Abstract:
The present invention disloses anthraquinone compound according to Formula (1) or its pharmaceutical acceptable salts, prodrug and solvates thereof for use in suppressing the expression of mutated KRAS and mutated p53 genes in colorectal cancer cell. In a specific embodiment, the anthraquinone compound according to Formula (1) is also generally named with the chemical compound name of morindone. The anthraquinone compound according to Formula (1) is able to suppress the expression of mutated KRAS and mutated p53 genes of the colorectal cancer cell to prevent the colorectal cancer cells therapies resistance and poor prognosis.
Abstract:
The present invention relates to a biosensor (100, 200) for detecting and characterising a biological material. The biosensor detects and characterises the biological material based on its electronic properties. The biosensor (100, 200) comprises at least two electrodes (110, 210) disposed on a substrate (120, 220), a supply module, a frequency controller (130, 230) and a measurement module (140, 240). The supply module, frequency controller (130, 230) and measurement module (140, 240) are connected to the at least two electrodes (110, 210).
Abstract:
A three dimensional bio-model for simulating a simulated cranial surgical procedure, the bio-model comprises a synthetic skull layer; a synthetic dura layer under the synthetic skin layer; and a spacer layer between the synthetic skull layer and the synthetic dura layer. The bio-model may be manufactured based on medical image data using three-dimensional printing.
Abstract:
A method of manufacturing a three dimensional bio-model from medical image data is described. The method comprises: identifying a skin layer in the medical image data; determining a thickness of the skin layer; generating three dimensional model data from the medical image data, the three dimensional model data comprising an indication of a synthetic skin layer, the synthetic skin layer comprising a surface layer and a backing layer, wherein a combined thickness of the surface layer and the backing layer is determined from the thickness of the skin layer; and three dimensional printing the three dimensional model data to provide a three dimensional bio-model.
Abstract:
The present invention provides a HMM (Hidden Markov Model) based Malay text to Malay speech synthesis system (100) comprising of a plurality of software modules (105, 110) in the form of computer readable instructions residing in memory (22) of a computer (20) and executed by a central processing unit (CPU) (21) of said computer (20), the system (100) comprising of a training module (105) for the training of a plurality of HMM (Hidden Markov Model) statistical predictive models residing in a statistical parameter model database (113) to generate an acoustic speech model of Malay speech and a synthesizing module (110) for synthesizing Malay speech from a Malay text input string (111) utilizing context dependent labels generated from the Malay text input string (111) and the acoustic model for Malay speech; characterized in that, the speech synthesis module (110) includes a context dependent label generation unit (112) that automatically generates context dependent labels for Malay language from Malay language input text string (111) derived in part from syllabification rules that are exclusive to Malay language.
Abstract:
A bio-model for simulating a surgical procedure comprises a synthetic anatomical structure which has a cavity. A fluid system is coupled to the cavity. In one embodiment the fluid system allows fluid to be pressurized. In one embodiment, the fluid system allows fluid to flow through the cavity. The bio-model may be manufactured based on medical image data using three-dimensional printing.
Abstract:
Disclosed herein is an iron oxide nanoparticle comprising ≥95% magnetite (Fe 3 O 4 ) and having a particle diameter size of from 7 to 27 nm when measured using transmission electron microscopy and a magnetisation strength (Ms) of from 60 to 80 emu/g. Also disclosed herein are coated iron oxide nanoparticles, methods to make said iron oxide nanoparticles and articles containing the same.
Abstract translation:本文公开的是包含≥95%磁铁矿(Fe 3 O 4:4)并且具有7至10μm的粒径的氧化铁纳米颗粒 当使用透射电子显微镜测量时为27nm,磁化强度(Ms)为60至80emu / g。 本文还公开了涂布的氧化铁纳米颗粒,制备所述氧化铁纳米颗粒的方法和包含其的制品。 p>
Abstract:
Disclosed herein is a magnetically detectable glove comprising at least one layer of a polymeric material that includes coated iron oxide nanoparticles, wherein the coated iron oxide nanoparticles are present in an amount of from 5 to 25 per hundred parts of the material, wherein the coated iron oxide nanoparticles are ≥90% magnetite; have a particle diameter size of from 6 to 25 nm; and have a magnetisation strength (Ms) of from 82 to 75 emu/g.
Abstract:
8ABSTRACT WIND TURBINE A dual flow wind turbine is disclosed to harvest wind from two cross axis. The wind5 turbine comprises three vertical airfoil blades [103] driven by two sets of three horizontal airfoil blades [104a, 104b]. The horizontal blades [104a, 104b] serve as radial arms that link the vertical blades [103]. Elbows [102a, 102b] are used to couple horizontal airfoil blades [104a, 104b] to vertical airfoil blades [103]. Each horizontal blade [104a, 104b] is arranged at an upward angle over horizontal plane. Incident10 horizontal wind [303] from any direction can be harvested by vertical blades. Vertical air stream from bottom of turbine [304] can be harvested by horizontal blades [104a, 104b] which improves self-starting capability of turbine. Fig. 5 15
Abstract:
The present invention relates to an apparatus (100) to mount a capillary (200) for use in fabricating a flat microstructured fiber. The apparatus (100) comprises a first member (101) configured for holding a preform (300); and a second member (104) coupled to the first member (101) having an extension (106) extending from the body for engaging a portion of the capillary (200) positioned in the preform (300). The apparatus also comprises a connecting member (103) that couples the first member (101) with the second member (104). The apparatus (100) to mount the capillary (200) is capable to prevent deformation and misalignment of the air holes in the flat microstructured fiber.