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公开(公告)号：WO2023088638A1
公开(公告)日：2023-05-25
申请号：PCT/EP2022/079519
申请日：2022-10-24
发明人： HEESE, Harald Sepp , VIK, Torbjoern , ISOLA, Alfonso Agatino , BONDAR, Maria Luiza , BROSCH, Tom , BAL, Matthieu Frédéric
摘要： System (OGS) and related method for generating an objective function for use in radiation treatment, RT, planning. The system may include a machine learning model (M) and a training system (TS) for training the model (M) based on training data. The training data may include previous (at least partial) RT plans, and a user awarded ranking thereof. The model, once trained, may be used as the objective function. The system allows a user to turn, in a defined manner, clinical objectives or goals into a computable objective function which can be used for RT planning.
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公开(公告)号：WO2023083637A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/080263
申请日：2022-10-28
发明人： BONDAR, Maria, Luiza , FLÄSCHNER, Nick , WEESE, Rolf, Jürgen , NEUKIRCHEN, Christoph , HEESE, Harald, Sepp , WIEGERT, Jens
摘要： A computing system (SYS) and relates method for supporting radiation therapy planning. An input interface (IF1; UI-I) is provided for receiving input radiation treatment plan templates, or types of such plan templates, for plural radiation treatment plans. A trained machine learning model (M) of the system (SYS) is configured to compute plural dose maps associated with the received radiation treatment plan templates or with the types of such plan templates.
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公开(公告)号：WO2023069489A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047093
申请日：2022-10-19
申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , CHANCELLOR, Jeff , CHESAL, Megan
发明人： CHANCELLOR, Jeff , CHESAL, Megan
摘要： Systems, methods, and computer-readable storage media for simulating a non-homogenous space environment. A system can include a ion beam generator, a moderator block, a radiation detector, at least one processor which can execute operations including: transmitting, 7o the ion beam generator, a beam generation signal, the beam generation signal specifying an energy level of an ion beam and a duration of the ion beam, the ion beam making first contact with the moderator block and subsequent contact with a test animal; receiving, from the radiation detector after the duration of the ion beam is completed, energy deposition within the test animal. The system can then execute computational models to determine moderator block computational results animal computational results, then generate projected human results for the ion beam based on the moderator block computational results and the animal computational results.
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公开(公告)号：WO2023068365A1
公开(公告)日：2023-04-27
申请号：PCT/JP2022/039314
申请日：2022-10-21
申请人： 国立大学法人筑波大学
摘要： 被検者の体内情報が撮影された第１の画像（２３）と、体内の標的（６３）を示す第２の画像（３０）と、第１の画像（２３）とは異なる装置で同一の被検者を撮影した第３の画像（２０）と、に基づいて学習をした識別器（６１）を使用して、標的（３０）の外形を推定することを特徴とする治療装置（１）により、ＣＴ画像から加工されたＤＲＲ画像を使用して標的対象部位の形状を学習する構成において、標的対象部位の形状を精度よく推定することができる。
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5.发明申请
公开(公告)号：WO2023067006A1
公开(公告)日：2023-04-27
申请号：PCT/EP2022/079109
申请日：2022-10-19
申请人： INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE GIRONA DR. JOSEP TRUETA (IDIBGI) , INSTIUT CATALÀ D'ONCOLOGIA (ICO) , COMPOXI SL
发明人： ROMERA MARTÍNEZ, Ingrid , MUÑOZ MONTPLET, Carles , JURADO BRUGGEMAN, Diego , MARRUECOS QUEROL, Jordi , BOU SÁNCHEZ, Salvador , GRÈBOL CANAL, Roger , GASCONS TARRÉS, Marc , VICENS CUYÀS, Pep
摘要： The invention refers to a system for positioning patients during treatment and/ or diagnosis processes, preferably for radiotherapy treatments, in which patients must be irradiated in a deep inspiration breath hold position. The system is synchronized with an electron accelerator, in a way that radiation is applied on a patient only if the patient is in a proper deep inspiration hold position. The electron accelerator is controlled by the contact sensor (12), preferably a pressure sensor, so that radiation can be applied on a patient only when a correct pressure is exerted on the contact sensor (12). In addition, while the contact sensor is pressed correctly, signalling means are activated, to inform a patient and an accelerator operator, that the patient is in a proper deep inspiration hold position. The invention achieves high reproducibility in patient positioning while irradiating patients in deep inspiration breath hold position, and avoiding undesired radiation to other vital organs such as the heart.
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公开(公告)号：WO2023058831A1
公开(公告)日：2023-04-13
申请号：PCT/KR2022/004097
申请日：2022-03-23
申请人： (주)창림이엔지
摘要： 본 발명은 수지 성분의 기재에 산화비스무트와 산화텅스텐을 포함하는 방사선 차폐 성분을 혼합한 원료를 기반으로 하여 인체에 착용 가능한 형태로 생성되는 성형품으로서, 상기 성형품은 원료 펠렛을 몰드에 주입하여 인체의 주요 부분에 대응하도록 분할된 부분품 형태로 형성되고, 상기 부분품은 인접하게 이어지는 부분에 연결부를 구비하는 것을 특징으로 한다. 이에 따라, 방사선 노출 환경에서 신체를 보호함에 차폐성, 경량성, 착용과 활동의 편의성을 확보하면서 다양한 규격으로 양산하는 과정에서 품질과 생산성을 유지하므로 실질적인 활용성을 증대하는 효과가 있다.
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公开(公告)号：WO2023045017A1
公开(公告)日：2023-03-30
申请号：PCT/CN2021/126381
申请日：2021-10-26
申请人： 合肥中科离子医学技术装备有限公司
摘要： 本发明公开了一种放射治疗用的摆位设备，所述摆位设备包括：床板，床板用于固定患者；六自由度机械臂，六自由度机械臂与床板相连，并用于调节床板的位置；位置检测装置，位置检测装置可用于对床板和六自由度机械臂所处环境中的人或物体距离进行检测，以获取位置信息；力矩检测装置，力矩检测装置设置在床板和床板调节组件之间，并用于获取床板在多个方向上的力矩参数；控制器，控制器用于与六自由度机械臂、位置检测装置和力矩检测装置通讯，以根据位置信息、力矩参数控制六自由度机械臂调节床板位置。由此，通过设置位置检测装置和力矩检测装置提升床板调节过程的稳定性、可靠性，同时缩短床板摆位需要的时间，提高治疗效率。
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公开(公告)号：WO2023042553A1
公开(公告)日：2023-03-23
申请号：PCT/JP2022/029214
申请日：2022-07-28
申请人： 株式会社日立製作所
IPC分类号： A61N5/10
摘要： 開示の放射線照射装置は、治療の対象者に放射線を照射する放射線照射部と、前記放射線の照射に係る設定を行う放射線照射設定部と、前記対象者の体表において前記放射線が照射される範囲を可視光で照射し、光照射野を形成する可視光照射部と、前記可視光の照射態様を前記放射線の照射に係る設定に応じて異ならせる光照射野制御部とを備える。かかる構成により、放射線の照射に係る設定を視覚的に確認可能となる。このため、放射線の照射に係る設定を効率的に報知可能となる。
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公开(公告)号：WO2023040878A1
公开(公告)日：2023-03-23
申请号：PCT/CN2022/118657
申请日：2022-09-14
申请人： 翰斯泰医疗科技（苏州）有限公司
发明人： 宋世鹏
IPC分类号： A61N5/10
摘要： 本申请公开了一种双轨运动聚焦放疗设备，包括：固定机架和旋转机架，所述固定机架设有环套结构件；所述旋转机架设有圆环型结构件和支撑结构件，所述圆环型结构件连接支撑结构件，所述圆环型结构件位于环套结构件内侧，并通过轴承与环套结构件连接，所述圆环型结构件与环套结构件连接转动驱动装置，所述转动驱动装置驱动圆环型结构件沿环套结构件转动；所述支撑结构件上安装有治疗组件和成像部件，驱动机构安装于支撑结构上，可驱动治疗组件滑动。本装置通过将成像部件和治疗组件的一体化提高了影像引导和靶点定位准确度，缩短了放射治疗的时间，通过双轨道聚焦的方法减少了对患者正常的组织、脏器细胞的损伤，使治疗方案可以更加优化。
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公开(公告)号：WO2023019240A2
公开(公告)日：2023-02-16
申请号：PCT/US2022/074901
申请日：2022-08-12
发明人： BREDLAU, Amy-Lee , LOWY, Israel , SKOLNIK, Jeffrey , YAN, Jian , FERRARO, Bernadette , WALTERS, Jewell , SYLVESTER, III, Albert J. , KRAYNYAK, Kimberly A. , MORROW, Matthew P. , GILLESPIE, Elisabeth
IPC分类号： C12Q1/6886 , A61K39/00 , A61K39/395 , A61P35/00 , C12N15/113 , A61K2039/51 , A61K2039/54 , A61K2039/545 , A61K2039/555 , A61K2039/57 , A61K2039/70 , A61K31/495 , A61K38/19 , A61K38/208 , A61K39/001153 , A61K39/001157 , A61K39/001195 , A61K39/3955 , A61K41/0047 , A61N5/10 , C07K16/2818 , C12Q1/6869 , C12Q2600/158 , C12Q2600/178
摘要： Provided herein are methods of treating brain cancer in a subject, comprising evaluating one or more biological samples from a subject who has brain cancer for the presence of a miRNAs and administering interleukin-12 (IL-12); an immunogenic composition of human telomerase reverse transcriptase (hTERT), Wilms Tumor-1 (WT-1), and prostate specific membrane antigen (PSMA); and an anti-programmed cell death receptor 1 (PD-1) antibody to said subject if the subject has an increased expression level of the mIR-331-3p miRNA or isomiRs thereof and the miR-1537-3p miRNA or isomiRs thereof relative to a control population of subjects. Also provided herein are methods of treating brain cancer in a subject, comprising measuring an expression level of at least one mRNA biomarker selected from SYNGR3, OTX1, GABBR2, LHX1, CADM3, MLLT11, MNX1, GRB14, SLC34A2, PHYHIP, WNT10B, SLC17A6, CRLF1, HOXD13, TGFβR3, UBA7, SFRP4, or any combination thereof, in a tumor sample from a subject and administering IL-12; an immunogenic composition hTERT, WT-1, and PSMA; and an anti-PD-1 antibody to said subject if the expression level of SYNGR3, OTX1, GABBR2, LHX1, CADM3, MLLT11, MNX1, GRB14, SLC34A2, PHYHIP, WNT10B, SLC17A6, CRLF1 and HOXD13 is decreased or if the expression level of TGFβR3, UBA7, SFRP4 is increased.
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