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公开(公告)号：WO2009102743A3
公开(公告)日：2009-08-20
申请号：PCT/US2009/033725
申请日：2009-02-11
IPC分类号： F02M37/22
摘要： A collection device that captures liquid sample that may spill or leak during the process of loading or unloading liquid sample while a centrifuge rotor is spinning. Such capture prevents the leaked liquid sample from coming into contact with sensitive components inside the centrifuge chamber, thereby protecting the centrifuge from damage.
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公开(公告)号：WO2009102743A2
公开(公告)日：2009-08-20
申请号：PCT/US2009033725
申请日：2009-02-11
IPC分类号： B04B7/06
摘要： A collection device that captures liquid sample that may spill or leak during the process of loading or unloading liquid sample while a centrifuge rotor is spinning. Such capture prevents the leaked liquid sample from coming into contact with sensitive components inside the centrifuge chamber, thereby protecting the centrifuge from damage.
摘要翻译： 收集装置，捕集在离心机转子旋转时装载或卸载液体样品的过程中可能溢出或泄漏的液体样品。 这种捕获可防止泄漏的液体样品与离心机室内的敏感部件接触，从而保护离心机免受损坏。
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63.发明申请
公开(公告)号：WO2009085330A3
公开(公告)日：2009-07-09
申请号：PCT/US2008/054649
申请日：2008-02-22
IPC分类号： B04B5/00
摘要： An automated method and apparatus for separating and harvesting cells of interest, e.g., mononuclear cells, in a whole blood sample. The method of the invention uses the aspirating/dispensing probe of an automated sample preparation instrument to underlay a density gradient medium beneath a whole blood sample in a centrifugation tube, and the same probe is used to harvest cells of interest from a cell layer formed in the tube as a result of a centrifugation step. In harvesting cells, the probe is advanced inside the tube by a fixed, predetermined distance at which the probe tip (i.e., its aspiration port) is known to be located at, or within a predetermined distance below, the bottom of the cell layer. A predetermined volume of liquid is then aspirated through the probe tip, whereby most cells of interest (and more than 90% of those cells that can be harvested by a flawless manual method) are removed from the cell layer and collected for analysis. Preferably, the probe is caused to move laterally with respect to the tube during the aspiration of the cell layer, whereby cells offset from the center of the container are readily harvested.
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64.发明申请
公开(公告)号：WO2008051659A8
公开(公告)日：2009-04-16
申请号：PCT/US2007077834
申请日：2007-09-07
申请人： BECKMAN COULTER INC
发明人： LI WILLIAM W , CASEY WILLIAM J , VEINER CRAIG R , GONZALEZ CARLOS R , CANO JOSE M , DEL VALLE ROBERTO , GALVEZ SANTIAGO
IPC分类号： G01N30/20
CPC分类号： G01N35/1097
摘要： Apparatus (20) for aspirating and dispensing liquid samples in an analytical instrument, e g, a hematology instrument, includes a liquid-sampling valve (LSV) that, while operating to segment and position for dispensing one or more precise volumes of a liquid sample that has been aspirated into the valve by a pump (30), simultaneously enables the apparatus to be operated in an aspirate/dispense (suck-and-spit) mode in which a liquid sample can be selectively driven through the valve in opposite directions by a pump, e g, a syringe pump.
摘要翻译： 用于在分析仪器（例如血液仪器）中吸取和分配液体样品的装置（20）包括液体取样阀（LSV），其在操作以分配和定位以分配一个或多个精确体积的液体样品时， 已经通过泵（30）吸入阀中，同时使得装置能够以抽吸/分配（吸吮）模式操作，其中液体样品可以通过相反方向选择性地通过阀驱动 泵，例如注射泵。
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公开(公告)号：WO2006101833A3
公开(公告)日：2009-04-16
申请号：PCT/US2006009106
申请日：2006-03-16
申请人： BECKMAN COULTER INC
发明人： LI WILLIAM W , VEINER CRAIG R , CABRERA SERGIO
CPC分类号： G01N35/1079 , B01L3/0293 , B01L9/52 , G01N2035/0405
摘要： Apparatus for aspirating liquid from a container (C), e.g., a test tube, having a puncturable stopper (S) includes a pair of stepper motors (M2, M3) that share a common linear actuate or drive member (30). One motor operates to axially advance the linear drive member (preferably a lead screw) to a position in which it serves to position a rigidly connected tube-detector/stripper member (36) in engagement with the top of a stopper on a tube. Thereafter, the second motor operates to move along the surface of the same drive member to advance an aspiration probe through the engaged stopper and into a liquid aspirating position within the tube. Preferably, a linear guide rail (32), slidably-mounted on frame (12) that supports the liquid-aspirating apparatus, serves to guide both the movement of the aspiration probe and the linear drive member. As a result of the shared components, the apparatus is highly precise and reliable.
摘要翻译： 用于从具有可穿刺止动件（S）的容器（C），例如试管抽吸液体的装置包括共享共同的线性致动器或驱动构件（30）的一对步进马达（M2，M3）。 一个马达操作以将线性驱动构件（优选导螺杆）轴向推进到其用于定位刚性连接的管 - 检测器/剥离器构件（36）与管上的塞子的顶部接合的位置。 此后，第二马达操作以沿着相同的驱动部件的表面移动，以将抽吸探头通过接合的塞子推进到管内的液体吸入位置。 优选地，可滑动地安装在支撑液体吸入装置的框架（12）上的线性导轨（32）用于引导吸入探针和线性驱动构件的移动。 作为共享组件的结果，该设备是高度精确和可靠的。
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公开(公告)号：WO2008115882A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057258
申请日：2008-03-17
发明人： O'DONNELL, Mary , WHITE, Jon , DAVIDSON, Douglas
IPC分类号： A61B5/00
摘要： The efficient and accurate auto-validation of results from medical diagnostic tests ordered on a biological sample are provided. Test results are received once an instrument completes that test. Upon receiving a test result, a computer system analyzes the received test results to determine if that test is initially valid. Once a test is known to be initially invalid, the computer system contains validation rules that know if the final validity of a first test is dependent on the results of a different test. Accordingly, the initial validation of only some of the tests may need to be performed for the validation rules to confidently validate the first test. Thus, the first test can advantageously be released for diagnosis of the patient before all of the ordered tests are completed.
摘要翻译： 提供了在生物学样品上订购的医学诊断测试结果的高效和准确的自动验证。 仪器完成该测试后将收到测试结果。 在接收到测试结果后，计算机系统分析接收到的测试结果以确定该测试是否最初有效。 一旦知道测试最初是无效的，计算机系统就包含验证规则，知道第一个测试的最终有效性是否取决于不同测试的结果。 因此，可能需要对验证规则进行仅一些测试的初始验证，以确信地验证第一测试。 因此，在完成所有有序测试之前，可以有利地释放第一测试用于对患者进行诊断。
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公开(公告)号：WO2007078722A3
公开(公告)日：2008-06-19
申请号：PCT/US2006047359
申请日：2006-12-12
申请人： BECKMAN COULTER INC , ZIGON ROBERT
发明人： ZIGON ROBERT
IPC分类号： G06F7/00
CPC分类号： G06F17/30292
摘要： An adaptable relational database system comprises a database schema having relational integrity, wherein the database schema includes a plurality of entities associated with a plurality of attributes. The plurality of attributes in the database may be varied such that the database includes a first set of attributes associated with a first time and a second set of attributes associated with a second time. The second set of attributes includes at least one attribute that is not included in the first set of attributes. The relational integrity of the database is maintained as the plurality of attributes in the database is varied. In one embodiment, the relational database is displayed in rectangular/table format, including a display of the first set of attributes, the second set of attributes and data associated with the first set of attributes and the second set of attributes.
摘要翻译： 适应性关系数据库系统包括具有关系完整性的数据库模式，其中数据库模式包括与多个属性相关联的多个实体。 可以改变数据库中的多个属性，使得数据库包括与第一时间相关联的第一组属性和与第二时间相关联的第二组属性。 第二组属性包括不包括在第一组属性中的至少一个属性。 随着数据库中的多个属性的变化，维护数据库的关系完整性。 在一个实施例中，关系数据库以矩形/表格格式显示，包括第一组属性的显示，第二组属性和与第一组属性相关联的数据和第二组属性。
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公开(公告)号：WO2007076188A3
公开(公告)日：2008-04-10
申请号：PCT/US2006061029
申请日：2006-11-17
申请人： BECKMAN COULTER INC
发明人： ZHANG SHULIANG , ZHENG MIN , LIN DONGQING , HUO ZILING
IPC分类号： G01N31/00
CPC分类号： G01N15/12 , G01N35/00584 , G01N2015/1062 , G01N2015/1068 , G01N2015/1081 , G01N2015/1087
摘要： Systems and methods consistent with embodiments of the present invention provide a method for the measurement and analysis of particle counts in flow cytometry and hematology instruments. In some methods for the measurement and analysis of particle counts, a corrected histogram of particle distributions is calculated and used to obtain an accurate count of particles and an accurate measurement of other particle parameters.
摘要翻译： 与本发明的实施方案一致的系统和方法提供了流式细胞术和血液学仪器中的颗粒计数的测量和分析方法。 在一些用于测量和分析颗粒计数的方法中，计算颗粒分布的校正直方图并用于获得颗粒的精确计数和其他颗粒参数的精确测量。
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公开(公告)号：WO2008021653A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/073870
申请日：2007-07-19
IPC分类号： G01N33/53
摘要： A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a neutralization reagent to inhibit further reactions of the permeation reagent; performing a cell-by-cell measurement of side scatter signals of the red blood cells in the sample mixture on a flow cytometer; and obtaining cellular hemoglobin (Hgb cell ) of each red blood cell using the obtained side scatter signals. The method further includes measuring cellular hemoglobin of reticulocytes (Hgb retic ) by differentiating reticulocytes using a simultaneous fluorescence measurement. The method also includes measuring cellular percentage of a hemoglobin variant in mature red blood cells or reticulocytes by adding a fluorescent antibody in the neutralization reagent and detecting fluorescence signals of antibody bound hemoglobin variant.
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公开(公告)号：WO2007124234A3
公开(公告)日：2008-01-17
申请号：PCT/US2007065494
申请日：2007-03-29
申请人： BECKMAN COULTER INC
发明人： HUO ZILING , LI XI , CHEWPUTTANAGUL PHAISIT
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/6284 , G06T2207/30024
摘要： In accordance with the principles of the invention, methods, systems, and computer- readable mediums are provided for processing image data representing cellular analysis result data including accessing image data; generating an intensity histogram based on the image data; transforming the intensity histogram into a stepped image; performing normalized cross-correlation between the stepped image and a reference image to measure similarity; and determining an abnormality based on the measured similarity.
摘要翻译： 根据本发明的原理，提供方法，系统和计算机可读介质来处理表示包括访问图像数据的蜂窝分析结果数据的图像数据; 基于图像数据生成强度直方图; 将强度直方图变换为阶梯图像; 执行阶梯图像和参考图像之间的归一化互相关以测量相似度; 以及基于所测量的相似度来确定异常。
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