公开(公告)号：WO2019199518A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/025281

申请日：2019-04-02

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： BRAZDIL, James ,  ROGNESS, Donald ,  MA, Chi Cheng

IPC: C07C221/00 ,  C07C225/06 ,  C07C45/66 ,  C07C49/24 ,  C07C49/12 ,  B01J23/30 ,  B01J23/46

Abstract: Processes are disclosed for synthesizing an α-amino acid or α-amino acid derivative, from a starting compound having a carbonyl functional group (C=O), with hydroxy-substituted carbon atoms at alpha (α) and beta (β) positions, relative to the carbonyl functional group. An α-, β-dihydroxy carboxylic acid or carboxylate is dehydrated to form a dicarbonyl intermediate by transformation of the α-hydroxy group to a second carbonyl group (adjacent a carbonyl group of the starting compound) and removal of the β-hydroxy group. This dicarbonyl intermediate is optionally cracked to form a second dicarbonyl intermediate having fewer carbon atoms but preserving the first and second carbonyl groups. Either or both of the dicarbonyl intermediate and the cracked dicarbonyl intermediate are then reductively aminated.

公开(公告)号：WO2019156854A1

公开(公告)日：2019-08-15

申请号：PCT/US2019/015626

申请日：2019-01-29

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： MA, Chi Cheng

IPC: C07C29/14 ,  C07C31/20 ,  B01J23/46 ,  B01J23/28 ,  B01J23/30

Abstract: A hydrogenolysis process is disclosed for directly converting a sugar feed comprised of a high fructose feedstock, a high sucrose feedstock, or a combination of these to a mixed lower polyols product including both propylene glycol and ethylene glycol. The process provides greater propylene glycol selectivity than ethylene glycol selectivity such that the propylene glycol is present to a greater extent than the ethylene glycol in the mixed lower polyols product. The sugar feed and a source of hydrogen are supplied to a reaction vessel and reacted in the presence of a hydrogenolysis catalyst comprising molybdenum (Mo) and ruthenium (Ru).

公开(公告)号：WO2019118548A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/065095

申请日：2018-12-12

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： MANCHESTER, Shawn ,  ENYEART, Peter

IPC: C07K14/195 ,  C12N1/20 ,  C12N15/01 ,  C12P13/04 ,  C12P13/08 ,  C12R1/15

Abstract: This disclosure provides engineered strains of Corynebacteria for the cost-effective production of lysine, tools and methods used to produce the engineered strains, and methods of using the engineered strains to produce lysine.

公开(公告)号：WO2018187031A1

公开(公告)日：2018-10-11

申请号：PCT/US2018/023354

申请日：2018-03-20

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： HAGBERG, Erik ,  INGRAM, Andrew, J. ,  ROCKAFELLOW, Erin, J. ,  SULLIVAN, Jaime ,  STENSRUD, Kenneth, F.

IPC: B01J23/14 ,  B01J31/04 ,  C07C67/08

Abstract: Tin (II) glucarate is found to be effective alone and in combination with other tin compounds for catalyzing the reaction of carboxylic acids such as furan-2,5- dicarboxylic acid, terephthalic acid and adipic acid with alcohols such as the C1-C3 alcohols.

公开(公告)号：WO2018132440A1

公开(公告)日：2018-07-19

申请号：PCT/US2018/013112

申请日：2018-01-10

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： MA, Chi Cheng

IPC: C08G63/183 ,  C07C31/18 ,  C10G1/06

Abstract: An improved process for making bioderived propylene glycol by reacting a feed composition including glycerol with hydrogen in the presence of a catalyst, wherein the improvement involves causing the reaction to take place in the presence of one or more additives selected 10 from the group consisting of the soluble acetate, citrate, lactate, gluconate, propionate and glycerate salts.

公开(公告)号：WO2017100402A1

公开(公告)日：2017-06-15

申请号：PCT/US2016/065523

申请日：2016-12-08

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： STENSRUD, Kenneth

IPC: C07D307/20 ,  A61K31/25

CPC classification number: C07D307/20 ,  C07D309/10 ,  Y02P20/582

Abstract: A procedure for preparing anhydropentitol mono, di, and tri esters is described. The process is performed in a single vessel and involves sequential dehydrative cyclization and carboxylic acid acylation steps. Each step is catalyzed by low loadings of a water-tolerant Lewis acid catalyst. The method of synthesis is efficacious and depending on the reaction condition, generates modest to high yields of the target mono-, di-, and triesters. The esters can be practical surrogates of incumbent petroleum materials of similar structure used for surfactants and plasticizers.

Abstract translation: 描述了制备脱水戊糖醇单酯，二酯和三酯的方法。 该过程在单个容器中进行并且涉及顺序的脱水环化和羧酸酰化步骤。 低载量的耐水路易斯酸催化剂催化每一步。 合成方法是有效的并且取决于反应条件，产生目标单酯，二酯和三酯的中等至高产率。 这些酯可以作为用于表面活性剂和增塑剂的类似结构的现有石油材料的实际代用品。

公开(公告)号：WO2017044750A1

公开(公告)日：2017-03-16

申请号：PCT/US2016/050952

申请日：2016-09-09

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： MA, Chicheng ,  SMITH, Brennan

IPC: C07D493/04 ,  B01J23/46 ,  C07C29/00 ,  C07C31/00 ,  C07C31/26 ,  C07D493/00

CPC classification number: C07D493/04 ,  C07C29/132 ,  C07C31/26

Abstract: A process is provided for making isoidide, wherein a dextrose feed is first converted by a combination of epimerization and hydrogenation to an iditol-enriched mixture of hexitols in the presence of hydrogen and in the further presence of a single, dual purpose catalyst, and the iditol is then conventionally fully dehydrated to provide isoidide. In one general embodiment, the dehydration is performed on the iditol-enriched mixture of hexitols to provide an isohexides product mixture including isoidide, and the isoidide is recovered therefrom. In another general embodiment, iditol is separated from the iditol-enriched mixture of hexitols, and at least a portion of this iditol is then dehydrated to provide an isoidide product.

Abstract translation: 提供了一种制备胰岛素的方法，其中葡萄糖进料首先通过差向异构化和氢化的组合转化成富含碘醇的富含己糖醇的混合物，在氢气存在下，以及在单一的双重目的催化剂的存在下， 然后常规地将全身脱水以提供isoidide。 在一个一般的实施方案中，在富含甘油的富含己糖醇的混合物上进行脱水以提供包含异蝶甙的异六烯体产物混合物，并从其中回收昆虫素。 在另一个一般实施方案中，从所述富含甘油的富含己糖醇的混合物中分离出碘醇，然后将该糖醇的至少一部分脱水以提供类植物产品。

公开(公告)号：WO2017030685A1

公开(公告)日：2017-02-23

申请号：PCT/US2016/041988

申请日：2016-07-13

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： STENSRUD, Kenneth

IPC: C07D307/20 ,  B01J31/12

CPC classification number: B01J31/12 ,  C07D307/20 ,  C07D309/10

Abstract: A process for preparing anhydropentitol mono- and diethers from C 5 sugar alcohols is described. The process involves performing in a single reaction vessel consolidated reactions that a) cyclize dehydratively a linear C 5 sugar alcohol and b) etherify a resulting anhydropentitol. Each of the reactions is catalyzed by a very low amount of a water-tolerant Lewis acid catalyst relative to the starting sugar-alcohol. Depending on the reaction conditions, the synthesis method is efficient, selective and affords good yields of mono- and diethers. The anhydropentiol ethers can serve as renewable substitute precursors of petroleum incumbents for use in the making of surfactants and plasticizers.

Abstract translation: 描述了从C5糖醇制备氢化异构醇单醚和二醚的方法。 该方法包括在单个反应容器中进行固化反应，a）使线性C5糖醇脱水环化，和b）醚化所得的脱水异戊醇。 相对于起始糖醇，每个反应都由非常少量的耐水路易斯酸催化剂催化。 根据反应条件，合成方法是有效的，选择性的，并提供单酯和二醚的良好产率。 脱氢醚醚可以作为用于制备表面活性剂和增塑剂的石油在职者的可再生替代前体。

公开(公告)号：WO2016201209A1

公开(公告)日：2016-12-15

申请号：PCT/US2016/036865

申请日：2016-06-10

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： BASEETH, Shireen

IPC: A23G4/00 ,  A23J7/00 ,  A23L1/09 ,  C11B1/10 ,  C11B13/00

CPC classification number: B01F17/0092 ,  A23D9/007 ,  A23D9/013 ,  A23D9/04 ,  A23G4/066 ,  A23G4/08 ,  A23G4/10 ,  A23V2002/00 ,  C11B3/16 ,  C11B13/00 ,  Y02W30/74

Abstract: The present invention is directed towards compositions comprising a lecithin; a sugar alcohol, a sugar, or combinations of any thereof; and an alcohol. Compositions comprising a water soluble surfactant are further disclosed. Methods of separating oil from a mixture are disclosed. Methods of dispersing an oil are further disclosed. Compositions comprising a water-dilutable microemulsion are disclosed. Methods of making chewing gum are disclosed. Methods of recovering oil from a mixture are further disclosed.

Abstract translation: 本发明涉及包含卵磷脂的组合物; 糖醇，糖或其任何组合; 和酒精。 进一步公开了包含水溶性表面活性剂的组合物。 公开了从混合物中分离油的方法。 进一步公开分散油的方法。 公开了包含水可稀释微乳液的组合物。 公开了制作口香糖的方法。 进一步公开了从混合物中回收油的方法。

公开(公告)号：WO2016099788A1

公开(公告)日：2016-06-23

申请号：PCT/US2015/061547

申请日：2015-11-19

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： STENSRUD, Kenneth

IPC: C08K5/15

CPC classification number: C07D493/04

Abstract: Isohexide mono and bis trifluoroacetates and a method of preparing the same are described. The method involves contacting a mixture of an isohexide, a trifluoroacetic anhydride, and a reagent of either 1) a nucleophile base or 2) a combination of a non-nucleophilic base and a nucleophile. The isohexide mono and bis trifluoroacetate compounds can serve as precursor materials from which various derivative compounds can be synthesized.

Abstract translation: 描述了异己二醇单和双三氟乙酸盐及其制备方法。 该方法包括使异己烯酯，三氟乙酸酐和1）亲核基质的试剂或2）非亲核碱和亲核试剂的组合物的混合物接触。 异己二醇单和二氟三氟乙酸盐化合物可以作为各种衍生化合物可以合成的前体材料。