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224 条记录 (耗时 0.035 秒)

    CONTROLLING STOMATAL DENSITY IN PLANTS
    83.
    发明申请
    CONTROLLING STOMATAL DENSITY IN PLANTS 审中-公开

    公开(公告)号：WO2018197878A1

    公开(公告)日：2018-11-01

    申请号：PCT/GB2018/051096

    申请日：2018-04-26

    申请人： THE UNIVERSITY OF SHEFFIELD

    发明人： GRAY, Julie Elizabeth ,  HUNT, Lee ,  QUICK, William Paul

    IPC分类号： C07K14/415 ,  C12N15/82

    摘要： The present invention relates to the modification of gene expression in plants in order to manipulate stomatal number, in particular to the modification of expression in plants of epidermal patterning factor (EPF). The invention also relates to genetically modified plants or plant parts with altered stomatal patterning compared to corresponding wild type plants or plant parts, where the plant stomatal development is altered by modification of the expression of EPF.

    PROBE
    84.
    发明申请
    PROBE 审中-公开

    公开(公告)号：WO2018196975A1

    公开(公告)日：2018-11-01

    申请号：PCT/EP2017/060043

    申请日：2017-04-27

    申请人： THE UNIVERSITY OF SHEFFIELD

    发明人： EL-KHAMISY, Sherif ,  SHAWKY, Sherif

    IPC分类号： C12Q1/68 ,  C12Q1/70

    CPC分类号： C12Q1/707 ,  C12Q1/6816 ,  C12Q1/6886 ,  C12Q2563/116 ,  C12Q2563/137 ,  C12Q2563/155 ,  C12Q2563/173

    摘要： A capture ligand for an analyte comprising SEQ ID NO:1, or comprising an antisense primer of at least 25 bases complementary to SEQ ID NO:2, wherein the primer initiates hybridisation from any of nucleotides 5 to 20, 43 to 118, 156 to 238, 253 to 279 or 291 to 314 of SEQ ID NO:2. A probe for an analyte comprising this capture ligand and a probe comprising a metal nanoparticle and one or more capture ligand specifically for the indicator of disease conjugated thereto. Also assay kits and methods of detecting the presence of an analyte.

    APPARATUS AND METHODS FOR DETERMINING FORCE APPLIED TO THE TIP OF A PROBE
    88.
    发明申请
    APPARATUS AND METHODS FOR DETERMINING FORCE APPLIED TO THE TIP OF A PROBE 审中-公开
    用于确定应用于探针尖端的力的装置和方法

    公开(公告)号：WO2017109481A1

    公开(公告)日：2017-06-29

    申请号：PCT/GB2016/054008

    申请日：2016-12-21

    申请人： THE UNIVERSITY OF SHEFFIELD

    发明人： ANUMBA, Dilichukwu ,  HEALEY, Timothy James

    IPC分类号： A61B5/00 ,  A61B5/053

    CPC分类号： A61B5/6843 ,  A61B5/0538 ,  A61B5/435 ,  A61B2562/0219 ,  A61B2562/0252

    摘要： An apparatus capable of determining the force applied to the tip of an electrical impedance spectroscopy probe comprises: • an elongate probe comprising a probe tip attached to a handle, the probe tip having a substantially planar distal end for contacting human or animal tissue; • a load cell located in said handle and capable of measuring a force F load cell applied axially along a longitudinal axis when said probe tip is in contact with said human or animal tissue; • an accelerometer located in the handle for measuring a gravity vector A axial ; • processing means for compensating for the mass of the probe tip using said measured force and gravity vector to produce a calibrated measurement of force F applied to said probe tip.

    摘要翻译： 能够确定施加到电阻抗谱分析探针的尖端的力的设备包括：·包括附接到手柄的探针尖端的细长探针，所述探针尖端具有基本平坦的远端，用于 接触人体或动物组织; ·位于所述手柄中的测力传感器，当所述探针尖端与所述人体或动物组织接触时，所述测力传感器能够测量沿着纵向轴线轴向施加的力的载荷子单元 ; •位于手柄中的加速度计，用于测量重力矢量A axial ; ●处理装置，用于使用所述测量的力和重力矢量来补偿探针尖端的质量，以产生施加到所述探针尖端的力F的校准测量。

    METHOD AND APPARATUS FOR MODELLING NON-RIGID NETWORKS
    89.
    发明申请
    METHOD AND APPARATUS FOR MODELLING NON-RIGID NETWORKS 审中-公开
    用于建模非刚性网络的方法和装置

    公开(公告)号：WO2016030692A1

    公开(公告)日：2016-03-03

    申请号：PCT/GB2015/052495

    申请日：2015-08-28

    申请人： THE UNIVERSITY OF SHEFFIELD

    发明人： ÇIMEN, Serkan ,  FRANGI, Alejandro Federico

    IPC分类号： G06T7/00 ,  G06T17/00

    CPC分类号： G06T17/00 ,  G06T7/35 ,  G06T2207/10016 ,  G06T2207/10081 ,  G06T2207/10116 ,  G06T2207/20076 ,  G06T2207/30048 ,  G06T2207/30101

    摘要： Embodiments of the present invention provide a computer-implemented method of determining three-dimensionallocations of a non-rigid network, comprising receiving from a detector data indicative of a plurality two-dimensional (2D) projections through the network, identifying a plurality of network landmarks in the 2D projections, determining a correspondence between the network landmarks and landmark points of a three-dimensional (3D) model comprising a plurality of landmark points defining a surface associated with the network, and adapting, based on the correspondence, one or more parameters of the model.

    摘要翻译： 本发明的实施例提供了一种用于确定非刚性网络的三维位置的计算机实现的方法，包括从检测器接收指示通过网络的多个二维（2D）投影的数据，识别多个网络地标 在2D投影中，确定包括定义与网络相关联的表面的多个界标点的三维（3D）模型的网络界标和地标点之间的对应关系，并且基于该对应关系来调整一个或多个参数 的模型。

    THERAPEUTIC USES OF BISPHOSPHONATES
    90.
    发明申请
    THERAPEUTIC USES OF BISPHOSPHONATES 审中-公开
    双膦酸的治疗用途

    公开(公告)号：WO2014162124A1

    公开(公告)日：2014-10-09

    申请号：PCT/GB2014/051020

    申请日：2014-04-01

    申请人： THE UNIVERSITY OF SHEFFIELD

    发明人： RUSSELL, Robert, Graham, Goodwin ,  BELLANTUONO, Ilaria

    IPC分类号： A61K31/663

    CPC分类号： A61K31/663 ,  A61K31/675 ,  A61K45/06

    摘要： The invention relates to a method for extending the lifespan of stem cells, comprising administering an effective amount of a bisphosphonate (BP) compound, or a pharmaceutically acceptable salt or solvate or pro-drug thereof to the cells.

    摘要翻译： 本发明涉及一种延长干细胞寿命的方法，包括向细胞施用有效量的双膦酸（BP）化合物或其药学上可接受的盐或溶剂合物或前药。