公开(公告)号：WO2006028545A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/021445

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

Inventor： STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是在1位被环状取代基取代的喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘啶），含有化合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005051324A2

公开(公告)日：2005-06-09

申请号：PCT/US2004/039673

申请日：2004-11-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KREPSKI, Larry R., ,  DELLARIA, Joseph F., Jr., ,  DUFFY, Daniel E., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  SQUIRE, David J., ,  MARSZALEK, Gregory J., ,  HEPPNER, Philip D., ,  KSHIRSAGAR, Tushar A.,

Inventor： KREPSKI, Larry R., ,  DELLARIA, Joseph F., Jr., ,  DUFFY, Daniel E., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  SQUIRE, David J., ,  MARSZALEK, Gregory J., ,  HEPPNER, Philip D., ,  KSHIRSAGAR, Tushar A.,

IPC: A61K

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1-位取代的咪唑并喹啉，吡啶和萘啶环体系，含有这些化合物的化合物，中间体和使用方法作为免疫调节剂的药物组合物，用于在动物中诱导细胞因子生物合成和治疗疾病，包括 公开了病毒和肿瘤疾病。

公开(公告)号：WO2010039395A3

公开(公告)日：2010-08-19

申请号：PCT/US2009056180

申请日：2009-09-08

Applicant: 3M INNOVATIVE PROPERTIES CO ,  AMOS DAVID T ,  MORRIS GEOFFREY P

Inventor： AMOS DAVID T ,  MORRIS GEOFFREY P

IPC: A61K6/02 ,  A61K6/083

CPC classification number: A61K6/0023

Abstract: The invention provides an orthodontic composition, related methods and packaged articles that include a hardenable component, a hardener, and a heat-modified inorganic mineral filler. The composition displays improved hardened remnant cleanup compared with compositions using traditional hard mineral fillers, while maintaining acceptable handling, bond strength and mechanical properties. Bond strength enhancement is achieved by heat-modifying a soft mineral filler, a process by which water of hydration is eliminated from the microstructure of the mineral to form a non-hydrated phase. By using heat-modified mineral fillers that are soft relative to human enamel, the hardened orthodontic composition can be conveniently removed using a low-speed abrasive disk or other mild abrasion process that is safer and more comfortable for the patient. The composition is especially beneficial for use in bonding orthodontic appliances to teeth.

Abstract translation: 本发明提供包括可硬化组分，硬化剂和热改性无机矿物填料的正牙组合物，相关方法和包装物品。 与使用传统硬质矿物填料的组合物相比，该组合物显示出改进的硬化残余物清洁，同时保持可接受的处理，粘合强度和机械性能。 通过对软矿物填料进行热改性来实现粘结强度提高，该矿物填料是从矿物的微观结构中消除水合水以形成非水合相的过程。 通过使用相对于人类牙釉质柔软的热改性矿物填料，可以使用低速研磨盘或其他适用于患者更安全和舒适的温和研磨方法来方便地去除硬化的正牙组合物。 该组合物特别有利于将正畸矫正器与牙齿结合。

公开(公告)号：WO2006028545A3

公开(公告)日：2007-08-23

申请号：PCT/US2005021445

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES CO ,  STOERMER DORIS ,  DELLARIA JOSEPH F JR ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  DRESSEL LUKE T ,  BONK JASON D ,  RADMER MATTHEW R

Inventor： STOERMER DORIS ,  DELLARIA JOSEPH F JR ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  DRESSEL LUKE T ,  BONK JASON D ,  RADMER MATTHEW R

IPC: C07D471/14 ,  A61K31/437

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2006107771A2

公开(公告)日：2006-10-12

申请号：PCT/US2006/012031

申请日：2006-03-31

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  MERRILL, Bryon, A. ,  DANIELSON, Michael, E. ,  HAYS, David, S. ,  AMOS, David, T. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  MOSER, William, H.

Inventor： MERRILL, Bryon, A. ,  DANIELSON, Michael, E. ,  HAYS, David, S. ,  AMOS, David, T. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  MOSER, William, H.

IPC: A61K31/4745 ,  C07D471/14

CPC classification number: C07D471/04

Abstract: Pyrazolo[3,4- c ]quinolines, pyrazolo[4,5- c ]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4- c ]quinolines, and, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inhibiting cytokine biosynthesis in animals and in the therapeutic or prophylactic treatment of diseases by inhibiting cytokine biosynthesis are disclosed.

Abstract translation: 吡唑并[3,4-c]喹啉，吡唑并[4,5-c]萘啶及其类似物，例如6,7,8,9-四氢吡唑并[3,4-c]喹啉，以及药物组合物 公开了含有化合物，中间体，制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于抑制动物中的细胞因子生物合成以及通过抑制细胞因子生物合成来治疗或预防性治疗疾病。

公开(公告)号：WO2006038923A3

公开(公告)日：2006-06-01

申请号：PCT/US2005021436

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES CO ,  NIWAS SHRI ,  MERRILL BRYON A ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  LINDSTROM KYLE J

Inventor： NIWAS SHRI ,  MERRILL BRYON A ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  LINDSTROM KYLE J

IPC: A61K31/44 ,  C07D471/04 ,  C07D471/06

CPC classification number: C07D471/14

Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 公开了用芳基取代基取代的咪唑并萘啶环系统，含有该化合物的药物组合物，以及将这些化合物用作免疫调节剂的方法，用于在动物中诱导细胞因子生物合成以及治疗疾病，包括病毒和肿瘤疾病。

公开(公告)号：WO2005051317A3

公开(公告)日：2006-05-11

申请号：PCT/US2004039512

申请日：2004-11-24

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  RADMER MATTHEW R ,  AMOS DAVID T

Inventor： KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  RADMER MATTHEW R ,  AMOS DAVID T

IPC: A61K20060101 ,  A61K31/4745 ,  A61P37/00 ,  C07D213/74 ,  C07D221/00 ,  C07D235/00 ,  C07D471/02 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D213/74 ,  C07D255/02 ,  C07D471/14

Abstract: Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位置取代的咪唑环体系，含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病 疾病被披露。

公开(公告)号：WO2005018551A3

公开(公告)日：2006-05-11

申请号：PCT/US2004026065

申请日：2004-08-12

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  HEPPNER PHILIP D ,  LANGER SCOTT E ,  ZIMMERMANN BERNHARD M

Inventor： KSHIRSAGAR TUSHAR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  HEPPNER PHILIP D ,  LANGER SCOTT E ,  ZIMMERMANN BERNHARD M

IPC: A61K20060101 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4745 ,  A61P31/12 ,  A61P37/02 ,  C07D471/04 ,  C07D471/14 ,  C07D471/12

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位具有肟取代基的含咪唑的化合物（例如咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法用于在动物中诱导细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：WO2006038923A2

公开(公告)日：2006-04-13

申请号：PCT/US2005/021436

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  NIWAS, Shri ,  MERRILL, Bryon, A. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  LINDSTROM, Kyle, J.

Inventor： NIWAS, Shri ,  MERRILL, Bryon, A. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  LINDSTROM, Kyle, J.

IPC: A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/14

Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 公开了用芳基取代基取代的咪唑并萘啶环体系，含有这些化合物的药物组合物，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2006029115A2

公开(公告)日：2006-03-16

申请号：PCT/US2005031616

申请日：2005-09-01

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  LANGER SCOTT E ,  NIWAS SHRI ,  HEPPNER PHILIP D ,  AMOS DAVID T

Inventor： KSHIRSAGAR TUSHAR A ,  LANGER SCOTT E ,  NIWAS SHRI ,  HEPPNER PHILIP D ,  AMOS DAVID T

IPC: A61K31/4172

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: 1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 在2-位具有氨基取代基的1H-咪唑环体系（例如咪唑并吡啶，咪唑并喹啉，咪唑并吡啶，6,7,8,9-四氢咪唑并喹啉和咪唑并吡啶），含这些化合物的药物组合物，制备化合物的方法，中间体 ，以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。