日：1995-04-25
Applicant: BASF AKTIENGESELLSCHAFT , OBERDORF, Klaus , KÖNIG, Hartmann , MÜLLER, Bernd , KIRSTGEN, Reinhard , GRAMMENOS, Wassilios , SAUTER, Hubert , LORENZ, Gisela , AMMERMANN, Eberhard , HARRIES, Volker
Inventor： BASF AKTIENGESELLSCHAFT
IPC: C07D231/20
CPC classification number: C07D401/04 , A01N43/56 , C07D231/08 , C07D231/20 , C07D403/04
Abstract: alpha -phenylbutenic acid methyl esters of formula (I) are disclosed, wherein -- represents a single or double bond and the index and substituents have the following meanings: n is 0, 1, 2, 3, or 4; R represents nitro, cyano, halogen, alkyl, alkyl halide or alkoxy; R represents hydrogen, nitro, cyano, halogen, alkyl, alkyl halide, alkoxy, alkylthio or alkoxycarbonyl; R represents optionally substituted alkyl, alkenyl or alkinyl; an optionally substituted saturated or mono or biunsaturated ring which in addition to carbon atoms can contain 1-3 heteroatoms chosen from oxygen, sulphur and nitrogen, as ring members, or an optionally, substituted mono or binuclear aromatic group which in addition to carbon atoms can contain 1-4 nitrogen atoms or one or two nitrogen atoms and an oxygen or sulphur atom or an oxygen or sulphur atom as ring members. Also disclosed is a process for the production of the claimed compounds and the use thereof against harmful fungi or animal pests.
Abstract translation: 式（I）的阿尔法-Phenylbutensäuremethylester其中 - 代表单键或双键，所述索引和所述取代基具有以下含义：n是0，1，2，3或4; [R <1>硝基，氰基，卤素，烷基，卤代烷基或烷氧基; [R <2>为氢，硝基，氰基，卤素，烷基，卤代烷基，烷氧基，烷硫基或烷氧基羰; [R <3>是未取代的或取代的。 烷基，烯基或炔基; 未取代的或取代的。 饱和的或单 - 或二不饱和环，其作为除碳原子环成员，1至3个以下的杂原子的：氧，硫和氮，或一个未取代的或取代的。 单 - 或双核的芳族基团，其可以含有作为除碳原子数1〜四个氮原子或一个或两个氮原子和一个氧或硫原子或氧原子或硫原子，它们的制备方法和它们在防治有害真菌或动物害虫中的用途的处理环成员 ，
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公开(公告)号：WO2016036966A8
公开(公告)日：2016-09-15
申请号：PCT/US2015048381
申请日：2015-09-03
Applicant: PRECERES INC
Inventor： HEIDEBRECHT RICHARD W , ZHONG CHENG
IPC: C07C243/14
CPC classification number: C07C243/14 , A01N25/00 , A01N25/08 , A01N25/12 , A01N33/26 , A01N37/44 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N57/16 , A61K9/1617 , A61K9/5015 , A61K9/51 , A61K9/5123 , A61K31/7105 , A61K31/713 , A61K47/16 , A61K47/22 , C07C229/26 , C07C243/16 , C07C243/22 , C07D213/77 , C07D231/08 , C07D233/52 , C07D295/30 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/351 , C12N2320/30 , C12N2320/32 , C12N2320/50
Abstract: The present disclosure is directed to hydrazinyl lipidoids, formulations thereof further comprising at least one active agent, as well as methods of delivering the at least one active agent to a target organism. The present disclosure also relates generally to methods of preparing such hydrazinyl lipidoids, their formulation with one or more active agents, and the delivery of such formulations to target organisms.
Abstract translation: 本公开涉及肼基类脂质，其制剂还包含至少一种活性剂，以及将至少一种活性剂递送至靶生物体的方法。 本公开内容还通常涉及制备这种肼基类固醇的方法，其用一种或多种活性剂的制剂，以及将这些制剂递送至靶生物。
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10.发明申请BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE 审中-公开苯并呋喃及其相关化合物作为RORγ的激素和疾病的治疗
公开(公告)号：WO2015171558A2
公开(公告)日：2015-11-12
申请号：PCT/US2015/029167
申请日：2015-05-05
Applicant: LYCERA CORPORATION
Inventor： AICHER, Thomas Daniel , SKALITZKY, Donald J. , TAYLOR, Clarke B. , VAN HUIS, Chad A.
CPC classification number: C07C311/21 , C07C317/18 , C07C2101/14 , C07C2102/08 , C07C2601/14 , C07C2602/08 , C07D207/09 , C07D209/14 , C07D231/08 , C07D231/20 , C07D231/56 , C07D263/58 , C07D309/08
Abstract: The invention provides benzenesulfonamido and related compounds, pharmaceutical compositions, methods of promoting RORγ activity, increasing the amount of IL-17 in a subject, and treating cancer using such benzenesulfonamido and related compounds.
Abstract translation: 本发明提供苯磺酰胺和相关化合物，药物组合物，促进RORγ活性的方法，增加受试者中IL-17的量，以及使用这些苯磺酰胺和相关化合物治疗癌症。
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