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    COMPOSITIONS COMPRISING HMOS, THEIR PRODUCTION AND USE FOR THE PREVENTION AND/OR TREATMENT OF VIRAL AND/OR BACTERIAL INFECTIONS
    76.
    发明申请
    COMPOSITIONS COMPRISING HMOS, THEIR PRODUCTION AND USE FOR THE PREVENTION AND/OR TREATMENT OF VIRAL AND/OR BACTERIAL INFECTIONS 审中-公开
    包含HMOS的组合物，其生产和用于预防和/或治疗病毒和/或细菌感染的用途

    公开(公告)号：WO2017221208A1

    公开(公告)日：2017-12-28

    申请号：PCT/IB2017/053760

    申请日：2017-06-23

    Applicant: GLYCOM A/S

    Inventor： KHANZHIN, Nikolay ,  HEDEROS, Markus ,  VIGSNÆS, Louise Kristine ,  MCCONNELL, Bruce

    IPC: A61K31/702 ,  A61K31/715 ,  C12P1/04 ,  C12P19/04 ,  C07H3/04 ,  C07H5/06

    Abstract: A mixture of human milk oligosaccharides that comprises or consists essentially of a) LNTri II, LNT, pLNH II and optionally lactose, or b) LNTri II, LNnT, pLNnH and optionally lactose, and is useful for preventing or treating viral or bacterial, intestinal and respiratory infections and for modulating the human gastrointestinal microbiota to increase Bifidobacterium abundance. A process for preparing the mixture and methods of crystallizing LNnT and LNT is also described.

    Abstract translation: 人乳寡糖的混合物，其包含a）LNTri II，LNT，pLNH II和任选的乳糖，或b）LNTri II，LNnT，pLNnH和任选的乳糖，或者基本上由以下组分组成： 预防或治疗病毒或细菌，肠道和呼吸道感染以及调节人类胃肠微生物群以增加双歧杆菌丰度。 还描述了制备混合物的方法和使LNnT和LNT结晶的方法。

    SYNTHETIC COMPOSITION
    77.
    发明申请
    SYNTHETIC COMPOSITION 审中-公开
    合成组合物

    公开(公告)号：WO2017198276A1

    公开(公告)日：2017-11-23

    申请号：PCT/DK2017/050165

    申请日：2017-05-19

    Applicant: GLYCOM A/S

    Inventor： VIGSNÆS, Louise Kristine ,  MCCONNELL, Bruce ,  ELISON, Emma

    IPC: A61K31/702 ,  A61P1/00 ,  A61P25/00

    Abstract: The application relates to synthetic compositions containing one or more human milk oligosaccharides for treating serotonin and/or tryptophan dysregulation.

    Abstract translation: 本申请涉及用于治疗血清素和/或色氨酸失调的含有一种或多种人乳寡糖的合成组合物。

    SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH
    78.
    发明申请
    SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH 审中-公开
    从发酵液中分离低聚糖

    公开(公告)号：WO2017182965A1

    公开(公告)日：2017-10-26

    申请号：PCT/IB2017/052252

    申请日：2017-04-19

    Applicant: GLYCOM A/S

    Inventor： CHASSAGNE, Pierre ,  KHANZHIN, Nikolay ,  MATWIEJUK, Martin ,  HEDEROS, Markus ,  BANKE, Niels

    IPC: C07H1/06 ,  B01D15/36 ,  B01D61/02 ,  B01D61/14 ,  B01J39/05 ,  B01J41/07 ,  C12N9/10 ,  C12P19/26 ,  G01N30/02

    Abstract: The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of producing said oligosaccharide from an internalized carbohydrate precursor, comprising the steps of: i) ultrafiltration (UF), preferably to separate biomass from the broth, ii) nanofiltration (NF), preferably to concentrate said oligosaccharide in the broth and/or reduce an inorganic salt content of the broth, and iii) treating the broth with an ion exchange resin, preferably to remove charged materials, and/or subjecting the broth to chromatography, preferably to remove hydrophobic impurities.

    Abstract translation: 本发明涉及用于从发酵液中获得含有N-乙酰氨基葡糖的中性寡糖的方法，其中所述寡糖通过培养能够由内化的碳水化合物前体产生所述寡糖的遗传修饰的微生物产生， 包括以下步骤：i）超滤（UF），优选从发酵液中分离生物质，ii）纳滤（NF），优选地将所述寡糖浓缩到发酵液中和/或降低发酵液的无机盐含量，以及iii） 用离子交换树脂处理发酵液，优选去除带电物质，和/或将发酵液进行色谱分离，优选去除疏水性杂质。

    SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH
    79.
    发明申请
    SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH 审中-公开
    从发酵液中分离低聚糖

    公开(公告)号：WO2017152918A1

    公开(公告)日：2017-09-14

    申请号：PCT/DK2017/050063

    申请日：2017-03-07

    Applicant: GLYCOM A/S

    Inventor： MATWIEJUK, Martin ,  KHANZHIN, Nikolay ,  CHASSAGNE, Pierre ,  HEDEROS, Markus

    IPC: C07H1/06

    Abstract: The present invention relates to a method for separating sialylated oligosaccharides from a fermentation broth in which they are produced by a genetically modified microorganism The separation comprises the steps of: i) ultrafiltration; ii) nanofiltration; iii) optionally, activated charcoal treatment; and iv) treatment with strong anion and/or cation exchange resin.

    Abstract translation: 本发明涉及从发酵液中分离唾液酸化寡糖的方法，其中它们由基因修饰的微生物产生。分离包括以下步骤：i）超滤; ii）纳滤; iii）任选的活性炭处理; 和iv）用强阴离子和/或阳离子交换树脂处理。

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