-
公开(公告)号：WO2022013143A1
公开(公告)日：2022-01-20
申请号：PCT/EP2021/069310
申请日：2021-07-12
Applicant: GLYCOM A/S
Inventor： PEDERSEN, Margit , PAPADAKIS, Manos , BECKER, Peter , SAMAIN, Eric , PELTIER-PAIN, Pauline , KAMPMANN, Katrine Bych , JOHANSON, Ted , CHAMPION, Elise , DEKANY, Gyula
IPC: C12P19/00 , C12P19/04 , C12P19/12 , C12P19/18 , C12P19/26 , C07K14/255 , C07K14/26 , C12N9/12 , C12N9/24 , C12N15/52
Abstract: The invention relates to a genetically modified microorganism for making an oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.
-
2.发明申请
公开(公告)号：WO2022157280A1
公开(公告)日：2022-07-28
申请号：PCT/EP2022/051295
申请日：2022-01-21
Applicant: GLYCOM A/S
Inventor： PEDERSEN, Margit , D'ARRIGO, Isotta , BYCH KAMPMANN, Katrine , PAPADAKIS, Manos
Abstract: The present invention relates to the field of recombinant production of biological molecules in genetically modified cells. More particularly, it relates to a method for recombinant production of sialylated human milk oligosaccharides (HMO) using a genetically modified cell expressing a protein of the major facilitator superfamily (MFS), the protein expressed being Fred.
-
公开(公告)号：WO2020115671A1
公开(公告)日：2020-06-11
申请号：PCT/IB2019/060423
申请日：2019-12-04
Applicant: GLYCOM A/S
Inventor： PAPADAKIS, Manos , PEDERSEN, Margit
Abstract: The present invention provides a method for biotechnological production of LNFP-V by using recombinant bacterial cells. LNFP-V is produced by using a polypeptide having an a1,3/4-fucosyl transferase activity and comprising or consisting of an amino acid sequence that has a sequence identity of at least 90 % with amino acid sequence of SEQ ID No. 1 or 3.
-
公开(公告)号：WO2021148618A1
公开(公告)日：2021-07-29
申请号：PCT/EP2021/051476
申请日：2021-01-22
Applicant: GLYCOM A/S
Inventor： PEDERSEN, Margit , D'ARRIGO, Isotta , KAMPMANN, Katrine, Bych , PAPADAKIS, Manos
Abstract: The present invention relates to the field of recombinant production of biological molecules in genetically modified cells. More particularly, it relates to a method for recombinant production of human milk oligosaccharides (HMO) using a genetically modified cell expressing a protein of the major facilitator superfamily (MFS), the protein expressed being Bad.
-
公开(公告)号：WO2021148615A1
公开(公告)日：2021-07-29
申请号：PCT/EP2021/051473
申请日：2021-01-22
Applicant: GLYCOM A/S
Inventor： PEDERSEN, Margit , PAPADAKIS, Manos , KAMPMANN, Katrine, Bych
Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic encoding a putative transporter protein of the MFS superfamily; and methods using said cell for the production of oligosaccharide(s), preferably an HMO.
-
Patent Agency Ranking
公开(公告)号：WO2021148610A1
公开(公告)日：2021-07-29
申请号：PCT/EP2021/051466
申请日：2021-01-22
Applicant: GLYCOM A/S
Inventor： PAPADAKIS, Manos
Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic acid encoding a protein of the MFS superfamily; and methods using said cell for the production the oligosaccharide, preferably an HMO.
-
公开(公告)号：WO2017101958A1
公开(公告)日：2017-06-22
申请号：PCT/DK2016/050447
申请日：2016-12-19
Applicant: GLYCOM A/S
Inventor： PAPADAKIS, Manos , PEDERSEN, Margit , BYCH, Katrine
CPC classification number: C12P19/18 , C12N9/1048 , C12N9/1051 , C12N9/1081
Abstract: The invention relates to a microbial production of recombinant oligosaccharides, particularly of human milk oligosaccharides (HMOs), using a genetically modified microorganism, particularly E. coli , in antibiotic-free cultivating medium.
Abstract translation: 本发明涉及使用遗传修饰的微生物，特别是大肠杆菌的微生物生产重组寡糖，特别是人乳寡糖（HMOs）的微生物， i>，无抗生素培养基。
-
公开(公告)号：WO2021148620A1
公开(公告)日：2021-07-29
申请号：PCT/EP2021/051479
申请日：2021-01-22
Applicant: GLYCOM A/S
Inventor： PEDERSEN, Margit , D'ARRIGO, Isotta , KAMPMANN, Katrine, Bych , PAPADAKIS, Manos
Abstract: The present invention relates to the field of recombinant production of biological molecules in genetically modified cells. More particularly, it relates to a method for recombinant production of human milk oligosaccharides (HMO) using a genetically modified cell expressing a protein of the major facilitator superfamily (MFS), the protein expressed being Fred.
-
公开(公告)号：WO2021148611A1
公开(公告)日：2021-07-29
申请号：PCT/EP2021/051468
申请日：2021-01-22
Applicant: GLYCOM A/S
Inventor： PAPADAKIS, Manos , KAMPMANN, Katrine, Bych
Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic acid encoding a protein of the MFS superfamily; and methods using said cell for the production the oligosaccharide, preferably an HMO.
-
公开(公告)号：WO2019123324A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/060355
申请日：2018-12-19
Applicant: GLYCOM A/S
Inventor： PEDERSEN, Margit , PAPADAKIS, Manos
IPC: C12N15/113 , C12N15/70 , C07H3/06
Abstract: The present invention relates to the field of recombinant production of biological molecules in host cells. The invention provides nucleic acid constructs that allow to modify expression of a desired gene using both in vitro and in vivo gene expression systems. The constructs can advantageously be used to produce a variety of biological molecules recombinantly in industrial scales, e.g. human milk oligosaccharides (HMO).
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.017 seconds)
