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公开(公告)号：WO2019140140A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/013118
申请日：2019-01-10
Inventor： CHANG, Yung , YAN, Hao , QI, Xiaodong , ZHANG, Fei
IPC: C12N15/117 , A61K31/713 , A61K39/39 , B82Y5/00 , C12N15/115
CPC classification number: C12N15/117 , A61K39/0011 , A61K39/001176 , A61K39/39 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2310/16 , C12N2310/17 , C12N2310/3519 , C12N2310/51 , C12N2320/32
Abstract: Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.
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公开(公告)号：WO2019097697A1
公开(公告)日：2019-05-23
申请号：PCT/JP2017/041562
申请日：2017-11-17
Applicant: 株式会社島津製作所 , 国立研究開発法人産業技術総合研究所
IPC: A61K49/00 , B82Y5/00 , C01B32/174
CPC classification number: A61K49/00 , B82Y5/00 , C01B32/174
Abstract: 半導体ＳＷＣＮＴが凝集せず、生体に投与した際に、特定の部位に集積することなく、肺等の血管を閉塞させることがない、毒性の低い生体イメージング用ＳＷＣＮＴ分散液を提供することを目的とする。 上記課題を解決するため、本発明の生体イメージング用半導体ＳＷＣＮＴ分散液は、平均粒子径が１０ｎｍより小さい半導体単層カーボンナノチューブと、前記半導体単層カーボンナノチューブの表面をコーティングする両親媒性物質からなる分散剤とを含むことを特徴とする。
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3.发明申请
公开(公告)号：WO2019087155A1
公开(公告)日：2019-05-09
申请号：PCT/IB2018/058655
申请日：2018-11-05
Applicant: THENA BIOTECH S.R.L.
Inventor： BRACA, Aldo
CPC classification number: C07K14/47 , B82Y5/00 , C07K2319/31 , C07K2319/33 , C07K2319/50 , C07K2319/735
Abstract: A fusion protein, a nanoparticle composed by a plurality of monomers of said fusion protein, and uses thereof. A fusion protein based on the heavy chain of human ferritin is de- scribed, which includes at the N terminus of the protein at least one metalloproteinase cleavage sequence and a modified PAS polypeptide that acts as a masking polymer that in- creases the protein drug stability, as well as a nanoparticle composed of multiple monomers of said fusion protein, a nucleic acid encoding for said fusion protein, and diagnostic and therapeutic applications thereof.
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公开(公告)号：WO2019022610A1
公开(公告)日：2019-01-31
申请号：PCT/NL2018/050526
申请日：2018-07-27
Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n.LUMC)
Inventor： VAN LEEUWEN, Fijs W.B. , WELLING, Mick
CPC classification number: A61K51/1251 , A61K49/0002 , A61K49/0032 , A61K49/0093 , A61K51/1268 , B82Y5/00 , B82Y15/00
Abstract: The present invention provides, in general, compositions comprising a microparticle-based pre-targeting vector comprising a diagnostic and/or therapeutic functionality, and a second component that selectively binds to the pre-targeting vector component. This secondary component carries a diagnostic or preferably a therapeutic functionality, for in vivo parenteral topical administration and target tissue specific delivery. The invention also features compositions comprising secondary compounds that can be coupled with a label, for instance a diagnostic or therapeutic label and that selectively bind to the pre-targeting vector, and methods for its use in treating patient.
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公开(公告)号：WO2019006425A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040494
申请日：2018-06-29
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： JOHNSON, Jeremiah, A. , NGUYEN, Hung, Vanthanh , RAJCA, Andrzej
CPC classification number: A61K49/124 , A61K49/0032 , A61K49/0054 , A61K49/0093 , A61K49/186 , A61K49/1881 , A61K49/20 , A61K2123/00 , B82Y5/00
Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide- functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field 1 H MRI techniques.
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Patent Agency Ranking
公开(公告)号：WO2018157160A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/020035
申请日：2018-02-27
Applicant: NANOVATION PARTNERS LLC
Inventor： JIN, Sungho , JUSTIN, Daniel F.
CPC classification number: B08B7/0057 , A61B90/70 , A61L2/10 , A61L2/14 , A61L27/06 , A61L27/50 , A61L31/086 , A61L31/088 , A61L31/16 , A61L2202/24 , A61L2300/406 , A61L2300/412 , A61L2400/12 , A61L2400/18 , B08B3/041 , B08B7/0071 , B08B11/00 , B08B17/065 , B82Y5/00 , B82Y40/00
Abstract: Methods and treatments for removing contaminants from nanotube surfaces covering a medical device are disclosed herein. These methods and treatments include commencing exposure of a nanotube surface to at least one condition that at least partially removes the contaminants including: ultraviolet light, elevated temperature, plasma, and/or combinations thereof. These methods and treatments may also include orienting the nanotube surface relative to the at least one condition in order to enhance removal of the contaminants by the at least one condition. Exposure of the nanotube surface to the at least one condition may be ceased after the contaminants are at least partially removed from the nanotube surface.
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公开(公告)号：WO2018154165A1
公开(公告)日：2018-08-30
申请号：PCT/ES2018/070130
申请日：2018-02-21
Applicant: FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD
Abstract: Nanopartícula obtenida por descomposición térmica que comprende al menos dos derivados alcoxi-silanos. La invención también se refiere a una composición, usos y un método de síntesis.
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公开(公告)号：WO2018128706A2
公开(公告)日：2018-07-12
申请号：PCT/US2017/060206
申请日：2017-11-06
Applicant: IBIS BIOSCIENCES, INC.
Inventor： ECKER, David J. , MOTLEY, Stanley T. , HANNIS, James C. , KRIEG, Lara G. , MICHAEL, Todd P. , DUNCAN, David D. , POPLAWSKI, Shane G. , CHIESL, Thomas N.
CPC classification number: G01N33/48721 , B82Y5/00 , C12Q1/6806 , C12Q1/6869 , C12Q2525/113 , C12Q2525/117 , C12Q2525/119 , C12Q2525/191 , C12Q2535/00 , C12Q2521/531 , C12Q2563/116 , C12Q2565/631
Abstract: Provided herein is technology relating to nanopore analysis of nucleic acids and particularly, but not exclusively, to compositions, methods, systems, and kits for analysis of nucleic acids or other assays comprising nucleic acid components.
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9.发明申请NANOCARRIERS HAVING SURFACE CONJUGATED PEPTIDES AND USES THEREOF FOR SUSTAINED LOCAL RELEASE OF DRUGS 审中-公开具有表面缀合肽的纳米载体及其用于药物持续局部释放的用途
公开(公告)号：WO2018089465A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060596
申请日：2017-11-08
Applicant: NORTHWESTERN UNIVERSITY
Inventor： HENKIN, Jack , MELGAR-ASENSIO, Ignacio
CPC classification number: C07K17/10 , A61K9/0019 , A61K9/0051 , A61K9/5161 , A61K47/62 , A61K47/6903 , B82Y5/00 , C07K5/1016 , C07K5/1024 , C07K7/06 , C07K14/75 , C07K14/78 , C07K14/811
Abstract: Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may be administered for localized and sustained delivery of the drug.
Abstract translation: 公开了具有净正表面电荷和在约+2至约+ 20mV之间的ζ电位的生物可降解纳米载体。 纳米载体的正表面电荷由共价连接至纳米载体表面的肽提供。 纳米载体可以包含药物并且可以被施用用于局部和持续递送药物。
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公开(公告)号：WO2018073593A1
公开(公告)日：2018-04-26
申请号：PCT/GB2017/053164
申请日：2017-10-19
Applicant: IMPERIAL INNOVATIONS LIMITED
Inventor： BALDWIN, Geoffrey , FIELD, James
CPC classification number: A61K38/08 , A61K9/0019 , A61K9/5169 , A61K33/00 , A61K41/0028 , A61K47/42 , A61K47/62 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K49/00 , A61K49/0047 , A61K49/0093 , A61P35/00 , B82Y5/00 , B82Y30/00 , C07K7/06 , C07K14/245 , C07K14/47 , C07K2319/21 , G01N33/84 , G01N2333/47 , G01N2500/00
Abstract: The invention provides nanocages, and in particular to protein nanocages, and especially ferritin nanocages. The invention extends to variant ferritin polypeptides and their encoding nucleic acids, mutant ferritin nanocages, and their uses in diagnostics and drug delivery, as well as in phenotypic screens in drug development.
Abstract translation: 本发明提供纳米笼，特别是蛋白质纳米笼，特别是铁蛋白纳米笼。 本发明延伸至变体铁蛋白多肽及其编码核酸，突变铁蛋白纳米笼，以及它们在诊断和药物递送以及药物开发中的表型筛选中的用途。
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