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公开(公告)号：WO2022184606A1
公开(公告)日：2022-09-09
申请号：PCT/EP2022/054915
申请日：2022-02-28
Applicant: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
Inventor： WEERTS, Johan Erwin Edmond , AUFIERO, Marialuisa , GAUPP, Sebastian , MEDINA, Florian Damien
IPC: C07D403/12 , C07D471/04
Abstract: The present invention relates to a multi-step chemical synthesis route for preparing rilematovir, a small molecule inhibitor of the F-glycoprotein-mediated complex membrane fusion process of the respiratory syncytial virus (RSV), that is in clinical development for the treatment of infection by RSV.
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公开(公告)号：WO2022106487A1
公开(公告)日：2022-05-27
申请号：PCT/EP2021/082031
申请日：2021-11-17
Applicant: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
Inventor： HOLM, René , VESOLE, Steven M. , KRAUS, Guenter Karl Wilhelm
IPC: A61K9/00 , A61K9/14 , A61K9/16 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61K31/505 , A61P31/12 , A61P35/00 , A61K38/47
Abstract: The present invention relates to the treatment or prevention of a disease or disorder using a drug in the form of micro- or nanoparticles in suspension, in combination with a hyaluronidase.
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3.发明申请
公开(公告)号：WO2022043531A1
公开(公告)日：2022-03-03
申请号：PCT/EP2021/073803
申请日：2021-08-27
Applicant: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY , UNIVERSITE DE ROUEN NORMANDIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN NORMANDIE
Inventor： BEIGELMAN, Leonid , GUILLEMONT, Jérôme Émile Georges , PIETTRE, Serge , BRIOCHE, Julien , SUNCHU, Prabhakar
IPC: C07H19/00 , C07H19/06 , C07H21/00 , C07D493/08 , A61K31/712 , A61P31/12
Abstract: The present disclosure relates to ethylene-bridged nucleic acid (ENA) compounds, which may find use in therapy and/or prophylaxis. These ENA compounds may also find use as building blocks for preparing oligonucleotides, said oligonucleotides also finding use in therapy and/or prophylaxis. These compounds may be mono- or oligonucleotide derivatives comprising at least one of the following fragment: Formula (IV), wherein R1 is an optionally substituted C1-C6 alkyl moiety.
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公开(公告)号：WO2021250180A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/065661
申请日：2021-06-10
Applicant: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
Inventor： BEVERNAGE, Jan, Jos, L , BOGAERTS, Jasmine , KIMPE, Kristof, Leonard , TIEGER, Eszter
IPC: C07D403/06 , A61K31/12 , C07D471/04 , A61K31/4184 , A61P31/12 , A61K31/437 , A61K47/02 , A61K47/26 , A61K47/38 , A61K9/0095 , C07B2200/13
Abstract: The present invention relates to hemi (L)-tartrate forms of the RSV fusion inhibitor 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H- imidazo[4,5-c]pyridin-2-one (also known under its INN as rilematovir), and to processes for preparing said forms and the use of these forms in a pharmaceutical composition.
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公开(公告)号：WO2021214136A1
公开(公告)日：2021-10-28
申请号：PCT/EP2021/060384
申请日：2021-04-21
Applicant: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
Inventor： GROSSE, Sandrine, Céline , GUILLEMONT, Jérôme, Émile, Georges , RABOISSON, Pierre, Jean-Marie, Bernard , MC GOWAN, David, Craig , EMBRECHTS, Werner, Constant, Johan , COOYMANS, Ludwig, Paul , JONCKERS, Tim, Hugo, Maria
IPC: C07D401/12 , A61K31/4709 , A61K31/502 , A61P31/14
Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.
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Patent Agency Ranking
公开(公告)号：WO2021083998A1
公开(公告)日：2021-05-06
申请号：PCT/EP2020/080381
申请日：2020-10-29
Inventor： RASPARINI, Marcello , WEERTS, Johan, Erwin, Edmond , JANSEN, Corina, Mathilde , LU, Zhihui , TAN, Hongyu , HAN, Licheng
IPC: C07D209/42 , C07D401/12 , C07D471/04
Abstract: The present invention relates to a chemical synthesis route for preparing the RSV inhibiting compound 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-10 1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, and to new compounds used as intermediate compounds in the multistep process.
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公开(公告)号：WO2021023662A1
公开(公告)日：2021-02-11
申请号：PCT/EP2020/071672
申请日：2020-07-31
Applicant: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
Inventor： KUDUK, Scott, D.
IPC: A61P31/14 , C07D471/04 , A61K31/437
Abstract: Certain pyrazolo[4,3-c]pyridine compounds, pharmaceutical compositions thereof, are useful in treating diseases associated with HBV infection in animals, in particular humans
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8.发明申请
公开(公告)号：WO2021018239A1
公开(公告)日：2021-02-04
申请号：PCT/CN2020/105767
申请日：2020-07-30
Inventor： JIANG, Yimin , CHENG, Zhanling , DENG, Gang , LIU, Zhiguo , LIANG, Chao , WU, Jianping , KONG, Linglong , DENG, Xiangjun , XU, Yanping
IPC: C07D417/04 , A61K31/506 , A61P31/20
Abstract: Provided herein are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
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9.发明申请
公开(公告)号：WO2021018238A1
公开(公告)日：2021-02-04
申请号：PCT/CN2020/105765
申请日：2020-07-30
Inventor： JIANG, Yimin , CHENG, Zhanling , DENG, Gang , LIU, Zhiguo , LIANG, Chao , WU, Jianping , KONG, Linglong , DENG, Xiangjun , XU, Yanping
IPC: C07D487/04 , A61K31/4985 , A61P31/20
Abstract: Provided herein are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
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公开(公告)号：WO2021001568A1
公开(公告)日：2021-01-07
申请号：PCT/EP2020/068913
申请日：2020-07-03
Applicant: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
Inventor： CRAUWELS, Herta , VANVEGGEL, Simon , VAN EYGEN, Veerle
IPC: A61K31/505 , A61K31/5365 , A61K31/675 , A61K31/683 , A61K31/7068 , A61P31/18
Abstract: The disclosure is directed to the use of rilpivirine, or a salt thereof, to treat HIV infection in pediatric subjects.
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