公开(公告)号：WO2018107236A1

公开(公告)日：2018-06-21

申请号：PCT/AU2017/051394

申请日：2017-12-15

Applicant: THE UNIVERSITY OF SYDNEY

Inventor： PAYNE, Richard J. ,  BRITTON, Warwick John ,  TRAN, Anh ,  TRAN, Wendy

IPC: C07K5/037 ,  A61K38/04 ,  A61K38/07 ,  A61P11/00 ,  A61P31/04 ,  A61P31/06 ,  A61P31/08

Abstract: The present disclosure relates to antibacterial compounds. In particular, the compounds are for inhibiting the growth of bacteria, particularly Mycobacterium tuberculosis (Mtb) , and/or targeting bacteria having phospho-MurNAc-pentapeptide translocase . The present disclosure also relates to compositions containing these compounds and methods of the use of these compounds and compositions.

公开(公告)号：WO2018081370A1

公开(公告)日：2018-05-03

申请号：PCT/US2017/058455

申请日：2017-10-26

Applicant: JANSSEN PHARMACEUTICA NV ,  MACIELAG, Mark

Inventor： MACIELAG, Mark ,  MACIELAG, Mark ,  PATCH, Raymond, J. ,  ZHANG, Rui ,  CASE, Martin, A. ,  RANGWALA, Shamina, M. ,  LEONARD, James, N. ,  CAMACHO, Raul, C. ,  HUNTER, Michael, J. ,  D'AQUINO, Katharine, E. ,  EDWARDS, Wilson ,  SWANSON, Ronald, V. ,  JIAN, Wenying ,  ZHANG, Yue-Mei ,  WALL, Mark ,  CHI, Ellen

IPC: C07K14/47 ,  A61K38/04

Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

Abstract translation: 本发明包含缀合物，其包含偶联于环状PYY肽的单克隆抗体。 本发明还涉及药物组合物及其使用方法。 新的结合物可用于预防，治疗或改善本文公开的疾病和病症。

公开(公告)号：WO2018071767A1

公开(公告)日：2018-04-19

申请号：PCT/US2017/056515

申请日：2017-10-13

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： YANG, Jiyuan ,  KOEPECEK, Jindrich ,  ZHANG, Libin ,  FANG, Yixin

IPC: A61K38/04 ,  A61K47/48 ,  A61P35/00

Abstract: Disclosed herein, are antibody-polymer-drug conjugates. The conjugate comprises a targeting moiety, one or more polymers, and one or more therapeutic agents. Also described herein, are compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract translation: 本文公开了抗体 - 聚合物 - 药物缀合物。 缀合物包含靶向部分，一种或多种聚合物和一种或多种治疗剂。 本文还描述了包含缀合物的组合物，它们的制备方法以及用缀合物或其组合物治疗各种病症的方法。 本摘要旨在作为用于在特定领域中进行搜索的目的的扫描工具，并且不旨在限制本发明。

公开(公告)号：WO2018071640A1

公开(公告)日：2018-04-19

申请号：PCT/US2017/056300

申请日：2017-10-12

Applicant: LUBRIZOL ADVANCED MATERIALS, INC.

Inventor： VAN DEN NEST, Wim ,  DOMENECH, Nuria Alminana ,  GARCIA, Consuelo ,  FERRER MONTIEL, Antonio Vincente

IPC: C07K5/087 ,  A61K38/04 ,  C07K7/06 ,  C07K5/107

Abstract: The invention relates to a peptide of formula (I) R 1 -W m -X n -AA 1 -AA 2 -AA 3 -Y p -Z q -R 2 , cosmetic or pharmaceutical compositions comprising same and its use, for example, in the reduction of lipid accumulation in the skin, the treatment of cellulite and/or the treatment of the symptoms of skin aging.

Abstract translation: 本发明涉及式（I）的肽R 1 -W m -X n -AA -AA <子> 1 -AA <子> 2 -AA <子> 3 -Y <子> p -Z <子> q -R 包含其的化妆品或药物组合物及其用途，例如用于减少皮肤中的脂质积聚，治疗橘皮组织和/或治疗皮肤老化症状的用途。 p>

公开(公告)号：WO2017136312A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/015754

申请日：2017-01-31

Applicant: SPLASH PHARMACEUTICALS, INC.

Inventor： FINLAYSON, Malcolm ,  NELSON, David

IPC: A61K38/04 ,  A61K38/08 ,  C07K7/06 ,  A61P35/00 ,  A61P35/04

CPC classification number: A61K38/04 ,  A61K38/08 ,  C07K7/06

Abstract: Provided herein are therapeutic combinations of A6 peptide (SEQ ID NO: 1) and more anti-cancer agents, radiation therapy, or a combination thereof and the use of such combinations in the treatment of cancer.

Abstract translation: 本文提供了A6肽（SEQ ID NO：1）和更多抗癌剂，放射疗法或其组合的治疗组合以及这些组合在治疗癌症中的用途。 / p>

公开(公告)号：WO2017117411A1

公开(公告)日：2017-07-06

申请号：PCT/US2016/069255

申请日：2016-12-29

Applicant: PROTAGONIST THERAPEUTICS, INC.

Inventor： BOURNE, Gregory Thomas ,  SMYTHE, Mark Leslie ,  FREDERICK, Brian Troy ,  BHANDARI, Ashok

IPC: A61K38/04 ,  A61K38/10 ,  C07K7/00 ,  C07K7/08

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K14/00

Abstract: The present invention provides hepcidin analogues with improved in vivo half-lives, and related pharmaceutical compositions and methods of use thereof.

Abstract translation: 本发明提供具有改善的体内半衰期的铁调素类似物，以及相关的药物组合物及其使用方法。

公开(公告)号：WO2017117381A1

公开(公告)日：2017-07-06

申请号：PCT/US2016/069185

申请日：2016-12-29

Applicant: DUNCAN, Scott

Inventor： DUNCAN, Scott

IPC: A61K38/00 ,  A61K38/04 ,  A61K38/06 ,  A61K38/07 ,  A61K38/12

CPC classification number: C07K5/1019 ,  A61K38/00

Abstract: Disclosed herein are methods and compositions for the treatment and/or prevention of ischemia and ischemia-reperfusion injury comprising administration of at least one peptide disclosed herein, or a pharmaceutically acceptable salt thereof.

Abstract translation: 本文公开了用于治疗和/或预防局部缺血和局部缺血 - 再灌注损伤的方法和组合物，其包括施用本文公开的至少一种肽或其药学上可接受的盐。

公开(公告)号：WO2017106460A1

公开(公告)日：2017-06-22

申请号：PCT/US2016/066859

申请日：2016-12-15

Applicant: 3-D MATRIX, LTD. ,  GIL, Eun, Seok ,  GILBERT, Karl, Patrick

Inventor： GIL, Eun, Seok ,  GILBERT, Karl, Patrick ,  RIOULT, Marc ,  NAGANO, Keiji ,  KIYOFUJI, Toshiro ,  HASEGAWA, Yuya

IPC: A61L27/20 ,  A61L27/22 ,  C07K7/08 ,  C07K14/00 ,  A61K38/03 ,  A61K38/04 ,  A61P17/02 ,  A61K38/08

CPC classification number: A61K38/03 ,  A61K38/04 ,  A61K38/08 ,  A61L27/227 ,  A61L27/52 ,  A61L2400/06 ,  C07K7/08

Abstract: Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.

Abstract translation: 本文提供了包含用于抗粘连的非离子极性氨基酸的自组装肽。 提供基本上由非离子，极性氨基酸组成的自组装肽的组合物，肽溶液和宏观支架以防止粘附或提供抗粘附性能。 具体的肽包括基本上由丝氨酸，苏氨酸，酪氨酸，半胱氨酸，谷氨酰胺，天冬酰胺，甲硫氨酸，色氨酸，羟基脯氨酸及其组合组成的那些肽。 还提供了方法和工具包。

公开(公告)号：WO2017103200A1

公开(公告)日：2017-06-22

申请号：PCT/EP2016/081572

申请日：2016-12-16

Applicant: DIET4LIFE APS

Inventor： STAGSTED, Jan ,  ZHOU, Jiehui ,  JESSEN, Randi ,  PALMFELDT, Johan ,  HANSEN, Erik Torngaard

IPC: C07K7/06 ,  A61K38/04 ,  C07K7/08 ,  C07K14/00

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K14/57509

Abstract: The present invention relates to novel peptides, composition comprising such peptides including nutritional supplements and methods for inducing satiation and satiety, for weight management and preventing or reducing the incidence of obesity, or for preventing or reducing cardiovascular diseases, atherosclerosis, hypertension, hepatosteatosis, cancer and/or diabetes.

Abstract translation: 本发明涉及新型肽，包含此类肽的组合物，所述肽包括营养补充剂和用于诱导饱食和饱腹感的方法，用于体重控制和预防或减少肥胖症的发生，或用于预防或减少心血管疾病 ，动脉粥样硬化，高血压，肝脂肪变性，癌症和/或糖尿病。

公开(公告)号：WO2017009843A3

公开(公告)日：2017-06-08

申请号：PCT/IL2016050765

申请日：2016-07-14

Applicant: BIOKINE THERAPEUTICS LTD ,  BIOLINERX LTD

Inventor： PELED AMNON ,  PEREG YARON

IPC: A61K38/04 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K38/04 ,  A61K38/395 ,  A61K2300/00

Abstract: A method of treating cancer in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a peptide having an amino acid sequence as set forth in SEQ ID NO: 1 or an analog or derivative thereof; and an anti-cancer agent, thereby treating the cancer in the subject.

Abstract translation: 提供了在有需要的受试者中治疗癌症的方法。 所述方法包括向所述受试者施用治疗有效量的具有如SEQ ID NO：1所示氨基酸序列的肽或其类似物或衍生物; 和抗癌剂，由此治疗受试者中的癌症。