公开(公告)号：WO00015760A1

公开(公告)日：2000-03-23

申请号：PCT/US1999/021643

申请日：1999-09-17

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/09 ,  A61P31/04 ,  C07K1/14 ,  C07K1/18 ,  C07K1/22 ,  C07K14/315 ,  C07K16/12 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12P21/04 ,  C12R1/46 ,  C12N1/06 ,  A01N43/04 ,  A61K38/00 ,  A61K39/02 ,  A61K39/116 ,  A61K39/385 ,  A61K45/00 ,  C07H21/02 ,  C07H21/04 ,  C07K1/00 ,  C12N1/12 ,  C12N15/00

CPC classification number: C07K14/315 ,  A61K39/00 ,  C07K16/1275

Abstract: The invention relates to protein fragments or peptides that elicit antibodies to Gram positive bacteria which are bactericidal with complement alone without involving an opsonophagocytic mechanism, and to vaccines and conjugates comprising the same. The protein fragments or peptides comprise an immunogenic IgG binding domain, which comprises a peptide sequence of at least 8 amino acids between positions 828 and 1027 of the amino acid sequence shown in Fig. 1. The invention also relates to a polynucleotide molecule encoding the protein fragments or peptides, vectors comprising such polynucleotide molecules and host cells transformed therewith. The invention relates to a process for obtaining a substantially pure C beta protein or fragment and/or mutant thereof. The invention also relates to a method of inducing an immune response in an animal, comprising administering the vaccine of the invention to an animal in a therapeutically effective amount in a pharmaceutically acceptable carrier.

Abstract translation: 本发明涉及引起革兰氏阳性细菌的抗体的蛋白质片段或肽，所述革兰氏阳性细菌在不涉及调理吞噬机理的情况下是单独的补体而具有杀菌作用，以及包含其的疫苗和缀合物。 蛋白质片段或肽包含免疫原性IgG结合结构域，其包含图8所示氨基酸序列的828和1027位之间至少8个氨基酸的肽序列。 本发明还涉及编码蛋白质片段或多肽的多核苷酸分子，包含这种多核苷酸分子的载体和用其转化的宿主细胞。 本发明涉及获得基本上纯的Cβ蛋白或其片段和/或突变体的方法。 本发明还涉及在动物中诱导免疫应答的方法，其包括以治疗有效量将药用载体中的本发明的疫苗给予动物。

公开(公告)号：WO9924052A3

公开(公告)日：1999-07-22

申请号：PCT/GB9803387

申请日：1998-11-11

Applicant: ACTINOVA LTD ,  BJORCK LARS HENRIK ,  FRICK INGA MARIA ,  LEANDERSSON TOMAS BORJE ,  AXCRONA EUGEN JAN KAROL

Inventor： BJORCK LARS HENRIK ,  FRICK INGA-MARIA ,  LEANDERSSON TOMAS BORJE ,  AXCRONA EUGEN JAN KAROL

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/16 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  C07K14/47 ,  C12R1/46

CPC classification number: A61K38/164 ,  Y10S530/825

Abstract: The use of protein H, and fragments or derivatives thereof, as cytostatic agents, especially in the treatment of diseases involving undesired cell proliferation.

Abstract translation: 蛋白质H及其片段或衍生物作为细胞抑制剂的用途，特别是在治疗涉及不希望的细胞增殖的疾病中。

公开(公告)号：WO9858945A9

公开(公告)日：1999-04-15

申请号：PCT/US9812962

申请日：1998-06-23

Applicant: TIMONEY JOHN F ,  ARTIUSHIN SERGEY

Inventor： TIMONEY JOHN F ,  ARTIUSHIN SERGEY

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  A61P37/04 ,  C07K14/315 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12Q1/68 ,  C12R1/19 ,  C12R1/42 ,  C12R1/46 ,  C07H21/04 ,  C07K1/00 ,  C12N1/14 ,  C12N1/20 ,  C12N5/00 ,  C12N5/06 ,  C12N5/08

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: The present invention relates generally to molecular compounds which encode the protective M-like protein of Streptococcus equi (SeM), the amino acid compound which is thereby encoded, and compositions of matter which incorporate either the encoding compounds or the cellular components for which they encode. For instance, vaccines which utilize the amino acid compounds or vectors and cell lines useful to make the amino acid compounds described herein are subjects of the present invention. The present invention provides methods to stimulate S. equi-specific immune response in horses. It also provides diagnostic assays for Streptococcus equi.

Abstract translation: 本发明一般涉及编码马链球菌（SeM）的保护性M样蛋白（SeM）的分子化合物，由此编码的氨基酸化合物和包含编码化合物或其编码的细胞成分的物质组合物 。 例如，利用氨基酸化合物或用于制备本文所述的氨基酸化合物的载体和细胞系的疫苗是本发明的受试者。 本发明提供了刺激马匹马氏体特异性免疫应答的方法。 它还提供了马链球菌的诊断测定。

公开(公告)号：WO9848022A9

公开(公告)日：1999-04-15

申请号：PCT/US9808281

申请日：1998-04-24

Applicant: UNIV MINNESOTA ,  HOSTETTER MARGARET K ,  DUNNY GARY ,  NANDIWADA LAKSHMI S

Inventor： HOSTETTER MARGARET K ,  DUNNY GARY ,  NANDIWADA LAKSHMI S

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/00 ,  A61P37/04 ,  C07K14/315 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/52 ,  C12N15/57 ,  C12P21/08 ,  C12R1/46 ,  A61K38/48

CPC classification number: C12N9/52 ,  A61K39/00

Abstract: The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by S. pneumoniae. The proteinase has a molecular weight of about 24 kD to about 34 kD as determined on a 10 % SDS polyacrylamide gel. A preferred proteinase of this invention includes the amino acid sequence of SEQ ID NO:2.

Abstract translation: 本发明涉及鉴定和使用由肺炎链球菌表达的人补体C3降解蛋白酶家族。 在10％SDS聚丙烯酰胺凝胶上测定，蛋白酶的分子量约为24kD至约34kD。 本发明优选的蛋白酶包括SEQ ID NO：2的氨基酸序列。

公开(公告)号：WO9520658A3

公开(公告)日：1995-10-19

申请号：PCT/GB9500186

申请日：1995-01-30

Applicant: UNIV MANCHESTER ,  BURNIE JAMES P ,  MATTHEWS RUTH CHRISTINE

Inventor： BURNIE JAMES PETER ,  MATTHEWS RUTH CHRISTINE

IPC: G01N33/569 ,  A61K38/00 ,  A61K39/02 ,  A61K39/09 ,  A61K39/395 ,  A61P31/04 ,  C07H21/04 ,  C07K14/315 ,  C07K14/78 ,  C07K16/12 ,  C07K16/18 ,  C12N15/00 ,  C12N15/09 ,  C12N15/31 ,  C12P21/00 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/01 ,  C12R1/46

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/315 ,  C07K16/18 ,  C07K2319/00

Abstract: The present invention provides a purified bacterial protein expressed during infection due to streptococci or enterococci and isolated from human sera, together with immunogenic fragments, analogs, inhibitors, antibodies and antigenic fragments specific thereto. Also provided is a DNA sequence coding for a bacterial protein or an immunogenic fragment or an analogue thereof expressed during infection due to Streptococci or Enterococci, together with homologues thereof, together with vectors, probes and inhibitors therefor. Also provided is fibronectin or an immunogenic fragment thereof or an analogue thereof or an antibody thereto or an antigen binding fragment thereof when used in a method of treatment or diagnosis of the human or animal body for infection due to Streptococci or Enterococci. Also provided are antibodies specific to HSP 90 or immunogenic fragments or analogues thereof for use in a method of diagnosis or treatment of the human or animal body of infection due to streptococci or enterococci due to any one of the group of S.oralis, S.gordonii, S.sanguis.

公开(公告)号：WO2023065460A1

公开(公告)日：2023-04-27

申请号：PCT/CN2021/133350

申请日：2021-11-26

Applicant: 君乐宝乳业集团有限公司

Inventor： 魏立华 ,  张栋 ,  王世杰 ,  冯丽莉 ,  荀一萍 ,  薛玉玲 ,  封肖颖 ,  杨婉秋 ,  袁庆彬

IPC: C12N1/20 ,  A23C9/123 ,  C12R1/46

Abstract: 一种嗜热链球菌JMCC0033及其应用，该菌是从内蒙古传统发酵乳中分离筛选出来的，已于2021年5月18日保藏于北京市朝阳区北辰西路1号院3号中国微生物菌种保藏管理委员会普通微生物中心，保藏编号为CGMCC NO.22560。该菌可作为发酵剂的辅助菌株，提高发酵速度，有效缩短发酵时间。

公开(公告)号：WO2023001633A1

公开(公告)日：2023-01-26

申请号：PCT/EP2022/069446

申请日：2022-07-12

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： MANOURY, Elise ,  FOURCASSIE, Pascal

IPC: A23C20/02 ,  A23C11/10 ,  A23L11/00 ,  C12N1/20 ,  C12R1/46

Abstract: The present invention relates to bacterial strains of Lactococcus lactis or Lactococcus cremoris, usable as starter cultures, able to provide both satisfactory rheological and organoleptic proper-ties, and satisfactory shelf life to a plant-based media into which they are incorporated. The in-vention also provides a composition comprising one of these strains of Lactococcus lactis or Lactococcus cremoris, and feed or food products, in particular a plant-based feed or food product obtained with these strains.

公开(公告)号：WO2023285105A1

公开(公告)日：2023-01-19

申请号：PCT/EP2022/067263

申请日：2022-06-23

Applicant: BIOMILLENIA SAS

Inventor： JORDAN, Prieto ,  DAJKOVIC, Aleksander ,  DU, Guansheng ,  LOEFFERT, Dirk

IPC: G01N33/569 ,  B01L3/00 ,  C12M3/06 ,  C12M1/12 ,  C12M1/42 ,  C12Q1/02 ,  C40B30/06 ,  C12R1/45 ,  C12R1/46

Abstract: The present invention uses microfluidics droplets for studying the growth dynamics of communities of bacteria in the presence of various perturbations such as various chemicals or other microorganisms and to establish microbial assemblies model which is representative of a microbiota of interest and to examine their growth dynamics after perturbations such as with an array of chemicals or other microorganisms. In particular, the present invention refers to a method and apparatus for assessing the effect of a chemical or biological substance on the growth of microorganisms.

公开(公告)号：WO2022152615A1

公开(公告)日：2022-07-21

申请号：PCT/EP2022/050208

申请日：2022-01-06

Applicant: CHR. HANSEN A/S

Inventor： JANZEN, Thomas ,  CHRISTIANSEN, Ditte ,  BROEND, Jesper ,  PREBNER, Victoria ,  MANUGUERRA, Ilenia ,  RAS, Geoffrey

IPC: C12N9/12 ,  C12N1/20 ,  C07K14/315 ,  C12P19/04 ,  A23C9/123 ,  C12R1/225 ,  C12R1/46

Abstract: The present invention relates to a novel Streptococcus thermophilus strain having improved texturizing properties, compositions comprising said strain as well as fermented products manufactured using said strain.

公开(公告)号：WO2022106405A1

公开(公告)日：2022-05-27

申请号：PCT/EP2021/081821

申请日：2021-11-16

Applicant: CHR. HANSEN A/S

Inventor： JANZEN, Thomas ,  CHRISTIANSEN, Ditte Ellegaard ,  BROEND, Jesper ,  PREBNER, Victoria

IPC: A23C9/123 ,  C12R1/46

Abstract: The present invention relates to a novel Streptococcus thermophilus strain having improved texturizing properties, compositions comprising said strain as well as fermented products manufactured using said strain.