公开(公告)号：WO2023041574A1

公开(公告)日：2023-03-23

申请号：PCT/EP2022/075514

申请日：2022-09-14

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： ADRIANI, Marsilio ,  ETTORRE, Anna ,  MULDER, Imke ,  COUTURIER, Aurelie

IPC: A61K35/744 ,  A61P35/04 ,  A61P35/00 ,  C12N1/20 ,  C12R1/46 ,  G01N33/569 ,  G01N33/574 ,  G01N33/50 ,  C12N1/00

Abstract: The invention is in the field of bacterial strains isolated from the mammalian digestive tract and the use of such strains, and compositions comprising these strains, in the treatment of disease.

公开(公告)号：WO2023277654A1

公开(公告)日：2023-01-05

申请号：PCT/KR2022/009539

申请日：2022-07-01

Applicant: 이현구

Inventor： 이현구 LEE, Hyun Goo

IPC: C12G3/02 ,  C12H1/07 ,  C12R1/865 ,  C12R1/46 ,  C12R1/24

Abstract: 본 발명은 커피체리를 이용한 커피와인의 제조방법에 관한 것으로 (A) 파치먼트와 상기 파치먼트를 감싸는 외과피로 이루어진 커피체리를 으깬 후 가수하여 고형분이 40 내지 60 brix가 되도록 하는 단계; (B) 상기 으깬 커피체리에 누룩을 투입하여 1차 발효시키는 단계; (C) 상기 1차 발효된 커피체리에 효모를 투입하여 2차 발효시키는 단계; (D) 상기 2차 발효된 커피체리를 여과하여 여과물과 여과액으로 분리하는 단계;를 포함하여 상기 여과액으로 커피와인을 수득하며, 상기 여과물로는 발효커피콩을 수득할 수 있다.

公开(公告)号：WO2022160358A1

公开(公告)日：2022-08-04

申请号：PCT/CN2021/074737

申请日：2021-02-01

Applicant: 苏州大学附属儿童医院

Inventor： 朱雪萍 ,  朱晓黎 ,  范佳英 ,  李静兰 ,  吴志新 ,  王华伟 ,  陈小倩 ,  俞贇

IPC: C12Q1/689 ,  C12Q1/06 ,  C12Q1/14 ,  C12Q1/10 ,  C12R1/22 ,  C12R1/46

Abstract: 肠道微生物作为早产儿支气管肺发育不良症标志物的应用，所述肠道微生物为克雷伯氏菌属(Klebsiella)、普雷沃菌属(Prevotella)、链球菌属(Streptococcus)中的一种或几种。对分离的肠道菌群核酸样本进行测序，以获得测序结果，根据测序结果，对肠道菌群中的肠道微生物的相对丰度进行检测，得到相对丰度值，将得到的肠道微生物相对丰度值与设定值进行比较，得到的结果可作为中间信息辅助诊断早产儿支气管肺发育不良。通过高通量测序技术对早产儿粪便样本16SrDNA基因进行测序，首次探讨肠道菌群与早产儿BPD发生的关系，为BPD的预防及治疗提供可靠依据。

公开(公告)号：WO2021250183A1

公开(公告)日：2021-12-16

申请号：PCT/EP2021/065664

申请日：2021-06-10

Applicant: CHR. HANSEN A/S

Inventor： JANZEN, Thomas ,  CHRISTIANSEN, Ditte Ellegaard ,  MIKKELSEN, Mia Vissing ,  ECKHARDT, Thomas

IPC: A23C19/032 ,  C12R1/225 ,  A23C9/12 ,  C12N15/01 ,  C12P21/02 ,  C12R1/46 ,  C07K14/195 ,  C07K14/315 ,  C12N1/20 ,  A23V2300/21 ,  C12N1/205 ,  C12R2001/46

Abstract: The present invention provides a method of increasing nisin production in nisin- producing Lactococcus lactis by inactivating the phage infection protein Pip. The invention also provides nisin-producing Lactococcus lactis in which the phage infection protein is inactivated. The nisin-producing Lactococcus lactis can be used in starter culture for manufacturing food products or other industrial applications.

公开(公告)号：WO2021080537A1

公开(公告)日：2021-04-29

申请号：PCT/TR2020/050956

申请日：2020-10-19

Applicant: PANAGRO TARIM HAYVANCILIK GIDA SAN. VE TİC.A.Ş.

Inventor： ŞAHİNER, Mehmet

IPC: A23C9/123 ,  C12N1/20 ,  C12R1/46 ,  C12R1/225

Abstract: With the invention, it is possible to commercialize Streptococcus thermophilus and Lactobacillus bulgaricus bacteria, which are naturally found in local village yogurts in Anatolia, after isolation and purification, and with a process designed for the use of starter cultures containing different combinations of these bacteria, creamy yogurt, homogenized yogurt, fermented milk products such as yogurt and ayran with different fat/dry matter contents are produced. With the invention, by using completely natural isolates isolated from yogurt taken from the local villages of Anatolia, which does not have any modifications; a sustainable method has been developed that can be applied industrially within the scope of mass production and is suitable for the standard structure and taste that consumers in our country want to see in yogurt. With the invention, natural fermented milk products are produced with starter cultures known as yeast/living yogurt cultures in colloquial language and TGK Nutrition and Health Declarations Regulation.

公开(公告)号：WO2020261289A1

公开(公告)日：2020-12-30

申请号：PCT/IN2020/050447

申请日：2020-05-19

Applicant: INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IIT MADRAS)

Inventor： JAYARAMAN, Guhan ,  PUVENDRAN, Kirubhakaran

IPC: C12M1/00 ,  A61K31/728 ,  C12R1/46

Abstract: The molecular weight of hyaluronic acid (HA) is a critical property which determines its usage in various biomedical applications. The invention pertains to a process for production of higher MWHA (3.4 MDa) throughout the fermentation time with high yield in anaerobic microbial fermentation with control of process parameter. The recombinant cocci for the production of hyaluronic acid is strain of Lactococcus lactis MKG6 throughout the fermentation time with high yield. The fermentation process is one of batch acetate pulse feed, batch process with acetate and glucose pulse feed, constant fed batch and pH feedback fed batch fermentation.

公开(公告)号：WO2020182976A1

公开(公告)日：2020-09-17

申请号：PCT/EP2020/056766

申请日：2020-03-13

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： JEDRZEJOWSKI, Anäis ,  FREMAUX, Christophe ,  VAN DILLEN, Sabine ,  DESFOUGÈRES, Thomas ,  JODEAU, Max Charles ,  LUGAND, Damien

IPC: C12R1/46 ,  C12P7/56 ,  A23C9/12 ,  C12N9/38

Abstract: The invention relates to a polynucleotide comprising a lacZ gene ( lacZ FS ) encoding a β-galactosidase characterized by a particular profile regarding its efficiency of hydrolysis of lactose. The invention is also directed to a Streptococcus thermophilus strain comprising a lacZ FS allele and bacterial composition thereof, and their use to obtain fermented milk not undergoing post-acidification.

公开(公告)号：WO2019151901A1

公开(公告)日：2019-08-08

申请号：PCT/RU2019/000045

申请日：2019-01-25

Applicant: ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "МЕЖДУНАРОДНЫЙ БИОТЕХНИЧЕСКИЙ ЦЕНТР "ГЕНЕРИУМ"

Inventor： ЕРШОВ, Александр Викторович ,  ЕРШОВА, Ольга Анатольевна ,  ЛЕОНОВ, Вячеслав Сергеевич

IPC: C07K14/315 ,  C07K1/16 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22 ,  C07K1/34 ,  C07K1/36 ,  C12N9/24 ,  C12R1/46

Abstract: Изобретение относится к области биотехнологии, а именно к способам получения и производства терапевтических препаратов, выделения и очистки рекомбинантных белков. Раскрыт промышленный способ получения биологически активного препарата рекомбинантной экзо-бета-N-ацетилглюкозаминидазы StrH (β-N-GlcNAcase StrH), продуцированного в соответствии с правилами GMP, пригодного для использования на стадии ремоделирования в получении терапевтически функциональных препаратов гликопротеинов с заданными свойствами, а также для разработки инструментов для высокочувствительного анализа гликановых цепей гликопротеинов тканей растений, животных и эукариотических микроорганизмов.

公开(公告)号：WO2019077393A1

公开(公告)日：2019-04-25

申请号：PCT/IB2017/056506

申请日：2017-10-19

Applicant: INSTITUTO DE SALUD PÚBLICA

Inventor： VÁSQUEZ VELOSO, Abel Eduardo ,  SOTO CARRASCO, Daniel Andrés ,  DÍAZ DINAMARCA, Diego Andrés

IPC: G01N33/50 ,  C12Q1/68 ,  C12R1/46 ,  C12Q1/14

CPC classification number: C12Q1/14 ,  C12Q1/68 ,  C12R1/46 ,  G01N33/50

Abstract: Un kit de diagnóstico para la determinación de Streptococcus agalactiae (SGB) a través de metodologías basadas en PCR (por sus siglas en inglés polymerase chain reaction) y sus variantes, que comprende (A) un partidor forward que contiene la SEQ N°1; (B) una sonda que contiene la SEQ N°2; y (C) un partidor reverse que contiene la SEQ N°3, y método in vitro para detectar la presencia de Streptococcus agalactiae (SGB).

公开(公告)号：WO2018220104A1

公开(公告)日：2018-12-06

申请号：PCT/EP2018/064325

申请日：2018-05-31

Applicant: CHR. HANSEN A/S

Inventor： TRIHAAS, Jeorgos ,  JANZEN, Thomas ,  DERKX, Patrick

IPC: C12N1/20 ,  C12N15/01 ,  C12P1/04 ,  C12R1/46 ,  A23C9/12 ,  A23C9/123

Abstract: The present invention is directed to a method of producing a Streptococcus thermophilus strain comprising the steps of a) Providing a mother strain in the form of Streptococcus thermophilus DSM32502, b) Growing a culture of the mother strain in the presence of a bacteriophage, to which the mother strain is not resistant, to obtain a number of mutant strains, which are resistant to the said bacteriophage, c) Measuring the acidification time of the bacteriophage-resistant mutant strains and the mother strain in a milk base and selecting at least one mutant strain with a reduced acidification time as compared to the mother strain to obtain a fast-acidifying mutant strain.