公开(公告)号：WO2008145000A1

公开(公告)日：2008-12-04

申请号：PCT/CN2008/000563

申请日：2008-03-21

Applicant: 中国农业科学院兰州兽医研究所 ,  柳纪省 ,  杨彬 ,  兰喜 ,  殷相平 ,  白银梅 ,  韩晓荣 ,  李学瑞 ,  李宝玉 ,  方玉萍 ,  李志勇

Inventor： 柳纪省 ,  杨彬 ,  兰喜 ,  殷相平 ,  白银梅 ,  韩晓荣 ,  李学瑞 ,  李宝玉 ,  方玉萍 ,  李志勇

IPC: C12N15/85 ,  C12N15/42 ,  A61K39/135 ,  A61P31/14

CPC classification number: A61K39/135 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/552 ,  C12N15/1131 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2770/32134 ,  C12N2830/20 ,  C12N2840/203

Abstract: A foot-and-mouth disease virus double effect vaccine vector and the construction method and uses thereof are disclosed. The foot-and-mouth disease virus double -effective vaccine vector mainly consists of bicistronic expression vector sequence, and it comprises the antisense gene sequence that can bind to 5' non-coding region RNA of foot-and-mouth disease virus genome, and the gene sequence encoding complete VP1 structural protein of foot-and-mouth disease virus. Animal experiment shows that the foot-and-mouth disease virus double effective vaccine has double effects of gene therapy and gene immunization in the prevention and treatment of foot-and-mouth disease in animal.