公开(公告)号：WO2023068921A1

公开(公告)日：2023-04-27

申请号：PCT/MY2022/000009

申请日：2022-12-08

Applicant: UNIVERSITI MALAYA

Inventor： NURSHAMIMI, Binti Nor Rashid ,  CHEE, Cheok Wui ,  NAJIHAH, Binti Mohd Hashim ,  ROZANA, Binti Othman ,  ISKANDAR, Bin Abdullah ,  CHEE, Chin Fei ,  VANNAJAN, Sanghiran Lee ,  LEE, Yean Kee ,  NOR HISAM, Binti Zamakshshari

IPC: A61K31/122 ,  A61P35/00

Abstract: The present invention disloses anthraquinone compound according to Formula (1) or its pharmaceutical acceptable salts, prodrug and solvates thereof for use in suppressing the expression of mutated KRAS and mutated p53 genes in colorectal cancer cell. In a specific embodiment, the anthraquinone compound according to Formula (1) is also generally named with the chemical compound name of morindone. The anthraquinone compound according to Formula (1) is able to suppress the expression of mutated KRAS and mutated p53 genes of the colorectal cancer cell to prevent the colorectal cancer cells therapies resistance and poor prognosis.

公开(公告)号：WO2020080928A1

公开(公告)日：2020-04-23

申请号：PCT/MY2019/000041

申请日：2019-09-26

Applicant: YY PANG TRADING SDN BHD

Inventor： PANG, Yok You ,  SOONG, Kam Soi

IPC: F02D9/10 ,  B62M7/00

Abstract: The present invention disclosed a throttle body (10) of the motorcycle comprising a throttle body housing (20); a cylinder-shaped valve assemble (30); and a valve cover plate (40). Unlike the conventional throttle body, the invented throttle body (10) is constructed without any shaft or butterfly plate blocking the flow of the air into the engine. The throttle body (10) invented according to the present invention consists of the cylinder-shaped valve assemble (30) that is able to be rotated within throttle body housing (20) between the air flow open and close position. The cylinder-shaped valve assemble (30) further consists of a cylindrical opening (32) which can be fully and widely opened and able to enhance the air flow into the engine and further magnify the engine power.

公开(公告)号：WO2015030569A1

公开(公告)日：2015-03-05

申请号：PCT/MY2014/000205

申请日：2014-06-27

Applicant: UNIVERSITY OF MALAYA

Inventor： PUA, Chang Hong

IPC: H04R23/00 ,  H04B10/80

CPC classification number: H04B10/80 ,  H04R23/008 ,  H04R2410/00

Abstract: An all fibre based optical microphone with dual wavelength fibre laser and fibre laser dynamics operating principles is fabricated according to the present invention to settle the difficulty of sound sensing using optical fibre without any intermediate or diaphragm. The optical microphone developed according to the present invention consists of a Single Mode Fibre (SMF), a 980 nm laser diode, a Wavelength Division Multiplexer (WDM), a single channel SMF output, an Erbium Doped Fibre (EDF), a 1 x 16 Arrayed Waveguide Gratings (AWG) with 16 channels (SMF) output (with jacket) and 2 channels SMF (without jacket) connected to the chosen channels as acoustic waves sensing element. The optical microphone can be used under harsh environment such as high electromagnetic interference especially for medical instruments like Magnetic Resonance Imaging (MRI) and able to bend into any sensor shape to fit in to any position. The optical microphone also can be used as hydrophone as it functions normally even under water.

Abstract translation: 根据本发明制造了具有双波长光纤激光器和光纤激光器动力学工作原理的全光纤式光学麦克风，以解决使用光纤的声音传感的困难，而没有任何中间或隔膜。 根据本发明开发的光学麦克风由单模光纤（SMF），980nm激光二极管，波分复用器（WDM），单通道SMF输出，掺铒光纤（EDF），1× 16声道波导光栅（AWG），16通道（SMF）输出（带护套）和2通道SMF（无夹套）连接到所选通道作为声波感测元件。 光学麦克风可以在诸如磁共振成像（MRI）等医疗器械等恶劣环境恶劣的环境下使用，能够弯曲成任何传感器形状，以适应任何位置。 光学麦克风也可以用作水听器，因为即使在水下也能正常工作。

公开(公告)号：WO2013070060A1

公开(公告)日：2013-05-16

申请号：PCT/MY2012/000271

申请日：2012-11-09

Applicant: UNIVERSITY OF MALAYSIA

Inventor： THONG, Kwai Lin ,  CHUA, Kek Heng

IPC: C12N15/11 ,  C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q2600/16 ,  Y02A50/451 ,  Y02A50/59

Abstract: The present invention discloses a system which consists of 4 pairs of primers that specifically detect Salmonella spp., S. Typhi and S. Paratyphi A with an internal control. The system, when applied in polymerase chain reaction (PCR) under specific conditions, reaction mixture and cycling temperatures produce four bands 784bp, 496bp, 332bp and 187bp. The DNA band 784bp is present in all Salmonella spp., while the bands of 496bp and 332bp are only present in S. Paratyphi A and S. Typhi respectively. An internal amplification control as indicated by the 187bp should be present in all the tests.

Abstract translation: 本发明公开了一种由4对引物组成的系统，其特异性检测沙门氏菌属，伤寒沙门氏菌和副伤寒沙门氏菌A内部对照。 该系统在特定条件下应用于聚合酶链反应（PCR）时，反应混合物和循环温度产生784bp，496bp，332bp和187bp四个条带。 DNA条带784bp存在于所有沙门氏菌属中，而496bp和332bp的条带分别仅存在于副伤寒沙门氏菌和伤寒沙门氏菌中。 所有测试中应存在187bp所示的内部放大控制。

公开(公告)号：WO2015037981A2

公开(公告)日：2015-03-19

申请号：PCT/MY2014/000238

申请日：2014-09-25

Applicant: UNIVERSITY OF MALAYA

Inventor： GHAFOUR, Amouzad Mahdiraji ,  FAISAL, Rafiq Bin Mahamd Adikan

IPC: C03B37/029

CPC classification number: C03B37/02754 ,  C03B2205/08 ,  G01T1/02 ,  G01T5/08

Abstract: The present invention discloses a method of fiber pulling that the output optical fiber can sense radiation dose with very high sensitivity. In a specific embodiment, the method comprising steps of applying temperature with or without vacuum pressure onto a preform during optical fiber fabrication to form collapsed air holes optical fiber. The collapsed or fused area made in the invented fiber increases radiation dose sensitivity. The output fiber is not limited to any specific diameter, shape, single mode or multimode. The method can be applied for any diameter size, any shapes (flat, circle, hollow or solid), single mode, multi-mode and micro structured optical fibers. Also, the method can be used for doped or undoped or combination of them. The invented fiber can be used for detecting irradiation dose using either thermoluminescence or photo luminescence approaches.

Abstract translation: 本发明公开了一种光纤拉制方法，其中输出光纤能够以非常高的灵敏度感测辐射剂量。 在一个具体实施例中，该方法包括以下步骤：在光纤制造期间将具有或不具有真空压力的温度施加到预成型件上以形成折叠气孔光纤。 在本发明的纤维中制成的塌陷或融合区域增加了辐射剂量灵敏度。 输出光纤不限于任何特定的直径，形状，单模或多模。 该方法可应用于任何直径尺寸，任何形状（平面，圆形，空心或实心），单模，多模和微结构光纤。 此外，该方法可用于掺杂或未掺杂或它们的组合。 本发明的纤维可以用于利用热发光或光致发光方法检测照射剂量。

公开(公告)号：WO2013133690A1

公开(公告)日：2013-09-12

申请号：PCT/MY2013/000064

申请日：2013-03-28

Applicant: UNIVERSITY OF MALAYA

Inventor： DHAFER, Abdul-Ameer Shnawah ,  MOHD Faizul Mohd Sabri ,  IRFAN, Anjum Badruddin ,  SUHANA, Binti Mohd Said

IPC: B23K35/26 ,  C22C30/04 ,  B23K35/363

CPC classification number: B23K35/262 ,  C22C13/00

Abstract: A technique to increase the elastic compliance and plastic energy dissipation ability and reduce the aging effect of the low Ag-content Sn-Ag-Cu lead-free solder alloy is disclosed. In this particular exemplary embodiment, the technique may be realized as a Sn-Ag-Cu-Fe composition comprising (0.05-2) wt.% Ag, (0.05-5) wt.% Cu, (0.05-10) wt.% Fe, balanced with Sn.

Abstract translation: 公开了一种增加低Ag含量Sn-Ag-Cu无铅焊料合金的弹性柔量和塑性能量耗散能力以及降低老化效果的技术。 在该特定示例性实施方案中，该技术可以实现为Sn-Ag-Cu-Fe组合物，其包含（0.05-2）重量％Ag，（0.05-5）重量％Cu，（0.05-10）重量％ Fe，与Sn平衡。

公开(公告)号：WO2012021054A2

公开(公告)日：2012-02-16

申请号：PCT/MY2011/000158

申请日：2011-06-28

Applicant: UNIVERSITY OF MALAYA ,  CHUA, Kek Heng ,  LEE, Ping Chin ,  LIM, Ai Lian ,  CHEW, Ching Hoong

Inventor： CHUA, Kek Heng ,  LEE, Ping Chin ,  LIM, Ai Lian ,  CHEW, Ching Hoong

IPC: C12N15/11 ,  C12Q1/68

CPC classification number: C12Q1/6893 ,  C12Q1/686 ,  C12Q2600/16 ,  Y02A50/58 ,  C12Q2537/143

Abstract: This invention discloses obtaining of a multiplex PCR-based detection system targeting 5 types of Plasmodium sepsis ( P. falciparum, P. vivax, P. knowlesi, P. Malariae, P. ovale ). Generally, all novel primers used in the present invention were specially designed using bioinformatics approach. This system involved only 1 step PCR with specific optimized conditions. This PCR-based detection system is sensitive enough to detect particular plasmodium species at low parasitemia level.

Abstract translation: 本发明公开了获得靶向5种类型的疟原虫疟原虫（恶性疟原虫，间日疟原虫，知识产权，P型）的基于多重PCR的检测系统 ，疟疾，卵形疟原虫）。 通常，本发明中使用的所有新型引物都是使用生物信息学方法特别设计的。 该系统仅包含具有特定优化条件的1步PCR。 这种基于PCR的检测系统足够灵敏，可以在低寄生虫血症水平检测特定的疟原虫种类。

公开(公告)号：WO2016117999A1

公开(公告)日：2016-07-28

申请号：PCT/MY2016/000002

申请日：2016-01-20

Applicant: UNIVERSITY OF MALAYA

Inventor： Sh. Mohd Saifuddeen Bin Sh. Mohd Salleh ,  Nur Farhani Binti Zarmani ,  Mohd Anuar Bin Ramli

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q1/6888 ,  C12Q2527/125

Abstract: The present invention disclosed a method to trace porcine DNA in a catgut suture by extracting the DNA from the catgut suture and analyzing the extracted DNA. The method of tracing porcine DNA in a catgut suture comprising steps of: homogenizing the catgut suture into a mixture of plant tissue lysis buffer and proteinase K; separating the DNA from the homogenous solution by using the column; and analyzing the extracted DNA by using polymerase chain reaction, PCR.

Abstract translation: 本发明公开了一种通过从肠缝合线提取DNA并分析提取的DNA来追踪肠道缝线中的猪DNA的方法。 在肠道缝合线中追踪猪DNA的方法包括以下步骤：将肠缝线匀浆成植物组织裂解缓冲液和蛋白酶K的混合物; 通过使用柱分离DNA与均匀溶液; 并通过PCR聚合酶链反应分析提取的DNA。

公开(公告)号：WO2014014337A3

公开(公告)日：2014-01-23

申请号：PCT/MY2013/000121

申请日：2013-06-24

Applicant: UNIVERSITY OF MALAYA

Inventor： TAN, Irene Kit Ping ,  GAN, Seng Neon ,  ANNUAR, Mohamad Suffian Bin Mohamad ,  SIN, Mei Chan

IPC: C12P1/04 ,  C08L27/06 ,  C08L67/00

Abstract: The present invention disclosed a medium-chain-length poly(3 -hydroxy alkanoates) (mcl-PHA) for use as natural based eco-friendly plasticizer for Poly(vinyl chloride) (PVC). In the present invention, mcl-PHA was bio synthesized by Pseudomonas putida PGAl via fermentation using oleic acid and palm kernel oil as renewable carbon source. Mcl-PHA is a source of green natural polymers which can be used to improve material properties of PVC. Compare with the conventional petrochemical based plasticizer, mcl-PHA would not be hazardous to human health and the environment due to the non-toxic, biodegradable and biocompatible properties.

公开(公告)号：WO2013176538A2

公开(公告)日：2013-11-28

申请号：PCT/MY2013/000108

申请日：2013-06-13

Applicant: UNIVERSITY OF MALAYA

Inventor： MADYA, Tunku Kamarul Zaman Tunku Zainol Abidin ,  TAN, Sik Loo

IPC: C12N5/0775 ,  C12N5/02

CPC classification number: C12N5/066 ,  C12N2501/19

Abstract: Tenocytes are highly differentiated cells which have a limited potential for replication. Therefore, in vitro propagation of tenocytes may still not be able to supply enough seed cells for tendon tissue engineering. Bone marrow mesenchymal stem cells (MSCs) are able to self-renew and capable to differentiate into multi lineage including tenocytes. Therefore, it is possible that MSCs could serve as seed cells in tendon tissue engineering. In the present invention, method and culture medium for promoting human bone marrow mesenchymal stem cells (MSCs) differentiation into tenogenic lineage is provided.

Abstract translation: 天细胞是高度分化的细胞，其复制潜力有限。 因此，腱细胞的体外繁殖仍然无法为肌腱组织工程提供足够的种子细胞。 骨髓间充质干细胞（MSC）能够自我更新并能够分化成多系，包括腱细胞。 因此，MSCs可能作为肌腱组织工程中的种子细胞。 在本发明中，提供了促进人骨髓间充质干细胞（MSC）分化为成因谱系的方法和培养基。