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    DEVICES AND METHODS FOR MICROARRAY SELECTION
    61.
    发明申请
    DEVICES AND METHODS FOR MICROARRAY SELECTION 审中-公开
    用于微阵列选择的装置和方法

    公开(公告)号：WO2011027268A2

    公开(公告)日：2011-03-10

    申请号：PCT/IB2010/053839

    申请日：2010-08-26

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  VAN DER ZAAG, Pieter, Jan ,  FEITSMA, Harma, Martine ,  DEN TOONDER, Jacob, Marinus, Jan ,  WIMBERGER-FRIEDL, Reinhold

    Inventor： VAN DER ZAAG, Pieter, Jan ,  FEITSMA, Harma, Martine ,  DEN TOONDER, Jacob, Marinus, Jan ,  WIMBERGER-FRIEDL, Reinhold

    IPC: C12Q1/68

    CPC classification number: C12Q1/6834 ,  C12Q2537/149 ,  C12Q2527/107

    Abstract: The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.

    Abstract translation: 本发明涉及用于特异性选择靶分子的装置，其包含：（a）至少一个包含微阵列的反应区，其中所述微阵列包含底物，一种或多种物质 捕捉分子被固定，包括一个或多个温度控制和/或调节单元，用于控制和/或调节区域内的温度; （b）至少一个非反应区，其包含一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）至少一个能够产生和/或调节所述反应区（a）和包含一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的运输工具。 本发明进一步涉及用于特异性选择靶分子的装置，其中固定的捕获分子以点，细长点和/或线的形式在微阵列中组织。 在另一方面，本发明涉及特异性选择靶分子的方法，包括将介质引入这样的装置，在反应区中进行相互作用反应，将未相互作用或未结合的靶分子转运至允许再激活 靶分子并且在反应区与再活化的靶分子进行另外的相互作用反应，以及使用这样的装置用于特异性选择靶分子，例如 目标富集在文献中也被称为基于微阵列的基因组选择（MGS）。

    METHOD AND DEVICE FOR MEASURING CONDUCTIVITY OF AN OBJECT
    63.
    发明申请
    METHOD AND DEVICE FOR MEASURING CONDUCTIVITY OF AN OBJECT 审中-公开
    用于测量物体电导率的方法和装置

    公开(公告)号：WO2011018744A1

    公开(公告)日：2011-02-17

    申请号：PCT/IB2010/053581

    申请日：2010-08-09

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  YAN, Ming ,  CHEN, Dayu ,  LI, Hui ,  JIN, Hua

    Inventor： YAN, Ming ,  CHEN, Dayu ,  LI, Hui ,  JIN, Hua

    IPC: A61B5/053

    CPC classification number: A61B5/0536 ,  A61B5/0522

    Abstract: The invention provides a device (10) for measuring the conductivity of an object (20), and the device (10) comprises: a measuring unit (11) for measuring a first voltage when the object (20) is not placed in the measuring unit (11), for measuring the voltage of the object (20) when the object (20) is placed in the measuring unit (11) after measuring the first voltage, and for measuring a second voltage when the object (20) is moved away from the measuring unit (11) after measuring the voltage of the object (20); a calculating unit (12) for calculating the difference between the first voltage and the second voltage; and an adjusting unit (13) for adjusting the voltage of the object (20), based on said difference, to generate an adjusted voltage of the object (20).

    Abstract translation: 本发明提供了一种用于测量物体（20）的导电性的装置（10），并且装置（10）包括：测量单元（11），用于当物体（20）未被放置在测量中时测量第一电压 单元（11），用于在物体（20）在测量第一电压之后放置在测量单元（11）中时测量物体（20）的电压，并且当物体（20）移动时测量第二电压 在测量对象（20）的电压之后离开测量单元（11）; 计算单元（12），用于计算第一电压和第二电压之间的差; 以及调整单元（13），用于基于所述差值调节所述物体（20）的电压，以产生所述物体（20）的调节电压。

    DEVICE AND METHOD FOR ASSISTING A COUGH
    65.
    发明申请
    DEVICE AND METHOD FOR ASSISTING A COUGH 审中-公开
    用于辅助食物的装置和方法

    公开(公告)号：WO2011010279A1

    公开(公告)日：2011-01-27

    申请号：PCT/IB2010/053292

    申请日：2010-07-20

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  BRAND, Maarten Leonardus Christian ,  JIN, Sheng

    Inventor： BRAND, Maarten Leonardus Christian ,  JIN, Sheng

    IPC: A61M16/00

    CPC classification number: A61M16/202 ,  A61H23/00 ,  A61H31/00 ,  A61H2201/5007 ,  A61H2201/5071 ,  A61M16/0006 ,  A61M16/024 ,  A61M16/204 ,  A61M16/205 ,  A61M2016/0027 ,  A61M2016/0036

    Abstract: The invention provides a device (11) for assisting a cough, based on an oscillation pressure. The oscillation pressure causes a periodic oscillation airflow in a lung system and the periodic oscillation airflow comprises an oscillation exhalation airflow and an oscillation inhalation airflow. The device (10) comprises a controlling unit (11), and the controlling unit (11) comprises: - a first determining unit (111) for determining whether an inhalation of the lung system is complete, so as to control a valve (13) which is to be closed for isolating the lung system from the external environment, - a second determining unit (112) for determining whether an internal air pressure in the lung system is larger than a pre-defined pressure threshold, and - a detecting unit (113) for detecting the start of the oscillation exhalation airflow, so as to control the valve (13) which is to be opened for starting a cough.

    Abstract translation: 本发明提供了一种用于根据振荡压力帮助咳嗽的装置（11）。 振荡压力导致肺系统中的周期性振荡气流，并且周期性振荡气流包括振荡呼气气流和振荡吸入气流。 所述装置（10）包括控制单元（11），所述控制单元（11）包括： - 第一确定单元（111），用于确定所述肺系统的吸入是否完整，以便控制阀（13 ），其用于将肺系统与外部环境隔离;第二确定单元（112），用于确定肺系统中的内部空气压力是否大于预定义的压力阈值;以及 - 检测单元 （113），用于检测振动呼气气流的开始，以便控制要打开的阀（13）以开始咳嗽。

    WRIST MOUNTED MICRO-JET FLUID DELIVERY DEVICE
    66.
    发明申请
    WRIST MOUNTED MICRO-JET FLUID DELIVERY DEVICE 审中-公开
    WRIS安装微型流体输送装置

    公开(公告)号：WO2011007316A1

    公开(公告)日：2011-01-20

    申请号：PCT/IB2010/053191

    申请日：2010-07-13

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  HIJLKEMA, Markus

    Inventor： HIJLKEMA, Markus

    IPC: A61M5/30 ,  A61M5/14 ,  A61M5/142

    CPC classification number: A61M5/14248 ,  A61M2005/14268 ,  A61M2005/3022 ,  A61M2205/50

    Abstract: A fluid delivery device (200) is provided, that comprises a disposable part (320) and a durable or retainable part (230) that contains the power supply, the drive electronics and the actuator for a micro- jet pump. The disposable part comprises a fluid container and the micro- jet nozzle (460) associated optionally with the membrane of the micro- jet pump. The two housing parts of the device may be assembled by a twisting operation from outside in a manner as operating a diving watch which screws the two housing parts together that are equipped with associated threaded fixing means (310).

    Abstract translation: 提供流体输送装置（200），其包括一次性部件（320）和容纳电源，驱动电子装置和用于微型喷射泵的致动器的耐用或可保持部件（230）。 一次性部件包括流体容器和可选地与微喷射泵的膜相关联的微喷嘴（460）。 装置的两个壳体部件可以通过从操作潜水表的方式通过外部的扭转操作来组装，所述潜水表将两个壳体部件拧在一起，所述潜水表将配备有相关联的螺纹固定装置（310）。

    APPARATUS AND METHOD FOR SAFEGUARDING THE OPERATION OF A FLUID DELIVERY DEVICE
    68.
    发明申请
    APPARATUS AND METHOD FOR SAFEGUARDING THE OPERATION OF A FLUID DELIVERY DEVICE 审中-公开
    用于保护流体输送装置的操作的装置和方法

    公开(公告)号：WO2011007282A1

    公开(公告)日：2011-01-20

    申请号：PCT/IB2010/052988

    申请日：2010-06-30

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  HIJLKEMA, Markus ,  NISATO, Giovanni ,  KASSIES, Roelf

    Inventor： HIJLKEMA, Markus ,  NISATO, Giovanni ,  KASSIES, Roelf

    IPC: A61M5/30

    CPC classification number: A61M5/30 ,  A61M5/204 ,  A61M5/365 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/52

    Abstract: The apparatus allows the detection of light bubbles in the area of the pressurized fluid chamber or the nozzle of the micro-jet to detect bubbles by light scattering. Light is sent through the area of interest and detected behind it by a light detector. If the light intensity drops correspondingly a drop in the detector current is detected. This is indicative of unwanted bubbles. In this case the actuation of the electromechanical actuator to generate micro-jets may be stopped, alternatively or in additional signal may be output in order to inform a user to replace a fluid reservoir, or to simply issue an alarm. The fluid delivery device may comprise a durable and a disposable section, wherein the active parts such as power source, light source and light detector are integrated in the durable section and the disposable section comprises a nozzle and the fluid chamber which presents significant advantages, as the contact interface to the skin is frequently replaced and thus hygienic conditions are easy to maintain.

    Abstract translation: 该装置允许在加压流体室的区域或微喷嘴的喷嘴的区域中检测光气泡，以通过光散射来检测气泡。 光通过感兴趣的区域发送并通过光检测器检测到。 如果光强度相应降低，则检测器电流的下降。 这表示不需要的气泡。 在这种情况下，可以停止用于产生微射流的机电致动器的致动，或者可选地输出附加信号，以通知用户更换流体储存器，或简单地发出报警。 流体输送装置可以包括耐用和一次性部分，其中诸如动力源，光源和光检测器的有源部件集成在耐用部分中，并且一次性部分包括喷嘴和流体室，其具有显着的优点，如 经常更换与皮肤的接触界面，因此卫生条件易于维护。

    VISUALIZATION OF PHYSIOLOGICAL PARAMETERS
    69.
    发明申请
    VISUALIZATION OF PHYSIOLOGICAL PARAMETERS 审中-公开
    生理参数的可视化

    公开(公告)号：WO2011004288A1

    公开(公告)日：2011-01-13

    申请号：PCT/IB2010/052955

    申请日：2010-06-29

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  NACHABÉ, Rami ,  HENDRIKS, Bernardus, Hendrikus, Wilhelmus ,  BABIC, Drazenko ,  BRAUN, Augustinus, Laurentius ,  VAN DER VOORT, Marjolein ,  DESJARDINS, Adrien, Emmanuel ,  MIHAJLOVIC, Nenad ,  HARBERS, Rik

    Inventor： NACHABÉ, Rami ,  HENDRIKS, Bernardus, Hendrikus, Wilhelmus ,  BABIC, Drazenko ,  BRAUN, Augustinus, Laurentius ,  VAN DER VOORT, Marjolein ,  DESJARDINS, Adrien, Emmanuel ,  MIHAJLOVIC, Nenad ,  HARBERS, Rik

    IPC: A61B6/12 ,  A61B19/00

    CPC classification number: A61B6/12 ,  A61B1/00147 ,  A61B5/065 ,  A61B6/463 ,  A61B6/5247 ,  A61B8/463 ,  A61B34/20 ,  A61B2034/256 ,  A61B2090/365 ,  G06F19/00

    Abstract: The invention relates to a medical imaging apparatus for providing information about an object. The invention further relates to a method for providing information about an object. In order to improve the preparation and the visual reception of information relating to an object during medical interventions, a medical imaging apparatus for providing information about an object is provided that comprises an image acquisition device an interventional device, a processing device and a display device. The image acquisition device detects object data from at least one region of interest of an object and provides the object data to the processing device. The interventional device detects physiological parameters of the object depending on the position of a predetermined area of the interventional device in relation to the object and provides the physiological parameters to the processing device. Further, the processing device transforms at least a part of the object data into image data and converts the physiological parameters into physiological data. The processing device then modifies at least one image parameter of the image data depending on the physiological data and thereby transforms the image data into modified live image data which is provided to the display device displaying a modified live image.

    Abstract translation: 本发明涉及一种用于提供关于物体的信息的医学成像设备。 本发明还涉及一种用于提供关于对象的信息的方法。 为了改善在医疗干预期间与物体有关的信息的准备和视觉接收，提供了一种用于提供关于物体的信息的医学成像装置，其包括图像获取装置，介入装置，处理装置和显示装置。 图像获取装置从对象的至少一个感兴趣区域检测对象数据，并将对象数据提供给处理装置。 介入装置根据介入装置相对于物体的预定区域的位置来检测物体的生理参数，并将生理参数提供给处理装置。 此外，处理装置将至少一部分对象数据变换为图像数据，并将生理参数转换为生理数据。 处理装置然后根据生理数据修改图像数据的至少一个图像参数，从而将图像数据变换为提供给显示修改的实时图像的显示装置的修改的实况图像数据。

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