公开(公告)号：WO2012012595A2

公开(公告)日：2012-01-26

申请号：PCT/US2011/044776

申请日：2011-07-21

Applicant: BECTON, DICKINSON AND COMPANY ,  AAT BIOQUEST, INC. ,  DIWU, Zhenjun ,  MENG, Qinglin ,  LIAO, Jinfang ,  GUO, Haitao ,  DUBROVSKY, Timothy ,  ABRAMS, Barnaby

Inventor： DIWU, Zhenjun ,  MENG, Qinglin ,  LIAO, Jinfang ,  GUO, Haitao ,  DUBROVSKY, Timothy ,  ABRAMS, Barnaby

IPC: C09B11/24 ,  C09B23/00 ,  C09B49/06 ,  G01N33/533

CPC classification number: C09B23/083 ,  C09B11/08 ,  C09B11/24 ,  C09B11/26 ,  C09B57/00 ,  C09B57/10 ,  G01N33/533

Abstract: Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive fluorescent dyes, their biological conjugates and uses.

Abstract translation: 描述了与水溶性桥分子内交联的化学活性染料，它们的生物共轭物及其用途。 具有水溶性桥的反应性荧光染料优于光谱非交联染料的共轭物或与疏水桥交联的染料的那些。 本发明包括反应性荧光染料，它们的生物缀合物和用途。

公开(公告)号：WO2012012595A3

公开(公告)日：2012-04-26

申请号：PCT/US2011044776

申请日：2011-07-21

Applicant: BECTON DICKINSON CO ,  AAT BIOQUEST INC ,  DIWU ZHENJUN ,  MENG QINGLIN ,  LIAO JINFANG ,  GUO HAITAO ,  DUBROVSKY TIMOTHY ,  ABRAMS BARNABY

Inventor： DIWU ZHENJUN ,  MENG QINGLIN ,  LIAO JINFANG ,  GUO HAITAO ,  DUBROVSKY TIMOTHY ,  ABRAMS BARNABY

IPC: C09B11/24 ,  C09B23/00 ,  C09B49/06 ,  G01N33/533

CPC classification number: C09B23/083 ,  C09B11/08 ,  C09B11/24 ,  C09B11/26 ,  C09B57/00 ,  C09B57/10 ,  G01N33/533

Abstract: Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive fluorescent dyes, their biological conjugates and uses.

Abstract translation: 描述了与水溶性桥分子内交联的化学活性染料及其生物共轭物及其用途。 具有水溶性桥梁的活性荧光染料优于光谱非交联染料或与疏水桥交联的染料的共轭物。 本发明包括反应性荧光染料，它们的生物共轭物和用途。