公开(公告)号：WO2008051287A2

公开(公告)日：2008-05-02

申请号：PCT/US2007/008731

申请日：2007-04-06

Applicant: AMERIGENICS. INC. ,  BEATTIE, Kenneth, L. ,  TONUCCI, Ronald, J.

Inventor： BEATTIE, Kenneth, L. ,  TONUCCI, Ronald, J.

IPC: G02B6/00

CPC classification number: G01N21/77 ,  G01N21/05 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/7783 ,  Y02A50/51 ,  Y02A50/60

Abstract: Provided herein is a photonic bandgap (PBG) detector effective to detect inorganic molecules, organic biomolecules or biopolymers, cells, subcellular organelles, and particles. The PBG detector utilizes photonic crystals having a binding agent attached to channel surfaces comprising the crystals to selectively bind a molecule, cell or particle of interest so that an increase in light transmission is detectably induced within the photonic bandgap upon binding. Also provided are methods of optically detectiing an analyte and of identifying the presence of a cell or a particle in a biological sample.

Abstract translation: 本文提供了有效检测无机分子，有机生物分子或生物聚合物，细胞，亚细胞细胞器和颗粒的光子带隙（PBG）检测器。 PBG检测器利用光子晶体，其具有连接到包含晶体的通道表面的结合剂，以选择性地结合感兴趣的分子，细胞或颗粒，使得在结合时在光子带隙内可检测地诱导光透射的增加。 还提供了光学检测分析物和鉴定生物样品中细胞或颗粒的存在的方法。