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    PER(3,6-ANHYDRO)CYCLODEXTRIN DERIVATIVES, PREPARATION AND USE THEREOF FOR SEPARATING IONS
    72.
    发明申请
    PER(3,6-ANHYDRO)CYCLODEXTRIN DERIVATIVES, PREPARATION AND USE THEREOF FOR SEPARATING IONS 审中-公开
    PER（3,6-ANHYDRO）环糊精衍生物，其制备和用于分离离子

    公开(公告)号：WO01072849A1

    公开(公告)日：2001-10-04

    申请号：PCT/FR2001/000923

    申请日：2001-03-27

    IPC: A61K31/724 ,  A61P39/04 ,  B01J20/26 ,  B01J45/00 ,  C02F1/68 ,  C08B37/00 ,  C08B37/16 ,  A61K31/715 ,  B01J20/24 ,  C02F1/28

    CPC classification number: C02F1/683 ,  A61K31/724 ,  B01J20/26 ,  B01J45/00 ,  C02F2101/20 ,  C02F2101/22 ,  C08B37/0012 ,  C08B37/0015

    Abstract: The invention concerns per(3,6-anhydro)cyclodextrin derivatives, their preparation and their use for separating polluting ions, for example, for human decontamination. Said derivatives correspond to one of the formulae (I) and (II) wherein one R at least represents the -OCH2COOH group and the other R 's, identical or different, correspond to one of the formulae: OH, OR , SH, SR , OCOR , NH2, NHR , NR R , CONH2, CONHR , CONR R , CN, COOR , COOH and R , wherein: R and R , identical or different, represent a saturated or unsaturated hydrocarbon, aliphatic or aromatic group, capable of comprising one several heteroatoms selected among O, S and N; and n is equal to 6, 7 or 8.

    Abstract translation: 本发明涉及每（3,6-脱水）环糊精衍生物，其制备及其用于分离污染离子的用途，例如用于人体去污。 所述衍生物对应于式（I）和（II）之一，其中一个R 1至少表示-OCH 2 COOH基团，另一个R 1相同或不同对应于下式之一：OH ，OR 2，SH，SR 2，OCOR 2，NH 2，NHR 2，NR 2 R 3，CONH 2，CONHR 2，CONR 2 R 3， CN，COOR 2，COOH和R 2，其中：R 2和R 3相同或不同，表示饱和或不饱和的烃，脂族或芳族基团，其能够包含选自以下的若干杂原子 O，S和N; 并且n等于6,7或8。

    USE OF CHEMICAL CHELATORS AS REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK
    73.
    发明申请
    USE OF CHEMICAL CHELATORS AS REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK 审中-公开
    化学品使用者作为药物诱导型神经阻滞剂的反向药物

    公开(公告)号：WO01012202A2

    公开(公告)日：2001-02-22

    申请号：PCT/EP2000/007694

    申请日：2000-08-07

    IPC: A61K45/00 ,  A61K31/14 ,  A61K31/194 ,  A61K31/335 ,  A61K31/395 ,  A61K31/4741 ,  A61K31/58 ,  A61K31/715 ,  A61K31/724 ,  A61K45/06 ,  A61P21/02 ,  A61P25/00 ,  A61P25/30 ,  A61P39/04

    CPC classification number: A61K31/194 ,  A61K31/724

    Abstract: The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) wherein R is (a), (b) or (c); or general formula (B) wherein X is (a), (b) or (d), or a pharmaceutically acceptable salt thereof.

    Abstract translation: 本发明涉及化学螯合剂用于制备用于逆转药物诱导的神经肌肉阻滞的药物，用于提供神经肌肉阻滞及其逆转的试剂盒，以及具有通式（A）的环戊烷衍生物，其中R为（ a），（b）或（c）; 或通式（B），其中X为（a），（b）或（d），或其药学上可接受的盐。

    TREATMENT OF GAIT DYSFUNCTION IN NEURODEGENERATIVE DISEASE
    75.
    发明申请
    TREATMENT OF GAIT DYSFUNCTION IN NEURODEGENERATIVE DISEASE 审中-公开

    公开(公告)号：WO2022099095A1

    公开(公告)日：2022-05-12

    申请号：PCT/US2021/058361

    申请日：2021-11-05

    Applicant: EIP PHARMA, INC.

    Inventor： ALAM, John, Jahangir

    IPC: A61P25/28 ,  A61K31/724 ,  A61K45/06

    Abstract: The present invention provides methods and compositions for treatment of gait dysfunction in subjects with neurodegenerative disease of the cholinergic forebrain. In some embodiments, methods are provided for treatment of gait dysfunction related to an alpha synuclein disease, such as Parkinson's disease (PD) or Dementia with Lewy Bodies (DLB).

    ORAL TERPENE CYCLODEXTRIN INCLUSION COMPLEX VEHICLES
    77.
    发明申请
    ORAL TERPENE CYCLODEXTRIN INCLUSION COMPLEX VEHICLES 审中-公开

    公开(公告)号：WO2021191803A1

    公开(公告)日：2021-09-30

    申请号：PCT/IB2021/052411

    申请日：2021-03-23

    Applicant: CZAP RESEARCH AND DEVELOPMENT, LLC

    Inventor： CZAP, Al

    IPC: A61K31/015 ,  A61K31/724 ,  A61K38/47 ,  A61K47/40 ,  A61P11/10 ,  A61P11/12

    Abstract: The invention provides oral terpene cyclodextrin inclusion complex delivery vehicles, including formulations in which the cyclodextrin inclusion complex is provided together with enzyme having a cyclodextrin-degrading activity capable of digesting the cyclodextrin, so that upon delivery of the vehicle to a target the enzyme is activated and releases the guest molecule from the cyclodextrin cavity. In alternative aspects, these cyclodextrin inclusion complex delivery vehicles are for example provided in the form of time release formulations, for example for treatment of airway mucus dysfunction. Formulations are also provided with erectogenic efficacy.

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