公开(公告)号：WO2020093029A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/059566

申请日：2019-11-01

申请人： ACCUDX CORPORATION

发明人： POTTATHIL, Raveendran ,  DESHMUKH, Sanjay ,  KHARAT, Kiran

IPC分类号： A61K33/24 ,  A61K41/00 ,  C01B31/30

摘要： Provided herein are compositions including biocompatible magnetizeable nanoparticles. The nanoparticles have a diameter (average diameter) from about 10 to about 300 nanometers and are biocompatible and magnetic. The nanoparticles may be a disc formed from iron oxide. The disc may be comjugated to a target-binding moiety capable of binding a target. The target may be cancer cells, pathogens, fat cells, or atherosclerotic plaques.

公开(公告)号：WO2015168342A1

公开(公告)日：2015-11-05

申请号：PCT/US2015/028374

申请日：2015-04-29

申请人： ACCUDX CORPORATION

发明人： POTTATHIL, Raveendran

IPC分类号： C12N15/10

CPC分类号： C12N15/101 ,  B01D15/1871 ,  B01D15/3804 ,  B01L3/5023 ,  B01L9/52 ,  B01L2300/043 ,  B01L2300/048 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2400/0406

摘要： The present disclosure relates to nucleic acid extraction and purification methods and devices to accomplish the same. The present disclosure proposes a novel approach to this problem wherein cell isolation and nucleic acid purification can be integrated in a single "step," by using the same solid phase for both cell adsorption and nucleic acid purification. This is achieved by binding the cells to a solid support as a first step. The same solid support is then used under conditions that lyse the bound cells, and then subsequently enable the nucleic acid to bind to the support. Methods of the present disclosure relate to the isolation of nucleic acid, and especially to a method for isolating DNA from cells, biological or environmental samples using antibiotics, which bind nucleic acids.

摘要翻译： 本公开涉及完成其的核酸提取和纯化方法和装置。 本公开提出了一种新的方法，其中通过使用相同的固相进行细胞吸附和核酸纯化，细胞分离和核酸纯化可以整合在单个“步骤”中。 这是通过将细胞作为第一步骤将细胞结合到固体支持物来实现的。 然后在裂解结合的细胞的条件下使用相同的固体支持物，然后使核酸与载体结合。 本公开的方法涉及核酸的分离，特别是涉及使用结合核酸的抗生素从细胞，生物或环境样品中分离DNA的方法。

公开(公告)号：WO2023049217A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/044295

申请日：2022-09-21

申请人： ACCUDX CORPORATION

发明人： POTTATHIL, Raveendran ,  KHARAT, Kiran

IPC分类号： B01D67/00 ,  B01D61/24 ,  A61M1/16 ,  C08K3/08 ,  C08K5/55 ,  C08L101/00 ,  C08L39/06

摘要： Provided herein are compositions, devices, and methods including nanofiber compositions comprising a polymer and nanoparticles including one or more of nickel, cobalt, silver, and tetraphenylborate, wherein the compositions are capable of binding targets in the blood related to blood disorders symptomatic of kidney disease and/or failure.