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公开(公告)号：WO2020201754A1
公开(公告)日：2020-10-08
申请号：PCT/GB2020/050875
申请日：2020-04-02
IPC分类号： C07F15/00 , A61K31/555 , A61P31/04
摘要： A compound according to formula (I) or formula (la), and a composition comprising the compound for use as an antimicrobial: wherein, X 1 , X 2 , X 3 and X 4 are each independently selected from: N, O, S; Y 1 and Y 2 are each independently selected from: N, O, S, C(R a ); M 1 and M 2 are each a metal centre; R 1 , R 2 , R 3 , R 4 and Ra are each independently selected from: hydrogen, alkyl, alkenyl, aryl, halogen, haloalkyl, haloalkenyl, haloaryl, hydroxy, alkoxy, carboxylic acid, amino, amido, nitro or combination thereof; A 1 , A 2 , A 3 and A 4 are each bidentate ligands; and rings D 1 and D 2 are each independently comprise one or more heteroatoms selected from N, O, S, C(R a ); wherein said compound is for use as an antimicrobial.
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公开(公告)号：WO2020081975A1
公开(公告)日：2020-04-23
申请号：PCT/US2019/056998
申请日：2019-10-18
IPC分类号： A61K31/4375 , A61P25/28 , C07D221/18
摘要： The invention is directed to (6aS)-6-methyl-5,6,6a,7-tetrahydro-4H- dibenzo[de,g]quinoline-10,11-diol for the treatment of diseases mediated by protein misfolding of Cu/Zn Superoxide Dismutase (SOD1) or mediated by astrocyte toxicity affecting motor neuron survival.
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公开(公告)号：WO2020044047A1
公开(公告)日：2020-03-05
申请号：PCT/GB2019/052413
申请日：2019-08-30
发明人： STAVISH, Dylan
IPC分类号： C12N5/00 , C12N5/0735
摘要： The invention relates to a culture medium that is suitable for use in the propagation of mammalian pluripotent stem cells in a mesoderm-biased phenotype, and to methods for propagating mammalian pluripotent stem cells in a mesoderm-biased phenotype. The invention further relates to a population of mammalian pluripotent stem cells wherein said population of cells displays a mesoderm-biased phenotype.
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公开(公告)号：WO2018203094A1
公开(公告)日：2018-11-08
申请号：PCT/GB2018/051232
申请日：2018-05-08
发明人： COPE, Alex
IPC分类号： G06N3/067
摘要： Examples relate to detectors for determining motion from visual cues, said determining being invariant to changes in at least one of temporal and spatial frequencies of said visual cues.
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公开(公告)号：WO2018055394A1
公开(公告)日：2018-03-29
申请号：PCT/GB2017/052840
申请日：2017-09-22
摘要： A tuneable quantum cascade or interband cascade laser (100) has a gain (medium110), a cavity mirror (20), an interference filter (130) and a positioning (mechanism140). The gain medium (110) has an emission spectrum and the gain medium (110) is configured to emit a laser (beam111). The interference filter (130) is located between the gain medium (110) and the cavity (mirror120). The interference filter (130) is configured to transmit a portion of the emission spectrum in order to suppress laser emission by the gain medium at wavelengths other than the transmitted portion. The portion of the emission spectrum transmitted by the interference filter (130) varies across the interference (filter130). The positioning mechanism (140) is configured to move the interference filter (30) relative to the laser beam (111) in order to select the portion of the emission spectrum transmitted by the interference (filter130), thereby determining the emission spectrum of the tuneable (laser100).
摘要翻译： 可调谐量子级联或带间级联激光器（100）具有增益（介质110），腔镜（20），干涉滤光器（130）和定位（机构140）。 增益介质（110）具有发射光谱，并且增益介质（110）被配置为发射激光（光束111）。 干涉滤波器（130）位于增益介质（110）和空腔（反射镜120）之间。 干涉滤光片（130）被配置为透射发射光谱的一部分，以抑制增益介质在除透射部分以外的波长处的激光发射。 由干涉滤波器（130）发射的部分发射频谱在干扰（滤波器130）两端变化。 定位机构（140）被配置为相对于激光束（111）移动干涉滤光片（30）以选择由干涉发射的发射光谱的一部分（滤光片130），由此确定可调谐的发射光谱 （laser100）。
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公开(公告)号：WO2017153787A1
公开(公告)日：2017-09-14
申请号：PCT/GB2017/050682
申请日：2017-03-13
IPC分类号： H01L29/778 , H01L29/20
摘要： A normally-off transistor comprising a first layer (102) of semiconductor material, a second layer (104) of semiconductor material comprising first (106) and second (108) regions and a third region (110) between the first and second region, a source electrode (130) connected to the first region (104) and a drain electrode (132) connected to the second region (108), and a gate electrode (134) located over the third region (110), wherein the first (104) and second (108) regions are of a material arranged to form a polarization having a first polarity at the interface (114, 116) between the first and second regions and the first semiconductor layer (102), and the third region (110) is of a material arranged to form a polarization having a second polarity opposite to the first polarity at the interface (118) between the third region and the first semiconductor layer of opposite polarity.
摘要翻译： 包括半导体材料的第一层（102），包括第一（106）和第二（108）区域的半导体材料的第二层（104）以及第三区域（110）的常关晶体管 ），连接到第一区域（104）的源电极（130）和连接到第二区域（108）的漏电极（132）;以及位于第三区域之上的栅电极（134） （110），其中所述第一区域（104）和所述第二区域（108）是被布置成在所述第一区域和第二区域与所述第一半导体层（102）之间的界面（114,116）处形成具有第一极性的偏振的材料 ），并且第三区域（110）是用于在第三区域和极性相反的第一半导体层之间的界面（118）处形成具有与第一极性相反的第二极性的极化的材料。
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公开(公告)号：WO2016156831A1
公开(公告)日：2016-10-06
申请号：PCT/GB2016/050882
申请日：2016-03-30
IPC分类号： C12N5/0793 , C12N5/0797
CPC分类号： C12N5/062 , C12N5/0623
摘要： This invention relates to an improved method for generating otic progenitor cells. The invention also relates to uses of such otic progenitor cells, for example as a medicament (e.g. in the treatment of hearing loss, deafness or other auditory disorder associated with loss of inner ear function) and/or in drug screening methods.
摘要翻译： 本发明涉及一种用于产生耳状祖细胞的改进方法。 本发明还涉及这种耳状祖细胞的用途，例如作为药物（例如在治疗听力损失，耳聋或与内耳功能丧失相关的其他听觉障碍）和/或药物筛选方法中的用途。
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公开(公告)号：WO2016128775A1
公开(公告)日：2016-08-18
申请号：PCT/GB2016/050356
申请日：2016-02-12
发明人： DAW, Edward John , EDO, Tega Boro
IPC分类号： G01R23/167 , G06F17/10
CPC分类号： G01R23/167 , G01R31/343 , G06F17/141
摘要： A method for recursively estimating at least one parameter of a first oscillating component represented by one or more sampled noisy input signal waveforms, the method comprising, recursively generating from the one or more sampled noisy input signals an estimate of a Z-transform component corresponding to the first oscillating component, forming, from the estimated Z-transform component, one or more signals providing an indication of one or more of a frequency and an amplitude of the Z-transform component; and estimating, from the one or more signals, one or more of a frequency, a relative phase and an amplitude parameter of the first oscillating component.
摘要翻译： 一种用于递归地估计由一个或多个采样噪声输入信号波形表示的第一振荡分量的至少一个参数的方法，所述方法包括：从所述一个或多个采样噪声输入信号递归地产生对应于 所述第一振荡分量从所述估计的Z变换分量形成提供所述Z变换分量的频率和幅度中的一个或多个的指示的一个或多个信号; 以及从所述一个或多个信号估计所述第一振荡分量的频率，相对相位和振幅参数中的一个或多个。
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9.发明申请METHOD OF TREATING OR PREVENTION OF ATHEROTHROMBOTIC EVENTS IN PATIENTS WITH HISTORY OF MYOCARDIAL INFARCTION 审中-公开治疗或预防患有心肌梗塞病史的患者的自身免疫性事件的方法
公开(公告)号：WO2016120729A1
公开(公告)日：2016-08-04
申请号：PCT/IB2016/000275
申请日：2016-01-27
申请人： ASTRAZENECA AB , STOREY, Robert , THE UNIVERSITY OF SHEFFIELD , SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST
发明人： STOREY, Robert
IPC分类号： A61K31/519 , A61K31/60 , A61K31/609 , A61P9/00 , A61P9/10
CPC分类号： A61K31/519 , A61K9/20 , A61K31/60 , A61K31/609 , A61K31/616 , A61K2300/00
摘要： The present disclosure relates to methods for reducing the rate of cardiovascular death, myocardial infarction, or stroke in a patient in recognized need thereof, comprising administering to the patient a pharmaceutical composition comprising 60 mg ticagrelor twice daily.
摘要翻译： 本公开涉及在公认的需要中降低患者心血管死亡，心肌梗死或中风的发生率的方法，包括向患者施用包含60mg替卡格雷每天两次的药物组合物。
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公开(公告)号：WO2016034730A1
公开(公告)日：2016-03-10
申请号：PCT/EP2015/070303
申请日：2015-09-04
CPC分类号： A61K9/0092 , A61K9/5052 , C07K14/43518 , C07K14/43586 , D01D5/34 , D01F4/00 , D01F4/02 , D01F8/02
摘要： The present invention provides a capsule having a shell of material that comprises an assembly of a silk protein, such as an assembly that is a non-aggregated assembly of the silk protein, such as an assembly where the a-helix, β-sheet (native) and random coil content is at least 55%. Also provided are methods for preparing the capsule, which comprises the step of contacting a flow of a first phase and a flow of a second phase in a channel, thereby to generate in the channel a dispersion of discrete regions, preferably droplets, of the second phase in the first phase, wherein the second phase comprises a silk protein suitable for forming an assembly of a protein, thereby to form a capsule shell at the boundary of the discrete region, wherein the first and second phases are immiscible.
摘要翻译： 本发明提供了一种具有材料壳的胶囊，其包含丝蛋白的组合，例如作为丝蛋白的非聚集组件的组件，例如其中α-螺旋，β-折叠（ 天然）和无规卷曲含量至少为55％。 还提供了制备胶囊的方法，其包括使通道中的第一相流和第二相的流接触的步骤，从而在通道中产生第二相的离散区域，优选液滴的分散体 其中第二相包含适于形成蛋白质组合的丝蛋白，从而在离散区域的边界处形成胶囊壳，其中第一相和第二相是不混溶的。
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