公开(公告)号：WO2023068921A1

公开(公告)日：2023-04-27

申请号：PCT/MY2022/000009

申请日：2022-12-08

Applicant: UNIVERSITI MALAYA

Inventor： NURSHAMIMI, Binti Nor Rashid ,  CHEE, Cheok Wui ,  NAJIHAH, Binti Mohd Hashim ,  ROZANA, Binti Othman ,  ISKANDAR, Bin Abdullah ,  CHEE, Chin Fei ,  VANNAJAN, Sanghiran Lee ,  LEE, Yean Kee ,  NOR HISAM, Binti Zamakshshari

IPC: A61K31/122 ,  A61P35/00

Abstract: The present invention disloses anthraquinone compound according to Formula (1) or its pharmaceutical acceptable salts, prodrug and solvates thereof for use in suppressing the expression of mutated KRAS and mutated p53 genes in colorectal cancer cell. In a specific embodiment, the anthraquinone compound according to Formula (1) is also generally named with the chemical compound name of morindone. The anthraquinone compound according to Formula (1) is able to suppress the expression of mutated KRAS and mutated p53 genes of the colorectal cancer cell to prevent the colorectal cancer cells therapies resistance and poor prognosis.