公开(公告)号：WO2015148121A1

公开(公告)日：2015-10-01

申请号：PCT/US2015/019891

申请日：2015-03-11

Applicant: ETHICON ENDO-SURGERY, INC.

Inventor： STULEN, Foster B. ,  LAMPING, Michael R. ,  KIMBALL, Cory G. ,  STOKES, Michael J. ,  HENRY, Emron J.

IPC: A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B17/28

CPC classification number: A61B17/320068 ,  A61B17/285 ,  A61B17/320092 ,  A61B18/14 ,  A61B2017/0046 ,  A61B2017/00473 ,  A61B2017/2825 ,  A61B2018/00172 ,  A61B2018/00178 ,  A61B2018/0019 ,  A61B2018/00202 ,  A61B2018/00339 ,  A61B2018/00434 ,  A61B2018/00601 ,  A61B2018/00607 ,  A61B2018/00952 ,  A61B2018/1405 ,  A61B2018/1457 ,  A61B2018/1462 ,  A61F7/00 ,  A61F2007/0054

Abstract: An ultrasonic forceps comprises a housing, an acoustic assembly, and a tine. The housing joins the acoustic assembly and the tine to the forceps and permits the tine to pivot relative to the acoustic assembly. The acoustic assembly comprises a transducer, a waveguide, and ultrasonic blade, and a waveguide sheath. The transducer is configured to generate ultrasonic vibrations directing the ultrasonic vibrations to the waveguide. The waveguide communicates the ultrasonic vibrations distally to the ultrasonic blade. The ultrasonic blade is configured to vibrate in response to the ultrasonic vibrations generated by the transducer. When the tine is pivoted relative to the transducer, the tine is configured to move toward the ultrasonic blade. Tissue may be grasped between the tine and the ultrasonic blade. The tissue may be denatured when the ultrasonic vibrations generated by the transducer vibrate the ultrasonic blade, thus resulting in the tissue being cut and/or sealed.

Abstract translation: 超声波镊子包括壳体，声学组件和齿。 壳体将声学组件和齿连接到镊子，并允许齿相对于声学组件枢转。 声学组件包括换能器，波导和超声波叶片以及波导护套。 换能器被配置为产生将超声振动引导到波导的超声波振动。 波导将超声波振动向远端传递到超声波叶片。 超声波刀片被配置为响应于由换能器产生的超声波振动而振动。 当齿相对于换能器枢转时，齿构造成朝向超声波叶片移动。 可以在齿和超声刀之间夹持组织。 当由传感器产生的超声波振动使超声波叶片振动时，组织可能变性，从而导致组织被切割和/或密封。

公开(公告)号：WO2015057206A1

公开(公告)日：2015-04-23

申请号：PCT/US2013/065053

申请日：2013-10-15

Applicant: JANSSEN PHARMACEUTICA NV ,  LEONARD, Kristi, A.

Inventor： LEONARD, Kristi, A. ,  BARBAY, Kent ,  EDWARDS, James, P. ,  KREUTTER, Kevin, D. ,  KUMMER, David, A. ,  MAHAROOF, Umar ,  NISHIMURA, Rachel ,  URBANSKI, Maud ,  VENKATESAN, Hariharan ,  WANG, Aihua ,  WOLIN, Ronald, L. ,  WOODS, Craig, R. ,  FOURIE, Anne ,  XUE, Xiaohua ,  CUMMINGS, Maxwell, D.

IPC: C07D401/14 ,  C07D215/227 ,  C07D401/06 ,  C07D413/06 ,  A61K31/47 ,  A61K31/4709 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D401/06 ,  C07D215/227 ,  C07D401/14 ,  C07D413/06

Abstract: The present invention comprises compounds of Formula I. Formula I wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Abstract translation: 本发明包括式I化合物。其中：R1，R2，R3，R4，R5，R6，R7，R8和R9如说明书中所定义。 本发明还包括治疗或改善综合征，病症或疾病的方法，其中所述综合征，病症或疾病是类风湿性关节炎或牛皮癣。 本发明还包括通过施用治疗有效量的至少一种权利要求1的化合物来调节哺乳动物的RORγt活性的方法。

公开(公告)号：WO2014164254A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/021525

申请日：2014-03-07

Applicant: DEPUY SYNTHES PRODUCTS, LLC

Inventor： LEUENBERGER, Samuel ,  SCHMIDLI, Dieter

IPC: A61N5/06 ,  A61B18/20

CPC classification number: A61B18/203 ,  A61B18/20 ,  A61B2017/00371 ,  A61B2017/005 ,  A61B2017/00508 ,  A61B2017/00517 ,  A61B2017/00951 ,  A61B2017/12072 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00916 ,  A61B2018/202 ,  A61N5/06

Abstract: A laser device having a proximal end and a distal end spaced from the proximal end, the distal end configured to receive a fixation member to be affixed to a target surgical site. The laser device includes a laser source supported by the laser device body and capable of emitting a laser beam to the distal end, wherein the laser source is responsive to at least one input so as to selectively switch between an inactive configuration whereby the laser source does not emit the laser beam, and an active configuration whereby the laser source emits the laser beam.

Abstract translation: 一种激光装置，其具有近端和远端与所述近端隔开的远端，所述远端构造成接收待固定到目标手术部位的固定构件。 激光装置包括由激光装置主体支撑并且能够向远端发射激光束的激光源，其中激光源响应于至少一个输入，以便选择性地在非激活配置之间切换，由此激光源 不发射激光束，激光源发射激光束的有效配置。

公开(公告)号：WO2014164052A2

公开(公告)日：2014-10-09

申请号：PCT/US2014/020230

申请日：2014-03-04

Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.

Inventor： BALLESTEROS, Ann, Theodore ,  PITT, Stephen, William

IPC: A61Q1/02

CPC classification number: A61Q1/02 ,  A61K8/0258 ,  A61K2800/412 ,  A61K2800/436 ,  A61K2800/5922

Abstract: A pigmented skin care composition including a dermatologically acceptable carrier and at least a first and second interference pigment. The composition according to the invention is useful in improving the appearance of the skin and in particular in reducing the appearance of skin discontinuities.

公开(公告)号：WO2014164050A2

公开(公告)日：2014-10-09

申请号：PCT/US2014/020209

申请日：2014-03-04

Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.

Inventor： BALLESTEROS, Ann, Theodore ,  PITT, Stephen, William

IPC: A61Q1/02

CPC classification number: A61Q1/02 ,  A61K8/0254 ,  A61K2800/412 ,  A61K2800/436

Abstract: A pigmented skin care composition including a dermatologically acceptable carrier and at least a first and second interference pigment. The composition according to the invention is useful in improving the appearance of the skin and in particular in reducing the appearance of skin discontinuities.

公开(公告)号：WO2014164049A2

公开(公告)日：2014-10-09

申请号：PCT/US2014/020203

申请日：2014-03-04

Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.

Inventor： BALLESTEROS, Ann Theodore ,  PITT, Stephen William

IPC: A61Q1/02

CPC classification number: A61Q1/02 ,  A61K8/0241 ,  A61K8/26 ,  A61K8/29 ,  A61K2800/412 ,  A61K2800/436 ,  A61K2800/5922 ,  A61Q19/02 ,  A61Q19/08

Abstract: A pigmented skin care composition including a dermatologically acceptable carrier and at least a first and second interference pigment. The composition according to the invention is useful in improving the appearance of the skin and in particular in reducing the appearance of skin discontinuities.

Abstract translation: 一种有色皮肤护理组合物，其包含皮肤病学可接受的载体和至少第一和第二干涉颜料。 根据本发明的组合物可用于改善皮肤的外观，特别是减少皮肤不连续性的外观。

公开(公告)号：WO2014163919A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/018890

申请日：2014-02-27

Applicant: DEPUY SYNTHES PRODUCTS, LLC

Inventor： THORWARTH, Kerstin ,  HAUERT, Roland ,  THORWARTH, Gotz

IPC: A61L27/04 ,  A61L27/06 ,  A61L27/30

CPC classification number: A61F2/30 ,  A61L27/045 ,  A61L27/06 ,  A61L27/303 ,  A61L2420/02 ,  A61L2420/08

Abstract: The present disclosure relates, at least in part, to a surgical implant and a method for manufacturing the surgical implant. In one embodiment, the surgical implant comprises a metallic substrate; a tantalum interlayer disposed adjacent to the metallic substrate and comprising ?-tantalum and amorphous tantalum; at least one DLC layer disposed adjacent the tantalum interlayer; wherein the amorphous tantalum has a phase gradient increasing from the metallic substrate side to the DLC side; wherein the DLC layer has a hardness value and an elastic modulus value; and wherein the hardness value has a gradient increasing away from the tantalum side; and wherein the elastic modulus value has a gradient from the tantalum side.

Abstract translation: 本公开至少部分地涉及外科植入物和用于制造外科植入物的方法。 在一个实施例中，手术植入物包括金属基底; 设置在金属基底附近并包含α钽和非晶钽的钽中间层; 设置在钽中间层附近的至少一个DLC层; 其中所述非晶钽具有从所述金属衬底侧向所述DLC侧增加的相位梯度; 其中所述DLC层具有硬度值和弹性模量值; 并且其中所述硬度值具有从所述钽侧增加的梯度; 并且其中所述弹性模量值具有来自所述钽侧的梯度。

公开(公告)号：WO2014163847A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/018042

申请日：2014-02-24

Applicant: ACCLARENT, INC.

Inventor： LAM, Sivette ,  MUNI, Ketan, P.

IPC: A61M25/10 ,  A61M16/04

CPC classification number: A61M29/02 ,  A61M25/104 ,  A61M2025/1081 ,  A61M2025/1084 ,  A61M2210/1028 ,  A61M2210/1032 ,  A61M2210/1035

Abstract: A dilation device (10) comprises an elongate shaft (12), an inflatable balloon (18), and a resilient tube (50). The inflatable balloon is disposed along the shaft. The resilient tube is also disposed along the shaft and is positioned to encompass at least part of the inflatable balloon. The resilient tube is configured to impose an inwardly directed resilient bias on at least a portion of the exterior of the inflatable balloon. At least part of the resilient tube is secured to one or both of the elongate shaft or the inflatable balloon.

Abstract translation: 膨胀装置（10）包括细长轴（12），可充气气囊（18）和弹性管（50）。 可膨胀气囊沿着轴设置。 弹性管还沿着轴设置并且被定位成包围可充气气囊的至少一部分。 弹性管构造成在可充气气囊的外部的至少一部分上施加向内指向的弹性偏压。 弹性管的至少一部分固定到细长轴或可充气气囊中的一个或两个。

公开(公告)号：WO2014159824A2

公开(公告)日：2014-10-02

申请号：PCT/US2014/025263

申请日：2014-03-13

Applicant: DEPUY SYNTHES PRODUCTS, LLC

Inventor： BORDEAUX, Jean-Noel ,  WAHL, Michael ,  MAUGHAN, Thomas ,  MURRY, Nicole

IPC: A61B17/62

CPC classification number: A61B17/60 ,  A61B17/62 ,  A61B17/64 ,  A61B17/6416 ,  A61B17/6441 ,  A61B17/6466 ,  A61B17/66 ,  A61B2017/606

Abstract: The present application discloses embodiments related to an external bone fixation device configured to correct bone deformities or repair bone injuries. The device can include a plurality of bases configured to be attached to portions of a bone and a plurality of struts configured to be adjustable in length to change the position and orientation of the plurality of bases and the attached bone portions.

Abstract translation: 本申请公开了与被配置为矫正骨畸形或修复骨损伤的外部骨固定装置有关的实施例。 该装置可以包括被配置为附接到骨的部分的多个基部和多个支柱，所述多个支柱被构造成在长度上可调节以改变多个基部和所附接的骨部分的位置和取向。

公开(公告)号：WO2014159183A2

公开(公告)日：2014-10-02

申请号：PCT/US2014/022418

申请日：2014-03-10

Applicant: ETHICON ENDO-SURGERY, INC.

Inventor： LEIMBACH, Richard L. ,  OVERMYER, Mark D. ,  ADAMS, Shane R.

CPC classification number: A61B17/07207 ,  A61B2017/00017 ,  A61B2017/00398 ,  A61B2017/0046 ,  A61B2017/00734 ,  A61B2017/2927 ,  A61B2090/0808

Abstract: Surgical instruments and control systems therefor are disclosed. A surgical instrument can comprise: a power circuit comprising a power source and a switch, a microcontroller coupled to the power circuit, a handle comprising an attachment portion, and a control circuit in signal communication with the microcontroller. The attachment portion can comprise a first electrical contact in signal communication with the microcontroller. The control circuit can comprise a sensor configured to detect an attachment state of the attachment portion. The control circuit can communicate the detected attachment state to the microcontroller, and the microcontroller can ignore signals from the first electrical contact when the control circuit communicates a detached state. The attachment portion can comprise a second electrical contact coupled to a second power circuit, and the second power circuit can decouple the second electrical contact and the second power source when the sensor detects the detached state.

Abstract translation: 公开了外科手术器械及其控制系统。 手术器械可以包括：电源电路，包括电源和开关，耦合到电源电路的微控制器，包括附接部分的手柄以及与微控制器进行信号通信的控制电路。 附接部分可以包括与微控制器进行信号通信的第一电触头。 控制电路可以包括被配置为检测附接部分的附接状态的传感器。 控制电路可以将检测到的附着状态传送到微控制器，并且当控制电路通信分离状态时，微控制器可以忽略来自第一电触点的信号。 附接部分可以包括耦合到第二电源电路的第二电触点，并且当传感器检测到分离状态时，第二电源电路可以解耦第二电触点和第二电源。