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    CALIBRATION AND VALIDATION OF CUVETTES IN AUTOMATED CHEMICAL ANALYZERS
    6.
    发明申请
    CALIBRATION AND VALIDATION OF CUVETTES IN AUTOMATED CHEMICAL ANALYZERS 审中-公开

    公开(公告)号：WO2022146591A1

    公开(公告)日：2022-07-07

    申请号：PCT/US2021/060930

    申请日：2021-11-29

    申请人： BECKMAN COULTER, INC.

    发明人： KAMI, Kana ,  OKADA, Noriyoshi ,  ITO, Noriyuki ,  MIZUTANI, Takayuki

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N21/90

    摘要： The presently claimed and described technology provides improved calibration and validation procedures for sample containers (e.g., cuvettes) in automated chemical analyzers. The claimed and described technology further provides methods of operating an automated analyzer that allows for the automation of calibrating and tracking the integrity of individual sample containers (e.g., cuvettes) in parallel with measuring constituent samples. These methods eliminate the need to alternate between a diagnostic mode and measurement mode when performing system maintenance, such as validating cuvette integrity, calibrating absorbance baseline, and replacing cuvettes. As such, the presently claimed and described technology can reduce downtime and improve the clinical lab productivity significantly by allowing for this system maintenance to occur simultaneously with sample analysis.

    CLINICAL LABORATORY AUTOMATION SYSTEM WITH SINGLE CALIBRATOR
    7.
    发明申请
    CLINICAL LABORATORY AUTOMATION SYSTEM WITH SINGLE CALIBRATOR 审中-公开

    公开(公告)号：WO2022146582A1

    公开(公告)日：2022-07-07

    申请号：PCT/US2021/060528

    申请日：2021-11-23

    申请人： BECKMAN COULTER, INC. ,  DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    发明人： MIZUTANI, Takayuki ,  ROSCOE, Thomas W. ,  BLACKWOOD, John J.

    IPC分类号： G01N35/10 ,  G01N33/68

    摘要： An external calibration curve relies on external calibrators containing known concentrations of a target analyte that can deteriorate over time, leading to inaccurate results. Generating new calibration curves often requires preparing several calibrators to obtain calibration points needed for generating the calibration curves. Preparing the calibrators necessary for multi-point calibration curves requires operator preparation time and can introduce handling errors. The presently claimed and described technology provides a clinical laboratory automation system, including a fluid handling system, an analyzer component, and a mass spectrometer. The clinical laboratory automation system can provide automated calibration using one calibrator to prepare one or more calibrator dilutions used to generate a calibration curve for the quantitative measurement of a target analyte in a sample. The clinical laboratory automation analyzer may also provide an automated evaluation of pipettor dispensing volume and adjustment of the pipettor actuator to deliver an accurate dispensing volume.

    DISTRIBUTED REINFORCEMENT LEARNING ON A GPU
    8.
    发明申请
    DISTRIBUTED REINFORCEMENT LEARNING ON A GPU 审中-公开

    公开(公告)号：WO2021247777A1

    公开(公告)日：2021-12-09

    申请号：PCT/US2021/035553

    申请日：2021-06-02

    申请人： BECKMAN COULTER, INC.

    发明人： ZIGON, Robert J.

    IPC分类号： G06N20/00 ,  G06N3/00 ,  G06N7/00 ,  G06N3/04 ,  G06N3/006 ,  G06N7/005

    摘要： A method is performed at a graphics processing unit (GPU) comprising multiple GPU processor cores. The method includes: at each GPU processor core of at least a subset of the multiple GPU processor cores of the GPU: training, for a plurality of episodes, a reinforcement learning (RL) engine to solve a given problem by updating coefficients of the RL engine. The method includes: upon completion of the plurality of episodes at each GPU processor core of the at least the subset of the multiple GPU processor cores of the GPU: combining, using the GPU and without using a central processing unit (CPU) external to the GPU, the coefficients from the multiple GPU processor cores using a transformation function, and providing the combined coefficients to each GPU processor core for further training. The method includes: stopping training the RL engine upon determining that a stopping condition has been reached.

    SOLID STATE ION SELECTIVE ELECTRODES
    9.
    发明申请
    SOLID STATE ION SELECTIVE ELECTRODES 审中-公开

    公开(公告)号：WO2021146107A1

    公开(公告)日：2021-07-22

    申请号：PCT/US2021/012664

    申请日：2021-01-08

    申请人： BECKMAN COULTER, INC.

    发明人： WALLACH, John, M. ,  MU, Xihai

    IPC分类号： G01N27/28 ,  G01N27/333 ,  G01N27/283 ,  G01N33/48735

    摘要： An ion selective electrode ("ISE") assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion.